Baker Bros. Advisors Lp - Insider Trading Tracker

ACADIA Pharmaceuticals Inc.

US ˙ NasdaqGS ˙ US0042251084

Introdução

Esta página fornece uma análise abrangente do histórico conhecido de negociações internas de Baker Bros. Advisors Lp. Insiders são oficiais, diretores ou investidores significativos em uma empresa. É ilegal para insiders realizarem negociações em suas próprias empresas baseados em informações específicas, não públicas. Isso não significa que seja ilegal para eles realizarem qualquer negociação em suas próprias empresas. No entanto, eles devem reportar todas as negociações à SEC através de um Formulário 4. Apesar dessas restrições, pesquisas acadêmicas sugerem que insiders - em geral - tendem a superar o mercado em suas próprias empresas.

Rentabilidade Média de Negociação

A rentabilidade média de negociação é o retorno médio de todas as compras de mercado abertas feitas pelo insider nos últimos três anos. Para calcular isso, examinamos cada compra de mercado aberto, não planejada, feita pelo insider, excluindo todas as negociações que foram marcadas como parte de um plano de negociação 10b5-1. Em seguida, calculamos o desempenho médio dessas negociações ao longo de 3, 6 e 12 meses, fazendo a média de cada uma dessas durações para gerar uma métrica de desempenho final para cada negociação. Finalmente, fazemos a média de todas as métricas de desempenho para calcular uma métrica de desempenho para o insider. Esta lista inclui apenas insiders que fizeram pelo menos três negociações nos últimos dois anos.

Se a rentabilidade de negociação deste insider é "N/A", então o insider ou não fez quaisquer compras de mercado aberto nos últimos três anos, ou as negociações que eles fizeram são muito recentes para calcular uma métrica de desempenho confiável.

Frequência de Atualização: Diariamente

Veja a lista dos negociantes internos mais rentáveis.

Veja os Insiders com Maior Classificação

Empresas com Posições Internas Reportadas

As declarações à SEC indicam que Baker Bros. Advisors Lp reportou posses ou negociações nas seguintes empresas:

Ativo	Título	Últimas Posições Reportadas
US:DNLI / Denali Therapeutics Inc.	Director	3,422,366
US:KNSA / Kiniksa Pharmaceuticals International, plc	Director	2,744,894
US:ACAD / ACADIA Pharmaceuticals Inc.	Director, 10% Owner	39,384,587
US:ONC / BeOne Medicines AG - Depositary Receipt (Common Stock)	Director	142,570
US:INCY / Incyte Corporation	Director, 10% Owner	28,203,718
US:BCYC / Bicycle Therapeutics plc - Depositary Receipt (Common Stock)	Director, 10% Owner	10,018,674
US:KOD / Kodiak Sciences Inc.	Director, 10% Owner	18,358,772
US:KYMR / Kymera Therapeutics, Inc.	Director, 10% Owner	7,955,916
US:TRDA / Entrada Therapeutics, Inc.	10% Owner	4,691,392
US:KALA / KALA BIO, Inc.		425,006
US:CELC / Celcuity Inc.	10% Owner	7,211,484
US:VTVT / vTv Therapeutics Inc.	Director	135,946
US:MDGL / Madrigal Pharmaceuticals, Inc.	Director	1,859,091
US:IGMS / IGM Biosciences, Inc.		0
US:IMCR / Immunocore Holdings plc - Depositary Receipt (Common Stock)	Director	2,144,060
US:REPL / Replimune Group, Inc.	Director, 10% Owner	929,241
US:SERA / Sera Prognostics, Inc.	10% Owner	432,434
US:SGEN / Seagen Inc	Director	0
US:BLCM / Bellicum Pharmaceuticals, Inc.	10% Owner	2,168,818
US:BCEL / Atreca, Inc.		2,971,128
US:NLTX / Neoleukin Therapeutics, Inc.	Director, 10% Owner	1,658,190
US:DBVT / DBV Technologies S.A. - Depositary Receipt (Common Stock)	Director, 10% Owner	14,575,984
US:TCRX / TScan Therapeutics, Inc.	Director, 10% Owner	2,528,583
US:TLIS / Talis Biomedical Corporation	Director, 10% Owner	7,053,176
US:PRLD / Prelude Therapeutics Incorporated	Director, 10% Owner	23,344
US:AGLE / Aeglea BioTherapeutics Inc	Director	40,000
US:US00C4W3Z001 / Alexion Pharmaceuticals, Inc.	Director	7,846,213
US:ZYME / Zymeworks Inc.	Director	9,000
US:GHDX / Genomic Health, Inc.	Director, 10% Owner	7,642,042
US:IDRA / Idera Pharmaceuticals, Inc.	10% Owner	4,290,995
US:HOOK / HOOKIPA Pharma Inc.		529,758
US:NVTA / Invitae Corporation	10% Owner	7,480,182
US:MRTX / Mirati Therapeutics, Inc.		1,618,684
US:RYTM / Rhythm Pharmaceuticals, Inc.		0
US:BCRX / BioCryst Pharmaceuticals, Inc.	10% Owner	9,418,390
US:NTLA / Intellia Therapeutics, Inc.		0
US:XOMA / XOMA Royalty Corporation		90,538
US:GEVA / Synageva Biopharma Corp		0
US:RDEA / Ardea Biosciences, Inc.	Director, 10% Owner	0

Como Interpretar os Gráficos

Os gráficos a seguir mostram o desempenho das ações dos a ativos ubsequentes a cada transação de mercado aberto, não planejada feita por Baker Bros. Advisors Lp. Transações não planejadas são negociações que não foram feitas como parte de um plano de negociação 10b5-1. O desempenho das ações é representado como mudança percentual cumulativa no preço das ações. Por exemplo, se uma transação interna foi feita em 1 de janeiro de 2019, o gráfico mostrará a mudança percentual diária da segurança até o dia presente. Se o preço da ação passasse de $10 para $15 durante este período, a mudança percentual cumulativa no preço das ações seria de 50%. Uma mudança no preço de $10 para $20 seria de 100%, e uma mudança no preço de $10 para $5 seria de -50%.

Ultimamente, estamos tentando determinar quão estreitamente as negociações do interno correlacionam-se a retornos excessivos (positivos ou negativos) no preço da ação para ver se o interno está cronometrando suas transações para lucrar com informações internas. Considere a situação onde um interno estava fazendo isso. Nesta situação, esperaríamos (a) retornos positivos após compras, ou (b) retornos negativos após vendas. No caso de (a), o gráfico de COMPRA mostraria uma série de curvas ascendentes, indicando retornos positivos após cada transação de compra. No caso de (b), o gráfico de VENDA mostraria uma série de curvas descendentes, indicando retornos negativos após cada transação de venda.

No entanto, isso sozinho não é suficiente para tirar conclusões. Se, por exemplo, o preço da ação da empresa estivesse em uma escalada não cíclica ao longo de muitos anos, então esperaríamos que todos os gráficos pós-compra tivessem uma inclinação ascendente. Da mesma forma, declínios não cíclicos ao longo de muitos anos resultariam em gráficos pós-negociação inclinados para baixo. Nenhum desses gráficos sugeriria atividade de negociação interna.

O indicador mais forte seria uma situação em que o preço da ação fosse extremamente cíclico, e houvesse sinais positivos no gráfico de COMPRA e gráficos negativos no gráfico de VENDA. Esta situação seria altamente sugestiva de um interno que estava cronometrando transações para sua vantagem financeira.

Compras Internas ACAD / ACADIA Pharmaceuticals Inc. - Análise de Lucro de Curto Prazo

Nesta seção, analisamos a lucratividade de cada compra interna de mercado aberto, não planejada, feita em ACAD / ACADIA Pharmaceuticals Inc.. Esta análise ajuda a entender se o interno gera consistentemente retornos anormais, e vale a pena seguir. Esta análise é para um ano seguinte a cada transação, e os resultados são teóricos.

A tabela a seguir mostra as compras de mercado aberto mais recentes que não faziam parte de um plano de negociação automático.

Data de Negociação	Ticker	Insider	Ações Reportadas	Preço Reportado	Ações Ajustadas	Preço Ajustado	Base de Custos	Dias para Máx	Preço em Máx	Lucro Máx ($)	Retorno Máx (%)
2023-05-24	ACAD	BAKER BROS. ADVISORS LP	20,304	25.2723	20,304	25.2723	513,129	54	33.4650	166,345	32.42
2023-05-24	ACAD	BAKER BROS. ADVISORS LP	218,171	25.2723	218,171	25.2723	5,513,683
2023-05-24	ACAD	BAKER BROS. ADVISORS LP	2,688	25.5138	2,688	25.5138	68,581
2023-05-24	ACAD	BAKER BROS. ADVISORS LP	28,878	25.5138	28,878	25.5138	736,788
2023-05-24	ACAD	BAKER BROS. ADVISORS LP	24,113	25.6500	24,113	25.6500	618,498
2023-05-24	ACAD	BAKER BROS. ADVISORS LP	259,109	25.6500	259,109	25.6500	6,646,146
2023-05-23	ACAD	BAKER BROS. ADVISORS LP	10,858	25.3302	10,858	25.3302	275,035
2023-05-23	ACAD	BAKER BROS. ADVISORS LP	116,672	25.3302	116,672	25.3302	2,955,325
2023-05-23	ACAD	BAKER BROS. ADVISORS LP	6,941	25.5400	6,941	25.5400	177,273
2023-05-23	ACAD	BAKER BROS. ADVISORS LP	74,582	25.5400	74,582	25.5400	1,904,824
2023-05-22	ACAD	BAKER BROS. ADVISORS LP	7,645	24.4604	7,645	24.4604	187,000
2023-05-22	ACAD	BAKER BROS. ADVISORS LP	82,148	24.4604	82,148	24.4604	2,009,373
2023-05-22	ACAD	BAKER BROS. ADVISORS LP	3,781	24.8000	3,781	24.8000	93,769
2023-05-22	ACAD	BAKER BROS. ADVISORS LP	40,632	24.8000	40,632	24.8000	1,007,674
2020-03-18	ACAD	BAKER BROS. ADVISORS LP	25	31.9350	25	31.9350	798
2020-03-18	ACAD	BAKER BROS. ADVISORS LP	275	31.9350	275	31.9350	8,782
2020-03-18	ACAD	BAKER BROS. ADVISORS LP	4,175	32.6072	4,175	32.6072	136,135
2020-03-18	ACAD	BAKER BROS. ADVISORS LP	46,225	32.6072	46,225	32.6072	1,507,268
2020-03-18	ACAD	BAKER BROS. ADVISORS LP	199	32.8498	199	32.8498	6,537
2020-03-18	ACAD	BAKER BROS. ADVISORS LP	2,201	32.8498	2,201	32.8498	72,302
2020-03-18	ACAD	BAKER BROS. ADVISORS LP	3,023	33.6321	3,023	33.6321	101,670
2020-03-18	ACAD	BAKER BROS. ADVISORS LP	33,464	33.6321	33,464	33.6321	1,125,465
2020-03-18	ACAD	BAKER BROS. ADVISORS LP	3,837	34.4665	3,837	34.4665	132,248
2020-03-18	ACAD	BAKER BROS. ADVISORS LP	42,473	34.4665	42,473	34.4665	1,463,896
2020-03-17	ACAD	BAKER BROS. ADVISORS LP	353	30.9955	353	30.9955	10,941
2020-03-17	ACAD	BAKER BROS. ADVISORS LP	3,913	30.9955	3,913	30.9955	121,285
2020-03-17	ACAD	BAKER BROS. ADVISORS LP	3,903	31.7356	3,903	31.7356	123,864
2020-03-17	ACAD	BAKER BROS. ADVISORS LP	43,212	31.7356	43,212	31.7356	1,371,359
2020-03-17	ACAD	BAKER BROS. ADVISORS LP	688	31.8300	688	31.8300	21,899
2020-03-17	ACAD	BAKER BROS. ADVISORS LP	7,612	31.8300	7,612	31.8300	242,290
2020-03-17	ACAD	BAKER BROS. ADVISORS LP	2,676	32.1908	2,676	32.1908	86,143
2020-03-17	ACAD	BAKER BROS. ADVISORS LP	29,624	32.1908	29,624	32.1908	953,620
2020-03-17	ACAD	BAKER BROS. ADVISORS LP	2,188	32.3194	2,188	32.3194	70,715
2020-03-17	ACAD	BAKER BROS. ADVISORS LP	24,223	32.3194	24,223	32.3194	782,873
2020-03-17	ACAD	BAKER BROS. ADVISORS LP	8,402	33.8624	8,402	33.8624	284,512
2020-03-17	ACAD	BAKER BROS. ADVISORS LP	93,006	33.8624	93,006	33.8624	3,149,406
2020-03-16	ACAD	BAKER BROS. ADVISORS LP	497	31.1853	497	31.1853	15,499
2020-03-16	ACAD	BAKER BROS. ADVISORS LP	5,503	31.1853	5,503	31.1853	171,613
2020-03-16	ACAD	BAKER BROS. ADVISORS LP	57,022	31.5136	57,022	31.5136	1,796,968
2020-03-16	ACAD	BAKER BROS. ADVISORS LP	631,281	31.5136	631,281	31.5136	19,893,937
2019-09-20	ACAD	BAKER BROS. ADVISORS LP	68,475	40.0000	68,475	40.0000	2,739,000
2019-09-20	ACAD	BAKER BROS. ADVISORS LP	1,494,025	40.0000	1,494,025	40.0000	59,761,000
2018-11-30	ACAD	BAKER BROS. ADVISORS LP	585,882	17.0000	585,882	17.0000	9,959,994
2018-11-30	ACAD	BAKER BROS. ADVISORS LP	11,178,823	17.0000	11,178,823	17.0000	190,039,991
2018-09-20	ACAD	BAKER BROS. ADVISORS LP	102,267	18.6366	102,267	18.6366	1,905,909
2018-09-20	ACAD	BAKER BROS. ADVISORS LP	920,495	18.6366	920,495	18.6366	17,154,897
2018-09-20	ACAD	BAKER BROS. ADVISORS LP	4,245	19.0110	4,245	19.0110	80,702
2018-09-20	ACAD	BAKER BROS. ADVISORS LP	38,207	19.0110	38,207	19.0110	726,353
2018-09-20	ACAD	BAKER BROS. ADVISORS LP	14,555	19.0924	14,555	19.0924	277,890
2018-09-20	ACAD	BAKER BROS. ADVISORS LP	131,007	19.0924	131,007	19.0924	2,501,238
2016-08-10	ACAD	BAKER BROS. ADVISORS LP	133,153	33.0000	133,153	33.0000	4,394,049
2016-08-10	ACAD	BAKER BROS. ADVISORS LP	1,169,877	33.0000	1,169,877	33.0000	38,605,941
2016-04-01	ACAD	BAKER BROS. ADVISORS LP	1,182	27.8202	1,182	27.8202	32,883
2016-04-01	ACAD	BAKER BROS. ADVISORS LP	10,818	27.8202	10,818	27.8202	300,959
2016-04-01	ACAD	BAKER BROS. ADVISORS LP	28,647	28.5484	28,647	28.5484	817,826
2016-04-01	ACAD	BAKER BROS. ADVISORS LP	262,253	28.5484	262,253	28.5484	7,486,904
2016-03-31	ACAD	BAKER BROS. ADVISORS LP	1,614	25.6070	1,614	25.6070	41,330
2016-03-31	ACAD	BAKER BROS. ADVISORS LP	14,775	25.6070	14,775	25.6070	378,343
2016-03-31	ACAD	BAKER BROS. ADVISORS LP	1,467	26.2850	1,467	26.2850	38,560
2016-03-31	ACAD	BAKER BROS. ADVISORS LP	13,433	26.2850	13,433	26.2850	353,086
2016-03-31	ACAD	BAKER BROS. ADVISORS LP	19,676	26.4944	19,676	26.4944	521,304
2016-03-31	ACAD	BAKER BROS. ADVISORS LP	180,122	26.4944	180,122	26.4944	4,772,224
2016-03-31	ACAD	BAKER BROS. ADVISORS LP	3,106	26.5545	3,106	26.5545	82,478
2016-03-31	ACAD	BAKER BROS. ADVISORS LP	28,433	26.5545	28,433	26.5545	755,024
2016-03-31	ACAD	BAKER BROS. ADVISORS LP	6,618	27.5588	6,618	27.5588	182,384
2016-03-31	ACAD	BAKER BROS. ADVISORS LP	60,587	27.5588	60,587	27.5588	1,669,705
2016-03-31	ACAD	BAKER BROS. ADVISORS LP	34,844	27.7173	34,844	27.7173	965,782
2016-03-31	ACAD	BAKER BROS. ADVISORS LP	318,969	27.7173	318,969	27.7173	8,840,959
2016-03-30	ACAD	BAKER BROS. ADVISORS LP	408,607	25.9247	408,607	25.9247	10,593,014
2016-03-30	ACAD	BAKER BROS. ADVISORS LP	37,882	25.9750	37,882	25.9750	983,985
2016-03-30	ACAD	BAKER BROS. ADVISORS LP	16,057	26.3472	16,057	26.3472	423,057
2016-01-07	ACAD	BAKER BROS. ADVISORS LP	785,045	29.0000	785,045	29.0000	22,766,305
2016-01-07	ACAD	BAKER BROS. ADVISORS LP	1,801,161	29.0000	1,801,161	29.0000	52,233,669
2014-03-05	ACAD	BAKER BROS. ADVISORS LP	38,934	28.5000	38,934	28.5000	1,109,619
2014-03-05	ACAD	BAKER BROS. ADVISORS LP	475,644	28.5000	475,644	28.5000	13,555,854
2014-03-05	ACAD	BAKER BROS. ADVISORS LP	11,738	28.5000	11,738	28.5000	334,533
2013-06-05	ACAD	BAKER FELIX	26,577	14.4565	26,577	14.4565	384,210
2013-06-05	ACAD	BAKER FELIX	217,986	14.4565	217,986	14.4565	3,151,315
2013-06-05	ACAD	BAKER FELIX	5,437	14.4565	5,437	14.4565	78,600
2013-06-05	ACAD	BAKER FELIX	21,080	14.5838	21,080	14.5838	307,427
2013-06-05	ACAD	BAKER FELIX	172,893	14.5838	172,893	14.5838	2,521,437
2013-06-05	ACAD	BAKER FELIX	4,312	14.5838	4,312	14.5838	62,885
2013-06-05	ACAD	BAKER FELIX	18,530	14.5502	18,530	14.5502	269,615
2013-06-05	ACAD	BAKER FELIX	151,980	14.5502	151,980	14.5502	2,211,339
2013-06-05	ACAD	BAKER FELIX	3,790	14.5502	3,790	14.5502	55,145
2013-06-05	ACAD	BAKER FELIX	26,577	14.4641	26,577	14.4641	384,412
2013-06-05	ACAD	BAKER FELIX	217,986	14.4641	217,986	14.4641	3,152,971
2013-06-05	ACAD	BAKER FELIX	5,437	14.4641	5,437	14.4641	78,641
2013-06-04	ACAD	BAKER FELIX	4,353	14.4977	4,353	14.4977	63,108
2013-06-04	ACAD	BAKER FELIX	35,702	14.4977	35,702	14.4977	517,597
2013-06-04	ACAD	BAKER FELIX	890	14.4977	890	14.4977	12,903
2013-06-04	ACAD	BAKER FELIX	56,475	14.4525	56,475	14.4525	816,205
2013-06-04	ACAD	BAKER FELIX	463,197	14.4525	463,197	14.4525	6,694,355
2013-06-04	ACAD	BAKER FELIX	11,552	14.4525	11,552	14.4525	166,955
2013-06-04	ACAD	BAKER FELIX	13,566	14.4159	13,566	14.4159	195,566
2013-06-04	ACAD	BAKER FELIX	111,266	14.4159	111,266	14.4159	1,604,000
2013-06-04	ACAD	BAKER FELIX	2,775	14.4159	2,775	14.4159	40,004
2013-06-03	ACAD	BAKER FELIX	56,274	14.0822	56,274	14.0822	792,462
2013-06-03	ACAD	BAKER FELIX	461,548	14.0822	461,548	14.0822	6,499,611
2013-06-03	ACAD	BAKER FELIX	11,511	14.0822	11,511	14.0822	162,100
2013-06-03	ACAD	BAKER FELIX	25,368	13.9990	25,368	13.9990	355,127
2013-06-03	ACAD	BAKER FELIX	208,063	13.9990	208,063	13.9990	2,912,674
2013-06-03	ACAD	BAKER FELIX	5,189	13.9990	5,189	13.9990	72,641
2013-05-15	ACAD	BAKER FELIX	218,846	12.5000	218,846	12.5000	2,735,575
2013-05-15	ACAD	BAKER FELIX	1,730,970	12.5000	1,730,970	12.5000	21,637,125
2013-05-15	ACAD	BAKER FELIX	43,184	12.5000	43,184	12.5000	539,800

O Preço Ajustado é o preço ajustado pela divisão. Ações Ajustadas são as ações ajustadas pela divisão.

Vendas Internas ACAD / ACADIA Pharmaceuticals Inc. - Análise de Perda de Curto Prazo

Nesta seção, analisamos a evitação de perdas de curto prazo de cada venda interna de mercado aberto, não planejada feita em ACAD / ACADIA Pharmaceuticals Inc.. Um padrão consistente de evitação de perdas pode sugerir que transações futuras de venda possam prever declínios no preço. Esta análise é para um ano seguinte a cada transação, e os resultados são teóricos.

A tabela a seguir mostra as vendas de mercado aberto mais recentes que não faziam parte de um plano de negociação automático.

Data de Negociação Ticker Insider Ações
Reportadas Preço
Reportado Ações
Ajustadas Preço
Ajustado Base de Custos Dias para
Mín Preço em
Mín Máxima Perda
Evitada ($) Máxima Perda
Evitada (%)

Não há negociações abertas de mercado não planejadas conhecidas para esta combinação de insider e ativo

O Preço Ajustado é o preço ajustado pela divisão. Ações Ajustadas são as ações ajustadas pela divisão.

Compras Internas BCRX / BioCryst Pharmaceuticals, Inc. - Análise de Lucro de Curto Prazo

Nesta seção, analisamos a lucratividade de cada compra interna de mercado aberto, não planejada, feita em ACAD / ACADIA Pharmaceuticals Inc.. Esta análise ajuda a entender se o interno gera consistentemente retornos anormais, e vale a pena seguir. Esta análise é para um ano seguinte a cada transação, e os resultados são teóricos.

A tabela a seguir mostra as compras de mercado aberto mais recentes que não faziam parte de um plano de negociação automático.

Data de Negociação Ticker Insider Ações
Reportadas Preço
Reportado Ações
Ajustadas Preço
Ajustado Base de Custos Dias para
Máx Preço em
Máx Lucro
Máx ($) Retorno Máx (%)

2016-02-05 BCRX BAKER BROS. ADVISORS LP 45,000 6.3257 45,000 6.3257 284,656 336 7.13 36,194 12.71

2016-02-04 BCRX BAKER BROS. ADVISORS LP 24,800 6.6498 24,800 6.6498 164,915

2016-02-03 BCRX BAKER BROS. ADVISORS LP 91,187 6.2872 91,187 6.2872 573,311

2016-02-02 BCRX BAKER BROS. ADVISORS LP 91,728 6.5232 91,728 6.5232 598,360

2016-01-28 BCRX BAKER BROS. ADVISORS LP 25,000 6.8806 25,000 6.8806 172,015

2016-01-27 BCRX BAKER BROS. ADVISORS LP 63,345 6.9772 63,345 6.9772 441,971

2016-01-22 BCRX BAKER BROS. ADVISORS LP 3,200 6.9966 3,200 6.9966 22,389

2016-01-21 BCRX BAKER BROS. ADVISORS LP 103,600 7.2912 103,600 7.2912 755,368

2016-01-20 BCRX BAKER BROS. ADVISORS LP 51,370 6.8712 51,370 6.8712 352,974

2016-01-20 BCRX BAKER BROS. ADVISORS LP 1,325 6.9415 1,325 6.9415 9,197

2016-01-19 BCRX BAKER BROS. ADVISORS LP 92,200 7.1231 92,200 7.1231 656,750

2016-01-15 BCRX BAKER BROS. ADVISORS LP 175,000 7.4508 175,000 7.4508 1,303,890

2016-01-15 BCRX BAKER BROS. ADVISORS LP 25,000 7.4933 25,000 7.4933 187,332

2013-08-01 BCRX BAKER FELIX 120,498 4.4000 120,498 4.4000 530,191

2013-08-01 BCRX BAKER FELIX 991,161 4.4000 991,161 4.4000 4,361,108

2013-08-01 BCRX BAKER FELIX 24,705 4.4000 24,705 4.4000 108,702

O Preço Ajustado é o preço ajustado pela divisão. Ações Ajustadas são as ações ajustadas pela divisão.

Vendas Internas BCRX / BioCryst Pharmaceuticals, Inc. - Análise de Perda de Curto Prazo

Nesta seção, analisamos a evitação de perdas de curto prazo de cada venda interna de mercado aberto, não planejada feita em ACAD / ACADIA Pharmaceuticals Inc.. Um padrão consistente de evitação de perdas pode sugerir que transações futuras de venda possam prever declínios no preço. Esta análise é para um ano seguinte a cada transação, e os resultados são teóricos.

A tabela a seguir mostra as vendas de mercado aberto mais recentes que não faziam parte de um plano de negociação automático.

Data de Negociação Ticker Insider Ações
Reportadas Preço
Reportado Ações
Ajustadas Preço
Ajustado Base de Custos Dias para
Mín Preço em
Mín Máxima Perda
Evitada ($) Máxima Perda
Evitada (%)

2016-08-16 BCRX BAKER BROS. ADVISORS LP 140 4.2887 140 4.2887 600 79 3.76 -74 -12.27

2016-08-16 BCRX BAKER BROS. ADVISORS LP 850 4.2887 850 4.2887 3,645

2016-08-15 BCRX BAKER BROS. ADVISORS LP 56,417 4.8276 56,417 4.8276 272,359

2016-08-15 BCRX BAKER BROS. ADVISORS LP 343,583 4.8276 343,583 4.8276 1,658,681

2016-08-12 BCRX BAKER BROS. ADVISORS LP 465,439 5.0000 465,439 5.0000 2,327,195

2016-08-12 BCRX BAKER BROS. ADVISORS LP 2,834,561 5.0000 2,834,561 5.0000 14,172,805

2016-08-12 BCRX BAKER BROS. ADVISORS LP 48,744 5.2541 48,744 5.2541 256,106

2016-08-12 BCRX BAKER BROS. ADVISORS LP 296,856 5.2541 296,856 5.2541 1,559,711

O Preço Ajustado é o preço ajustado pela divisão. Ações Ajustadas são as ações ajustadas pela divisão.

Compras Internas BCYC / Bicycle Therapeutics plc - Depositary Receipt (Common Stock) - Análise de Lucro de Curto Prazo

Nesta seção, analisamos a lucratividade de cada compra interna de mercado aberto, não planejada, feita em ACAD / ACADIA Pharmaceuticals Inc.. Esta análise ajuda a entender se o interno gera consistentemente retornos anormais, e vale a pena seguir. Esta análise é para um ano seguinte a cada transação, e os resultados são teóricos.

A tabela a seguir mostra as compras de mercado aberto mais recentes que não faziam parte de um plano de negociação automático.

Data de Negociação Ticker Insider Ações
Reportadas Preço
Reportado Ações
Ajustadas Preço
Ajustado Base de Custos Dias para
Máx Preço em
Máx Lucro
Máx ($) Retorno Máx (%)

2024-12-16 BCYC BAKER BROS. ADVISORS LP 42,369 15.3418 42,369 15.3418 650,017 2 15.3150 -1,135 -0.17

2024-12-16 BCYC BAKER BROS. ADVISORS LP 457,631 15.3418 457,631 15.3418 7,020,883

2024-12-13 BCYC BAKER BROS. ADVISORS LP 2,809 13.4979 2,809 13.4979 37,916

2024-12-13 BCYC BAKER BROS. ADVISORS LP 30,241 13.4979 30,241 13.4979 408,190

2024-12-13 BCYC BAKER BROS. ADVISORS LP 5,573 13.6288 5,573 13.6288 75,953

2024-12-13 BCYC BAKER BROS. ADVISORS LP 59,995 13.6288 59,995 13.6288 817,660

2024-12-13 BCYC BAKER BROS. ADVISORS LP 22,722 13.7242 22,722 13.7242 311,841

2024-12-13 BCYC BAKER BROS. ADVISORS LP 244,587 13.7242 244,587 13.7242 3,356,761

2024-12-13 BCYC BAKER BROS. ADVISORS LP 52,656 13.8040 52,656 13.8040 726,863

2024-12-13 BCYC BAKER BROS. ADVISORS LP 566,814 13.8040 566,814 13.8040 7,824,300

O Preço Ajustado é o preço ajustado pela divisão. Ações Ajustadas são as ações ajustadas pela divisão.

Vendas Internas BCYC / Bicycle Therapeutics plc - Depositary Receipt (Common Stock) - Análise de Perda de Curto Prazo

Nesta seção, analisamos a evitação de perdas de curto prazo de cada venda interna de mercado aberto, não planejada feita em ACAD / ACADIA Pharmaceuticals Inc.. Um padrão consistente de evitação de perdas pode sugerir que transações futuras de venda possam prever declínios no preço. Esta análise é para um ano seguinte a cada transação, e os resultados são teóricos.

A tabela a seguir mostra as vendas de mercado aberto mais recentes que não faziam parte de um plano de negociação automático.

Data de Negociação Ticker Insider Ações
Reportadas Preço
Reportado Ações
Ajustadas Preço
Ajustado Base de Custos Dias para
Mín Preço em
Mín Máxima Perda
Evitada ($) Máxima Perda
Evitada (%)

Não há negociações abertas de mercado não planejadas conhecidas para esta combinação de insider e ativo

O Preço Ajustado é o preço ajustado pela divisão. Ações Ajustadas são as ações ajustadas pela divisão.

Compras Internas CELC / Celcuity Inc. - Análise de Lucro de Curto Prazo

Nesta seção, analisamos a lucratividade de cada compra interna de mercado aberto, não planejada, feita em ACAD / ACADIA Pharmaceuticals Inc.. Esta análise ajuda a entender se o interno gera consistentemente retornos anormais, e vale a pena seguir. Esta análise é para um ano seguinte a cada transação, e os resultados são teóricos.

A tabela a seguir mostra as compras de mercado aberto mais recentes que não faziam parte de um plano de negociação automático.

Data de Negociação Ticker Insider Ações
Reportadas Preço
Reportado Ações
Ajustadas Preço
Ajustado Base de Custos Dias para
Máx Preço em
Máx Lucro
Máx ($) Retorno Máx (%)

2025-09-08 CELC BAKER BROS. ADVISORS LP 13,976 56.2200 13,976 56.2200 785,731 238 144.9800 1,240,510 157.88

2025-09-08 CELC BAKER BROS. ADVISORS LP 151,524 56.2200 151,524 56.2200 8,518,679

2025-09-08 CELC BAKER BROS. ADVISORS LP 388 58.0236 388 58.0236 22,513

2025-09-08 CELC BAKER BROS. ADVISORS LP 4,212 58.0236 4,212 58.0236 244,395

O Preço Ajustado é o preço ajustado pela divisão. Ações Ajustadas são as ações ajustadas pela divisão.

Vendas Internas CELC / Celcuity Inc. - Análise de Perda de Curto Prazo

Nesta seção, analisamos a evitação de perdas de curto prazo de cada venda interna de mercado aberto, não planejada feita em ACAD / ACADIA Pharmaceuticals Inc.. Um padrão consistente de evitação de perdas pode sugerir que transações futuras de venda possam prever declínios no preço. Esta análise é para um ano seguinte a cada transação, e os resultados são teóricos.

A tabela a seguir mostra as vendas de mercado aberto mais recentes que não faziam parte de um plano de negociação automático.

Data de Negociação Ticker Insider Ações
Reportadas Preço
Reportado Ações
Ajustadas Preço
Ajustado Base de Custos Dias para
Mín Preço em
Mín Máxima Perda
Evitada ($) Máxima Perda
Evitada (%)

Não há negociações abertas de mercado não planejadas conhecidas para esta combinação de insider e ativo

O Preço Ajustado é o preço ajustado pela divisão. Ações Ajustadas são as ações ajustadas pela divisão.

Compras Internas IMCR / Immunocore Holdings plc - Depositary Receipt (Common Stock) - Análise de Lucro de Curto Prazo

Nesta seção, analisamos a lucratividade de cada compra interna de mercado aberto, não planejada, feita em ACAD / ACADIA Pharmaceuticals Inc.. Esta análise ajuda a entender se o interno gera consistentemente retornos anormais, e vale a pena seguir. Esta análise é para um ano seguinte a cada transação, e os resultados são teóricos.

A tabela a seguir mostra as compras de mercado aberto mais recentes que não faziam parte de um plano de negociação automático.

Data de Negociação Ticker Insider Ações
Reportadas Preço
Reportado Ações
Ajustadas Preço
Ajustado Base de Custos Dias para
Máx Preço em
Máx Lucro
Máx ($) Retorno Máx (%)

2025-03-17 IMCR BAKER BROS. ADVISORS LP 60,110 29.7416 60,110 29.7416 1,787,768 262 40.2150 629,557 35.21

2025-03-17 IMCR BAKER BROS. ADVISORS LP 646,290 29.7416 646,290 29.7416 19,221,699

2025-03-17 IMCR BAKER BROS. ADVISORS LP 8,589 29.5603 8,589 29.5603 253,893

2025-03-17 IMCR BAKER BROS. ADVISORS LP 92,349 29.5603 92,349 29.5603 2,729,864

O Preço Ajustado é o preço ajustado pela divisão. Ações Ajustadas são as ações ajustadas pela divisão.

Vendas Internas IMCR / Immunocore Holdings plc - Depositary Receipt (Common Stock) - Análise de Perda de Curto Prazo

Nesta seção, analisamos a evitação de perdas de curto prazo de cada venda interna de mercado aberto, não planejada feita em ACAD / ACADIA Pharmaceuticals Inc.. Um padrão consistente de evitação de perdas pode sugerir que transações futuras de venda possam prever declínios no preço. Esta análise é para um ano seguinte a cada transação, e os resultados são teóricos.

A tabela a seguir mostra as vendas de mercado aberto mais recentes que não faziam parte de um plano de negociação automático.

Data de Negociação Ticker Insider Ações
Reportadas Preço
Reportado Ações
Ajustadas Preço
Ajustado Base de Custos Dias para
Mín Preço em
Mín Máxima Perda
Evitada ($) Máxima Perda
Evitada (%)

Não há negociações abertas de mercado não planejadas conhecidas para esta combinação de insider e ativo

O Preço Ajustado é o preço ajustado pela divisão. Ações Ajustadas são as ações ajustadas pela divisão.

Compras Internas KALA / KALA BIO, Inc. - Análise de Lucro de Curto Prazo

Nesta seção, analisamos a lucratividade de cada compra interna de mercado aberto, não planejada, feita em ACAD / ACADIA Pharmaceuticals Inc.. Esta análise ajuda a entender se o interno gera consistentemente retornos anormais, e vale a pena seguir. Esta análise é para um ano seguinte a cada transação, e os resultados são teóricos.

A tabela a seguir mostra as compras de mercado aberto mais recentes que não faziam parte de um plano de negociação automático.

Data de Negociação Ticker Insider Ações
Reportadas Preço
Reportado Ações
Ajustadas Preço
Ajustado Base de Custos Dias para
Máx Preço em
Máx Lucro
Máx ($) Retorno Máx (%)

2024-12-30 KALA BAKER BROS. ADVISORS LP 30,620 6.4400 612 322.0000 197,193 263 19.6300 -185,178 -93.91

2024-12-30 KALA BAKER BROS. ADVISORS LP 279,939 6.4400 5,599 322.0000 1,802,807

O Preço Ajustado é o preço ajustado pela divisão. Ações Ajustadas são as ações ajustadas pela divisão.

Vendas Internas KALA / KALA BIO, Inc. - Análise de Perda de Curto Prazo

Nesta seção, analisamos a evitação de perdas de curto prazo de cada venda interna de mercado aberto, não planejada feita em ACAD / ACADIA Pharmaceuticals Inc.. Um padrão consistente de evitação de perdas pode sugerir que transações futuras de venda possam prever declínios no preço. Esta análise é para um ano seguinte a cada transação, e os resultados são teóricos.

A tabela a seguir mostra as vendas de mercado aberto mais recentes que não faziam parte de um plano de negociação automático.

Data de Negociação Ticker Insider Ações
Reportadas Preço
Reportado Ações
Ajustadas Preço
Ajustado Base de Custos Dias para
Mín Preço em
Mín Máxima Perda
Evitada ($) Máxima Perda
Evitada (%)

2025-10-01 KALA BAKER BROS. ADVISORS LP 50,640 1.3838 1,013 69.1900 70,076 219 0.0793 -69,995 -99.89

2025-10-01 KALA BAKER BROS. ADVISORS LP 462,967 1.3838 9,259 69.1900 640,654

2025-09-30 KALA BAKER BROS. ADVISORS LP 21,376 1.5959 428 79.7950 34,114

2025-09-30 KALA BAKER BROS. ADVISORS LP 195,425 1.5959 3,908 79.7950 311,879

O Preço Ajustado é o preço ajustado pela divisão. Ações Ajustadas são as ações ajustadas pela divisão.

Compras Internas KNSA / Kiniksa Pharmaceuticals International, plc - Análise de Lucro de Curto Prazo

Nesta seção, analisamos a lucratividade de cada compra interna de mercado aberto, não planejada, feita em ACAD / ACADIA Pharmaceuticals Inc.. Esta análise ajuda a entender se o interno gera consistentemente retornos anormais, e vale a pena seguir. Esta análise é para um ano seguinte a cada transação, e os resultados são teóricos.

A tabela a seguir mostra as compras de mercado aberto mais recentes que não faziam parte de um plano de negociação automático.

Data de Negociação Ticker Insider Ações
Reportadas Preço
Reportado Ações
Ajustadas Preço
Ajustado Base de Custos Dias para
Máx Preço em
Máx Lucro
Máx ($) Retorno Máx (%)

2018-05-29 KNSA BAKER BROS. ADVISORS LP 299,403 18.0000 299,403 18.0000 5,389,254 114 30.93 3,871,281 71.83

2018-05-29 KNSA BAKER BROS. ADVISORS LP 2,700,597 18.0000 2,700,597 18.0000 48,610,746

O Preço Ajustado é o preço ajustado pela divisão. Ações Ajustadas são as ações ajustadas pela divisão.

Vendas Internas KNSA / Kiniksa Pharmaceuticals International, plc - Análise de Perda de Curto Prazo

Nesta seção, analisamos a evitação de perdas de curto prazo de cada venda interna de mercado aberto, não planejada feita em ACAD / ACADIA Pharmaceuticals Inc.. Um padrão consistente de evitação de perdas pode sugerir que transações futuras de venda possam prever declínios no preço. Esta análise é para um ano seguinte a cada transação, e os resultados são teóricos.

A tabela a seguir mostra as vendas de mercado aberto mais recentes que não faziam parte de um plano de negociação automático.

Data de Negociação Ticker Insider Ações
Reportadas Preço
Reportado Ações
Ajustadas Preço
Ajustado Base de Custos Dias para
Mín Preço em
Mín Máxima Perda
Evitada ($) Máxima Perda
Evitada (%)

Não há negociações abertas de mercado não planejadas conhecidas para esta combinação de insider e ativo

O Preço Ajustado é o preço ajustado pela divisão. Ações Ajustadas são as ações ajustadas pela divisão.

Compras Internas KOD / Kodiak Sciences Inc. - Análise de Lucro de Curto Prazo

Nesta seção, analisamos a lucratividade de cada compra interna de mercado aberto, não planejada, feita em ACAD / ACADIA Pharmaceuticals Inc.. Esta análise ajuda a entender se o interno gera consistentemente retornos anormais, e vale a pena seguir. Esta análise é para um ano seguinte a cada transação, e os resultados são teóricos.

A tabela a seguir mostra as compras de mercado aberto mais recentes que não faziam parte de um plano de negociação automático.

Data de Negociação Ticker Insider Ações
Reportadas Preço
Reportado Ações
Ajustadas Preço
Ajustado Base de Custos Dias para
Máx Preço em
Máx Lucro
Máx ($) Retorno Máx (%)

2025-12-18 KOD BAKER BROS. ADVISORS LP 217,428 23.0000 217,428 23.0000 5,000,844 123 46.4400 5,096,512 101.91

2025-12-18 KOD BAKER BROS. ADVISORS LP 2,391,268 23.0000 2,391,268 23.0000 54,999,164

2022-06-06 KOD BAKER BROS. ADVISORS LP 11,945 7.7488 11,945 7.7488 92,559

2022-06-06 KOD BAKER BROS. ADVISORS LP 101,315 7.7488 101,315 7.7488 785,070

2022-06-06 KOD BAKER BROS. ADVISORS LP 20,108 7.7808 20,108 7.7808 156,456

2022-06-06 KOD BAKER BROS. ADVISORS LP 170,549 7.7808 170,549 7.7808 1,327,008

2022-06-03 KOD BAKER BROS. ADVISORS LP 1,550 7.9333 1,550 7.9333 12,297

2022-06-03 KOD BAKER BROS. ADVISORS LP 13,155 7.9333 13,155 7.9333 104,363

2022-06-03 KOD BAKER BROS. ADVISORS LP 9,224 7.9527 9,224 7.9527 73,356

2022-06-03 KOD BAKER BROS. ADVISORS LP 78,271 7.9527 78,271 7.9527 622,466

2022-06-02 KOD BAKER BROS. ADVISORS LP 1,247 7.5144 1,247 7.5144 9,370

2022-06-02 KOD BAKER BROS. ADVISORS LP 10,585 7.5144 10,585 7.5144 79,540

2022-06-02 KOD BAKER BROS. ADVISORS LP 16,278 7.6793 16,278 7.6793 125,004

2022-06-02 KOD BAKER BROS. ADVISORS LP 138,122 7.6793 138,122 7.6793 1,060,680

2022-05-27 KOD BAKER BROS. ADVISORS LP 42 6.6350 42 6.6350 279

2022-05-27 KOD BAKER BROS. ADVISORS LP 358 6.6350 358 6.6350 2,375

2022-05-27 KOD BAKER BROS. ADVISORS LP 6,026 6.7806 6,026 6.7806 40,860

2022-05-27 KOD BAKER BROS. ADVISORS LP 51,082 6.7806 51,082 6.7806 346,367

2022-05-27 KOD BAKER BROS. ADVISORS LP 10,386 6.9200 10,386 6.9200 71,871

2022-05-27 KOD BAKER BROS. ADVISORS LP 88,046 6.9200 88,046 6.9200 609,278

2022-05-26 KOD BAKER BROS. ADVISORS LP 3,432 6.7064 3,432 6.7064 23,016

2022-05-26 KOD BAKER BROS. ADVISORS LP 29,090 6.7064 29,090 6.7064 195,089

2022-05-26 KOD BAKER BROS. ADVISORS LP 6,299 6.7512 6,299 6.7512 42,526

2022-05-26 KOD BAKER BROS. ADVISORS LP 53,401 6.7512 53,401 6.7512 360,521

2022-05-26 KOD BAKER BROS. ADVISORS LP 116 6.7550 116 6.7550 784

2022-05-26 KOD BAKER BROS. ADVISORS LP 984 6.7550 984 6.7550 6,647

2022-05-25 KOD BAKER BROS. ADVISORS LP 5,688 6.5335 5,688 6.5335 37,163

2022-05-25 KOD BAKER BROS. ADVISORS LP 48,222 6.5335 48,222 6.5335 315,058

2022-05-25 KOD BAKER BROS. ADVISORS LP 4,984 6.6036 4,984 6.6036 32,912

2022-05-25 KOD BAKER BROS. ADVISORS LP 42,250 6.6036 42,250 6.6036 279,002

2022-05-18 KOD BAKER BROS. ADVISORS LP 1,115 5.9537 1,115 5.9537 6,638

2022-05-18 KOD BAKER BROS. ADVISORS LP 9,157 5.9537 9,157 5.9537 54,518

2022-05-18 KOD BAKER BROS. ADVISORS LP 22,266 5.9686 22,266 5.9686 132,897

2022-05-18 KOD BAKER BROS. ADVISORS LP 182,827 5.9686 182,827 5.9686 1,091,221

2022-05-18 KOD BAKER BROS. ADVISORS LP 912 5.9689 912 5.9689 5,444

2022-05-18 KOD BAKER BROS. ADVISORS LP 7,489 5.9689 7,489 5.9689 44,701

2022-05-17 KOD BAKER BROS. ADVISORS LP 989 5.9866 989 5.9866 5,921

2022-05-17 KOD BAKER BROS. ADVISORS LP 8,118 5.9866 8,118 5.9866 48,599

2022-05-17 KOD BAKER BROS. ADVISORS LP 11,043 5.9877 11,043 5.9877 66,122

2022-05-17 KOD BAKER BROS. ADVISORS LP 90,674 5.9877 90,674 5.9877 542,929

2022-05-16 KOD BAKER BROS. ADVISORS LP 11,410 5.7101 11,410 5.7101 65,152

2022-05-16 KOD BAKER BROS. ADVISORS LP 93,690 5.7101 93,690 5.7101 534,979

2022-05-16 KOD BAKER BROS. ADVISORS LP 1,846 5.7475 1,846 5.7475 10,610

2022-05-16 KOD BAKER BROS. ADVISORS LP 15,154 5.7475 15,154 5.7475 87,098

2022-02-17 KOD BAKER BROS. ADVISORS LP 426 53.8186 426 53.8186 22,927

2022-02-17 KOD BAKER BROS. ADVISORS LP 5,174 53.8186 5,174 53.8186 278,457

2022-02-17 KOD BAKER BROS. ADVISORS LP 22,403 54.5737 22,403 54.5737 1,222,615

2022-02-17 KOD BAKER BROS. ADVISORS LP 271,997 54.5737 271,997 54.5737 14,843,883

2022-02-16 KOD BAKER BROS. ADVISORS LP 1,961 53.7325 1,961 53.7325 105,369

2022-02-16 KOD BAKER BROS. ADVISORS LP 23,804 53.7325 23,804 53.7325 1,279,048

2022-02-16 KOD BAKER BROS. ADVISORS LP 5,281 54.2616 5,281 54.2616 286,556

2022-02-16 KOD BAKER BROS. ADVISORS LP 64,119 54.2616 64,119 54.2616 3,479,200

2022-02-15 KOD BAKER BROS. ADVISORS LP 441 54.1550 441 54.1550 23,882

2022-02-15 KOD BAKER BROS. ADVISORS LP 5,359 54.1550 5,359 54.1550 290,217

2022-01-31 KOD BAKER BROS. ADVISORS LP 2,307 57.2205 2,307 57.2205 132,008

2022-01-31 KOD BAKER BROS. ADVISORS LP 27,841 57.2205 27,841 57.2205 1,593,076

2022-01-28 KOD BAKER BROS. ADVISORS LP 1,851 49.7011 1,851 49.7011 91,997

2022-01-28 KOD BAKER BROS. ADVISORS LP 22,395 49.7011 22,395 49.7011 1,113,056

2022-01-28 KOD BAKER BROS. ADVISORS LP 1,414 50.5555 1,414 50.5555 71,485

2022-01-28 KOD BAKER BROS. ADVISORS LP 17,119 50.5555 17,119 50.5555 865,460

2022-01-28 KOD BAKER BROS. ADVISORS LP 953 51.6136 953 51.6136 49,188

2022-01-28 KOD BAKER BROS. ADVISORS LP 11,526 51.6136 11,526 51.6136 594,898

2022-01-27 KOD BAKER BROS. ADVISORS LP 86,479 52.0415 86,479 52.0415 4,500,497

2022-01-27 KOD BAKER BROS. ADVISORS LP 117,291 51.5881 117,291 51.5881 6,050,820

2022-01-27 KOD BAKER BROS. ADVISORS LP 4,465 51.6713 4,465 51.6713 230,712

2022-01-27 KOD BAKER BROS. ADVISORS LP 54,024 51.6713 54,024 51.6713 2,791,490

2022-01-25 KOD BAKER BROS. ADVISORS LP 5,500 58.8971 5,500 58.8971 323,934

2022-01-24 KOD BAKER BROS. ADVISORS LP 19,750 56.3873 19,750 56.3873 1,113,649

2022-01-24 KOD BAKER BROS. ADVISORS LP 1,200 56.5950 1,200 56.5950 67,914

2022-01-24 KOD BAKER BROS. ADVISORS LP 116,083 56.8650 116,083 56.8650 6,601,060

2022-01-24 KOD BAKER BROS. ADVISORS LP 25,900 57.5876 25,900 57.5876 1,491,519

2022-01-24 KOD BAKER BROS. ADVISORS LP 132,367 58.1258 132,367 58.1258 7,693,938

2022-01-24 KOD BAKER BROS. ADVISORS LP 9,350 58.7559 9,350 58.7559 549,368

2022-01-24 KOD BAKER BROS. ADVISORS LP 57,547 58.8709 57,547 58.8709 3,387,844

2022-01-21 KOD BAKER BROS. ADVISORS LP 102,207 56.5742 102,207 56.5742 5,782,279

2022-01-21 KOD BAKER BROS. ADVISORS LP 31,207 57.5285 31,207 57.5285 1,795,292

2021-09-30 KOD BAKER BROS. ADVISORS LP 86,932 95.8286 86,932 95.8286 8,330,572

2021-09-16 KOD BAKER BROS. ADVISORS LP 1,153 94.5918 1,153 94.5918 109,064

2021-09-15 KOD BAKER BROS. ADVISORS LP 30,285 94.3842 30,285 94.3842 2,858,425

2021-09-15 KOD BAKER BROS. ADVISORS LP 400 94.4775 400 94.4775 37,791

2021-09-07 KOD BAKER BROS. ADVISORS LP 5,300 92.8829 5,300 92.8829 492,279

2021-09-07 KOD BAKER BROS. ADVISORS LP 52,201 93.3497 52,201 93.3497 4,872,948

2021-08-19 KOD BAKER BROS. ADVISORS LP 2,968 86.9385 2,968 86.9385 258,033

2021-08-19 KOD BAKER BROS. ADVISORS LP 4,649 87.0710 4,649 87.0710 404,793

2021-08-19 KOD BAKER BROS. ADVISORS LP 2,396 87.4821 2,396 87.4821 209,607

2021-08-19 KOD BAKER BROS. ADVISORS LP 73,635 87.6141 73,635 87.6141 6,451,464

2021-08-18 KOD BAKER BROS. ADVISORS LP 12,898 87.7890 12,898 87.7890 1,132,303

2021-08-18 KOD BAKER BROS. ADVISORS LP 8,186 87.9134 8,186 87.9134 719,659

2021-08-18 KOD BAKER BROS. ADVISORS LP 1,100 88.1650 1,100 88.1650 96,982

2021-08-18 KOD BAKER BROS. ADVISORS LP 400 89.6563 400 89.6563 35,863

2021-08-17 KOD BAKER BROS. ADVISORS LP 400 84.8025 400 84.8025 33,921

2021-08-17 KOD BAKER BROS. ADVISORS LP 7,764 85.9522 7,764 85.9522 667,333

2021-08-13 KOD BAKER BROS. ADVISORS LP 21,595 88.5870 21,595 88.5870 1,913,036

2021-08-13 KOD BAKER BROS. ADVISORS LP 16,269 88.7588 16,269 88.7588 1,444,017

2021-08-13 KOD BAKER BROS. ADVISORS LP 400 88.8150 400 88.8150 35,526

2021-08-12 KOD BAKER BROS. ADVISORS LP 300 85.5800 300 85.5800 25,674

2021-08-12 KOD BAKER BROS. ADVISORS LP 4,600 86.4447 4,600 86.4447 397,646

2021-08-12 KOD BAKER BROS. ADVISORS LP 6,086 88.0109 6,086 88.0109 535,634

2021-08-11 KOD BAKER BROS. ADVISORS LP 3,723 84.3903 3,723 84.3903 314,185

2021-08-11 KOD BAKER BROS. ADVISORS LP 600 85.7229 600 85.7229 51,434

2021-08-11 KOD BAKER BROS. ADVISORS LP 44,700 86.0734 44,700 86.0734 3,847,481

2021-08-11 KOD BAKER BROS. ADVISORS LP 4,500 87.9978 4,500 87.9978 395,990

2021-06-30 KOD BAKER BROS. ADVISORS LP 4,603 89.7392 4,603 89.7392 413,070

2021-06-30 KOD BAKER BROS. ADVISORS LP 22,353 90.2041 22,353 90.2041 2,016,332

2021-06-30 KOD BAKER BROS. ADVISORS LP 7,009 91.6359 7,009 91.6359 642,276

2021-06-30 KOD BAKER BROS. ADVISORS LP 121,612 92.7459 121,612 92.7459 11,279,014

2021-06-29 KOD BAKER BROS. ADVISORS LP 7,079 89.8709 7,079 89.8709 636,196

2021-06-29 KOD BAKER BROS. ADVISORS LP 3,847 89.8956 3,847 89.8956 345,828

2021-06-29 KOD BAKER BROS. ADVISORS LP 11,731 90.3911 11,731 90.3911 1,060,378

2021-06-29 KOD BAKER BROS. ADVISORS LP 1,200 90.3950 1,200 90.3950 108,474

2021-06-29 KOD BAKER BROS. ADVISORS LP 30,221 90.7037 30,221 90.7037 2,741,157

2021-06-28 KOD BAKER BROS. ADVISORS LP 5,200 90.2731 5,200 90.2731 469,420

2021-06-28 KOD BAKER BROS. ADVISORS LP 10,170 90.7617 10,170 90.7617 923,046

2021-06-28 KOD BAKER BROS. ADVISORS LP 22,445 91.7974 22,445 91.7974 2,060,393

2021-06-28 KOD BAKER BROS. ADVISORS LP 10,459 91.8678 10,459 91.8678 960,845

2020-11-20 KOD BAKER BROS. ADVISORS LP 116,158 108.0000 116,158 108.0000 12,545,064

2020-11-20 KOD BAKER BROS. ADVISORS LP 1,411,619 108.0000 1,411,619 108.0000 152,454,852

2020-09-25 KOD BAKER BROS. ADVISORS LP 933 55.3529 933 55.3529 51,644

2020-09-25 KOD BAKER BROS. ADVISORS LP 13,153 55.3529 13,153 55.3529 728,057

2020-09-25 KOD BAKER BROS. ADVISORS LP 334 56.7599 334 56.7599 18,958

2020-09-25 KOD BAKER BROS. ADVISORS LP 4,705 56.7599 4,705 56.7599 267,055

2020-09-25 KOD BAKER BROS. ADVISORS LP 1,365 56.9199 1,365 56.9199 77,696

2020-09-25 KOD BAKER BROS. ADVISORS LP 19,235 56.9199 19,235 56.9199 1,094,854

2020-09-25 KOD BAKER BROS. ADVISORS LP 557 58.0855 557 58.0855 32,354

2020-09-25 KOD BAKER BROS. ADVISORS LP 7,843 58.0855 7,843 58.0855 455,565

2020-09-24 KOD BAKER BROS. ADVISORS LP 306 51.4092 306 51.4092 15,731

2020-09-24 KOD BAKER BROS. ADVISORS LP 4,306 51.4092 4,306 51.4092 221,368

2020-09-24 KOD BAKER BROS. ADVISORS LP 2,081 52.1149 2,081 52.1149 108,451

2020-09-24 KOD BAKER BROS. ADVISORS LP 29,327 52.1149 29,327 52.1149 1,528,374

2020-09-23 KOD BAKER BROS. ADVISORS LP 80 51.9700 80 51.9700 4,158

2020-09-23 KOD BAKER BROS. ADVISORS LP 1,120 51.9700 1,120 51.9700 58,206

2020-09-23 KOD BAKER BROS. ADVISORS LP 743 52.3997 743 52.3997 38,933

2020-09-23 KOD BAKER BROS. ADVISORS LP 10,467 52.3997 10,467 52.3997 548,468

2020-09-23 KOD BAKER BROS. ADVISORS LP 5,278 52.4359 5,278 52.4359 276,757

2020-09-23 KOD BAKER BROS. ADVISORS LP 74,381 52.4359 74,381 52.4359 3,900,235

2020-09-22 KOD BAKER BROS. ADVISORS LP 779 49.7225 779 49.7225 38,734

2020-09-22 KOD BAKER BROS. ADVISORS LP 10,983 49.7225 10,983 49.7225 546,102

2020-09-22 KOD BAKER BROS. ADVISORS LP 2,601 50.1517 2,601 50.1517 130,445

2020-09-22 KOD BAKER BROS. ADVISORS LP 36,647 50.1517 36,647 50.1517 1,837,909

2020-09-22 KOD BAKER BROS. ADVISORS LP 1,587 51.9760 1,587 51.9760 82,486

2020-09-22 KOD BAKER BROS. ADVISORS LP 22,361 51.9760 22,361 51.9760 1,162,235

2020-09-08 KOD BAKER BROS. ADVISORS LP 15 45.8750 15 45.8750 688

2020-09-08 KOD BAKER BROS. ADVISORS LP 185 45.8750 185 45.8750 8,487

2020-09-08 KOD BAKER BROS. ADVISORS LP 1,272 47.0350 1,272 47.0350 59,829

2020-09-08 KOD BAKER BROS. ADVISORS LP 15,807 47.0350 15,807 47.0350 743,482

2020-09-08 KOD BAKER BROS. ADVISORS LP 6,151 47.3874 6,151 47.3874 291,480

2020-09-08 KOD BAKER BROS. ADVISORS LP 76,473 47.3874 76,473 47.3874 3,623,857

2020-09-08 KOD BAKER BROS. ADVISORS LP 1,220 47.4690 1,220 47.4690 57,912

2020-09-08 KOD BAKER BROS. ADVISORS LP 15,172 47.4690 15,172 47.4690 720,200

2020-09-04 KOD BAKER BROS. ADVISORS LP 950 45.2963 950 45.2963 43,031

2020-09-04 KOD BAKER BROS. ADVISORS LP 12,132 45.2963 12,132 45.2963 549,535

2020-09-04 KOD BAKER BROS. ADVISORS LP 2,295 46.6171 2,295 46.6171 106,986

2020-09-04 KOD BAKER BROS. ADVISORS LP 29,319 46.6171 29,319 46.6171 1,366,767

2020-09-04 KOD BAKER BROS. ADVISORS LP 2,054 47.2591 2,054 47.2591 97,070

2020-09-04 KOD BAKER BROS. ADVISORS LP 26,238 47.2591 26,238 47.2591 1,239,984

2020-09-04 KOD BAKER BROS. ADVISORS LP 712 47.4982 712 47.4982 33,819

2020-09-04 KOD BAKER BROS. ADVISORS LP 9,101 47.4982 9,101 47.4982 432,281

2020-09-03 KOD BAKER BROS. ADVISORS LP 185 46.9681 185 46.9681 8,689

2020-09-03 KOD BAKER BROS. ADVISORS LP 2,359 46.9681 2,359 46.9681 110,798

2020-09-03 KOD BAKER BROS. ADVISORS LP 234 47.4472 234 47.4472 11,103

2020-09-03 KOD BAKER BROS. ADVISORS LP 2,987 47.4472 2,987 47.4472 141,725

2020-09-03 KOD BAKER BROS. ADVISORS LP 6,062 47.5968 6,062 47.5968 288,532

2020-09-03 KOD BAKER BROS. ADVISORS LP 77,456 47.5968 77,456 47.5968 3,686,658

2020-09-03 KOD BAKER BROS. ADVISORS LP 2,512 49.0000 2,512 49.0000 123,088

2020-09-03 KOD BAKER BROS. ADVISORS LP 32,088 49.0000 32,088 49.0000 1,572,312

2020-08-21 KOD BAKER BROS. ADVISORS LP 3,386 47.7421 3,386 47.7421 161,655

2020-08-21 KOD BAKER BROS. ADVISORS LP 42,714 47.7421 42,714 47.7421 2,039,256

2020-08-21 KOD BAKER BROS. ADVISORS LP 181 48.7447 181 48.7447 8,823

2020-08-21 KOD BAKER BROS. ADVISORS LP 2,286 48.7447 2,286 48.7447 111,430

2020-08-21 KOD BAKER BROS. ADVISORS LP 6,645 49.0831 6,645 49.0831 326,157

2020-08-21 KOD BAKER BROS. ADVISORS LP 83,832 49.0831 83,832 49.0831 4,114,734

2020-08-20 KOD BAKER BROS. ADVISORS LP 283 46.3018 283 46.3018 13,103

2020-08-20 KOD BAKER BROS. ADVISORS LP 3,576 46.3018 3,576 46.3018 165,575

2020-08-20 KOD BAKER BROS. ADVISORS LP 843 46.4959 843 46.4959 39,196

2020-08-20 KOD BAKER BROS. ADVISORS LP 10,640 46.4959 10,640 46.4959 494,716

2020-08-20 KOD BAKER BROS. ADVISORS LP 3,262 47.7213 3,262 47.7213 155,667

2020-08-20 KOD BAKER BROS. ADVISORS LP 41,155 47.7213 41,155 47.7213 1,963,970

2020-08-20 KOD BAKER BROS. ADVISORS LP 60 47.8226 60 47.8226 2,869

2020-08-20 KOD BAKER BROS. ADVISORS LP 754 47.8226 754 47.8226 36,058

2020-08-19 KOD BAKER BROS. ADVISORS LP 284 46.9865 284 46.9865 13,344

2020-08-19 KOD BAKER BROS. ADVISORS LP 3,585 46.9865 3,585 46.9865 168,447

2020-03-18 KOD BAKER BROS. ADVISORS LP 1,542 36.6933 1,542 36.6933 56,581

2020-03-18 KOD BAKER BROS. ADVISORS LP 17,058 36.6933 17,058 36.6933 625,914

2020-03-18 KOD BAKER BROS. ADVISORS LP 563 37.7478 563 37.7478 21,252

2020-03-18 KOD BAKER BROS. ADVISORS LP 6,237 37.7478 6,237 37.7478 235,433

2020-03-18 KOD BAKER BROS. ADVISORS LP 828 38.3797 828 38.3797 31,778

2020-03-18 KOD BAKER BROS. ADVISORS LP 9,172 38.3797 9,172 38.3797 352,019

2020-03-17 KOD BAKER BROS. ADVISORS LP 828 38.9850 828 38.9850 32,280

2020-03-17 KOD BAKER BROS. ADVISORS LP 9,172 38.9850 9,172 38.9850 357,570

2020-03-16 KOD BAKER BROS. ADVISORS LP 8,666 39.9711 8,666 39.9711 346,390

2020-03-16 KOD BAKER BROS. ADVISORS LP 95,934 39.9711 95,934 39.9711 3,834,588

2020-02-26 KOD BAKER BROS. ADVISORS LP 811 59.6089 811 59.6089 48,343

2020-02-26 KOD BAKER BROS. ADVISORS LP 8,989 59.6089 8,989 59.6089 535,824

2020-02-26 KOD BAKER BROS. ADVISORS LP 7,460 57.8190 7,460 57.8190 431,330

2020-02-26 KOD BAKER BROS. ADVISORS LP 82,740 57.8190 82,740 57.8190 4,783,944

2020-02-25 KOD BAKER BROS. ADVISORS LP 1,298 58.7987 1,298 58.7987 76,321

2020-02-25 KOD BAKER BROS. ADVISORS LP 14,402 58.7987 14,402 58.7987 846,819

2020-02-25 KOD BAKER BROS. ADVISORS LP 1,267 57.2187 1,267 57.2187 72,496

2020-02-25 KOD BAKER BROS. ADVISORS LP 14,051 57.2187 14,051 57.2187 803,980

2020-02-25 KOD BAKER BROS. ADVISORS LP 13,164 57.6840 13,164 57.6840 759,352

2020-02-25 KOD BAKER BROS. ADVISORS LP 145,994 57.6840 145,994 57.6840 8,421,518

2020-02-25 KOD BAKER BROS. ADVISORS LP 1,319 59.9851 1,319 59.9851 79,120

2020-02-25 KOD BAKER BROS. ADVISORS LP 14,631 59.9851 14,631 59.9851 877,642

2020-02-24 KOD BAKER BROS. ADVISORS LP 164 55.7734 164 55.7734 9,147

2020-02-24 KOD BAKER BROS. ADVISORS LP 1,813 55.7734 1,813 55.7734 101,117

2020-02-24 KOD BAKER BROS. ADVISORS LP 8 55.4525 8 55.4525 444

2020-02-24 KOD BAKER BROS. ADVISORS LP 92 55.4525 92 55.4525 5,102

2020-02-24 KOD BAKER BROS. ADVISORS LP 912 56.2471 912 56.2471 51,297

2020-02-24 KOD BAKER BROS. ADVISORS LP 10,121 56.2471 10,121 56.2471 569,277

2020-02-24 KOD BAKER BROS. ADVISORS LP 523 56.6215 523 56.6215 29,613

2020-02-24 KOD BAKER BROS. ADVISORS LP 5,804 56.6215 5,804 56.6215 328,631

2020-02-24 KOD BAKER BROS. ADVISORS LP 1,921 56.6881 1,921 56.6881 108,898

2020-02-24 KOD BAKER BROS. ADVISORS LP 21,301 56.6881 21,301 56.6881 1,207,513

2020-02-24 KOD BAKER BROS. ADVISORS LP 323 57.6204 323 57.6204 18,611

2020-02-24 KOD BAKER BROS. ADVISORS LP 3,577 57.6204 3,577 57.6204 206,108

2020-02-24 KOD BAKER BROS. ADVISORS LP 642 58.3861 642 58.3861 37,484

2020-02-24 KOD BAKER BROS. ADVISORS LP 7,122 58.3861 7,122 58.3861 415,826

2020-02-24 KOD BAKER BROS. ADVISORS LP 612 58.5434 612 58.5434 35,829

2020-02-24 KOD BAKER BROS. ADVISORS LP 6,788 58.5434 6,788 58.5434 397,393

2020-02-24 KOD BAKER BROS. ADVISORS LP 777 60.7727 777 60.7727 47,220

2020-02-24 KOD BAKER BROS. ADVISORS LP 8,623 60.7727 8,623 60.7727 524,043

2019-12-06 KOD BAKER BROS. ADVISORS LP 158,180 46.0000 158,180 46.0000 7,276,280

2019-12-06 KOD BAKER BROS. ADVISORS LP 1,743,993 46.0000 1,743,993 46.0000 80,223,678

2018-10-09 KOD BAKER BROS. ADVISORS LP 251,898 10.0000 251,898 10.0000 2,518,980

2018-10-09 KOD BAKER BROS. ADVISORS LP 2,248,102 10.0000 2,248,102 10.0000 22,481,020

O Preço Ajustado é o preço ajustado pela divisão. Ações Ajustadas são as ações ajustadas pela divisão.

Vendas Internas KOD / Kodiak Sciences Inc. - Análise de Perda de Curto Prazo

Nesta seção, analisamos a evitação de perdas de curto prazo de cada venda interna de mercado aberto, não planejada feita em ACAD / ACADIA Pharmaceuticals Inc.. Um padrão consistente de evitação de perdas pode sugerir que transações futuras de venda possam prever declínios no preço. Esta análise é para um ano seguinte a cada transação, e os resultados são teóricos.

A tabela a seguir mostra as vendas de mercado aberto mais recentes que não faziam parte de um plano de negociação automático.

Data de Negociação Ticker Insider Ações
Reportadas Preço
Reportado Ações
Ajustadas Preço
Ajustado Base de Custos Dias para
Mín Preço em
Mín Máxima Perda
Evitada ($) Máxima Perda
Evitada (%)

Não há negociações abertas de mercado não planejadas conhecidas para esta combinação de insider e ativo

O Preço Ajustado é o preço ajustado pela divisão. Ações Ajustadas são as ações ajustadas pela divisão.

Compras Internas KYMR / Kymera Therapeutics, Inc. - Análise de Lucro de Curto Prazo

Nesta seção, analisamos a lucratividade de cada compra interna de mercado aberto, não planejada, feita em ACAD / ACADIA Pharmaceuticals Inc.. Esta análise ajuda a entender se o interno gera consistentemente retornos anormais, e vale a pena seguir. Esta análise é para um ano seguinte a cada transação, e os resultados são teóricos.

A tabela a seguir mostra as compras de mercado aberto mais recentes que não faziam parte de um plano de negociação automático.

Data de Negociação Ticker Insider Ações
Reportadas Preço
Reportado Ações
Ajustadas Preço
Ajustado Base de Custos Dias para
Máx Preço em
Máx Lucro
Máx ($) Retorno Máx (%)

2025-12-11 KYMR BAKER BROS. ADVISORS LP 167,192 86.0000 167,192 86.0000 14,378,512 77 95.0300 1,509,744 10.50

2025-12-11 KYMR BAKER BROS. ADVISORS LP 1,838,621 86.0000 1,838,621 86.0000 158,121,406

2025-06-30 KYMR BAKER BROS. ADVISORS LP 55,191 44.0000 55,191 44.0000 2,428,404

2025-06-30 KYMR BAKER BROS. ADVISORS LP 600,309 44.0000 600,309 44.0000 26,413,596

2024-08-20 KYMR BAKER BROS. ADVISORS LP 1 46.4100 1 46.4100 46

O Preço Ajustado é o preço ajustado pela divisão. Ações Ajustadas são as ações ajustadas pela divisão.

Vendas Internas KYMR / Kymera Therapeutics, Inc. - Análise de Perda de Curto Prazo

Nesta seção, analisamos a evitação de perdas de curto prazo de cada venda interna de mercado aberto, não planejada feita em ACAD / ACADIA Pharmaceuticals Inc.. Um padrão consistente de evitação de perdas pode sugerir que transações futuras de venda possam prever declínios no preço. Esta análise é para um ano seguinte a cada transação, e os resultados são teóricos.

A tabela a seguir mostra as vendas de mercado aberto mais recentes que não faziam parte de um plano de negociação automático.

Data de Negociação Ticker Insider Ações
Reportadas Preço
Reportado Ações
Ajustadas Preço
Ajustado Base de Custos Dias para
Mín Preço em
Mín Máxima Perda
Evitada ($) Máxima Perda
Evitada (%)

Não há negociações abertas de mercado não planejadas conhecidas para esta combinação de insider e ativo

O Preço Ajustado é o preço ajustado pela divisão. Ações Ajustadas são as ações ajustadas pela divisão.

Compras Internas MDGL / Madrigal Pharmaceuticals, Inc. - Análise de Lucro de Curto Prazo

Nesta seção, analisamos a lucratividade de cada compra interna de mercado aberto, não planejada, feita em ACAD / ACADIA Pharmaceuticals Inc.. Esta análise ajuda a entender se o interno gera consistentemente retornos anormais, e vale a pena seguir. Esta análise é para um ano seguinte a cada transação, e os resultados são teóricos.

A tabela a seguir mostra as compras de mercado aberto mais recentes que não faziam parte de um plano de negociação automático.

Data de Negociação Ticker Insider Ações
Reportadas Preço
Reportado Ações
Ajustadas Preço
Ajustado Base de Custos Dias para
Máx Preço em
Máx Lucro
Máx ($) Retorno Máx (%)

2025-08-20 MDGL BAKER BROS. ADVISORS LP 480 380.4365 480 380.4365 182,610 124 602.8300 106,749 58.46

2025-08-20 MDGL BAKER BROS. ADVISORS LP 5,209 380.4365 5,209 380.4365 1,981,694

2025-08-20 MDGL BAKER BROS. ADVISORS LP 176 380.7800 176 380.7800 67,017

2025-08-20 MDGL BAKER BROS. ADVISORS LP 1,919 380.7800 1,919 380.7800 730,717

2025-08-20 MDGL BAKER BROS. ADVISORS LP 873 381.1216 873 381.1216 332,719

2025-08-20 MDGL BAKER BROS. ADVISORS LP 9,477 381.1216 9,477 381.1216 3,611,889

2025-08-20 MDGL BAKER BROS. ADVISORS LP 105 382.2891 105 382.2891 40,140

2025-08-20 MDGL BAKER BROS. ADVISORS LP 1,136 382.2891 1,136 382.2891 434,280

2025-08-20 MDGL BAKER BROS. ADVISORS LP 262 382.8213 262 382.8213 100,299

2025-08-20 MDGL BAKER BROS. ADVISORS LP 2,838 382.8213 2,838 382.8213 1,086,447

2025-08-20 MDGL BAKER BROS. ADVISORS LP 373 383.7872 373 383.7872 143,153

2025-08-20 MDGL BAKER BROS. ADVISORS LP 4,049 383.7872 4,049 383.7872 1,553,954

2025-08-20 MDGL BAKER BROS. ADVISORS LP 1,248 385.0573 1,248 385.0573 480,552

2025-08-20 MDGL BAKER BROS. ADVISORS LP 13,545 385.0573 13,545 385.0573 5,215,601

2025-08-20 MDGL BAKER BROS. ADVISORS LP 409 387.0680 409 387.0680 158,311

2025-08-20 MDGL BAKER BROS. ADVISORS LP 4,441 387.0680 4,441 387.0680 1,718,969

2025-08-20 MDGL BAKER BROS. ADVISORS LP 34 389.0000 34 389.0000 13,226

2025-08-20 MDGL BAKER BROS. ADVISORS LP 366 389.0000 366 389.0000 142,374

2025-08-20 MDGL BAKER BROS. ADVISORS LP 231 389.8878 231 389.8878 90,064

2025-08-20 MDGL BAKER BROS. ADVISORS LP 2,506 389.8878 2,506 389.8878 977,059

2025-08-20 MDGL BAKER BROS. ADVISORS LP 862 392.2429 862 392.2429 338,113

2025-08-20 MDGL BAKER BROS. ADVISORS LP 9,362 392.2429 9,362 392.2429 3,672,178

2025-08-18 MDGL BAKER BROS. ADVISORS LP 177 353.8755 177 353.8755 62,636

2025-08-18 MDGL BAKER BROS. ADVISORS LP 1,923 353.8755 1,923 353.8755 680,503

2025-08-18 MDGL BAKER BROS. ADVISORS LP 84 355.0000 84 355.0000 29,820

2025-08-18 MDGL BAKER BROS. ADVISORS LP 916 355.0000 916 355.0000 325,180

2025-08-18 MDGL BAKER BROS. ADVISORS LP 767 357.0232 767 357.0232 273,837

2025-08-18 MDGL BAKER BROS. ADVISORS LP 8,328 357.0232 8,328 357.0232 2,973,289

2025-08-18 MDGL BAKER BROS. ADVISORS LP 228 358.2100 228 358.2100 81,672

2025-08-18 MDGL BAKER BROS. ADVISORS LP 2,472 358.2100 2,472 358.2100 885,495

2025-08-18 MDGL BAKER BROS. ADVISORS LP 784 359.3931 784 359.3931 281,764

2025-08-18 MDGL BAKER BROS. ADVISORS LP 8,514 359.3931 8,514 359.3931 3,059,873

2025-08-18 MDGL BAKER BROS. ADVISORS LP 502 361.3736 502 361.3736 181,410

2025-08-18 MDGL BAKER BROS. ADVISORS LP 5,443 361.3736 5,443 361.3736 1,966,957

2025-08-18 MDGL BAKER BROS. ADVISORS LP 515 362.3881 515 362.3881 186,630

2025-08-18 MDGL BAKER BROS. ADVISORS LP 5,587 362.3881 5,587 362.3881 2,024,662

2025-08-18 MDGL BAKER BROS. ADVISORS LP 255 363.7474 255 363.7474 92,756

2025-08-18 MDGL BAKER BROS. ADVISORS LP 2,772 363.7474 2,772 363.7474 1,008,308

2025-08-18 MDGL BAKER BROS. ADVISORS LP 211 366.2992 211 366.2992 77,289

2025-08-18 MDGL BAKER BROS. ADVISORS LP 2,289 366.2992 2,289 366.2992 838,459

2025-08-18 MDGL BAKER BROS. ADVISORS LP 442 367.7710 442 367.7710 162,555

2025-08-18 MDGL BAKER BROS. ADVISORS LP 4,798 367.7710 4,798 367.7710 1,764,565

2025-08-18 MDGL BAKER BROS. ADVISORS LP 131 368.8400 131 368.8400 48,318

2025-08-18 MDGL BAKER BROS. ADVISORS LP 1,419 368.8400 1,419 368.8400 523,384

2025-08-18 MDGL BAKER BROS. ADVISORS LP 253 369.3350 253 369.3350 93,442

2025-08-18 MDGL BAKER BROS. ADVISORS LP 2,747 369.3350 2,747 369.3350 1,014,563

2025-08-18 MDGL BAKER BROS. ADVISORS LP 506 371.0050 506 371.0050 187,729

2025-08-18 MDGL BAKER BROS. ADVISORS LP 5,494 371.0050 5,494 371.0050 2,038,301

2025-08-18 MDGL BAKER BROS. ADVISORS LP 933 372.1573 933 372.1573 347,223

2025-08-18 MDGL BAKER BROS. ADVISORS LP 10,128 372.1573 10,128 372.1573 3,769,209

2025-08-18 MDGL BAKER BROS. ADVISORS LP 2,460 372.8693 2,460 372.8693 917,258

2025-08-18 MDGL BAKER BROS. ADVISORS LP 26,704 372.8693 26,704 372.8693 9,957,102

2025-08-18 MDGL BAKER BROS. ADVISORS LP 675 374.4338 675 374.4338 252,743

2025-08-18 MDGL BAKER BROS. ADVISORS LP 7,325 374.4338 7,325 374.4338 2,742,728

2023-12-14 MDGL BAKER BROS. ADVISORS LP 107 226.9710 107 226.9710 24,286

2023-12-14 MDGL BAKER BROS. ADVISORS LP 1,343 226.9710 1,343 226.9710 304,822

2023-12-14 MDGL BAKER BROS. ADVISORS LP 925 227.8570 925 227.8570 210,768

2023-12-14 MDGL BAKER BROS. ADVISORS LP 11,602 227.8570 11,602 227.8570 2,643,597

2023-12-14 MDGL BAKER BROS. ADVISORS LP 176 228.7893 176 228.7893 40,267

2023-12-14 MDGL BAKER BROS. ADVISORS LP 2,204 228.7893 2,204 228.7893 504,252

2023-12-14 MDGL BAKER BROS. ADVISORS LP 316 229.8647 316 229.8647 72,637

2023-12-14 MDGL BAKER BROS. ADVISORS LP 3,960 229.8647 3,960 229.8647 910,264

2023-12-13 MDGL BAKER BROS. ADVISORS LP 818 216.6994 818 216.6994 177,260

2023-12-13 MDGL BAKER BROS. ADVISORS LP 10,264 216.6994 10,264 216.6994 2,224,203

2023-12-13 MDGL BAKER BROS. ADVISORS LP 869 217.5152 869 217.5152 189,021

2023-12-13 MDGL BAKER BROS. ADVISORS LP 10,894 217.5152 10,894 217.5152 2,369,611

2023-12-13 MDGL BAKER BROS. ADVISORS LP 2,373 218.4583 2,373 218.4583 518,402

2023-12-13 MDGL BAKER BROS. ADVISORS LP 29,738 218.4583 29,738 218.4583 6,496,513

2023-12-13 MDGL BAKER BROS. ADVISORS LP 360 219.8652 360 219.8652 79,151

2023-12-13 MDGL BAKER BROS. ADVISORS LP 4,518 219.8652 4,518 219.8652 993,351

2023-12-13 MDGL BAKER BROS. ADVISORS LP 361 221.7787 361 221.7787 80,062

2023-12-13 MDGL BAKER BROS. ADVISORS LP 4,532 221.7787 4,532 221.7787 1,005,101

2023-12-13 MDGL BAKER BROS. ADVISORS LP 738 222.6760 738 222.6760 164,335

2023-12-13 MDGL BAKER BROS. ADVISORS LP 9,262 222.6760 9,262 222.6760 2,062,425

2023-12-13 MDGL BAKER BROS. ADVISORS LP 29 223.9374 29 223.9374 6,494

2023-12-13 MDGL BAKER BROS. ADVISORS LP 363 223.9374 363 223.9374 81,289

2023-12-13 MDGL BAKER BROS. ADVISORS LP 446 224.9117 446 224.9117 100,311

2023-12-13 MDGL BAKER BROS. ADVISORS LP 5,594 224.9117 5,594 224.9117 1,258,156

2023-12-12 MDGL BAKER BROS. ADVISORS LP 7 205.3200 7 205.3200 1,437

2023-12-12 MDGL BAKER BROS. ADVISORS LP 93 205.3200 93 205.3200 19,095

2023-12-12 MDGL BAKER BROS. ADVISORS LP 56 205.6000 56 205.6000 11,514

2023-12-12 MDGL BAKER BROS. ADVISORS LP 708 205.6000 708 205.6000 145,565

2023-12-12 MDGL BAKER BROS. ADVISORS LP 52 206.9321 52 206.9321 10,760

2023-12-12 MDGL BAKER BROS. ADVISORS LP 648 206.9321 648 206.9321 134,092

2023-12-12 MDGL BAKER BROS. ADVISORS LP 30 208.6913 30 208.6913 6,261

2023-12-12 MDGL BAKER BROS. ADVISORS LP 370 208.6913 370 208.6913 77,216

2023-12-12 MDGL BAKER BROS. ADVISORS LP 7 209.7650 7 209.7650 1,468

2023-12-12 MDGL BAKER BROS. ADVISORS LP 93 209.7650 93 209.7650 19,508

2023-12-12 MDGL BAKER BROS. ADVISORS LP 52 212.0414 52 212.0414 11,026

2023-12-12 MDGL BAKER BROS. ADVISORS LP 648 212.0414 648 212.0414 137,403

2023-12-12 MDGL BAKER BROS. ADVISORS LP 15 213.6250 15 213.6250 3,204

2023-12-12 MDGL BAKER BROS. ADVISORS LP 185 213.6250 185 213.6250 39,521

2023-12-12 MDGL BAKER BROS. ADVISORS LP 41 213.7994 41 213.7994 8,766

2023-12-12 MDGL BAKER BROS. ADVISORS LP 515 213.7994 515 213.7994 110,107

2023-12-12 MDGL BAKER BROS. ADVISORS LP 53 214.7223 53 214.7223 11,380

2023-12-12 MDGL BAKER BROS. ADVISORS LP 668 214.7223 668 214.7223 143,434

2023-12-12 MDGL BAKER BROS. ADVISORS LP 141 216.6683 141 216.6683 30,550

2023-12-12 MDGL BAKER BROS. ADVISORS LP 1,769 216.6683 1,769 216.6683 383,286

2023-12-12 MDGL BAKER BROS. ADVISORS LP 15 217.9000 15 217.9000 3,268

2023-12-12 MDGL BAKER BROS. ADVISORS LP 185 217.9000 185 217.9000 40,312

2023-12-12 MDGL BAKER BROS. ADVISORS LP 229 217.9078 229 217.9078 49,901

2023-12-12 MDGL BAKER BROS. ADVISORS LP 2,873 217.9078 2,873 217.9078 626,049

2023-12-12 MDGL BAKER BROS. ADVISORS LP 1,195 219.2410 1,195 219.2410 261,993

2023-12-12 MDGL BAKER BROS. ADVISORS LP 15,005 219.2410 15,005 219.2410 3,289,711

2023-12-12 MDGL BAKER BROS. ADVISORS LP 352 220.6546 352 220.6546 77,670

2023-12-12 MDGL BAKER BROS. ADVISORS LP 4,408 220.6546 4,408 220.6546 972,645

2023-12-12 MDGL BAKER BROS. ADVISORS LP 308 221.2418 308 221.2418 68,142

2023-12-12 MDGL BAKER BROS. ADVISORS LP 3,857 221.2418 3,857 221.2418 853,330

2023-11-21 MDGL BAKER BROS. ADVISORS LP 12 185.9442 12 185.9442 2,231

2023-11-21 MDGL BAKER BROS. ADVISORS LP 146 185.9442 146 185.9442 27,148

2023-11-21 MDGL BAKER BROS. ADVISORS LP 31 183.1600 31 183.1600 5,678

2023-11-21 MDGL BAKER BROS. ADVISORS LP 369 183.1600 369 183.1600 67,586

2023-11-21 MDGL BAKER BROS. ADVISORS LP 53 186.3171 53 186.3171 9,875

2023-11-21 MDGL BAKER BROS. ADVISORS LP 647 186.3171 647 186.3171 120,547

2023-11-21 MDGL BAKER BROS. ADVISORS LP 115 186.5930 115 186.5930 21,458

2023-11-21 MDGL BAKER BROS. ADVISORS LP 1,385 186.5930 1,385 186.5930 258,431

2023-11-21 MDGL BAKER BROS. ADVISORS LP 176 187.2439 176 187.2439 32,955

2023-11-21 MDGL BAKER BROS. ADVISORS LP 2,124 187.2439 2,124 187.2439 397,706

2023-11-21 MDGL BAKER BROS. ADVISORS LP 388 187.2707 388 187.2707 72,661

2023-11-21 MDGL BAKER BROS. ADVISORS LP 4,712 187.2707 4,712 187.2707 882,420

2023-11-21 MDGL BAKER BROS. ADVISORS LP 1,076 188.3232 1,076 188.3232 202,636

2023-11-21 MDGL BAKER BROS. ADVISORS LP 13,011 188.3232 13,011 188.3232 2,450,273

2023-11-21 MDGL BAKER BROS. ADVISORS LP 1,117 188.4649 1,117 188.4649 210,515

2023-11-21 MDGL BAKER BROS. ADVISORS LP 13,505 188.4649 13,505 188.4649 2,545,218

2023-11-21 MDGL BAKER BROS. ADVISORS LP 1,291 188.7029 1,291 188.7029 243,615

2023-11-21 MDGL BAKER BROS. ADVISORS LP 15,620 188.7029 15,620 188.7029 2,947,539

2023-11-21 MDGL BAKER BROS. ADVISORS LP 655 190.1361 655 190.1361 124,539

2023-11-21 MDGL BAKER BROS. ADVISORS LP 7,917 190.1361 7,917 190.1361 1,505,308

2023-11-20 MDGL BAKER BROS. ADVISORS LP 153 181.9300 153 181.9300 27,835

2023-11-20 MDGL BAKER BROS. ADVISORS LP 1,847 181.9300 1,847 181.9300 336,025

2023-11-20 MDGL BAKER BROS. ADVISORS LP 579 183.3999 579 183.3999 106,189

2023-11-20 MDGL BAKER BROS. ADVISORS LP 7,010 183.3999 7,010 183.3999 1,285,633

2023-11-20 MDGL BAKER BROS. ADVISORS LP 100 185.8650 100 185.8650 18,586

2023-11-20 MDGL BAKER BROS. ADVISORS LP 1,206 185.8650 1,206 185.8650 224,153

2023-11-20 MDGL BAKER BROS. ADVISORS LP 405 187.3450 405 187.3450 75,875

2023-11-20 MDGL BAKER BROS. ADVISORS LP 4,895 187.3450 4,895 187.3450 917,054

2023-11-20 MDGL BAKER BROS. ADVISORS LP 95 188.8359 95 188.8359 17,939

2023-11-20 MDGL BAKER BROS. ADVISORS LP 1,147 188.8359 1,147 188.8359 216,595

2023-11-20 MDGL BAKER BROS. ADVISORS LP 250 189.6978 250 189.6978 47,424

2023-11-20 MDGL BAKER BROS. ADVISORS LP 3,022 189.6978 3,022 189.6978 573,267

2023-11-17 MDGL BAKER BROS. ADVISORS LP 54 167.6300 54 167.6300 9,052

2023-11-17 MDGL BAKER BROS. ADVISORS LP 646 167.6300 646 167.6300 108,289

2023-11-17 MDGL BAKER BROS. ADVISORS LP 93 168.7825 93 168.7825 15,697

2023-11-17 MDGL BAKER BROS. ADVISORS LP 1,107 168.7825 1,107 168.7825 186,842

2023-11-17 MDGL BAKER BROS. ADVISORS LP 39 171.7900 39 171.7900 6,700

2023-11-17 MDGL BAKER BROS. ADVISORS LP 461 171.7900 461 171.7900 79,195

2023-11-17 MDGL BAKER BROS. ADVISORS LP 350 173.2016 350 173.2016 60,621

2023-11-17 MDGL BAKER BROS. ADVISORS LP 4,151 173.2016 4,151 173.2016 718,960

2023-11-17 MDGL BAKER BROS. ADVISORS LP 140 173.7481 140 173.7481 24,325

2023-11-17 MDGL BAKER BROS. ADVISORS LP 1,660 173.7481 1,660 173.7481 288,422

2023-11-17 MDGL BAKER BROS. ADVISORS LP 82 174.6698 82 174.6698 14,323

2023-11-17 MDGL BAKER BROS. ADVISORS LP 978 174.6698 978 174.6698 170,827

2023-11-17 MDGL BAKER BROS. ADVISORS LP 1,528 174.8748 1,528 174.8748 267,209

2023-11-17 MDGL BAKER BROS. ADVISORS LP 18,125 174.8748 18,125 174.8748 3,169,606

2023-11-17 MDGL BAKER BROS. ADVISORS LP 415 175.7185 415 175.7185 72,923

2023-11-17 MDGL BAKER BROS. ADVISORS LP 4,923 175.7185 4,923 175.7185 865,062

2023-11-17 MDGL BAKER BROS. ADVISORS LP 903 175.8179 903 175.8179 158,764

2023-11-17 MDGL BAKER BROS. ADVISORS LP 10,715 175.8179 10,715 175.8179 1,883,889

2023-11-15 MDGL BAKER BROS. ADVISORS LP 1,181 161.9660 1,181 161.9660 191,282

2023-11-15 MDGL BAKER BROS. ADVISORS LP 14,018 161.9660 14,018 161.9660 2,270,439

2023-11-14 MDGL BAKER BROS. ADVISORS LP 299 154.5969 299 154.5969 46,224

2023-11-14 MDGL BAKER BROS. ADVISORS LP 3,542 154.5969 3,542 154.5969 547,582

2023-11-14 MDGL BAKER BROS. ADVISORS LP 507 152.4800 507 152.4800 77,307

2023-11-14 MDGL BAKER BROS. ADVISORS LP 6,022 152.4800 6,022 152.4800 918,235

2023-11-14 MDGL BAKER BROS. ADVISORS LP 54 152.2129 54 152.2129 8,219

2023-11-14 MDGL BAKER BROS. ADVISORS LP 646 152.2129 646 152.2129 98,330

2023-11-14 MDGL BAKER BROS. ADVISORS LP 242 153.2523 242 153.2523 37,087

2023-11-14 MDGL BAKER BROS. ADVISORS LP 2,877 153.2523 2,877 153.2523 440,907

2023-11-14 MDGL BAKER BROS. ADVISORS LP 683 153.9736 683 153.9736 105,164

2023-11-14 MDGL BAKER BROS. ADVISORS LP 8,098 153.9736 8,098 153.9736 1,246,878

2023-11-14 MDGL BAKER BROS. ADVISORS LP 1,142 154.7801 1,142 154.7801 176,759

2023-11-14 MDGL BAKER BROS. ADVISORS LP 13,548 154.7801 13,548 154.7801 2,096,961

2023-11-14 MDGL BAKER BROS. ADVISORS LP 2,658 156.4244 2,658 156.4244 415,776

2023-11-14 MDGL BAKER BROS. ADVISORS LP 31,530 156.4244 31,530 156.4244 4,932,061

2023-11-13 MDGL BAKER BROS. ADVISORS LP 265 136.1805 265 136.1805 36,088

2023-11-13 MDGL BAKER BROS. ADVISORS LP 3,144 136.1805 3,144 136.1805 428,151

2023-11-13 MDGL BAKER BROS. ADVISORS LP 311 136.9089 311 136.9089 42,579

2023-11-13 MDGL BAKER BROS. ADVISORS LP 3,693 136.9089 3,693 136.9089 505,605

2023-11-13 MDGL BAKER BROS. ADVISORS LP 390 137.6855 390 137.6855 53,697

2023-11-13 MDGL BAKER BROS. ADVISORS LP 4,631 137.6855 4,631 137.6855 637,622

2023-11-13 MDGL BAKER BROS. ADVISORS LP 427 140.9024 427 140.9024 60,165

2023-11-13 MDGL BAKER BROS. ADVISORS LP 5,072 140.9024 5,072 140.9024 714,657

2023-11-13 MDGL BAKER BROS. ADVISORS LP 910 141.4450 910 141.4450 128,715

2023-11-13 MDGL BAKER BROS. ADVISORS LP 10,790 141.4450 10,790 141.4450 1,526,192

2023-11-13 MDGL BAKER BROS. ADVISORS LP 109 142.8575 109 142.8575 15,571

2023-11-13 MDGL BAKER BROS. ADVISORS LP 1,291 142.8575 1,291 142.8575 184,429

2023-11-13 MDGL BAKER BROS. ADVISORS LP 537 145.4592 537 145.4592 78,112

2023-11-13 MDGL BAKER BROS. ADVISORS LP 6,369 145.4592 6,369 145.4592 926,430

2023-11-13 MDGL BAKER BROS. ADVISORS LP 252 145.9775 252 145.9775 36,786

2023-11-13 MDGL BAKER BROS. ADVISORS LP 2,994 145.9775 2,994 145.9775 437,057

2023-11-13 MDGL BAKER BROS. ADVISORS LP 2,228 146.2104 2,228 146.2104 325,757

2023-11-13 MDGL BAKER BROS. ADVISORS LP 26,426 146.2104 26,426 146.2104 3,863,756

O Preço Ajustado é o preço ajustado pela divisão. Ações Ajustadas são as ações ajustadas pela divisão.

Vendas Internas MDGL / Madrigal Pharmaceuticals, Inc. - Análise de Perda de Curto Prazo

Nesta seção, analisamos a evitação de perdas de curto prazo de cada venda interna de mercado aberto, não planejada feita em ACAD / ACADIA Pharmaceuticals Inc.. Um padrão consistente de evitação de perdas pode sugerir que transações futuras de venda possam prever declínios no preço. Esta análise é para um ano seguinte a cada transação, e os resultados são teóricos.

A tabela a seguir mostra as vendas de mercado aberto mais recentes que não faziam parte de um plano de negociação automático.

Data de Negociação Ticker Insider Ações
Reportadas Preço
Reportado Ações
Ajustadas Preço
Ajustado Base de Custos Dias para
Mín Preço em
Mín Máxima Perda
Evitada ($) Máxima Perda
Evitada (%)

Não há negociações abertas de mercado não planejadas conhecidas para esta combinação de insider e ativo

O Preço Ajustado é o preço ajustado pela divisão. Ações Ajustadas são as ações ajustadas pela divisão.

Compras Internas NTLA / Intellia Therapeutics, Inc. - Análise de Lucro de Curto Prazo

Nesta seção, analisamos a lucratividade de cada compra interna de mercado aberto, não planejada, feita em ACAD / ACADIA Pharmaceuticals Inc.. Esta análise ajuda a entender se o interno gera consistentemente retornos anormais, e vale a pena seguir. Esta análise é para um ano seguinte a cada transação, e os resultados são teóricos.

A tabela a seguir mostra as compras de mercado aberto mais recentes que não faziam parte de um plano de negociação automático.

Data de Negociação Ticker Insider Ações
Reportadas Preço
Reportado Ações
Ajustadas Preço
Ajustado Base de Custos Dias para
Máx Preço em
Máx Lucro
Máx ($) Retorno Máx (%)

2016-05-11 NTLA BAKER BROS. ADVISORS LP 20,469 18.0000 20,469 18.0000 368,442 20 29.57 236,826 64.28

2016-05-11 NTLA BAKER BROS. ADVISORS LP 179,531 18.0000 179,531 18.0000 3,231,558

O Preço Ajustado é o preço ajustado pela divisão. Ações Ajustadas são as ações ajustadas pela divisão.

Vendas Internas NTLA / Intellia Therapeutics, Inc. - Análise de Perda de Curto Prazo

Nesta seção, analisamos a evitação de perdas de curto prazo de cada venda interna de mercado aberto, não planejada feita em ACAD / ACADIA Pharmaceuticals Inc.. Um padrão consistente de evitação de perdas pode sugerir que transações futuras de venda possam prever declínios no preço. Esta análise é para um ano seguinte a cada transação, e os resultados são teóricos.

A tabela a seguir mostra as vendas de mercado aberto mais recentes que não faziam parte de um plano de negociação automático.

Data de Negociação Ticker Insider Ações
Reportadas Preço
Reportado Ações
Ajustadas Preço
Ajustado Base de Custos Dias para
Mín Preço em
Mín Máxima Perda
Evitada ($) Máxima Perda
Evitada (%)

Não há negociações abertas de mercado não planejadas conhecidas para esta combinação de insider e ativo

O Preço Ajustado é o preço ajustado pela divisão. Ações Ajustadas são as ações ajustadas pela divisão.

Compras Internas PRLD / Prelude Therapeutics Incorporated - Análise de Lucro de Curto Prazo

Nesta seção, analisamos a lucratividade de cada compra interna de mercado aberto, não planejada, feita em ACAD / ACADIA Pharmaceuticals Inc.. Esta análise ajuda a entender se o interno gera consistentemente retornos anormais, e vale a pena seguir. Esta análise é para um ano seguinte a cada transação, e os resultados são teóricos.

A tabela a seguir mostra as compras de mercado aberto mais recentes que não faziam parte de um plano de negociação automático.

Data de Negociação Ticker Insider Ações
Reportadas Preço
Reportado Ações
Ajustadas Preço
Ajustado Base de Custos Dias para
Máx Preço em
Máx Lucro
Máx ($) Retorno Máx (%)

2021-01-11 PRLD BAKER BROS. ADVISORS LP 12,444 60.0000 12,444 60.0000 746,640 30 91.68 394,226 52.80

2021-01-11 PRLD BAKER BROS. ADVISORS LP 154,222 60.0000 154,222 60.0000 9,253,320

2020-09-29 PRLD BAKER BROS. ADVISORS LP 104,628 19.0000 104,628 19.0000 1,987,932

2020-09-29 PRLD BAKER BROS. ADVISORS LP 1,474,319 19.0000 1,474,319 19.0000 28,012,061

O Preço Ajustado é o preço ajustado pela divisão. Ações Ajustadas são as ações ajustadas pela divisão.

Vendas Internas PRLD / Prelude Therapeutics Incorporated - Análise de Perda de Curto Prazo

Nesta seção, analisamos a evitação de perdas de curto prazo de cada venda interna de mercado aberto, não planejada feita em ACAD / ACADIA Pharmaceuticals Inc.. Um padrão consistente de evitação de perdas pode sugerir que transações futuras de venda possam prever declínios no preço. Esta análise é para um ano seguinte a cada transação, e os resultados são teóricos.

A tabela a seguir mostra as vendas de mercado aberto mais recentes que não faziam parte de um plano de negociação automático.

Data de Negociação Ticker Insider Ações
Reportadas Preço
Reportado Ações
Ajustadas Preço
Ajustado Base de Custos Dias para
Mín Preço em
Mín Máxima Perda
Evitada ($) Máxima Perda
Evitada (%)

Não há negociações abertas de mercado não planejadas conhecidas para esta combinação de insider e ativo

O Preço Ajustado é o preço ajustado pela divisão. Ações Ajustadas são as ações ajustadas pela divisão.

Compras Internas REPL / Replimune Group, Inc. - Análise de Lucro de Curto Prazo

Nesta seção, analisamos a lucratividade de cada compra interna de mercado aberto, não planejada, feita em ACAD / ACADIA Pharmaceuticals Inc.. Esta análise ajuda a entender se o interno gera consistentemente retornos anormais, e vale a pena seguir. Esta análise é para um ano seguinte a cada transação, e os resultados são teóricos.

A tabela a seguir mostra as compras de mercado aberto mais recentes que não faziam parte de um plano de negociação automático.

Data de Negociação Ticker Insider Ações
Reportadas Preço
Reportado Ações
Ajustadas Preço
Ajustado Base de Custos Dias para
Máx Preço em
Máx Lucro
Máx ($) Retorno Máx (%)

Não há negociações abertas de mercado não planejadas conhecidas para esta combinação de insider e ativo

O Preço Ajustado é o preço ajustado pela divisão. Ações Ajustadas são as ações ajustadas pela divisão.

Vendas Internas REPL / Replimune Group, Inc. - Análise de Perda de Curto Prazo

Nesta seção, analisamos a evitação de perdas de curto prazo de cada venda interna de mercado aberto, não planejada feita em ACAD / ACADIA Pharmaceuticals Inc.. Um padrão consistente de evitação de perdas pode sugerir que transações futuras de venda possam prever declínios no preço. Esta análise é para um ano seguinte a cada transação, e os resultados são teóricos.

A tabela a seguir mostra as vendas de mercado aberto mais recentes que não faziam parte de um plano de negociação automático.

Data de Negociação Ticker Insider Ações
Reportadas Preço
Reportado Ações
Ajustadas Preço
Ajustado Base de Custos Dias para
Mín Preço em
Mín Máxima Perda
Evitada ($) Máxima Perda
Evitada (%)

Não há negociações abertas de mercado não planejadas conhecidas para esta combinação de insider e ativo

O Preço Ajustado é o preço ajustado pela divisão. Ações Ajustadas são as ações ajustadas pela divisão.

Compras Internas RYTM / Rhythm Pharmaceuticals, Inc. - Análise de Lucro de Curto Prazo

Nesta seção, analisamos a lucratividade de cada compra interna de mercado aberto, não planejada, feita em ACAD / ACADIA Pharmaceuticals Inc.. Esta análise ajuda a entender se o interno gera consistentemente retornos anormais, e vale a pena seguir. Esta análise é para um ano seguinte a cada transação, e os resultados são teóricos.

A tabela a seguir mostra as compras de mercado aberto mais recentes que não faziam parte de um plano de negociação automático.

Data de Negociação Ticker Insider Ações
Reportadas Preço
Reportado Ações
Ajustadas Preço
Ajustado Base de Custos Dias para
Máx Preço em
Máx Lucro
Máx ($) Retorno Máx (%)

2017-10-05 RYTM BAKER BROS. ADVISORS LP 87,809 17.0000 87,809 17.0000 1,492,753 273 35.85 1,655,200 110.88

2017-10-05 RYTM BAKER BROS. ADVISORS LP 797,191 17.0000 797,191 17.0000 13,552,247

O Preço Ajustado é o preço ajustado pela divisão. Ações Ajustadas são as ações ajustadas pela divisão.

Vendas Internas RYTM / Rhythm Pharmaceuticals, Inc. - Análise de Perda de Curto Prazo

Nesta seção, analisamos a evitação de perdas de curto prazo de cada venda interna de mercado aberto, não planejada feita em ACAD / ACADIA Pharmaceuticals Inc.. Um padrão consistente de evitação de perdas pode sugerir que transações futuras de venda possam prever declínios no preço. Esta análise é para um ano seguinte a cada transação, e os resultados são teóricos.

A tabela a seguir mostra as vendas de mercado aberto mais recentes que não faziam parte de um plano de negociação automático.

Data de Negociação Ticker Insider Ações
Reportadas Preço
Reportado Ações
Ajustadas Preço
Ajustado Base de Custos Dias para
Mín Preço em
Mín Máxima Perda
Evitada ($) Máxima Perda
Evitada (%)

Não há negociações abertas de mercado não planejadas conhecidas para esta combinação de insider e ativo

O Preço Ajustado é o preço ajustado pela divisão. Ações Ajustadas são as ações ajustadas pela divisão.

Compras Internas SERA / Sera Prognostics, Inc. - Análise de Lucro de Curto Prazo

Nesta seção, analisamos a lucratividade de cada compra interna de mercado aberto, não planejada, feita em ACAD / ACADIA Pharmaceuticals Inc.. Esta análise ajuda a entender se o interno gera consistentemente retornos anormais, e vale a pena seguir. Esta análise é para um ano seguinte a cada transação, e os resultados são teóricos.

A tabela a seguir mostra as compras de mercado aberto mais recentes que não faziam parte de um plano de negociação automático.

Data de Negociação Ticker Insider Ações
Reportadas Preço
Reportado Ações
Ajustadas Preço
Ajustado Base de Custos Dias para
Máx Preço em
Máx Lucro
Máx ($) Retorno Máx (%)

Não há negociações abertas de mercado não planejadas conhecidas para esta combinação de insider e ativo

O Preço Ajustado é o preço ajustado pela divisão. Ações Ajustadas são as ações ajustadas pela divisão.

Vendas Internas SERA / Sera Prognostics, Inc. - Análise de Perda de Curto Prazo

Nesta seção, analisamos a evitação de perdas de curto prazo de cada venda interna de mercado aberto, não planejada feita em ACAD / ACADIA Pharmaceuticals Inc.. Um padrão consistente de evitação de perdas pode sugerir que transações futuras de venda possam prever declínios no preço. Esta análise é para um ano seguinte a cada transação, e os resultados são teóricos.

A tabela a seguir mostra as vendas de mercado aberto mais recentes que não faziam parte de um plano de negociação automático.

Data de Negociação Ticker Insider Ações
Reportadas Preço
Reportado Ações
Ajustadas Preço
Ajustado Base de Custos Dias para
Mín Preço em
Mín Máxima Perda
Evitada ($) Máxima Perda
Evitada (%)

Não há negociações abertas de mercado não planejadas conhecidas para esta combinação de insider e ativo

O Preço Ajustado é o preço ajustado pela divisão. Ações Ajustadas são as ações ajustadas pela divisão.

Compras Internas SYRE / Spyre Therapeutics, Inc. - Análise de Lucro de Curto Prazo

Nesta seção, analisamos a lucratividade de cada compra interna de mercado aberto, não planejada, feita em ACAD / ACADIA Pharmaceuticals Inc.. Esta análise ajuda a entender se o interno gera consistentemente retornos anormais, e vale a pena seguir. Esta análise é para um ano seguinte a cada transação, e os resultados são teóricos.

A tabela a seguir mostra as compras de mercado aberto mais recentes que não faziam parte de um plano de negociação automático.

Data de Negociação Ticker Insider Ações
Reportadas Preço
Reportado Ações
Ajustadas Preço
Ajustado Base de Custos Dias para
Máx Preço em
Máx Lucro
Máx ($) Retorno Máx (%)

Não há negociações abertas de mercado não planejadas conhecidas para esta combinação de insider e ativo

O Preço Ajustado é o preço ajustado pela divisão. Ações Ajustadas são as ações ajustadas pela divisão.

Vendas Internas SYRE / Spyre Therapeutics, Inc. - Análise de Perda de Curto Prazo

Nesta seção, analisamos a evitação de perdas de curto prazo de cada venda interna de mercado aberto, não planejada feita em ACAD / ACADIA Pharmaceuticals Inc.. Um padrão consistente de evitação de perdas pode sugerir que transações futuras de venda possam prever declínios no preço. Esta análise é para um ano seguinte a cada transação, e os resultados são teóricos.

A tabela a seguir mostra as vendas de mercado aberto mais recentes que não faziam parte de um plano de negociação automático.

Data de Negociação Ticker Insider Ações
Reportadas Preço
Reportado Ações
Ajustadas Preço
Ajustado Base de Custos Dias para
Mín Preço em
Mín Máxima Perda
Evitada ($) Máxima Perda
Evitada (%)

Não há negociações abertas de mercado não planejadas conhecidas para esta combinação de insider e ativo

O Preço Ajustado é o preço ajustado pela divisão. Ações Ajustadas são as ações ajustadas pela divisão.

Compras Internas TCRX / TScan Therapeutics, Inc. - Análise de Lucro de Curto Prazo

Nesta seção, analisamos a lucratividade de cada compra interna de mercado aberto, não planejada, feita em ACAD / ACADIA Pharmaceuticals Inc.. Esta análise ajuda a entender se o interno gera consistentemente retornos anormais, e vale a pena seguir. Esta análise é para um ano seguinte a cada transação, e os resultados são teóricos.

A tabela a seguir mostra as compras de mercado aberto mais recentes que não faziam parte de um plano de negociação automático.

Data de Negociação Ticker Insider Ações
Reportadas Preço
Reportado Ações
Ajustadas Preço
Ajustado Base de Custos Dias para
Máx Preço em
Máx Lucro
Máx ($) Retorno Máx (%)

2022-05-11 TCRX BAKER BROS. ADVISORS LP 2,882 1.9853 2,882 1.9853 5,722 364 4.8500 8,257 144.32

2022-05-11 TCRX BAKER BROS. ADVISORS LP 22,983 1.9853 22,983 1.9853 45,628

2022-05-10 TCRX BAKER BROS. ADVISORS LP 40,800 1.7000 40,800 1.7000 69,360

2022-05-10 TCRX BAKER BROS. ADVISORS LP 325,373 1.7000 325,373 1.7000 553,134

2022-05-10 TCRX BAKER BROS. ADVISORS LP 12,769 1.9342 12,769 1.9342 24,698

2022-05-10 TCRX BAKER BROS. ADVISORS LP 101,831 1.9342 101,831 1.9342 196,962

2022-05-10 TCRX BAKER BROS. ADVISORS LP 95,060 1.9500 95,060 1.9500 185,367

2022-05-10 TCRX BAKER BROS. ADVISORS LP 758,094 1.9500 758,094 1.9500 1,478,283

2021-07-20 TCRX BAKER BROS. ADVISORS LP 104,698 15.0000 104,698 15.0000 1,570,470

2021-07-20 TCRX BAKER BROS. ADVISORS LP 1,320,302 15.0000 1,320,302 15.0000 19,804,530

O Preço Ajustado é o preço ajustado pela divisão. Ações Ajustadas são as ações ajustadas pela divisão.

Vendas Internas TCRX / TScan Therapeutics, Inc. - Análise de Perda de Curto Prazo

Nesta seção, analisamos a evitação de perdas de curto prazo de cada venda interna de mercado aberto, não planejada feita em ACAD / ACADIA Pharmaceuticals Inc.. Um padrão consistente de evitação de perdas pode sugerir que transações futuras de venda possam prever declínios no preço. Esta análise é para um ano seguinte a cada transação, e os resultados são teóricos.

A tabela a seguir mostra as vendas de mercado aberto mais recentes que não faziam parte de um plano de negociação automático.

Data de Negociação Ticker Insider Ações
Reportadas Preço
Reportado Ações
Ajustadas Preço
Ajustado Base de Custos Dias para
Mín Preço em
Mín Máxima Perda
Evitada ($) Máxima Perda
Evitada (%)

Não há negociações abertas de mercado não planejadas conhecidas para esta combinação de insider e ativo

O Preço Ajustado é o preço ajustado pela divisão. Ações Ajustadas são as ações ajustadas pela divisão.

Compras Internas TRDA / Entrada Therapeutics, Inc. - Análise de Lucro de Curto Prazo

Nesta seção, analisamos a lucratividade de cada compra interna de mercado aberto, não planejada, feita em ACAD / ACADIA Pharmaceuticals Inc.. Esta análise ajuda a entender se o interno gera consistentemente retornos anormais, e vale a pena seguir. Esta análise é para um ano seguinte a cada transação, e os resultados são teóricos.

A tabela a seguir mostra as compras de mercado aberto mais recentes que não faziam parte de um plano de negociação automático.

Data de Negociação Ticker Insider Ações
Reportadas Preço
Reportado Ações
Ajustadas Preço
Ajustado Base de Custos Dias para
Máx Preço em
Máx Lucro
Máx ($) Retorno Máx (%)

2025-11-20 TRDA BAKER BROS. ADVISORS LP 1,213 9.0688 1,213 9.0688 11,000 167 16.0300 8,444 76.77

2025-11-20 TRDA BAKER BROS. ADVISORS LP 13,386 9.0688 13,386 9.0688 121,395

2025-11-20 TRDA BAKER BROS. ADVISORS LP 1,186 9.0728 1,186 9.0728 10,760

2025-11-20 TRDA BAKER BROS. ADVISORS LP 13,082 9.0728 13,082 9.0728 118,690

2025-11-12 TRDA BAKER BROS. ADVISORS LP 7,321 7.7315 7,321 7.7315 56,602

2025-11-12 TRDA BAKER BROS. ADVISORS LP 80,881 7.7315 80,881 7.7315 625,331

2025-11-12 TRDA BAKER BROS. ADVISORS LP 1,040 7.9547 1,040 7.9547 8,273

2025-11-12 TRDA BAKER BROS. ADVISORS LP 11,494 7.9547 11,494 7.9547 91,431

2025-11-11 TRDA BAKER BROS. ADVISORS LP 1,059 7.3909 1,059 7.3909 7,827

2025-11-11 TRDA BAKER BROS. ADVISORS LP 11,701 7.3909 11,701 7.3909 86,481

2025-11-11 TRDA BAKER BROS. ADVISORS LP 2,795 7.5395 2,795 7.5395 21,073

2025-11-11 TRDA BAKER BROS. ADVISORS LP 30,879 7.5395 30,879 7.5395 232,812

2025-11-10 TRDA BAKER BROS. ADVISORS LP 2,296 7.2139 2,296 7.2139 16,563

2025-11-10 TRDA BAKER BROS. ADVISORS LP 25,364 7.2139 25,364 7.2139 182,973

2025-11-10 TRDA BAKER BROS. ADVISORS LP 267 7.2244 267 7.2244 1,929

2025-11-10 TRDA BAKER BROS. ADVISORS LP 2,947 7.2244 2,947 7.2244 21,290

2022-06-06 TRDA BAKER BROS. ADVISORS LP 921 6.3537 921 6.3537 5,852

2022-06-06 TRDA BAKER BROS. ADVISORS LP 7,815 6.3537 7,815 6.3537 49,654

2022-06-06 TRDA BAKER BROS. ADVISORS LP 3,118 6.4215 3,118 6.4215 20,022

2022-06-06 TRDA BAKER BROS. ADVISORS LP 26,450 6.4215 26,450 6.4215 169,849

2022-06-02 TRDA BAKER BROS. ADVISORS LP 279 5.8202 279 5.8202 1,624

2022-06-02 TRDA BAKER BROS. ADVISORS LP 2,364 5.8202 2,364 5.8202 13,759

2022-05-24 TRDA BAKER BROS. ADVISORS LP 179 5.9300 179 5.9300 1,061

2022-05-24 TRDA BAKER BROS. ADVISORS LP 1,521 5.9300 1,521 5.9300 9,020

2022-05-24 TRDA BAKER BROS. ADVISORS LP 2,334 5.7415 2,334 5.7415 13,401

2022-05-24 TRDA BAKER BROS. ADVISORS LP 19,789 5.7415 19,789 5.7415 113,619

2022-05-23 TRDA BAKER BROS. ADVISORS LP 827 5.9874 827 5.9874 4,952

2022-05-23 TRDA BAKER BROS. ADVISORS LP 7,010 5.9874 7,010 5.9874 41,972

2022-05-20 TRDA BAKER BROS. ADVISORS LP 883 5.8409 883 5.8409 5,158

2022-05-20 TRDA BAKER BROS. ADVISORS LP 7,248 5.8409 7,248 5.8409 42,335

2022-05-20 TRDA BAKER BROS. ADVISORS LP 946 5.8421 946 5.8421 5,527

2022-05-20 TRDA BAKER BROS. ADVISORS LP 7,772 5.8421 7,772 5.8421 45,405

2022-05-18 TRDA BAKER BROS. ADVISORS LP 84 5.9180 84 5.9180 497

2022-05-18 TRDA BAKER BROS. ADVISORS LP 692 5.9180 692 5.9180 4,095

2022-05-18 TRDA BAKER BROS. ADVISORS LP 3,654 6.0000 3,654 6.0000 21,924

2022-05-18 TRDA BAKER BROS. ADVISORS LP 30,003 6.0000 30,003 6.0000 180,018

2022-05-17 TRDA BAKER BROS. ADVISORS LP 2,010 6.1301 2,010 6.1301 12,322

2022-05-17 TRDA BAKER BROS. ADVISORS LP 16,501 6.1301 16,501 6.1301 101,153

2022-05-16 TRDA BAKER BROS. ADVISORS LP 2,063 5.8259 2,063 5.8259 12,019

2022-05-16 TRDA BAKER BROS. ADVISORS LP 16,937 5.8259 16,937 5.8259 98,673

O Preço Ajustado é o preço ajustado pela divisão. Ações Ajustadas são as ações ajustadas pela divisão.

Vendas Internas TRDA / Entrada Therapeutics, Inc. - Análise de Perda de Curto Prazo

Nesta seção, analisamos a evitação de perdas de curto prazo de cada venda interna de mercado aberto, não planejada feita em ACAD / ACADIA Pharmaceuticals Inc.. Um padrão consistente de evitação de perdas pode sugerir que transações futuras de venda possam prever declínios no preço. Esta análise é para um ano seguinte a cada transação, e os resultados são teóricos.

A tabela a seguir mostra as vendas de mercado aberto mais recentes que não faziam parte de um plano de negociação automático.

Data de Negociação Ticker Insider Ações
Reportadas Preço
Reportado Ações
Ajustadas Preço
Ajustado Base de Custos Dias para
Mín Preço em
Mín Máxima Perda
Evitada ($) Máxima Perda
Evitada (%)

Não há negociações abertas de mercado não planejadas conhecidas para esta combinação de insider e ativo

O Preço Ajustado é o preço ajustado pela divisão. Ações Ajustadas são as ações ajustadas pela divisão.

Compras Internas VTVT / vTv Therapeutics Inc. - Análise de Lucro de Curto Prazo

Nesta seção, analisamos a lucratividade de cada compra interna de mercado aberto, não planejada, feita em ACAD / ACADIA Pharmaceuticals Inc.. Esta análise ajuda a entender se o interno gera consistentemente retornos anormais, e vale a pena seguir. Esta análise é para um ano seguinte a cada transação, e os resultados são teóricos.

A tabela a seguir mostra as compras de mercado aberto mais recentes que não faziam parte de um plano de negociação automático.

Data de Negociação Ticker Insider Ações
Reportadas Preço
Reportado Ações
Ajustadas Preço
Ajustado Base de Custos Dias para
Máx Preço em
Máx Lucro
Máx ($) Retorno Máx (%)

Não há negociações abertas de mercado não planejadas conhecidas para esta combinação de insider e ativo

O Preço Ajustado é o preço ajustado pela divisão. Ações Ajustadas são as ações ajustadas pela divisão.

Vendas Internas VTVT / vTv Therapeutics Inc. - Análise de Perda de Curto Prazo

Nesta seção, analisamos a evitação de perdas de curto prazo de cada venda interna de mercado aberto, não planejada feita em ACAD / ACADIA Pharmaceuticals Inc.. Um padrão consistente de evitação de perdas pode sugerir que transações futuras de venda possam prever declínios no preço. Esta análise é para um ano seguinte a cada transação, e os resultados são teóricos.

A tabela a seguir mostra as vendas de mercado aberto mais recentes que não faziam parte de um plano de negociação automático.

Data de Negociação Ticker Insider Ações
Reportadas Preço
Reportado Ações
Ajustadas Preço
Ajustado Base de Custos Dias para
Mín Preço em
Mín Máxima Perda
Evitada ($) Máxima Perda
Evitada (%)

Não há negociações abertas de mercado não planejadas conhecidas para esta combinação de insider e ativo

O Preço Ajustado é o preço ajustado pela divisão. Ações Ajustadas são as ações ajustadas pela divisão.

Compras Internas XOMAO / XOMA Royalty Corporation - Preferred Stock - Análise de Lucro de Curto Prazo

Nesta seção, analisamos a lucratividade de cada compra interna de mercado aberto, não planejada, feita em ACAD / ACADIA Pharmaceuticals Inc.. Esta análise ajuda a entender se o interno gera consistentemente retornos anormais, e vale a pena seguir. Esta análise é para um ano seguinte a cada transação, e os resultados são teóricos.

A tabela a seguir mostra as compras de mercado aberto mais recentes que não faziam parte de um plano de negociação automático.

Data de Negociação Ticker Insider Ações
Reportadas Preço
Reportado Ações
Ajustadas Preço
Ajustado Base de Custos Dias para
Máx Preço em
Máx Lucro
Máx ($) Retorno Máx (%)

2013-08-19 XOMA BAKER BROS. ADVISORS LP 882,323 3.6200 44,116 72.4000 3,194,009 197 188.8 5,135,092 160.77

2013-08-19 XOMA BAKER BROS. ADVISORS LP 1,854,058 3.6200 92,703 72.4000 6,711,690

2013-08-19 XOMA BAKER BROS. ADVISORS LP 21,410 3.6200 1,070 72.4000 77,504

2012-10-29 XOMA BAKER JULIAN 336,639 3.0000 16,832 60.0000 1,009,917

2012-10-29 XOMA BAKER JULIAN 4,282,419 3.0000 214,121 60.0000 12,847,257

2012-10-29 XOMA BAKER JULIAN 103,608 3.0000 5,180 60.0000 310,824

O Preço Ajustado é o preço ajustado pela divisão. Ações Ajustadas são as ações ajustadas pela divisão.

Vendas Internas XOMAO / XOMA Royalty Corporation - Preferred Stock - Análise de Perda de Curto Prazo

Nesta seção, analisamos a evitação de perdas de curto prazo de cada venda interna de mercado aberto, não planejada feita em ACAD / ACADIA Pharmaceuticals Inc.. Um padrão consistente de evitação de perdas pode sugerir que transações futuras de venda possam prever declínios no preço. Esta análise é para um ano seguinte a cada transação, e os resultados são teóricos.

A tabela a seguir mostra as vendas de mercado aberto mais recentes que não faziam parte de um plano de negociação automático.

Data de Negociação Ticker Insider Ações
Reportadas Preço
Reportado Ações
Ajustadas Preço
Ajustado Base de Custos Dias para
Mín Preço em
Mín Máxima Perda
Evitada ($) Máxima Perda
Evitada (%)

2015-07-22 XOMA BAKER BROS. ADVISORS LP 1,359,253 1.0925 67,963 21.8500 1,484,984 341 9.01 -872,645 -58.76

2015-07-22 XOMA BAKER BROS. ADVISORS LP 9,411,311 1.0925 470,566 21.8500 10,281,857

2015-07-22 XOMA BAKER BROS. ADVISORS LP 229,436 1.0925 11,472 21.8500 250,659

2015-01-06 XOMA BAKER BROS. ADVISORS LP 118,571 3.8600 5,929 77.2000 457,684

2015-01-06 XOMA BAKER BROS. ADVISORS LP 859,988 3.8600 42,999 77.2000 3,319,554

2015-01-06 XOMA BAKER BROS. ADVISORS LP 21,441 3.8600 1,072 77.2000 82,762

2015-01-05 XOMA BAKER BROS. ADVISORS LP 118,652 3.8115 5,933 76.2300 452,242

2015-01-05 XOMA BAKER BROS. ADVISORS LP 863,100 3.8115 43,155 76.2300 3,289,706

2015-01-05 XOMA BAKER BROS. ADVISORS LP 21,548 3.8115 1,077 76.2300 82,130

2015-01-02 XOMA BAKER BROS. ADVISORS LP 25,092 3.5537 1,255 71.0740 89,169

2015-01-02 XOMA BAKER BROS. ADVISORS LP 182,454 3.5537 9,123 71.0740 648,387

2015-01-02 XOMA BAKER BROS. ADVISORS LP 4,554 3.5537 228 71.0740 16,184

2014-12-30 XOMA BAKER BROS. ADVISORS LP 46,362 3.6495 2,318 72.9900 169,198

2014-12-30 XOMA BAKER BROS. ADVISORS LP 337,123 3.6495 16,856 72.9900 1,230,330

2014-12-30 XOMA BAKER BROS. ADVISORS LP 8,415 3.6495 421 72.9900 30,711

2014-12-29 XOMA BAKER BROS. ADVISORS LP 26,137 3.6762 1,307 73.5240 96,085

2014-12-29 XOMA BAKER BROS. ADVISORS LP 190,117 3.6762 9,506 73.5240 698,908

2014-12-29 XOMA BAKER BROS. ADVISORS LP 4,746 3.6762 237 73.5240 17,447

2014-12-26 XOMA BAKER BROS. ADVISORS LP 15,420 3.7106 771 74.2120 57,217

2014-12-26 XOMA BAKER BROS. ADVISORS LP 112,855 3.7106 5,643 74.2120 418,760

2014-12-26 XOMA BAKER BROS. ADVISORS LP 2,825 3.7106 141 74.2120 10,482

2014-12-19 XOMA BAKER BROS. ADVISORS LP 88,937 4.2085 4,447 84.1700 374,291

2014-12-19 XOMA BAKER BROS. ADVISORS LP 647,781 4.2085 32,389 84.1700 2,726,186

2014-12-19 XOMA BAKER BROS. ADVISORS LP 16,182 4.2085 809 84.1700 68,102

2014-12-18 XOMA BAKER BROS. ADVISORS LP 19,599 4.2890 980 85.7800 84,060

2014-12-18 XOMA BAKER BROS. ADVISORS LP 142,543 4.2890 7,127 85.7800 611,367

2014-12-18 XOMA BAKER BROS. ADVISORS LP 3,558 4.2890 178 85.7800 15,260

2014-12-17 XOMA BAKER BROS. ADVISORS LP 81,109 4.3090 4,055 86.1800 349,499

2014-12-17 XOMA BAKER BROS. ADVISORS LP 590,638 4.3090 29,532 86.1800 2,545,059

2014-12-17 XOMA BAKER BROS. ADVISORS LP 14,753 4.3090 738 86.1800 63,571

2014-12-16 XOMA BAKER BROS. ADVISORS LP 37,592 4.2709 1,880 85.4180 160,552

2014-12-16 XOMA BAKER BROS. ADVISORS LP 274,734 4.2709 13,737 85.4180 1,173,361

2014-12-16 XOMA BAKER BROS. ADVISORS LP 6,874 4.2709 344 85.4180 29,358

2014-12-15 XOMA BAKER BROS. ADVISORS LP 54,396 4.4502 2,720 89.0040 242,073

2014-12-15 XOMA BAKER BROS. ADVISORS LP 396,496 4.4502 19,825 89.0040 1,764,486

2014-12-15 XOMA BAKER BROS. ADVISORS LP 9,908 4.4502 495 89.0040 44,093

2014-12-12 XOMA BAKER BROS. ADVISORS LP 29,960 4.7140 1,498 94.2800 141,231

2014-12-12 XOMA BAKER BROS. ADVISORS LP 218,383 4.7140 10,919 94.2800 1,029,457

2014-12-12 XOMA BAKER BROS. ADVISORS LP 5,457 4.7140 273 94.2800 25,724

2014-12-09 XOMA BAKER BROS. ADVISORS LP 46,383 4.6159 2,319 92.3180 214,099

2014-12-09 XOMA BAKER BROS. ADVISORS LP 337,541 4.6159 16,877 92.3180 1,558,056

2014-12-09 XOMA BAKER BROS. ADVISORS LP 8,429 4.6159 421 92.3180 38,907

2014-12-04 XOMA BAKER BROS. ADVISORS LP 153,618 4.5457 7,681 90.9140 698,301

2014-12-04 XOMA BAKER BROS. ADVISORS LP 1,122,584 4.5457 56,129 90.9140 5,102,930

2014-12-04 XOMA BAKER BROS. ADVISORS LP 28,086 4.5457 1,404 90.9140 127,671

2014-12-03 XOMA BAKER BROS. ADVISORS LP 69,153 4.8402 3,458 96.8040 334,714

2014-12-03 XOMA BAKER BROS. ADVISORS LP 486,800 4.8402 24,340 96.8040 2,356,209

2014-12-03 XOMA BAKER BROS. ADVISORS LP 11,965 4.8402 598 96.8040 57,913

2014-12-02 XOMA BAKER BROS. ADVISORS LP 60,883 5.3591 3,044 107.1820 326,278

2014-12-02 XOMA BAKER BROS. ADVISORS LP 428,583 5.3591 21,429 107.1820 2,296,819

2014-12-02 XOMA BAKER BROS. ADVISORS LP 10,534 5.3591 527 107.1820 56,453

O Preço Ajustado é o preço ajustado pela divisão. Ações Ajustadas são as ações ajustadas pela divisão.

Compras Internas ZYME / Zymeworks Inc. - Análise de Lucro de Curto Prazo

Nesta seção, analisamos a lucratividade de cada compra interna de mercado aberto, não planejada, feita em ACAD / ACADIA Pharmaceuticals Inc.. Esta análise ajuda a entender se o interno gera consistentemente retornos anormais, e vale a pena seguir. Esta análise é para um ano seguinte a cada transação, e os resultados são teóricos.

A tabela a seguir mostra as compras de mercado aberto mais recentes que não faziam parte de um plano de negociação automático.

Data de Negociação Ticker Insider Ações
Reportadas Preço
Reportado Ações
Ajustadas Preço
Ajustado Base de Custos Dias para
Máx Preço em
Máx Lucro
Máx ($) Retorno Máx (%)

Não há negociações abertas de mercado não planejadas conhecidas para esta combinação de insider e ativo

O Preço Ajustado é o preço ajustado pela divisão. Ações Ajustadas são as ações ajustadas pela divisão.

Vendas Internas ZYME / Zymeworks Inc. - Análise de Perda de Curto Prazo

Nesta seção, analisamos a evitação de perdas de curto prazo de cada venda interna de mercado aberto, não planejada feita em ACAD / ACADIA Pharmaceuticals Inc.. Um padrão consistente de evitação de perdas pode sugerir que transações futuras de venda possam prever declínios no preço. Esta análise é para um ano seguinte a cada transação, e os resultados são teóricos.

A tabela a seguir mostra as vendas de mercado aberto mais recentes que não faziam parte de um plano de negociação automático.

Data de Negociação Ticker Insider Ações
Reportadas Preço
Reportado Ações
Ajustadas Preço
Ajustado Base de Custos Dias para
Mín Preço em
Mín Máxima Perda
Evitada ($) Máxima Perda
Evitada (%)

Não há negociações abertas de mercado não planejadas conhecidas para esta combinação de insider e ativo

O Preço Ajustado é o preço ajustado pela divisão. Ações Ajustadas são as ações ajustadas pela divisão.

Histórico de Negociações Insider

Esta tabela mostra a lista completa de negociações insider realizadas por Baker Bros. Advisors Lp conforme divulgadas para a Comissão de Valores Mobiliários (SEC).

Data do Arquivo Data da Transação Formulário Ticker Ativo Código 10b5-1 Ações Ações Restantes Variação
Percentual Preço
da Ação Valor
da Transação Valor
Restante

2026-06-05 2026-06-03 4 DNLI Denali Therapeutics Inc.
Common Stock A - Award 6,408 3,422,366 0.19

2026-06-05 2026-06-03 4 DNLI Denali Therapeutics Inc.
Common Stock A - Award 6,408 343,275 1.90

2026-06-02 2026-05-29 4 KNSA Kiniksa Pharmaceuticals International, plc
Class A Ordinary Shares A - Award 6,078 2,744,894 0.22

2026-06-02 2026-05-29 4 KNSA Kiniksa Pharmaceuticals International, plc
Class A Ordinary Shares A - Award 6,078 143,277 4.43

2026-06-02 2026-05-29 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock A - Award 18,622 39,384,587 0.05

2026-06-02 2026-05-29 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock A - Award 18,622 3,677,357 0.51

2026-05-27 2026-05-22 4 ONC BeOne Medicines Ltd.
Ordinary Shares S - Sale -2,756 142,570 -1.90 23.79 -65,567 3,391,812

2026-05-27 2026-05-22 4 ONC BeOne Medicines Ltd.
Ordinary Shares S - Sale -2,756 142,566 -1.90 23.79 -65,567 3,391,716

2026-05-27 2026-05-22 4 ONC BeOne Medicines Ltd.
Ordinary Shares S - Sale -2,743 145,326 -1.85 23.85 -65,424 3,466,199

2026-05-27 2026-05-22 4 ONC BeOne Medicines Ltd.
Ordinary Shares S - Sale -2,743 145,322 -1.85 23.85 -65,424 3,466,104

2026-05-11 2026-05-08 4 INCY INCYTE CORP
Common Stock M - Exercise 15,000 28,203,718 0.05 84.53 1,267,950 2,384,060,283

2026-05-11 2026-05-08 4 INCY INCYTE CORP
Common Stock M - Exercise 15,000 2,833,039 0.53 84.53 1,267,950 239,476,787

2026-04-02 2026-03-31 4 INCY INCYTE CORP
Common Stock A - Award 421 28,188,718 0.00

2026-04-02 2026-03-31 4 INCY INCYTE CORP
Common Stock A - Award 421 2,818,039 0.01

2026-01-06 2026-01-02 4 BCYC BICYCLE THERAPEUTICS PLC
American Depositary Shares A - Award 19,000 10,018,674 0.19

2026-01-06 2026-01-02 4 BCYC BICYCLE THERAPEUTICS PLC
American Depositary Shares A - Award 19,000 10,018,674 0.19

2026-01-05 2025-12-31 4 INCY INCYTE CORP
Common Stock A - Award 328 28,188,297 0.00

2026-01-05 2025-12-31 4 INCY INCYTE CORP
Common Stock A - Award 328 28,188,297 0.00

2025-12-19 2025-12-18 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 2,391,268 18,358,772 14.98 23.00 54,999,164 422,251,756

2025-12-19 2025-12-18 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 217,428 1,560,414 16.19 23.00 5,000,844 35,889,522

2025-12-11 2025-12-11 4 KYMR Kymera Therapeutics, Inc.
Common Stock P - Purchase 1,838,621 7,955,916 30.06 86.00 158,121,406 684,208,776

2025-12-11 2025-12-11 4 KYMR Kymera Therapeutics, Inc.
Common Stock P - Purchase 167,192 701,326 31.30 86.00 14,378,512 60,314,036

2025-11-24 2025-11-20 4 TRDA Entrada Therapeutics, Inc.
Common Stock P - Purchase 13,082 4,691,392 0.28 9.07 118,690 42,564,061

2025-11-24 2025-11-20 4 TRDA Entrada Therapeutics, Inc.
Common Stock P - Purchase 1,186 381,338 0.31 9.07 10,760 3,459,803

2025-11-24 2025-11-20 4 TRDA Entrada Therapeutics, Inc.
Common Stock P - Purchase 13,386 4,678,310 0.29 9.07 121,395 42,426,658

2025-11-24 2025-11-20 4 TRDA Entrada Therapeutics, Inc.
Common Stock P - Purchase 1,213 380,152 0.32 9.07 11,000 3,447,522

2025-11-12 2025-11-12 4 TRDA Entrada Therapeutics, Inc.
Common Stock P - Purchase 11,494 4,664,924 0.25 7.95 91,431 37,108,071

2025-11-12 2025-11-12 4 TRDA Entrada Therapeutics, Inc.
Common Stock P - Purchase 1,040 378,939 0.28 7.95 8,273 3,014,346

2025-11-12 2025-11-12 4 TRDA Entrada Therapeutics, Inc.
Common Stock P - Purchase 80,881 4,653,430 1.77 7.73 625,331 35,977,994

2025-11-12 2025-11-12 4 TRDA Entrada Therapeutics, Inc.
Common Stock P - Purchase 7,321 377,899 1.98 7.73 56,602 2,921,726

2025-11-12 2025-11-11 4 TRDA Entrada Therapeutics, Inc.
Common Stock P - Purchase 30,879 4,572,549 0.68 7.54 232,812 34,474,733

2025-11-12 2025-11-11 4 TRDA Entrada Therapeutics, Inc.
Common Stock P - Purchase 2,795 370,578 0.76 7.54 21,073 2,793,973

2025-11-12 2025-11-11 4 TRDA Entrada Therapeutics, Inc.
Common Stock P - Purchase 11,701 4,541,670 0.26 7.39 86,481 33,567,029

2025-11-12 2025-11-11 4 TRDA Entrada Therapeutics, Inc.
Common Stock P - Purchase 1,059 367,783 0.29 7.39 7,827 2,718,247

2025-11-12 2025-11-10 4 TRDA Entrada Therapeutics, Inc.
Common Stock P - Purchase 2,947 4,529,969 0.07 7.22 21,290 32,726,308

2025-11-12 2025-11-10 4 TRDA Entrada Therapeutics, Inc.
Common Stock P - Purchase 267 366,724 0.07 7.22 1,929 2,649,361

2025-11-12 2025-11-10 4 TRDA Entrada Therapeutics, Inc.
Common Stock P - Purchase 25,364 4,527,022 0.56 7.21 182,973 32,657,484

2025-11-12 2025-11-10 4 TRDA Entrada Therapeutics, Inc.
Common Stock P - Purchase 2,296 366,457 0.63 7.21 16,563 2,643,584

2025-10-02 2025-09-30 4 INCY INCYTE CORP
Common Stock A - Award 388 28,187,969 0.00

2025-10-02 2025-09-30 4 INCY INCYTE CORP
Common Stock A - Award 388 2,817,290 0.01

2025-10-02 2025-10-01 4 KALA KALA BIO, Inc.
Common Stock S - Sale -462,967 425,006 -52.14 1.38 -640,654 588,123

2025-10-02 2025-10-01 4 KALA KALA BIO, Inc.
Common Stock S - Sale -50,640 46,480 -52.14 1.38 -70,076 64,319

2025-10-02 2025-09-30 4 KALA KALA BIO, Inc.
Common Stock S - Sale -195,425 887,973 -18.04 1.60 -311,879 1,417,116

2025-10-02 2025-09-30 4 KALA KALA BIO, Inc.
Common Stock S - Sale -21,376 97,120 -18.04 1.60 -34,114 154,994

2025-09-10 2025-09-08 4 CELC Celcuity Inc.
Common Stock P - Purchase 4,212 7,211,484 0.06 58.02 244,395 418,436,263

2025-09-10 2025-09-08 4 CELC Celcuity Inc.
Common Stock P - Purchase 388 704,308 0.06 58.02 22,513 40,866,486

2025-09-10 2025-09-08 4 CELC Celcuity Inc.
Common Stock P - Purchase 151,524 7,207,272 2.15 56.22 8,518,679 405,192,832

2025-09-10 2025-09-08 4 CELC Celcuity Inc.
Common Stock P - Purchase 13,976 703,920 2.03 56.22 785,731 39,574,382

2025-09-05 2025-09-03 4 VTVT vTv Therapeutics Inc.
Common Stock A - Award 46,692 135,946 52.31

2025-09-05 2025-09-03 4 VTVT vTv Therapeutics Inc.
Common Stock A - Award 4,308 12,368 53.45

2025-08-20 2025-08-18 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 10,128 1,859,091 0.55 372.16 3,769,209 691,874,287

2025-08-20 2025-08-18 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 933 194,625 0.48 372.16 347,223 72,431,115

2025-08-20 2025-08-18 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 5,494 1,848,963 0.30 371.00 2,038,301 685,974,518

2025-08-20 2025-08-18 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 506 193,692 0.26 371.00 187,729 71,860,700

2025-08-20 2025-08-18 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 2,747 1,843,469 0.15 369.34 1,014,563 680,857,623

2025-08-20 2025-08-18 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 253 193,186 0.13 369.34 93,442 71,350,351

2025-08-20 2025-08-18 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 1,419 1,840,722 0.08 368.84 523,384 678,931,902

2025-08-20 2025-08-18 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 131 192,933 0.07 368.84 48,318 71,161,408

2025-08-20 2025-08-18 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 4,798 1,839,303 0.26 367.77 1,764,565 676,442,304

2025-08-20 2025-08-18 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 442 192,802 0.23 367.77 162,555 70,906,984

2025-08-20 2025-08-18 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 2,289 1,834,505 0.12 366.30 838,459 671,977,714

2025-08-20 2025-08-18 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 211 192,360 0.11 366.30 77,289 70,461,314

2025-08-20 2025-08-18 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 2,772 1,832,216 0.15 363.75 1,008,308 666,463,806

2025-08-20 2025-08-18 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 255 192,149 0.13 363.75 92,756 69,893,699

2025-08-20 2025-08-18 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 5,587 1,829,444 0.31 362.39 2,024,662 662,968,735

2025-08-20 2025-08-18 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 515 191,894 0.27 362.39 186,630 69,540,102

2025-08-20 2025-08-18 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 5,443 1,823,857 0.30 361.37 1,966,957 659,093,770

2025-08-20 2025-08-18 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 502 191,379 0.26 361.37 181,410 69,159,318

2025-08-20 2025-08-18 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 8,514 1,818,414 0.47 359.39 3,059,873 653,525,445

2025-08-20 2025-08-18 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 784 190,877 0.41 359.39 281,764 68,599,877

2025-08-20 2025-08-18 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 2,472 1,809,900 0.14 358.21 885,495 648,324,279

2025-08-20 2025-08-18 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 228 190,093 0.12 358.21 81,672 68,093,214

2025-08-20 2025-08-18 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 8,328 1,807,428 0.46 357.02 2,973,289 645,293,728

2025-08-20 2025-08-18 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 767 189,865 0.41 357.02 273,837 67,786,210

2025-08-20 2025-08-18 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 916 1,799,100 0.05 355.00 325,180 638,680,500

2025-08-20 2025-08-18 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 84 189,098 0.04 355.00 29,820 67,129,790

2025-08-20 2025-08-18 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 1,923 1,798,184 0.11 353.88 680,503 636,333,262

2025-08-20 2025-08-18 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 177 189,014 0.09 353.88 62,636 66,887,424

2025-08-20 2025-08-20 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 9,362 1,947,968 0.48 392.24 3,672,178 764,076,617

2025-08-20 2025-08-20 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 862 202,813 0.43 392.24 338,113 79,551,959

2025-08-20 2025-08-20 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 2,506 1,938,606 0.13 389.89 977,059 755,838,828

2025-08-20 2025-08-20 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 231 201,951 0.11 389.89 90,064 78,738,231

2025-08-20 2025-08-20 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 366 1,936,100 0.02 389.00 142,374 753,142,900

2025-08-20 2025-08-20 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 34 201,720 0.02 389.00 13,226 78,469,080

2025-08-20 2025-08-20 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 4,441 1,935,734 0.23 387.07 1,718,969 749,260,688

2025-08-20 2025-08-20 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 409 201,686 0.20 387.07 158,311 78,066,197

2025-08-20 2025-08-20 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 13,545 1,931,293 0.71 385.06 5,215,601 743,658,468

2025-08-20 2025-08-20 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 1,248 201,277 0.62 385.06 480,552 77,503,178

2025-08-20 2025-08-20 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 4,049 1,917,748 0.21 383.79 1,553,954 736,007,135

2025-08-20 2025-08-20 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 373 200,029 0.19 383.79 143,153 76,768,570

2025-08-20 2025-08-20 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 2,838 1,913,699 0.15 382.82 1,086,447 732,604,739

2025-08-20 2025-08-20 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 262 199,656 0.13 382.82 100,299 76,432,569

2025-08-20 2025-08-20 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 1,136 1,910,861 0.06 382.29 434,280 730,501,332

2025-08-20 2025-08-20 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 105 199,394 0.05 382.29 40,140 76,226,153

2025-08-20 2025-08-20 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 9,477 1,909,725 0.50 381.12 3,611,889 727,837,448

2025-08-20 2025-08-20 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 873 199,289 0.44 381.12 332,719 75,953,343

2025-08-20 2025-08-20 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 1,919 1,900,248 0.10 380.78 730,717 723,576,433

2025-08-20 2025-08-20 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 176 198,416 0.09 380.78 67,017 75,552,844

2025-08-20 2025-08-20 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 5,209 1,898,329 0.28 380.44 1,981,694 722,193,641

2025-08-20 2025-08-20 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 480 198,240 0.24 380.44 182,610 75,417,732

2025-08-20 2025-08-18 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 7,325 1,893,120 0.39 374.43 2,742,728 708,848,115

2025-08-20 2025-08-18 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 675 197,760 0.34 374.43 252,743 74,048,028

2025-08-20 2025-08-18 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 26,704 1,885,795 1.44 372.87 9,957,102 703,155,062

2025-08-20 2025-08-18 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 2,460 197,085 1.26 372.87 917,258 73,486,946

2025-08-18 2025-08-14 4 IGMS IGM Biosciences, Inc.
Common Stock U - Other -3,763,362 0 -100.00

2025-08-18 2025-08-14 4 IGMS IGM Biosciences, Inc.
Common Stock U - Other -357,048 0 -100.00

2025-08-01 3 CELC Celcuity Inc.
Common Stock 689,944

2025-08-01 3 CELC Celcuity Inc.
Common Stock 7,055,748

2025-07-02 2025-06-30 4 INCY INCYTE CORP
Common Stock A - Award 492 28,187,581 0.00

2025-07-02 2025-06-30 4 INCY INCYTE CORP
Common Stock A - Award 492 28,187,581 0.00

2025-07-02 2025-06-30 4 IGMS IGM Biosciences, Inc.
Common Stock A - Award 953 3,763,362 0.03

2025-07-02 2025-06-30 4 IGMS IGM Biosciences, Inc.
Common Stock A - Award 953 3,763,362 0.03

2025-06-30 2025-06-30 4 KYMR Kymera Therapeutics, Inc.
Common Stock P - Purchase 600,309 6,117,295 10.88 44.00 26,413,596 269,160,980

2025-06-30 2025-06-30 4 KYMR Kymera Therapeutics, Inc.
Common Stock P - Purchase 55,191 534,134 11.52 44.00 2,428,404 23,501,896

2025-06-24 2025-06-20 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock A - Award 1,430 1,796,261 0.08

2025-06-24 2025-06-20 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock A - Award 1,430 1,796,261 0.08

2025-06-12 2025-06-10 4 INCY INCYTE CORP
Common Stock A - Award 2,518 28,187,089 0.01

2025-06-12 2025-06-10 4 INCY INCYTE CORP
Common Stock A - Award 2,518 28,187,089 0.01

2025-06-05 3 DNLI Denali Therapeutics Inc.
Common Stock 326,302

2025-06-05 3 DNLI Denali Therapeutics Inc.
Common Stock 3,405,393

2025-06-05 2025-06-03 4 DNLI Denali Therapeutics Inc.
Common Stock A - Award 10,565 3,415,958 0.31

2025-06-05 2025-06-03 4 DNLI Denali Therapeutics Inc.
Common Stock A - Award 10,565 3,415,958 0.31

2025-06-05 2025-06-03 4 KNSA Kiniksa Pharmaceuticals International, plc
Class A Ordinary Shares A - Award 8,397 2,738,816 0.31

2025-06-05 2025-06-03 4 KNSA Kiniksa Pharmaceuticals International, plc
Class A Ordinary Shares A - Award 8,397 2,738,816 0.31

2025-06-02 2025-05-29 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock A - Award 16,214 39,365,965 0.04

2025-06-02 2025-05-29 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock A - Award 16,214 39,365,965 0.04

2025-05-22 2025-05-21 4 ONC BeiGene, Ltd.
Ordinary Shares A - Award 21,970 148,069 17.42

2025-05-22 2025-05-21 4 ONC BeiGene, Ltd.
Ordinary Shares A - Award 21,970 148,065 17.42

2025-04-02 2025-03-31 4 INCY INCYTE CORP
Common Stock A - Award 487 28,184,571 0.00

2025-04-02 2025-03-31 4 INCY INCYTE CORP
Common Stock A - Award 487 2,813,892 0.02

2025-04-02 2025-03-31 4 IGMS IGM Biosciences, Inc.
Common Stock A - Award 953 3,762,409 0.03

2025-04-02 2025-03-31 4 IGMS IGM Biosciences, Inc.
Common Stock A - Award 953 356,095 0.27

2025-03-19 2025-03-17 4 IMCR Immunocore Holdings plc
American Depositary Shares P - Purchase 92,349 2,144,060 4.50 29.56 2,729,864 63,379,057

2025-03-19 2025-03-17 4 IMCR Immunocore Holdings plc
American Depositary Shares P - Purchase 8,589 178,596 5.05 29.56 253,893 5,279,351

2025-03-19 2025-03-17 4 IMCR Immunocore Holdings plc
American Depositary Shares P - Purchase 646,290 2,051,711 45.99 29.74 19,221,699 61,021,168

2025-03-19 2025-03-17 4 IMCR Immunocore Holdings plc
American Depositary Shares P - Purchase 60,110 170,007 54.70 29.74 1,787,768 5,056,280

2025-03-07 3 REPL Replimune Group, Inc.
Common Stock 929,241

2025-03-07 3 REPL Replimune Group, Inc.
Common Stock 10,116,095

2025-02-28 2025-02-28 4 ONC BeiGene, Ltd.
American Depositary Shares S - Sale -671,976 8,068,411 -7.69 260.00 -174,713,760 2,097,786,860

2025-02-28 2025-02-28 4 ONC BeiGene, Ltd.
American Depositary Shares S - Sale -60,851 730,642 -7.69 260.00 -15,821,260 189,966,920

2025-02-14 3 SERA SERA PROGNOSTICS, INC.
Common Stock 432,434

2025-02-14 3 SERA SERA PROGNOSTICS, INC.
Common Stock 5,065,736

2025-01-06 2025-01-02 4 BCYC BICYCLE THERAPEUTICS PLC
American Depositary Shares A - Award 4,400 9,999,674 0.04

2025-01-06 2025-01-02 4 BCYC BICYCLE THERAPEUTICS PLC
American Depositary Shares A - Award 4,400 918,483 0.48

2025-01-03 2024-12-31 4 INCY INCYTE CORP
Common Stock A - Award 446 28,184,084 0.00

2025-01-03 2024-12-31 4 INCY INCYTE CORP
Common Stock A - Award 446 28,184,084 0.00

2025-01-03 2024-12-31 4 IGMS IGM Biosciences, Inc.
Common Stock A - Award 1,994 3,761,456 0.05

2025-01-03 2024-12-31 4 IGMS IGM Biosciences, Inc.
Common Stock A - Award 1,994 355,142 0.56

2024-12-31 2024-12-30 4 KALA KALA BIO, Inc.
Common Stock P - Purchase 279,939 1,083,398 34.84 6.44 1,802,807 6,977,083

2024-12-31 2024-12-30 4 KALA KALA BIO, Inc.
Common Stock P - Purchase 30,620 118,496 34.84 6.44 197,193 763,114

2024-12-17 2024-12-16 4 BCYC BICYCLE THERAPEUTICS PLC
American Depositary Shares P - Purchase 457,631 9,995,274 4.80 15.34 7,020,883 153,345,495

2024-12-17 2024-12-16 4 BCYC BICYCLE THERAPEUTICS PLC
American Depositary Shares P - Purchase 42,369 914,083 4.86 15.34 650,017 14,023,679

2024-12-17 2024-12-13 4 BCYC BICYCLE THERAPEUTICS PLC
American Depositary Shares P - Purchase 566,814 9,537,643 6.32 13.80 7,824,300 131,657,624

2024-12-17 2024-12-13 4 BCYC BICYCLE THERAPEUTICS PLC
American Depositary Shares P - Purchase 52,656 871,714 6.43 13.80 726,863 12,033,140

2024-12-17 2024-12-13 4 BCYC BICYCLE THERAPEUTICS PLC
American Depositary Shares P - Purchase 244,587 8,970,829 2.80 13.72 3,356,761 123,117,451

2024-12-17 2024-12-13 4 BCYC BICYCLE THERAPEUTICS PLC
American Depositary Shares P - Purchase 22,722 819,058 2.85 13.72 311,841 11,240,916

2024-12-17 2024-12-13 4 BCYC BICYCLE THERAPEUTICS PLC
American Depositary Shares P - Purchase 59,995 8,726,242 0.69 13.63 817,660 118,928,207

2024-12-17 2024-12-13 4 BCYC BICYCLE THERAPEUTICS PLC
American Depositary Shares P - Purchase 5,573 796,336 0.70 13.63 75,953 10,853,104

2024-12-17 2024-12-13 4 BCYC BICYCLE THERAPEUTICS PLC
American Depositary Shares P - Purchase 30,241 8,666,247 0.35 13.50 408,190 116,976,135

2024-12-17 2024-12-13 4 BCYC BICYCLE THERAPEUTICS PLC
American Depositary Shares P - Purchase 2,809 790,763 0.36 13.50 37,916 10,673,640

2024-12-10 2024-12-09 4 BGNE BeiGene, Ltd.
American Depositary Shares S - Sale -916,964 8,740,387 -9.49 186.50 -171,013,786 1,630,082,176

2024-12-10 2024-12-09 4 BGNE BeiGene, Ltd.
American Depositary Shares S - Sale -83,036 791,493 -9.49 186.50 -15,486,214 147,613,444

2024-12-10 2024-12-09 4 BGNE BeiGene, Ltd.
American Depositary Shares S - Sale -33,943 9,657,351 -0.35 208.01 -7,060,609 2,008,861,314

2024-12-10 2024-12-09 4 BGNE BeiGene, Ltd.
American Depositary Shares S - Sale -3,074 874,529 -0.35 208.01 -639,434 181,914,013

2024-10-08 2024-10-04 4 KNSA Kiniksa Pharmaceuticals International, plc
Class A Ordinary Shares A - Award 4,730 2,730,419 0.17

2024-10-08 2024-10-04 4 KNSA Kiniksa Pharmaceuticals International, plc
Class A Ordinary Shares A - Award 4,730 2,730,419 0.17

2024-10-02 2024-09-30 4 INCY INCYTE CORP
Common Stock A - Award 496 28,183,638 0.00

2024-10-02 2024-09-30 4 INCY INCYTE CORP
Common Stock A - Award 496 2,812,959 0.02

2024-10-02 2024-09-30 4 IGMS IGM Biosciences, Inc.
Common Stock A - Award 1,994 3,759,462 0.05

2024-10-02 2024-09-30 4 IGMS IGM Biosciences, Inc.
Common Stock A - Award 1,994 353,148 0.57

2024-08-22 2024-08-20 4 KYMR Kymera Therapeutics, Inc.
Common Stock P - Purchase 1 5,516,986 0.00 46.41 46 256,043,320

2024-07-02 2024-06-28 4 INCY INCYTE CORP
Common Stock A - Award 537 28,183,142 0.00

2024-07-02 2024-06-28 4 INCY INCYTE CORP
Common Stock A - Award 537 28,183,142 0.00

2024-07-02 2024-06-28 4 IGMS IGM Biosciences, Inc.
Common Stock A - Award 1,994 3,757,468 0.05

2024-07-02 2024-06-28 4 IGMS IGM Biosciences, Inc.
Common Stock A - Award 1,994 3,757,468 0.05

2024-06-28 3 KALA KALA BIO, Inc.
Common Stock 87,876

2024-06-28 3 KALA KALA BIO, Inc.
Common Stock 803,459

2024-06-27 2024-06-25 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock A - Award 1,428 1,794,831 0.08

2024-06-27 2024-06-25 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock A - Award 1,428 1,794,831 0.08

2024-06-20 2024-06-17 4 BCYC BICYCLE THERAPEUTICS PLC
American Depositary Shares C - Conversion 2,186,686 8,636,006 33.91

2024-06-20 2024-06-17 4 BCYC BICYCLE THERAPEUTICS PLC
American Depositary Shares C - Conversion 196,098 787,954 33.13

2024-06-14 2024-06-12 4 INCY INCYTE CORP
Common Stock D - Sale to Issuer -5,283,206 28,182,605 -15.79 60.00 -316,992,360 1,690,956,300

2024-06-14 2024-06-12 4 INCY INCYTE CORP
Common Stock D - Sale to Issuer -175,977 2,811,926 -5.89 60.00 -10,558,620 168,715,560

2024-06-14 2024-06-12 4 INCY INCYTE CORP
Common Stock A - Award 2,830 33,465,811 0.01

2024-06-14 2024-06-12 4 INCY INCYTE CORP
Common Stock A - Award 2,830 33,465,811 0.01

2024-06-07 2024-06-05 4 BGNE BeiGene, Ltd.
Ordinary Shares A - Award 32,682 126,099 34.99

2024-06-07 2024-06-05 4 BGNE BeiGene, Ltd.
Ordinary Shares A - Award 32,682 126,099 34.99

2024-06-07 2024-06-05 4 KNSA Kiniksa Pharmaceuticals, Ltd.
Class A Common Shares A - Award 6,346 2,725,689 0.23

2024-06-07 2024-06-05 4 KNSA Kiniksa Pharmaceuticals, Ltd.
Class A Common Shares A - Award 6,346 2,725,689 0.23

2024-05-31 2024-05-29 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock A - Award 18,774 39,349,751 0.05

2024-05-31 2024-05-29 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock A - Award 18,774 39,349,751 0.05

2024-05-29 3 IMCR Immunocore Holdings plc
American Depositary Shares 109,897

2024-05-29 3 IMCR Immunocore Holdings plc
American Depositary Shares 1,405,421

2024-05-09 2024-05-07 4 INCY INCYTE CORP
Common Stock M - Exercise 15,000 33,462,981 0.04 49.01 735,150 1,640,020,699

2024-05-09 2024-05-07 4 INCY INCYTE CORP
Common Stock M - Exercise 15,000 2,985,073 0.51 49.01 735,150 146,298,428

2024-04-22 2024-04-18 4 BCYC BICYCLE THERAPEUTICS plc
American Depositary Shares A - Award 12,000 6,449,320 0.19

2024-04-22 2024-04-18 4 BCYC BICYCLE THERAPEUTICS plc
American Depositary Shares A - Award 12,000 6,449,320 0.19

2024-04-18 3 BCYC BICYCLE THERAPEUTICS plc
American Depositary Shares 579,856

2024-04-18 3 BCYC BICYCLE THERAPEUTICS plc
American Depositary Shares 6,437,320

2024-04-01 3 KYMR Kymera Therapeutics, Inc.
Common Stock 478,943

2024-04-01 3 KYMR Kymera Therapeutics, Inc.
Common Stock 5,516,985

2024-04-01 2024-03-29 4 IGMS IGM Biosciences, Inc.
Common Stock A - Award 1,994 3,755,474 0.05

2024-04-01 2024-03-29 4 IGMS IGM Biosciences, Inc.
Common Stock A - Award 1,994 3,755,474 0.05

2024-04-01 2024-03-28 4 INCY INCYTE CORP
Common Stock A - Award 543 33,447,981 0.00

2024-04-01 2024-03-28 4 INCY INCYTE CORP
Common Stock A - Award 543 2,970,073 0.02

2024-03-28 2024-03-28 4 IGMS IGM Biosciences, Inc.
Common Stock P - Purchase 89,407 3,753,480 2.44 9.62 860,042 36,106,226

2024-03-28 2024-03-28 4 IGMS IGM Biosciences, Inc.
Common Stock P - Purchase 8,066 347,166 2.38 9.62 77,590 3,339,529

2024-03-28 2024-03-27 4 IGMS IGM Biosciences, Inc.
Common Stock P - Purchase 8,439 3,664,073 0.23 9.27 78,207 33,956,064

2024-03-28 2024-03-27 4 IGMS IGM Biosciences, Inc.
Common Stock P - Purchase 761 339,100 0.22 9.27 7,052 3,142,541

2024-03-28 2024-03-27 4 IGMS IGM Biosciences, Inc.
Common Stock P - Purchase 17,101 3,655,634 0.47 9.22 157,683 33,707,504

2024-03-28 2024-03-27 4 IGMS IGM Biosciences, Inc.
Common Stock P - Purchase 1,543 338,339 0.46 9.22 14,228 3,119,722

2024-03-28 2024-03-26 4 IGMS IGM Biosciences, Inc.
Common Stock P - Purchase 247,656 3,638,533 7.30 8.26 2,046,159 30,061,923

2024-03-28 2024-03-26 4 IGMS IGM Biosciences, Inc.
Common Stock P - Purchase 22,344 336,796 7.11 8.26 184,608 2,782,642

2024-03-07 3 VTVT vTv Therapeutics Inc.
Common Stock 12,836

2024-03-07 3 VTVT vTv Therapeutics Inc.
Common Stock 142,135

2024-03-07 2024-03-05 4 VTVT vTv Therapeutics Inc.
Common Stock D - Sale to Issuer -52,881 89,254 -37.20

2024-03-07 2024-03-05 4 VTVT vTv Therapeutics Inc.
Common Stock D - Sale to Issuer -4,776 8,060 -37.21

2024-01-03 2023-12-29 4 INCY INCYTE CORP
Common Stock A - Award 556 33,447,438 0.00

2024-01-03 2023-12-29 4 INCY INCYTE CORP
Common Stock A - Award 556 33,447,438 0.00

2024-01-03 2023-12-29 4 IGMS IGM Biosciences, Inc.
Common Stock A - Award 554 3,390,877 0.02

2024-01-03 2023-12-29 4 IGMS IGM Biosciences, Inc.
Common Stock A - Award 554 3,390,877 0.02

2023-12-18 2023-12-14 4 SGEN Seagen Inc.
Common Stock D - Sale to Issuer -42,977,301 0 -100.00 229.00 -9,841,801,929

2023-12-18 2023-12-14 4 SGEN Seagen Inc.
Common Stock D - Sale to Issuer -1,731,202 0 -100.00 229.00 -396,445,258

2023-12-18 2023-12-14 4 SGEN Seagen Inc.
Common Stock D - Sale to Issuer -23,277 0 -100.00 229.00 -5,330,433

2023-12-18 2023-12-14 4 SGEN Seagen Inc.
Common Stock D - Sale to Issuer -23,280 0 -100.00 229.00 -5,331,120

2023-12-15 2023-12-15 4 IGMS IGM Biosciences, Inc.
Common Stock P - Purchase 214,025 3,390,323 6.74 6.60 1,412,565 22,376,132

2023-12-15 2023-12-15 4 IGMS IGM Biosciences, Inc.
Common Stock P - Purchase 17,066 313,898 5.75 6.60 112,636 2,071,727

2023-12-15 2023-12-15 4 IGMS IGM Biosciences, Inc.
Common Stock P - Purchase 52,528 3,176,298 1.68 6.37 334,399 20,220,631

2023-12-15 2023-12-15 4 IGMS IGM Biosciences, Inc.
Common Stock P - Purchase 4,188 296,832 1.43 6.37 26,661 1,889,662

2023-12-15 2023-12-15 4 IGMS IGM Biosciences, Inc.
Common Stock P - Purchase 185 3,123,770 0.01 6.36 1,176 19,851,558

2023-12-15 2023-12-15 4 IGMS IGM Biosciences, Inc.
Common Stock P - Purchase 15 292,644 0.01 6.36 95 1,859,753

2023-12-15 2023-12-14 4 IGMS IGM Biosciences, Inc.
Common Stock P - Purchase 145,749 3,123,585 4.89 6.50 947,602 20,308,300

2023-12-15 2023-12-14 4 IGMS IGM Biosciences, Inc.
Common Stock P - Purchase 11,621 292,629 4.14 6.50 75,555 1,902,557

2023-12-15 2023-12-13 4 IGMS IGM Biosciences, Inc.
Common Stock P - Purchase 71,219 2,977,836 2.45 5.99 426,751 17,843,491

2023-12-15 2023-12-13 4 IGMS IGM Biosciences, Inc.
Common Stock P - Purchase 5,679 281,008 2.06 5.99 34,029 1,683,828

2023-12-15 2023-12-13 4 IGMS IGM Biosciences, Inc.
Common Stock P - Purchase 9,649 2,906,617 0.33 5.76 55,567 16,738,626

2023-12-15 2023-12-13 4 IGMS IGM Biosciences, Inc.
Common Stock P - Purchase 769 275,329 0.28 5.76 4,429 1,585,565

2023-12-14 2023-12-12 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 3,857 1,699,129 0.23 221.24 853,330 375,918,358

2023-12-14 2023-12-12 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 308 178,461 0.17 221.24 68,142 39,483,033

2023-12-14 2023-12-12 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 4,408 1,695,272 0.26 220.65 972,645 374,069,565

2023-12-14 2023-12-12 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 352 178,153 0.20 220.65 77,670 39,310,279

2023-12-14 2023-12-12 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 15,005 1,690,864 0.90 219.24 3,289,711 370,706,714

2023-12-14 2023-12-12 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 1,195 177,801 0.68 219.24 261,993 38,981,269

2023-12-14 2023-12-12 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 2,873 1,675,859 0.17 217.91 626,049 365,182,748

2023-12-14 2023-12-12 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 229 176,606 0.13 217.91 49,901 38,483,825

2023-12-14 2023-12-12 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 185 1,672,986 0.01 217.90 40,312 364,543,649

2023-12-14 2023-12-12 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 15 176,377 0.01 217.90 3,268 38,432,548

2023-12-14 2023-12-12 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 1,769 1,672,801 0.11 216.67 383,286 362,442,949

2023-12-14 2023-12-12 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 141 176,362 0.08 216.67 30,550 38,212,055

2023-12-14 2023-12-12 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 668 1,671,032 0.04 214.72 143,434 358,807,834

2023-12-14 2023-12-12 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 53 176,221 0.03 214.72 11,380 37,838,578

2023-12-14 2023-12-12 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 515 1,670,364 0.03 213.80 110,107 357,122,821

2023-12-14 2023-12-12 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 41 176,168 0.02 213.80 8,766 37,664,613

2023-12-14 2023-12-12 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 185 1,669,849 0.01 213.62 39,521 356,721,493

2023-12-14 2023-12-12 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 15 176,127 0.01 213.62 3,204 37,625,130

2023-12-14 2023-12-12 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 648 1,669,664 0.04 212.04 137,403 354,037,892

2023-12-14 2023-12-12 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 52 176,112 0.03 212.04 11,026 37,343,035

2023-12-14 2023-12-12 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 93 1,669,016 0.01 209.76 19,508 350,101,141

2023-12-14 2023-12-12 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 7 176,060 0.00 209.76 1,468 36,931,226

2023-12-14 2023-12-12 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 370 1,668,923 0.02 208.69 77,216 348,289,710

2023-12-14 2023-12-12 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 30 176,053 0.02 208.69 6,261 36,740,729

2023-12-14 2023-12-12 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 648 1,668,553 0.04 206.93 134,092 345,277,176

2023-12-14 2023-12-12 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 52 176,023 0.03 206.93 10,760 36,424,809

2023-12-14 2023-12-12 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 708 1,667,905 0.04 205.60 145,565 342,921,268

2023-12-14 2023-12-12 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 56 175,971 0.03 205.60 11,514 36,179,638

2023-12-14 2023-12-12 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 93 1,667,197 0.01 205.32 19,095 342,308,888

2023-12-14 2023-12-12 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 7 175,915 0.00 205.32 1,437 36,118,868

2023-12-14 2023-12-14 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 3,960 1,793,403 0.22 229.86 910,264 412,240,043

2023-12-14 2023-12-14 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 316 185,979 0.17 229.86 72,637 42,750,007

2023-12-14 2023-12-14 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 2,204 1,789,443 0.12 228.79 504,252 409,405,411

2023-12-14 2023-12-14 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 176 185,663 0.09 228.79 40,267 42,477,708

2023-12-14 2023-12-14 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 11,602 1,787,239 0.65 227.86 2,643,597 407,234,917

2023-12-14 2023-12-14 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 925 185,487 0.50 227.86 210,768 42,264,511

2023-12-14 2023-12-14 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 1,343 1,775,637 0.08 226.97 304,822 403,018,106

2023-12-14 2023-12-14 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 107 184,562 0.06 226.97 24,286 41,890,222

2023-12-14 2023-12-13 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 5,594 1,774,294 0.32 224.91 1,258,156 399,059,480

2023-12-14 2023-12-13 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 446 184,455 0.24 224.91 100,311 41,486,088

2023-12-14 2023-12-13 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 363 1,768,700 0.02 223.94 81,289 396,078,079

2023-12-14 2023-12-13 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 29 184,009 0.02 223.94 6,494 41,206,497

2023-12-14 2023-12-13 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 9,262 1,768,337 0.53 222.68 2,062,425 393,766,210

2023-12-14 2023-12-13 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 738 183,980 0.40 222.68 164,335 40,967,930

2023-12-14 2023-12-13 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 4,532 1,759,075 0.26 221.78 1,005,101 390,125,367

2023-12-14 2023-12-13 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 361 183,242 0.20 221.78 80,062 40,639,173

2023-12-14 2023-12-13 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 4,518 1,754,543 0.26 219.87 993,351 385,762,948

2023-12-14 2023-12-13 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 360 182,881 0.20 219.87 79,151 40,209,168

2023-12-14 2023-12-13 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 29,738 1,750,025 1.73 218.46 6,496,513 382,307,486

2023-12-14 2023-12-13 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 2,373 182,521 1.32 218.46 518,402 39,873,227

2023-12-14 2023-12-13 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 10,894 1,720,287 0.64 217.52 2,369,611 374,188,571

2023-12-14 2023-12-13 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 869 180,148 0.48 217.52 189,021 39,184,928

2023-12-14 2023-12-13 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 10,264 1,709,393 0.60 216.70 2,224,203 370,424,437

2023-12-14 2023-12-13 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 818 179,279 0.46 216.70 177,260 38,849,652

2023-11-24 2023-11-22 4 BLCM BELLICUM PHARMACEUTICALS, INC
Common Stock X - Other 1,941,607 2,168,818 854.54 0.00 194 217

2023-11-24 2023-11-22 4 BLCM BELLICUM PHARMACEUTICALS, INC
Common Stock X - Other 174,742 196,654 797.47 0.00 17 20

2023-11-21 2023-11-21 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 7,917 1,667,104 0.48 190.14 1,505,308 316,976,653

2023-11-21 2023-11-21 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 655 175,908 0.37 190.14 124,539 33,446,461

2023-11-21 2023-11-21 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 15,620 1,659,187 0.95 188.70 2,947,539 313,093,399

2023-11-21 2023-11-21 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 1,291 175,253 0.74 188.70 243,615 33,070,749

2023-11-21 2023-11-21 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 13,505 1,643,567 0.83 188.46 2,545,218 309,754,690

2023-11-21 2023-11-21 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 1,117 173,962 0.65 188.46 210,515 32,785,731

2023-11-21 2023-11-21 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 13,011 1,630,062 0.80 188.32 2,450,273 306,978,492

2023-11-21 2023-11-21 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 1,076 172,845 0.63 188.32 202,636 32,550,724

2023-11-21 2023-11-21 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 4,712 1,617,051 0.29 187.27 882,420 302,826,273

2023-11-21 2023-11-21 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 388 171,769 0.23 187.27 72,661 32,167,301

2023-11-21 2023-11-21 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 2,124 1,612,339 0.13 187.24 397,706 301,900,642

2023-11-21 2023-11-21 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 176 171,381 0.10 187.24 32,955 32,090,047

2023-11-21 2023-11-21 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 1,385 1,610,215 0.09 186.59 258,431 300,454,847

2023-11-21 2023-11-21 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 115 171,205 0.07 186.59 21,458 31,945,655

2023-11-21 2023-11-21 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 647 1,608,830 0.04 186.32 120,547 299,752,540

2023-11-21 2023-11-21 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 53 171,090 0.03 186.32 9,875 31,876,993

2023-11-21 2023-11-21 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 369 1,608,183 0.02 183.16 67,586 294,554,798

2023-11-21 2023-11-21 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 31 171,037 0.02 183.16 5,678 31,327,137

2023-11-21 2023-11-21 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 146 1,607,814 0.01 185.94 27,148 298,963,688

2023-11-21 2023-11-21 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 12 171,006 0.01 185.94 2,231 31,797,574

2023-11-21 2023-11-20 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 3,022 1,607,668 0.19 189.70 573,267 304,971,083

2023-11-21 2023-11-20 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 250 170,994 0.15 189.70 47,424 32,437,186

2023-11-21 2023-11-20 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 1,147 1,604,646 0.07 188.84 216,595 303,014,772

2023-11-21 2023-11-20 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 95 170,744 0.06 188.84 17,939 32,242,597

2023-11-21 2023-11-20 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 4,895 1,603,499 0.31 187.34 917,054 300,407,520

2023-11-21 2023-11-20 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 405 170,649 0.24 187.34 75,875 31,970,237

2023-11-21 2023-11-20 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 1,206 1,598,604 0.08 185.86 224,153 297,124,532

2023-11-21 2023-11-20 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 100 170,244 0.06 185.86 18,586 31,642,401

2023-11-21 2023-11-20 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 7,010 1,597,398 0.44 183.40 1,285,633 292,962,633

2023-11-21 2023-11-20 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 579 170,144 0.34 183.40 106,189 31,204,393

2023-11-21 2023-11-20 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 1,847 1,590,388 0.12 181.93 336,025 289,339,289

2023-11-21 2023-11-20 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 153 169,565 0.09 181.93 27,835 30,848,960

2023-11-21 2023-11-17 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 10,715 1,588,541 0.68 175.82 1,883,889 279,293,943

2023-11-21 2023-11-17 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 903 169,412 0.54 175.82 158,764 29,785,662

2023-11-21 2023-11-17 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 4,923 1,577,826 0.31 175.72 865,062 277,253,218

2023-11-21 2023-11-17 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 415 168,509 0.25 175.72 72,923 29,610,149

2023-11-21 2023-11-17 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 18,125 1,572,903 1.17 174.87 3,169,606 275,061,098

2023-11-21 2023-11-17 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 1,528 168,094 0.92 174.87 267,209 29,395,405

2023-11-21 2023-11-17 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 978 1,554,778 0.06 174.67 170,827 271,572,762

2023-11-21 2023-11-17 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 82 166,566 0.05 174.67 14,323 29,094,050

2023-11-21 2023-11-17 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 1,660 1,553,800 0.11 173.75 288,422 269,969,798

2023-11-21 2023-11-17 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 140 166,484 0.08 173.75 24,325 28,926,279

2023-11-21 2023-11-17 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 4,151 1,552,140 0.27 173.20 718,960 268,833,131

2023-11-21 2023-11-17 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 350 166,344 0.21 173.20 60,621 28,811,047

2023-11-21 2023-11-17 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 461 1,547,989 0.03 171.79 79,195 265,929,030

2023-11-21 2023-11-17 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 39 165,994 0.02 171.79 6,700 28,516,109

2023-11-21 2023-11-17 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 1,107 1,547,528 0.07 168.78 186,842 261,195,645

2023-11-21 2023-11-17 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 93 165,955 0.06 168.78 15,697 28,010,300

2023-11-21 2023-11-17 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 646 1,546,421 0.04 167.63 108,289 259,226,552

2023-11-21 2023-11-17 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 54 165,862 0.03 167.63 9,052 27,803,447

2023-11-15 2023-11-14 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 13,548 1,500,227 0.91 154.78 2,096,961 232,205,285

2023-11-15 2023-11-14 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 1,142 161,969 0.71 154.78 176,759 25,069,578

2023-11-15 2023-11-14 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 8,098 1,486,679 0.55 153.97 1,246,878 228,909,318

2023-11-15 2023-11-14 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 683 160,827 0.43 153.97 105,164 24,763,112

2023-11-15 2023-11-14 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 2,877 1,478,581 0.19 153.25 440,907 226,595,939

2023-11-15 2023-11-14 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 242 160,144 0.15 153.25 37,087 24,542,436

2023-11-15 2023-11-14 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 646 1,475,704 0.04 152.21 98,330 224,621,185

2023-11-15 2023-11-14 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 54 159,902 0.03 152.21 8,219 24,339,147

2023-11-15 2023-11-14 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 6,022 1,475,058 0.41 152.48 918,235 224,916,844

2023-11-15 2023-11-14 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 507 159,848 0.32 152.48 77,307 24,373,623

2023-11-15 2023-11-14 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 3,542 1,469,036 0.24 154.60 547,582 227,108,412

2023-11-15 2023-11-14 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 299 159,341 0.19 154.60 46,224 24,633,625

2023-11-15 2023-11-13 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 26,426 1,465,494 1.84 146.21 3,863,756 214,270,464

2023-11-15 2023-11-13 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 2,228 159,042 1.42 146.21 325,757 23,253,594

2023-11-15 2023-11-13 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 2,994 1,439,068 0.21 145.98 437,057 210,071,549

2023-11-15 2023-11-13 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 252 156,814 0.16 145.98 36,786 22,891,316

2023-11-15 2023-11-13 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 6,369 1,436,074 0.45 145.46 926,430 208,890,175

2023-11-15 2023-11-13 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 537 156,562 0.34 145.46 78,112 22,773,383

2023-11-15 2023-11-13 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 1,291 1,429,705 0.09 142.86 184,429 204,244,082

2023-11-15 2023-11-13 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 109 156,025 0.07 142.86 15,571 22,289,341

2023-11-15 2023-11-13 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 10,790 1,428,414 0.76 141.44 1,526,192 202,042,018

2023-11-15 2023-11-13 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 910 155,916 0.59 141.44 128,715 22,053,539

2023-11-15 2023-11-13 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 5,072 1,417,624 0.36 140.90 714,657 199,746,624

2023-11-15 2023-11-13 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 427 155,006 0.28 140.90 60,165 21,840,717

2023-11-15 2023-11-13 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 4,631 1,412,552 0.33 137.69 637,622 194,487,928

2023-11-15 2023-11-13 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 390 154,579 0.25 137.69 53,697 21,283,287

2023-11-15 2023-11-13 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 3,693 1,407,921 0.26 136.91 505,605 192,756,915

2023-11-15 2023-11-13 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 311 154,189 0.20 136.91 42,579 21,109,846

2023-11-15 2023-11-13 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 3,144 1,404,228 0.22 136.18 428,151 191,228,471

2023-11-15 2023-11-13 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 265 153,878 0.17 136.18 36,088 20,955,183

2023-11-15 2023-11-15 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 14,018 1,545,775 0.92 161.97 2,270,439 250,362,994

2023-11-15 2023-11-15 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 1,181 165,808 0.72 161.97 191,282 26,855,259

2023-11-15 2023-11-14 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 31,530 1,531,757 2.10 156.42 4,932,061 239,604,170

2023-11-15 2023-11-14 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock P - Purchase 2,658 164,627 1.64 156.42 415,776 25,751,680

2023-11-14 2023-11-14 4 BGNE BeiGene, Ltd.
American Depositary Shares S - Sale -1,008,660 9,691,294 -9.43 180.50 -182,063,130 1,749,278,567

2023-11-14 2023-11-14 4 BGNE BeiGene, Ltd.
American Depositary Shares S - Sale -91,340 877,603 -9.43 180.50 -16,486,870 158,407,342

2023-10-23 2023-10-19 4 BCEL Atreca, Inc.
Class A common stock S - Sale -251,902 2,971,128 -7.82 0.40 -101,391 1,195,879

2023-10-23 2023-10-19 4 BCEL Atreca, Inc.
Class A common stock S - Sale -22,837 286,893 -7.37 0.40 -9,192 115,474

2023-10-10 2023-10-05 4 NLTX Neoleukin Therapeutics, Inc.
Common Stock X - Other 535,601 1,658,190 47.71

2023-10-10 2023-10-05 4 NLTX Neoleukin Therapeutics, Inc.
Common Stock X - Other 57,049 155,874 57.73

2023-10-03 2023-09-29 4 INCY INCYTE CORP
Common Stock A - Award 510 33,446,882 0.00

2023-10-03 2023-09-29 4 INCY INCYTE CORP
Common Stock A - Award 510 2,968,974 0.02

2023-10-03 2023-09-29 4 IGMS IGM Biosciences, Inc.
Common Stock A - Award 554 2,896,968 0.02

2023-10-03 2023-09-29 4 IGMS IGM Biosciences, Inc.
Common Stock A - Award 554 274,560 0.20

2023-08-17 2023-08-17 4 NLTX Neoleukin Therapeutics, Inc.
Common Stock P - Purchase 61,134 5,612,949 1.10 0.69 42,354 3,888,651

2023-08-17 2023-08-17 4 NLTX Neoleukin Therapeutics, Inc.
Common Stock P - Purchase 5,041 494,133 1.03 0.69 3,492 342,335

2023-08-17 2023-08-17 4 NLTX Neoleukin Therapeutics, Inc.
Common Stock P - Purchase 93,091 5,551,815 1.71 0.69 64,456 3,844,077

2023-08-17 2023-08-17 4 NLTX Neoleukin Therapeutics, Inc.
Common Stock P - Purchase 7,676 489,092 1.59 0.69 5,315 338,647

2023-08-17 2023-08-16 4 NLTX Neoleukin Therapeutics, Inc.
Common Stock P - Purchase 4,434 5,458,724 0.08 0.68 3,028 3,727,217

2023-08-17 2023-08-16 4 NLTX Neoleukin Therapeutics, Inc.
Common Stock P - Purchase 366 481,416 0.08 0.68 250 328,711

2023-08-17 2023-08-16 4 NLTX Neoleukin Therapeutics, Inc.
Common Stock P - Purchase 207,676 5,454,290 3.96 0.68 141,324 3,711,644

2023-08-17 2023-08-16 4 NLTX Neoleukin Therapeutics, Inc.
Common Stock P - Purchase 17,124 481,050 3.69 0.68 11,653 327,355

2023-08-17 2023-08-15 4 NLTX Neoleukin Therapeutics, Inc.
Common Stock P - Purchase 4,342 5,246,614 0.08 0.66 2,887 3,488,998

2023-08-17 2023-08-15 4 NLTX Neoleukin Therapeutics, Inc.
Common Stock P - Purchase 358 463,926 0.08 0.66 238 308,511

2023-08-17 2023-08-15 4 NLTX Neoleukin Therapeutics, Inc.
Common Stock P - Purchase 1,740,581 5,242,272 49.71 0.63 1,097,958 3,306,825

2023-08-17 2023-08-15 4 NLTX Neoleukin Therapeutics, Inc.
Common Stock P - Purchase 143,519 463,568 44.84 0.63 90,532 292,419

2023-07-05 2023-06-30 4 INCY INCYTE CORP
Common Stock A - Award 512 33,446,372 0.00

2023-07-05 2023-06-30 4 INCY INCYTE CORP
Common Stock A - Award 512 33,446,372 0.00

2023-07-05 2023-06-30 4 IGMS IGM Biosciences, Inc.
Common Stock A - Award 554 2,896,414 0.02

2023-07-05 2023-06-30 4 IGMS IGM Biosciences, Inc.
Common Stock A - Award 554 2,896,414 0.02

2023-06-20 3 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock 148,821

2023-06-20 3 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock 1,396,292

2023-06-20 2023-06-15 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock A - Award 4,792 1,401,084 0.34

2023-06-20 2023-06-15 4 MDGL MADRIGAL PHARMACEUTICALS, INC.
Common Stock A - Award 4,792 1,401,084 0.34

2023-06-20 2023-06-15 4 BGNE BeiGene, Ltd.
Ordinary Shares A - Award 25,844 93,417 38.25

2023-06-20 2023-06-15 4 BGNE BeiGene, Ltd.
Ordinary Shares A - Award 25,844 93,417 38.25

2023-06-16 2023-06-14 4 INCY INCYTE CORP
Common Stock A - Award 2,505 33,445,860 0.01

2023-06-16 2023-06-14 4 INCY INCYTE CORP
Common Stock A - Award 2,505 33,445,860 0.01

2023-06-08 2023-06-06 4 KNSA Kiniksa Pharmaceuticals, Ltd.
Class A Common Shares A - Award 8,746 2,719,343 0.32

2023-06-08 2023-06-06 4 KNSA Kiniksa Pharmaceuticals, Ltd.
Class A Common Shares A - Award 8,746 2,719,343 0.32

2023-06-05 2023-06-01 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock A - Award 13,304 39,330,977 0.03

2023-06-05 2023-06-01 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock A - Award 13,304 39,330,977 0.03

2023-06-02 2023-05-31 4 SGEN Seagen Inc.
Common Stock A - Award 2,044 42,977,301 0.00

2023-06-02 2023-05-31 4 SGEN Seagen Inc.
Common Stock A - Award 2,044 42,977,301 0.00

2023-05-24 2023-05-24 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 259,109 39,317,673 0.66 25.65 6,646,146 1,008,498,312

2023-05-24 2023-05-24 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 24,113 3,610,443 0.67 25.65 618,498 92,607,863

2023-05-24 2023-05-24 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 28,878 39,058,564 0.07 25.51 736,788 996,532,390

2023-05-24 2023-05-24 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 2,688 3,586,330 0.08 25.51 68,581 91,500,906

2023-05-24 2023-05-24 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 218,171 39,029,686 0.56 25.27 5,513,683 986,369,933

2023-05-24 2023-05-24 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 20,304 3,583,642 0.57 25.27 513,129 90,566,876

2023-05-24 2023-05-23 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 74,582 38,811,515 0.19 25.54 1,904,824 991,246,093

2023-05-24 2023-05-23 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 6,941 3,563,338 0.20 25.54 177,273 91,007,653

2023-05-24 2023-05-23 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 116,672 38,736,933 0.30 25.33 2,955,325 981,214,260

2023-05-24 2023-05-23 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 10,858 3,556,397 0.31 25.33 275,035 90,084,247

2023-05-24 2023-05-23 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock M - Exercise 12,500 38,620,261 0.03 17.01 212,625 656,930,640

2023-05-24 2023-05-23 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock M - Exercise 12,500 38,620,261 0.03 17.01 212,625 656,930,640

2023-05-24 2023-05-22 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 40,632 38,607,761 0.11 24.80 1,007,674 957,472,473

2023-05-24 2023-05-22 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 3,781 3,533,039 0.11 24.80 93,769 87,619,367

2023-05-24 2023-05-22 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 82,148 38,567,129 0.21 24.46 2,009,373 943,367,402

2023-05-24 2023-05-22 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 7,645 3,529,258 0.22 24.46 187,000 86,327,062

2023-05-05 3 BLCM BELLICUM PHARMACEUTICALS, INC
Common Stock 21,912

2023-05-05 3 BLCM BELLICUM PHARMACEUTICALS, INC
Common Stock 227,211

2023-05-03 2023-05-02 4 SGEN Seagen Inc.
Common Stock G - Gift -209,175 23,277 -89.99

2023-05-03 2023-05-02 4 SGEN Seagen Inc.
Common Stock G - Gift -209,175 23,277 -89.99

2023-05-03 2023-05-01 4 SGEN Seagen Inc.
Common Stock J - Other 209,175 232,452 898.63

2023-05-03 2023-05-01 4 SGEN Seagen Inc.
Common Stock J - Other 209,175 232,452 898.63

2023-05-03 2023-05-01 4 SGEN Seagen Inc.
Common Stock J - Other -2,368,357 1,729,158 -57.80

2023-05-03 2023-05-01 4 SGEN Seagen Inc.
Common Stock M - Exercise 8,750 42,975,257 0.02 36.70 321,125 1,577,191,932

2023-05-03 2023-05-01 4 SGEN Seagen Inc.
Common Stock M - Exercise 8,750 42,975,257 0.02 36.70 321,125 1,577,191,932

2023-04-04 2023-03-31 4 INCY INCYTE CORP
Common Stock A - Award 429 33,443,355 0.00

2023-04-04 2023-03-31 4 INCY INCYTE CORP
Common Stock A - Award 429 33,443,355 0.00

2023-04-04 2023-03-31 4 IGMS IGM Biosciences, Inc.
Common Stock A - Award 554 2,895,860 0.02

2023-04-04 2023-03-31 4 IGMS IGM Biosciences, Inc.
Common Stock A - Award 554 2,895,860 0.02

2023-03-15 2023-03-13 4 INCY INCYTE CORP
Common Stock M - Exercise 20,000 33,442,926 0.06 22.74 454,800 760,492,137

2023-03-15 2023-03-13 4 INCY INCYTE CORP
Common Stock M - Exercise 20,000 33,442,926 0.06 22.74 454,800 760,492,137

2023-01-17 2023-01-12 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock M - Exercise 15,000 38,484,981 0.04 5.22 78,300 200,891,601

2023-01-17 2023-01-12 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock M - Exercise 15,000 38,484,981 0.04 5.22 78,300 200,891,601

2023-01-04 2022-12-30 4 INCY INCYTE CORP
Common Stock A - Award 397 33,422,926 0.00

2023-01-04 2022-12-30 4 INCY INCYTE CORP
Common Stock A - Award 397 33,422,926 0.00

2022-10-04 2022-09-30 4 INCY INCYTE CORP
Common Stock A - Award 457 33,422,529 0.00

2022-10-04 2022-09-30 4 INCY INCYTE CORP
Common Stock A - Award 457 33,422,529 0.00

2022-07-01 2022-06-30 4 INCY INCYTE CORP
Common Stock A - Award 433 33,422,072 0.00

2022-07-01 2022-06-30 4 INCY INCYTE CORP
Common Stock A - Award 433 33,422,072 0.00

2022-06-30 2022-06-29 4 KNSA Kiniksa Pharmaceuticals, Ltd.
Class A Common Shares A - Award 10,000 2,710,597 0.37

2022-06-30 2022-06-29 4 KNSA Kiniksa Pharmaceuticals, Ltd.
Class A Common Shares A - Award 10,000 2,710,597 0.37

2022-06-24 2022-06-22 4 BGNE BeiGene, Ltd.
Ordinary Shares A - Award 33,384 67,573 97.65

2022-06-24 2022-06-22 4 BGNE BeiGene, Ltd.
Ordinary Shares A - Award 33,384 67,569 97.66

2022-06-17 2022-06-15 4 INCY INCYTE CORP
Common Stock A - Award 2,144 33,421,639 0.01

2022-06-17 2022-06-15 4 INCY INCYTE CORP
Common Stock A - Award 2,144 33,421,639 0.01

2022-06-13 2022-06-13 4 DBVT DBV Technologies S.A.
Ordinary Shares A - Award 10,622,568 14,575,984 268.69

2022-06-13 2022-06-13 4 DBVT DBV Technologies S.A.
Ordinary Shares A - Award 1,252,432 1,585,054 376.53

2022-06-09 2022-06-07 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock A - Award 17,104 38,469,981 0.04

2022-06-09 2022-06-07 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock A - Award 17,104 38,469,981 0.04

2022-06-06 2022-06-06 4 TRDA Entrada Therapeutics, Inc.
Common Stock P - Purchase 26,450 4,501,658 0.59 6.42 169,849 28,907,397

2022-06-06 2022-06-06 4 TRDA Entrada Therapeutics, Inc.
Common Stock P - Purchase 3,118 364,161 0.86 6.42 20,022 2,338,460

2022-06-06 2022-06-06 4 TRDA Entrada Therapeutics, Inc.
Common Stock P - Purchase 7,815 4,475,208 0.17 6.35 49,654 28,434,129

2022-06-06 2022-06-06 4 TRDA Entrada Therapeutics, Inc.
Common Stock P - Purchase 921 361,043 0.26 6.35 5,852 2,293,959

2022-06-06 2022-06-02 4 TRDA Entrada Therapeutics, Inc.
Common Stock P - Purchase 2,364 4,467,393 0.05 5.82 13,759 26,001,121

2022-06-06 2022-06-02 4 TRDA Entrada Therapeutics, Inc.
Common Stock P - Purchase 279 360,122 0.08 5.82 1,624 2,095,982

2022-06-06 2022-06-06 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 170,549 15,967,504 1.08 7.78 1,327,008 124,239,955

2022-06-06 2022-06-06 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 20,108 1,342,986 1.52 7.78 156,456 10,449,505

2022-06-06 2022-06-06 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 101,315 15,796,955 0.65 7.75 785,070 122,407,445

2022-06-06 2022-06-06 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 11,945 1,322,878 0.91 7.75 92,559 10,250,717

2022-06-06 2022-06-03 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 78,271 15,695,640 0.50 7.95 622,466 124,822,716

2022-06-06 2022-06-03 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 9,224 1,310,933 0.71 7.95 73,356 10,425,457

2022-06-06 2022-06-03 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 13,155 15,617,369 0.08 7.93 104,363 123,897,273

2022-06-06 2022-06-03 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 1,550 1,301,709 0.12 7.93 12,297 10,326,848

2022-06-06 2022-06-02 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 138,122 15,604,214 0.89 7.68 1,060,680 119,829,441

2022-06-06 2022-06-02 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 16,278 1,300,159 1.27 7.68 125,004 9,984,311

2022-06-06 2022-06-02 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 10,585 15,466,092 0.07 7.51 79,540 116,218,402

2022-06-06 2022-06-02 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 1,247 1,283,881 0.10 7.51 9,370 9,647,595

2022-05-27 2022-05-27 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 88,046 15,455,507 0.57 6.92 609,278 106,952,108

2022-05-27 2022-05-27 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 10,386 1,282,634 0.82 6.92 71,871 8,875,827

2022-05-27 2022-05-27 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 51,082 15,367,461 0.33 6.78 346,367 104,200,606

2022-05-27 2022-05-27 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 6,026 1,272,248 0.48 6.78 40,860 8,626,605

2022-05-27 2022-05-27 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 358 15,316,379 0.00 6.64 2,375 101,624,175

2022-05-27 2022-05-27 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 42 1,266,222 0.00 6.64 279 8,401,383

2022-05-27 2022-05-26 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 984 15,316,021 0.01 6.76 6,647 103,459,722

2022-05-27 2022-05-26 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 116 1,266,180 0.01 6.76 784 8,553,046

2022-05-27 2022-05-26 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 53,401 15,315,037 0.35 6.75 360,521 103,394,878

2022-05-27 2022-05-26 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 6,299 1,266,064 0.50 6.75 42,526 8,547,451

2022-05-27 2022-05-26 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 29,090 15,261,636 0.19 6.71 195,089 102,350,636

2022-05-27 2022-05-26 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 3,432 1,259,765 0.27 6.71 23,016 8,448,488

2022-05-27 2022-05-25 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 42,250 15,232,546 0.28 6.60 279,002 100,589,641

2022-05-27 2022-05-25 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 4,984 1,256,333 0.40 6.60 32,912 8,296,321

2022-05-27 2022-05-25 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 48,222 15,190,296 0.32 6.53 315,058 99,245,799

2022-05-27 2022-05-25 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 5,688 1,251,349 0.46 6.53 37,163 8,175,689

2022-05-24 2022-05-24 4 TRDA Entrada Therapeutics, Inc.
Common Stock P - Purchase 19,789 4,465,029 0.45 5.74 113,619 25,635,964

2022-05-24 2022-05-24 4 TRDA Entrada Therapeutics, Inc.
Common Stock P - Purchase 2,334 359,843 0.65 5.74 13,401 2,066,039

2022-05-24 2022-05-24 4 TRDA Entrada Therapeutics, Inc.
Common Stock P - Purchase 1,521 4,445,240 0.03 5.93 9,020 26,360,273

2022-05-24 2022-05-24 4 TRDA Entrada Therapeutics, Inc.
Common Stock P - Purchase 179 357,509 0.05 5.93 1,061 2,120,028

2022-05-24 2022-05-23 4 TRDA Entrada Therapeutics, Inc.
Common Stock P - Purchase 7,010 4,443,719 0.16 5.99 41,972 26,606,323

2022-05-24 2022-05-23 4 TRDA Entrada Therapeutics, Inc.
Common Stock P - Purchase 827 357,330 0.23 5.99 4,952 2,139,478

2022-05-24 2022-05-20 4 TRDA Entrada Therapeutics, Inc.
Common Stock P - Purchase 7,772 4,436,709 0.18 5.84 45,405 25,919,698

2022-05-24 2022-05-20 4 TRDA Entrada Therapeutics, Inc.
Common Stock P - Purchase 946 356,503 0.27 5.84 5,527 2,082,726

2022-05-24 2022-05-20 4 TRDA Entrada Therapeutics, Inc.
Common Stock P - Purchase 7,248 4,428,937 0.16 5.84 42,335 25,868,978

2022-05-24 2022-05-20 4 TRDA Entrada Therapeutics, Inc.
Common Stock P - Purchase 883 355,557 0.25 5.84 5,158 2,076,773

2022-05-18 2022-05-18 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 7,489 15,142,074 0.05 5.97 44,701 90,381,525

2022-05-18 2022-05-18 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 912 1,245,661 0.07 5.97 5,444 7,435,226

2022-05-18 2022-05-18 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 182,827 15,134,585 1.22 5.97 1,091,221 90,332,284

2022-05-18 2022-05-18 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 22,266 1,244,749 1.82 5.97 132,897 7,429,409

2022-05-18 2022-05-18 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 9,157 14,951,758 0.06 5.95 54,518 89,018,282

2022-05-18 2022-05-18 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 1,115 1,222,483 0.09 5.95 6,638 7,278,297

2022-05-18 2022-05-17 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 90,674 14,942,601 0.61 5.99 542,929 89,471,812

2022-05-18 2022-05-17 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 11,043 1,221,368 0.91 5.99 66,122 7,313,185

2022-05-18 2022-05-17 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 8,118 14,851,927 0.05 5.99 48,599 88,912,546

2022-05-18 2022-05-17 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 989 1,210,325 0.08 5.99 5,921 7,245,732

2022-05-18 2022-05-16 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 15,154 14,843,809 0.10 5.75 87,098 85,314,792

2022-05-18 2022-05-16 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 1,846 1,209,336 0.15 5.75 10,610 6,950,659

2022-05-18 2022-05-16 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 93,690 14,828,655 0.64 5.71 534,979 84,673,103

2022-05-18 2022-05-16 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 11,410 1,207,490 0.95 5.71 65,152 6,894,889

2022-05-18 2022-05-18 4 TRDA Entrada Therapeutics, Inc.
Common Stock P - Purchase 30,003 4,421,689 0.68 6.00 180,018 26,530,134

2022-05-18 2022-05-18 4 TRDA Entrada Therapeutics, Inc.
Common Stock P - Purchase 3,654 354,674 1.04 6.00 21,924 2,128,044

2022-05-18 2022-05-18 4 TRDA Entrada Therapeutics, Inc.
Common Stock P - Purchase 692 4,391,686 0.02 5.92 4,095 25,989,998

2022-05-18 2022-05-18 4 TRDA Entrada Therapeutics, Inc.
Common Stock P - Purchase 84 351,020 0.02 5.92 497 2,077,336

2022-05-18 2022-05-17 4 TRDA Entrada Therapeutics, Inc.
Common Stock P - Purchase 16,501 4,390,994 0.38 6.13 101,153 26,917,232

2022-05-18 2022-05-17 4 TRDA Entrada Therapeutics, Inc.
Common Stock P - Purchase 2,010 350,936 0.58 6.13 12,322 2,151,273

2022-05-18 2022-05-16 4 TRDA Entrada Therapeutics, Inc.
Common Stock P - Purchase 16,937 4,374,493 0.39 5.83 98,673 25,485,359

2022-05-18 2022-05-16 4 TRDA Entrada Therapeutics, Inc.
Common Stock P - Purchase 2,063 348,926 0.59 5.83 12,019 2,032,808

2022-05-17 2022-05-13 4 SGEN Seagen Inc.
Non-Qualified Stock Option (right to buy) A - Award 3,676 3,676

2022-05-17 2022-05-13 4 SGEN Seagen Inc.
Common Stock A - Award 1,503 42,966,507 0.00

2022-05-17 2022-05-13 4 SGEN Seagen Inc.
Common Stock A - Award 1,503 42,966,507 0.00

2022-05-16 2022-05-12 4 NLTX Neoleukin Therapeutics, Inc.
Non-Qualified Stock Option (right to buy) A - Award 25,000 25,000

2022-05-12 2022-05-11 4 TCRX TScan Therapeutics, Inc.
Common Stock P - Purchase 22,983 2,528,583 0.92 1.99 45,628 5,019,996

2022-05-12 2022-05-11 4 TCRX TScan Therapeutics, Inc.
Common Stock P - Purchase 2,882 256,209 1.14 1.99 5,722 508,652

2022-05-12 2022-05-10 4 TCRX TScan Therapeutics, Inc.
Common Stock P - Purchase 758,094 2,505,600 43.38 1.95 1,478,283 4,885,920

2022-05-12 2022-05-10 4 TCRX TScan Therapeutics, Inc.
Common Stock P - Purchase 95,060 253,327 60.06 1.95 185,367 493,988

2022-05-12 2022-05-10 4 TCRX TScan Therapeutics, Inc.
Common Stock P - Purchase 101,831 1,747,506 6.19 1.93 196,962 3,380,026

2022-05-12 2022-05-10 4 TCRX TScan Therapeutics, Inc.
Common Stock P - Purchase 12,769 158,267 8.78 1.93 24,698 306,120

2022-05-12 2022-05-10 4 TCRX TScan Therapeutics, Inc.
Common Stock P - Purchase 325,373 1,645,675 24.64 1.70 553,134 2,797,648

2022-05-12 2022-05-10 4 TCRX TScan Therapeutics, Inc.
Common Stock P - Purchase 40,800 145,498 38.97 1.70 69,360 247,347

2022-04-05 2022-04-01 4 IGMS IGM Biosciences, Inc.
Non-Voting Common Stock P - Purchase 2,592,497 4,674,392 124.53 23.00 59,627,431 107,511,016

2022-04-05 2022-04-01 4 IGMS IGM Biosciences, Inc.
Non-Voting Common Stock P - Purchase 233,590 421,532 124.29 23.00 5,372,570 9,695,236

2022-04-04 2022-03-31 4 INCY INCYTE CORP
Common Stock A - Award 440 33,419,495 0.00

2022-04-04 2022-03-31 4 INCY INCYTE CORP
Common Stock A - Award 440 33,419,495 0.00

2022-03-15 2022-03-12 4 IGMS IGM Biosciences, Inc.
Non-Qualified Stock Option (right to buy) A - Award 29,497 29,497

2022-03-10 2022-03-08 4 SGEN Seagen Inc.
Non-Qualified Stock Option (right to buy) M - Exercise -17,500 0 -100.00

2022-03-10 2022-03-08 4 SGEN Seagen Inc.
Non-Qualified Stock Option (right to buy) M - Exercise -17,500 0 -100.00

2022-03-10 2022-03-08 4 SGEN Seagen Inc.
Common Stock M - Exercise 17,500 42,965,004 0.04 20.06 351,050 861,877,980

2022-03-10 2022-03-08 4 SGEN Seagen Inc.
Common Stock M - Exercise 17,500 42,965,004 0.04 20.06 351,050 861,877,980

2022-03-10 2022-03-10 4 INCY INCYTE CORP
Common Stock P - Purchase 175,795 33,419,055 0.53 73.31 12,887,303 2,449,907,477

2022-03-10 2022-03-10 4 INCY INCYTE CORP
Common Stock P - Purchase 14,490 2,941,147 0.50 73.31 1,062,243 215,611,663

2022-03-10 2022-03-10 4 INCY INCYTE CORP
Common Stock P - Purchase 1,017 33,243,260 0.00 71.95 73,177 2,391,975,557

2022-03-10 2022-03-10 4 INCY INCYTE CORP
Common Stock P - Purchase 84 2,926,657 0.00 71.95 6,044 210,583,800

2022-03-10 2022-03-10 4 INCY INCYTE CORP
Common Stock P - Purchase 25,107 33,242,243 0.08 71.90 1,805,126 2,390,027,518

2022-03-10 2022-03-10 4 INCY INCYTE CORP
Common Stock P - Purchase 2,070 2,926,573 0.07 71.90 148,827 210,412,697

2022-03-10 2022-03-09 4 INCY INCYTE CORP
Common Stock P - Purchase 65,147 33,217,136 0.20 71.72 4,672,408 2,382,366,211

2022-03-10 2022-03-09 4 INCY INCYTE CORP
Common Stock P - Purchase 5,370 2,924,503 0.18 71.72 385,142 209,748,280

2022-03-10 2022-03-08 4 INCY INCYTE CORP
Non-Qualified Stock Options (right to buy) M - Exercise -20,000 0 -100.00

2022-03-10 2022-03-08 4 INCY INCYTE CORP
Non-Qualified Stock Options (right to buy) M - Exercise -20,000 0 -100.00

2022-03-10 2022-03-08 4 INCY INCYTE CORP
Common Stock P - Purchase 92,385 33,151,989 0.28 70.68 6,529,310 2,343,016,823

2022-03-10 2022-03-08 4 INCY INCYTE CORP
Common Stock P - Purchase 7,615 2,919,133 0.26 70.68 538,190 206,309,725

2022-03-10 2022-03-08 4 INCY INCYTE CORP
Common Stock M - Exercise 20,000 33,059,604 0.06 22.05 441,000 728,964,268

2022-03-10 2022-03-08 4 INCY INCYTE CORP
Common Stock M - Exercise 20,000 33,059,604 0.06 22.05 441,000 728,964,268

2022-02-22 2022-02-22 4 INCY INCYTE CORP
Common Stock P - Purchase 92,234 33,039,604 0.28 68.07 6,278,507 2,249,055,404

2022-02-22 2022-02-22 4 INCY INCYTE CORP
Common Stock P - Purchase 7,566 2,891,518 0.26 68.07 515,029 196,829,968

2022-02-22 2022-02-18 4 INCY INCYTE CORP
Common Stock P - Purchase 22,178 32,947,370 0.07 68.43 1,517,656 2,254,611,592

2022-02-22 2022-02-18 4 INCY INCYTE CORP
Common Stock P - Purchase 1,827 2,883,952 0.06 68.43 125,023 197,350,854

2022-02-22 2022-02-18 4 INCY INCYTE CORP
Common Stock P - Purchase 100,731 32,925,192 0.31 68.37 6,886,696 2,251,003,187

2022-02-22 2022-02-18 4 INCY INCYTE CORP
Common Stock P - Purchase 8,296 2,882,125 0.29 68.37 567,174 197,042,816

2022-02-22 2022-02-17 4 INCY INCYTE CORP
Common Stock P - Purchase 285,672 32,824,461 0.88 67.74 19,352,821 2,223,689,828

2022-02-22 2022-02-17 4 INCY INCYTE CORP
Common Stock P - Purchase 7,300 32,538,789 0.02 67.40 491,984 2,192,951,685

2022-02-17 2022-02-17 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 271,997 14,734,965 1.88 54.57 14,843,883 804,141,559

2022-02-17 2022-02-17 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 22,403 1,196,080 1.91 54.57 1,222,615 65,274,511

2022-02-17 2022-02-17 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 5,174 14,462,968 0.04 53.82 278,457 778,376,690

2022-02-17 2022-02-17 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 426 1,173,677 0.04 53.82 22,927 63,165,653

2022-02-17 2022-02-16 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 64,119 14,457,794 0.45 54.26 3,479,200 784,503,035

2022-02-17 2022-02-16 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 5,281 1,173,251 0.45 54.26 286,556 63,662,476

2022-02-17 2022-02-16 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 23,804 14,393,675 0.17 53.73 1,279,048 773,408,142

2022-02-17 2022-02-16 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 1,961 1,167,970 0.17 53.73 105,369 62,757,948

2022-02-17 2022-02-15 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 5,359 14,369,871 0.04 54.16 290,217 778,200,364

2022-02-17 2022-02-15 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 441 1,166,009 0.04 54.16 23,882 63,145,217

2022-02-14 2022-02-14 4 INCY INCYTE CORP
Common Stock P - Purchase 182,326 32,531,489 0.56 66.04 12,040,390 2,148,304,711

2022-02-14 2022-02-14 4 INCY INCYTE CORP
Common Stock P - Purchase 320,526 32,349,163 1.00 66.02 21,159,973 2,135,575,284

2022-02-14 2022-02-11 4 INCY INCYTE CORP
Common Stock P - Purchase 10,985 32,028,637 0.03 66.95 735,433 2,144,278,813

2022-02-14 2022-02-11 4 INCY INCYTE CORP
Common Stock P - Purchase 265,522 32,017,652 0.84 66.81 17,740,295 2,139,192,181

2022-02-14 2022-02-10 4 INCY INCYTE CORP
Common Stock P - Purchase 772,751 31,752,130 2.49 67.54 52,192,839 2,144,589,664

2022-02-14 2022-02-10 4 INCY INCYTE CORP
Common Stock P - Purchase 6,100 30,979,379 0.02 67.20 409,899 2,081,705,841

2022-02-14 2022-02-10 4 INCY INCYTE CORP
Common Stock P - Purchase 40,164 30,973,279 0.13 66.57 2,673,577 2,061,782,777

2022-01-31 2022-01-31 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 27,841 14,364,512 0.19 57.22 1,593,076 821,944,559

2022-01-31 2022-01-31 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 2,307 1,165,568 0.20 57.22 132,008 66,694,384

2022-01-31 2022-01-28 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 11,526 14,336,671 0.08 51.61 594,898 739,967,202

2022-01-31 2022-01-28 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 953 1,163,261 0.08 51.61 49,188 60,040,088

2022-01-31 2022-01-28 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 17,119 14,325,145 0.12 50.56 865,460 724,214,868

2022-01-31 2022-01-28 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 1,414 1,162,308 0.12 50.56 71,485 58,761,062

2022-01-31 2022-01-28 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 22,395 14,308,026 0.16 49.70 1,113,056 711,124,631

2022-01-31 2022-01-28 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 1,851 1,160,894 0.16 49.70 91,997 57,697,709

2022-01-31 2022-01-27 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 54,024 14,285,631 0.38 51.67 2,791,490 738,157,125

2022-01-31 2022-01-27 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 4,465 1,159,043 0.39 51.67 230,712 59,889,259

2022-01-31 2022-01-27 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 117,291 14,231,607 0.83 51.59 6,050,820 734,181,565

2022-01-31 2022-01-27 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 86,479 14,114,316 0.62 52.04 4,500,497 734,530,176

2022-01-25 2022-01-25 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 5,500 14,027,837 0.04 58.90 323,934 826,198,919

2022-01-25 2022-01-24 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 57,547 14,022,337 0.41 58.87 3,387,844 825,507,599

2022-01-25 2022-01-24 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 9,350 13,964,790 0.07 58.76 549,368 820,513,805

2022-01-25 2022-01-24 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 132,367 13,955,440 0.96 58.13 7,693,938 811,171,114

2022-01-25 2022-01-24 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 25,900 13,823,073 0.19 57.59 1,491,519 796,037,599

2022-01-25 2022-01-24 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 116,083 13,797,173 0.85 56.86 6,601,060 784,576,243

2022-01-25 2022-01-24 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 1,200 13,681,090 0.01 56.60 67,914 774,281,289

2022-01-25 2022-01-24 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 19,750 13,679,890 0.14 56.39 1,113,649 771,372,061

2022-01-25 2022-01-21 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 31,207 13,660,140 0.23 57.53 1,795,292 785,847,364

2022-01-25 2022-01-21 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 102,207 13,628,933 0.76 56.57 5,782,279 771,045,981

2022-01-04 2021-12-31 4 INCY INCYTE CORP
Common Stock A - Award 419 30,933,115 0.00

2022-01-04 2021-12-31 4 INCY INCYTE CORP
Common Stock A - Award 419 30,933,115 0.00

2021-12-17 2021-12-17 4 INCY INCYTE CORP
Common Stock P - Purchase 193,997 30,932,696 0.63 72.91 14,144,224 2,255,287,399

2021-12-17 2021-12-17 4 INCY INCYTE CORP
Common Stock P - Purchase 881,875 30,738,699 2.95 72.77 64,177,924 2,236,990,377

2021-12-17 2021-12-16 4 INCY INCYTE CORP
Common Stock P - Purchase 29,703 29,856,824 0.10 72.00 2,138,616 2,149,691,328

2021-12-17 2021-12-16 4 INCY INCYTE CORP
Common Stock P - Purchase 139,612 29,827,121 0.47 71.96 10,045,795 2,146,213,474

2021-12-17 2021-12-15 4 INCY INCYTE CORP
Common Stock P - Purchase 288,368 29,687,509 0.98 71.91 20,736,197 2,134,793,147

2021-12-17 2021-12-15 4 INCY INCYTE CORP
Common Stock P - Purchase 5,382 29,399,141 0.02 71.03 382,302 2,088,323,882

2021-12-17 2021-12-15 4 INCY INCYTE CORP
Common Stock P - Purchase 9,893 29,393,759 0.03 70.24 694,840 2,064,485,360

2021-12-17 2021-12-15 4 INCY INCYTE CORP
Common Stock P - Purchase 36,476 29,383,866 0.12 69.63 2,539,700 2,045,898,684

2021-12-17 2021-12-15 4 INCY INCYTE CORP
Common Stock P - Purchase 9,352 29,347,390 0.03 68.52 640,841 2,011,015,226

2021-12-17 2021-12-15 4 INCY INCYTE CORP
Common Stock P - Purchase 861 29,338,038 0.00 67.90 58,460 1,991,999,972

2021-12-16 3 TRDA Entrada Therapeutics, Inc.
Common Stock 346,863

2021-12-16 3 TRDA Entrada Therapeutics, Inc.
Common Stock 4,357,556

2021-12-02 2021-12-01 4 SGEN Seagen Inc.
Common Stock S - Sale -51,399 42,947,504 -0.12 161.39 -8,295,146 6,931,181,712

2021-12-02 2021-12-01 4 SGEN Seagen Inc.
Common Stock S - Sale -4,738 4,069,762 -0.12 161.39 -764,653 656,807,901

2021-12-02 2021-12-01 4 SGEN Seagen Inc.
Common Stock S - Sale -8,332 42,998,903 -0.02 161.34 -1,344,327 6,937,658,005

2021-12-02 2021-12-01 4 SGEN Seagen Inc.
Common Stock S - Sale -768 4,074,500 -0.02 161.34 -123,913 657,400,202

2021-12-02 2021-12-01 4 SGEN Seagen Inc.
Common Stock S - Sale -25,833 43,007,235 -0.06 160.80 -4,154,029 6,915,701,011

2021-12-02 2021-12-01 4 SGEN Seagen Inc.
Common Stock S - Sale -2,381 4,075,268 -0.06 160.80 -382,872 655,316,135

2021-12-02 2021-11-30 4 SGEN Seagen Inc.
Common Stock S - Sale -1,007 43,033,068 0.00 165.68 -166,844 7,129,895,142

2021-12-02 2021-11-30 4 SGEN Seagen Inc.
Common Stock S - Sale -93 4,077,649 0.00 165.68 -15,409 675,601,605

2021-12-02 2021-11-30 4 SGEN Seagen Inc.
Common Stock S - Sale -9,618 43,034,075 -0.02 164.82 -1,585,266 7,092,996,737

2021-12-02 2021-11-30 4 SGEN Seagen Inc.
Common Stock S - Sale -886 4,077,742 -0.02 164.82 -146,033 672,104,854

2021-12-02 2021-11-30 4 SGEN Seagen Inc.
Common Stock S - Sale -1,337 43,043,693 0.00 163.39 -218,449 7,032,809,999

2021-12-02 2021-11-30 4 SGEN Seagen Inc.
Common Stock S - Sale -123 4,078,628 0.00 163.39 -20,097 666,397,648

2021-12-02 2021-11-30 4 SGEN Seagen Inc.
Common Stock S - Sale -20,154 43,045,030 -0.05 160.96 -3,243,986 6,928,523,724

2021-12-02 2021-11-30 4 SGEN Seagen Inc.
Common Stock S - Sale -1,858 4,078,751 -0.05 160.96 -299,063 656,515,353

2021-12-02 2021-11-30 4 SGEN Seagen Inc.
Common Stock S - Sale -29,432 43,065,184 -0.07 160.53 -4,724,631 6,913,124,792

2021-12-02 2021-11-30 4 SGEN Seagen Inc.
Common Stock S - Sale -2,713 4,080,609 -0.07 160.53 -435,510 655,047,921

2021-12-02 2021-11-30 4 SGEN Seagen Inc.
Common Stock S - Sale -5,860 43,094,616 -0.01 160.08 -938,044 6,898,400,822

2021-12-02 2021-11-30 4 SGEN Seagen Inc.
Common Stock S - Sale -540 4,083,322 -0.01 160.08 -86,441 653,640,627

2021-12-02 2021-11-30 4 SGEN Seagen Inc.
Common Stock S - Sale -208,597 43,100,476 -0.48 160.00 -33,375,520 6,896,076,160

2021-12-02 2021-11-30 4 SGEN Seagen Inc.
Common Stock S - Sale -19,226 4,083,862 -0.47 160.00 -3,076,160 653,417,920

2021-11-19 2021-11-18 4 TLIS Talis Biomedical Corp
Common Stock P - Purchase 50,000 7,053,176 0.71 4.36 218,250 30,787,113

2021-10-04 2021-09-30 4 INCY INCYTE CORP
Common Stock A - Award 393 29,337,177 0.00

2021-10-04 2021-09-30 4 INCY INCYTE CORP
Common Stock A - Award 393 29,337,177 0.00

2021-10-01 2021-09-30 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 86,932 13,526,726 0.65 95.83 8,330,572 1,296,247,215

2021-10-01 2021-09-29 4 KOD Kodiak Sciences Inc.
Common Stock Warrant (right to buy) M - Exercise -138,815 0 -100.00

2021-10-01 2021-09-29 4 KOD Kodiak Sciences Inc.
Common Stock Warrant (right to buy) M - Exercise -11,184 0 -100.00

2021-10-01 2021-09-29 4 KOD Kodiak Sciences Inc.
Common Stock F - Taxes -14 13,439,794 0.00 102.00 -1,428 1,370,858,988

2021-10-01 2021-09-29 4 KOD Kodiak Sciences Inc.
Common Stock M - Exercise 138,815 13,439,808 1.04 0.01 1,388 134,398

2021-10-01 2021-09-29 4 KOD Kodiak Sciences Inc.
Common Stock F - Taxes -2 1,154,578 0.00 102.00 -204 117,766,956

2021-10-01 2021-09-29 4 KOD Kodiak Sciences Inc.
Common Stock M - Exercise 11,184 1,154,580 0.98 0.01 112 11,546

2021-09-17 2021-09-16 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 1,153 13,300,993 0.01 94.59 109,064 1,258,164,870

2021-09-17 2021-09-15 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 400 13,299,840 0.00 94.48 37,791 1,256,535,634

2021-09-17 2021-09-15 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 30,285 13,299,440 0.23 94.38 2,858,425 1,255,257,005

2021-09-09 2021-09-07 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 52,201 13,269,155 0.39 93.35 4,872,948 1,238,671,639

2021-09-09 2021-09-07 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 5,300 13,216,954 0.04 92.88 492,279 1,227,629,017

2021-08-19 2021-08-19 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 73,635 13,211,654 0.56 87.61 6,451,464 1,157,527,175

2021-08-19 2021-08-19 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 2,396 13,138,019 0.02 87.48 209,607 1,149,341,492

2021-08-19 2021-08-19 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 4,649 13,135,623 0.04 87.07 404,793 1,143,731,830

2021-08-19 2021-08-19 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 2,968 13,130,974 0.02 86.94 258,033 1,141,587,183

2021-08-19 2021-08-18 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 400 13,128,006 0.00 89.66 35,863 1,177,008,444

2021-08-19 2021-08-18 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 1,100 13,127,606 0.01 88.16 96,982 1,157,395,383

2021-08-19 2021-08-18 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 8,186 13,126,506 0.06 87.91 719,659 1,153,995,773

2021-08-19 2021-08-18 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 12,898 13,118,320 0.10 87.79 1,132,303 1,151,644,194

2021-08-19 2021-08-17 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 7,764 13,105,422 0.06 85.95 667,333 1,126,439,853

2021-08-19 2021-08-17 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 400 13,097,658 0.00 84.80 33,921 1,110,714,143

2021-08-13 2021-08-13 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 400 13,097,258 0.00 88.82 35,526 1,163,232,969

2021-08-13 2021-08-13 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 16,269 13,096,858 0.12 88.76 1,444,017 1,162,461,400

2021-08-13 2021-08-13 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 21,595 13,080,589 0.17 88.59 1,913,036 1,158,770,138

2021-08-13 2021-08-12 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 6,086 13,058,994 0.05 88.01 535,634 1,149,333,815

2021-08-13 2021-08-12 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 4,600 13,052,908 0.04 86.44 397,646 1,128,354,716

2021-08-13 2021-08-12 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 300 13,048,308 0.00 85.58 25,674 1,116,674,199

2021-08-13 2021-08-11 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 4,500 13,048,008 0.03 88.00 395,990 1,148,195,998

2021-08-13 2021-08-11 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 44,700 13,043,508 0.34 86.07 3,847,481 1,122,699,081

2021-08-13 2021-08-11 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 600 12,998,808 0.00 85.72 51,434 1,114,295,518

2021-08-13 2021-08-11 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 3,723 12,998,208 0.03 84.39 314,185 1,096,922,673

2021-07-22 2021-07-20 4 TCRX TScan Therapeutics, Inc.
Non-Voting Common Stock C - Conversion 3,960,811 3,960,811

2021-07-22 2021-07-20 4 TCRX TScan Therapeutics, Inc.
Series C Convertible Preferred Stock C - Conversion -3,960,811 0 -100.00

2021-07-22 2021-07-20 4 TCRX TScan Therapeutics, Inc.
Non-Voting Common Stock C - Conversion 315,777 315,777

2021-07-22 2021-07-20 4 TCRX TScan Therapeutics, Inc.
Series C Convertible Preferred Stock C - Conversion -315,777 0 -100.00

2021-07-22 2021-07-20 4 TCRX TScan Therapeutics, Inc.
Common Stock P - Purchase 1,320,302 1,320,302 15.00 19,804,530 19,804,530

2021-07-22 2021-07-20 4 TCRX TScan Therapeutics, Inc.
Common Stock P - Purchase 104,698 104,698 15.00 1,570,470 1,570,470

2021-07-02 2021-06-30 4 INCY INCYTE CORP
Common Stock A - Award 345 29,336,784 0.00

2021-07-02 2021-06-30 4 INCY INCYTE CORP
Common Stock A - Award 345 29,336,784 0.00

2021-07-01 2021-06-29 4 KNSA Kiniksa Pharmaceuticals, Ltd.
Non-Qualified Share Option (right to buy) A - Award 66,474 66,474

2021-06-30 2021-06-30 4 KOD Kodiak Sciences Inc.
Non-Qualified Stock Options (right to buy) A - Award 7,368 7,368

2021-06-30 2021-06-30 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 121,612 12,994,485 0.94 92.75 11,279,014 1,205,185,206

2021-06-30 2021-06-30 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 7,009 12,872,873 0.05 91.64 642,276 1,179,617,303

2021-06-30 2021-06-30 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 22,353 12,865,864 0.17 90.20 2,016,332 1,160,553,683

2021-06-30 2021-06-30 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 4,603 12,843,511 0.04 89.74 413,070 1,152,566,402

2021-06-30 2021-06-29 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 30,221 12,838,908 0.24 90.70 2,741,157 1,164,536,460

2021-06-30 2021-06-29 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 1,200 12,808,687 0.01 90.40 108,474 1,157,841,261

2021-06-30 2021-06-29 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 11,731 12,807,487 0.09 90.39 1,060,378 1,157,682,838

2021-06-30 2021-06-29 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 3,847 12,795,756 0.03 89.90 345,828 1,150,282,163

2021-06-30 2021-06-29 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 7,079 12,791,909 0.06 89.87 636,196 1,149,620,375

2021-06-30 2021-06-28 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 10,459 12,784,830 0.08 91.87 960,845 1,174,514,205

2021-06-30 2021-06-28 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 22,445 12,774,371 0.18 91.80 2,060,393 1,172,654,044

2021-06-30 2021-06-28 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 10,170 12,751,926 0.08 90.76 923,046 1,157,386,482

2021-06-30 2021-06-28 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 5,200 12,741,756 0.04 90.27 469,420 1,150,237,814

2021-06-24 2021-06-22 4 ACAD ACADIA PHARMACEUTICALS INC
Non-Qualified Stock Options (right to buy) A - Award 23,274 23,274

2021-06-24 2021-06-22 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock A - Award 12,782 38,452,877 0.03

2021-06-24 2021-06-22 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock A - Award 12,782 38,452,877 0.03

2021-06-22 2021-06-18 4 PRLD Prelude Therapeutics Inc
Non-Qualified Stock Options (right to buy) A - Award 23,344 23,344

2021-06-21 2021-06-16 4 BGNE BeiGene, Ltd.
Share Option (Right to Buy) A - Award 34,996 34,996

2021-06-21 2021-06-16 4 BGNE BeiGene, Ltd.
Ordinary Shares A - Award 15,600 34,189 83.92

2021-06-21 2021-06-16 4 BGNE BeiGene, Ltd.
Ordinary Shares A - Award 15,600 34,189 83.92

2021-06-10 2021-06-08 4 AGLE Aeglea BioTherapeutics, Inc.
Non-Qualified Stock Option (right to buy) A - Award 40,000 40,000

2021-05-28 2021-05-26 4 INCY INCYTE CORP
Non-Qualified Stock Options (right to buy) A - Award 8,010 8,010

2021-05-28 2021-05-26 4 INCY INCYTE CORP
Common Stock A - Award 1,923 29,336,439 0.01

2021-05-28 2021-05-26 4 INCY INCYTE CORP
Common Stock A - Award 1,923 29,336,439 0.01

2021-05-18 2021-05-14 4 SGEN Seagen Inc.
Non-Qualified Stock Option (right to buy) A - Award 3,462 3,462

2021-05-18 2021-05-14 4 SGEN Seagen Inc.
Non-Qualified Stock Option (right to buy) M - Exercise -17,500 0 -100.00

2021-05-18 2021-05-14 4 SGEN Seagen Inc.
Non-Qualified Stock Option (right to buy) M - Exercise -17,500 0 -100.00

2021-05-18 2021-05-14 4 SGEN Seagen Inc.
Common Stock A - Award 1,402 43,309,073 0.00

2021-05-18 2021-05-14 4 SGEN Seagen Inc.
Common Stock A - Award 1,402 43,309,073 0.00

2021-05-18 2021-05-14 4 SGEN Seagen Inc.
Common Stock M - Exercise 17,500 43,307,671 0.04 19.02 332,850 823,711,902

2021-05-18 2021-05-14 4 SGEN Seagen Inc.
Common Stock M - Exercise 17,500 43,307,671 0.04 19.02 332,850 823,711,902

2021-05-18 2021-05-14 4 INCY INCYTE CORP
Non-Qualified Stock Options (right to buy) M - Exercise -20,000 0 -100.00

2021-05-18 2021-05-14 4 INCY INCYTE CORP
Non-Qualified Stock Options (right to buy) M - Exercise -20,000 0 -100.00

2021-05-18 2021-05-14 4 INCY INCYTE CORP
Common Stock M - Exercise 20,000 29,334,516 0.07 18.97 379,400 556,475,769

2021-05-18 2021-05-14 4 INCY INCYTE CORP
Common Stock M - Exercise 20,000 2,870,749 0.70 18.97 379,400 54,458,109

2021-05-13 2021-05-11 4 NLTX Neoleukin Therapeutics, Inc.
Non-Qualified Stock Option (right to buy) A - Award 25,000 25,000

2021-04-01 2021-03-31 4 INCY INCYTE CORP
Common Stock A - Award 364 29,314,516 0.00

2021-04-01 2021-03-31 4 INCY INCYTE CORP
Common Stock A - Award 364 29,314,516 0.00

2021-02-25 2021-02-23 4 AGLE Aeglea BioTherapeutics, Inc.
Non-Qualified Stock Option (right to buy) A - Award 47,200 47,200

2021-02-25 3 AGLE Aeglea BioTherapeutics, Inc.
Common Stock 315,516

2021-02-25 3 AGLE Aeglea BioTherapeutics, Inc.
Common Stock 3,094,590

2021-02-23 2021-02-19 4 IGMS IGM Biosciences, Inc.
Non-Qualified Stock Option (right to buy) A - Award 6,423 6,423

2021-02-19 2021-02-17 4 TLIS Talis Biomedical Corp
Series 1 Convertible Preferred Stock M - Exercise 6,427,576 27,511,741 30.49

2021-02-19 2021-02-17 4 TLIS Talis Biomedical Corp
Series 1 Convertible Preferred Stock M - Exercise 536,438 2,345,481 29.65

2021-02-19 2021-02-17 4 TLIS Talis Biomedical Corp
Series 1 Convertible Preferred Stock M - Exercise 7,286,794 21,084,165 52.81

2021-02-19 2021-02-17 4 TLIS Talis Biomedical Corp
Series 1 Convertible Preferred Stock M - Exercise 536,414 1,809,043 42.15

2021-02-19 2021-02-17 4 TLIS Talis Biomedical Corp
Series 1 Convertible Preferred Stock M - Exercise 1,941 5,420 55.79

2021-02-19 2021-02-17 4 TLIS Talis Biomedical Corp
Series 1 Convertible Preferred Stock M - Exercise 6,654,603 13,797,371 93.17

2021-02-19 2021-02-17 4 TLIS Talis Biomedical Corp
Series 1 Convertible Preferred Stock M - Exercise 598,860 1,272,629 88.88

2021-02-19 2021-02-17 4 TLIS Talis Biomedical Corp
Series 1 Convertible Preferred Stock M - Exercise 7,142,768 7,142,768

2021-02-19 2021-02-17 4 TLIS Talis Biomedical Corp
Series 1 Convertible Preferred Stock M - Exercise 673,769 673,769

2021-02-19 2021-02-17 4 TLIS Talis Biomedical Corp
Series 1 Convertible Preferred Stock M - Exercise 3,479 3,479

2021-02-19 2021-02-17 4 TLIS Talis Biomedical Corp
Series F-2 Convertible Preferred Stock M - Exercise -9,191,433 0 -100.00

2021-02-19 2021-02-17 4 TLIS Talis Biomedical Corp
Series F-2 Convertible Preferred Stock M - Exercise -767,106 0 -100.00

2021-02-19 2021-02-17 4 TLIS Talis Biomedical Corp
Series E-2 Convertible Preferred Stock M - Exercise -10,420,117 0 -100.00

2021-02-19 2021-02-17 4 TLIS Talis Biomedical Corp
Series E-2 Convertible Preferred Stock M - Exercise -767,072 0 -100.00

2021-02-19 2021-02-17 4 TLIS Talis Biomedical Corp
Series E-1 Convertible Preferred Stock M - Exercise -2,776 0 -100.00

2021-02-19 2021-02-17 4 TLIS Talis Biomedical Corp
Series D-2 Convertible Preferred Stock M - Exercise -9,516,082 0 -100.00

2021-02-19 2021-02-17 4 TLIS Talis Biomedical Corp
Series D-2 Convertible Preferred Stock M - Exercise -856,370 0 -100.00

2021-02-19 2021-02-17 4 TLIS Talis Biomedical Corp
Series C-1 Convertible Preferred Stock M - Exercise -10,214,159 0 -100.00

2021-02-19 2021-02-17 4 TLIS Talis Biomedical Corp
Series C-1 Convertible Preferred Stock M - Exercise -963,490 0 -100.00

2021-02-19 2021-02-17 4 TLIS Talis Biomedical Corp
Series C-1 Convertible Preferred Stock M - Exercise -4,975 0 -100.00

2021-02-19 2021-02-17 4 TLIS Talis Biomedical Corp
Common Stock P - Purchase 5,792,538 7,003,176 478.47 16.00 92,680,608 112,050,816

2021-02-19 2021-02-17 4 TLIS Talis Biomedical Corp
Common Stock P - Purchase 457,462 571,659 400.59 16.00 7,319,392 9,146,544

2021-02-19 2020-11-02 4 TLIS Talis Biomedical Corp
Series F-2 Convertible Preferred Stock A - Award 9,191,433 9,191,433 8.55 78,586,752 78,586,752

2021-02-19 2020-11-02 4 TLIS Talis Biomedical Corp
Series F-2 Convertible Preferred Stock A - Award 767,106 767,106 8.55 6,558,756 6,558,756

2021-02-16 2020-10-13 5 SGEN Seagen Inc.
Common Stock G - Gift -158,456 23,277 -87.19

2021-02-16 2020-10-13 5 SGEN Seagen Inc.
Common Stock G - Gift -158,460 23,280 -87.19

2021-02-11 3 TLIS Talis Biomedical Corp
Common Stock 590

2021-02-11 3 TLIS Talis Biomedical Corp
Common Stock 114,197

2021-02-11 3 TLIS Talis Biomedical Corp
Common Stock 1,210,638

2021-01-29 2021-01-27 4 PRLD Prelude Therapeutics Inc
Non-Qualified Stock Options (right to buy) M - Exercise -5,188 41,500 -11.11

2021-01-29 2021-01-27 4 PRLD Prelude Therapeutics Inc
Non-Qualified Stock Options (right to buy) M - Exercise -5,188 41,500 -11.11

2021-01-29 2021-01-27 4 PRLD Prelude Therapeutics Inc
Common Stock M - Exercise 5,188 9,252,951 0.06 12.85 66,666 118,900,420

2021-01-29 2021-01-27 4 PRLD Prelude Therapeutics Inc
Common Stock M - Exercise 5,188 9,252,951 0.06 12.85 66,666 118,900,420

2021-01-29 2021-01-27 4 IGMS IGM Biosciences, Inc.
Non-Qualified Stock Options (right to buy) M - Exercise -5,833 2,527 -69.77

2021-01-29 2021-01-27 4 IGMS IGM Biosciences, Inc.
Non-Qualified Stock Options (right to buy) M - Exercise -5,833 2,527 -69.77

2021-01-29 2021-01-27 4 IGMS IGM Biosciences, Inc.
Non-Qualified Stock Options (right to buy) M - Exercise -5,377 6,723 -44.44

2021-01-29 2021-01-27 4 IGMS IGM Biosciences, Inc.
Non-Qualified Stock Options (right to buy) M - Exercise -5,377 6,723 -44.44

2021-01-29 2021-01-27 4 IGMS IGM Biosciences, Inc.
Common Stock M - Exercise 5,833 2,895,306 0.20 40.27 234,895 116,593,973

2021-01-29 2021-01-27 4 IGMS IGM Biosciences, Inc.
Common Stock M - Exercise 5,833 2,895,306 0.20 40.27 234,895 116,593,973

2021-01-29 2021-01-27 4 IGMS IGM Biosciences, Inc.
Common Stock M - Exercise 5,377 2,889,473 0.19 16.00 86,032 46,231,568

2021-01-29 2021-01-27 4 IGMS IGM Biosciences, Inc.
Common Stock M - Exercise 5,377 2,889,473 0.19 16.00 86,032 46,231,568

2021-01-13 2021-01-11 4 PRLD Prelude Therapeutics Inc
Non-Voting Common Stock P - Purchase 154,222 5,212,371 3.05 60.00 9,253,320 312,742,260

2021-01-13 2021-01-11 4 PRLD Prelude Therapeutics Inc
Non-Voting Common Stock P - Purchase 12,444 509,480 2.50 60.00 746,640 30,568,800

2021-01-11 3 DBVT DBV Technologies S.A.
Ordinary Shares 332,622

2021-01-11 3 DBVT DBV Technologies S.A.
Ordinary Shares 3,953,416

2021-01-11 3 DBVT DBV Technologies S.A.
American Depositary Shares 1,200,369

2021-01-11 3 DBVT DBV Technologies S.A.
American Depositary Shares 13,413,895

2021-01-06 2021-01-04 4 BGNE BeiGene, Ltd.
American Depositary Shares S - Sale -111,094 10,699,954 -1.03 220.50 -24,496,227 2,359,339,857

2021-01-06 2021-01-04 4 BGNE BeiGene, Ltd.
American Depositary Shares S - Sale -10,060 968,943 -1.03 220.50 -2,218,230 213,651,932

2021-01-05 2020-12-31 4 IGMS IGM Biosciences, Inc.
Common Stock A - Award 223 2,884,096 0.01

2021-01-05 2020-12-31 4 IGMS IGM Biosciences, Inc.
Common Stock A - Award 223 2,884,096 0.01

2021-01-05 2020-12-31 4 INCY INCYTE CORP
Common Stock A - Award 343 29,314,152 0.00

2021-01-05 2020-12-31 4 INCY INCYTE CORP
Common Stock A - Award 343 29,314,152 0.00

2020-12-23 2020-07-07 4 NLTX Neoleukin Therapeutics, Inc.
Pre-Funded Warrants P - Purchase 518,555 10,283,888 5.31

2020-12-23 2020-07-07 4 NLTX Neoleukin Therapeutics, Inc.
Pre-Funded Warrants P - Purchase 38,974 1,199,122 3.36

2020-12-23 2020-07-07 4 NLTX Neoleukin Therapeutics, Inc.
Common Stock P - Purchase 394,360 3,501,691 12.69 15.25 6,013,990 53,400,788

2020-12-23 2020-07-07 4 NLTX Neoleukin Therapeutics, Inc.
Common Stock P - Purchase 29,640 320,049 10.21 15.25 452,010 4,880,747

2020-12-11 2020-12-11 4 IGMS IGM Biosciences, Inc.
Pre-funded Warrants P - Purchase 616,846 616,846 89.99 55,509,972 55,509,972

2020-12-11 2020-12-11 4 IGMS IGM Biosciences, Inc.
Pre-funded Warrants P - Purchase 49,820 49,820 89.99 4,483,302 4,483,302

2020-12-04 2020-12-04 4 BGNE BeiGene, Ltd.
American Depositary Shares S - Sale -1,386,033 10,811,048 -11.36 220.50 -305,620,276 2,383,836,084

2020-12-04 2020-12-04 4 BGNE BeiGene, Ltd.
American Depositary Shares S - Sale -125,513 979,003 -11.36 220.50 -27,675,616 215,870,162

2020-12-04 2020-10-13 4 BGNE BeiGene, Ltd.
American Depositary Shares G - Gift -13,516 10,418 -56.47

2020-12-04 2020-10-13 4 BGNE BeiGene, Ltd.
American Depositary Shares G - Gift -13,516 10,418 -56.47

2020-11-24 2020-11-20 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 1,411,619 12,736,556 12.46 108.00 152,454,852 1,375,548,048

2020-11-24 2020-11-20 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 116,158 1,143,396 11.31 108.00 12,545,064 123,486,768

2020-10-05 2020-10-01 4 IGMS IGM Biosciences, Inc.
Common Stock A - Award 223 2,883,873 0.01

2020-10-05 2020-10-01 4 IGMS IGM Biosciences, Inc.
Common Stock A - Award 223 2,883,873 0.01

2020-10-02 2020-09-30 4 INCY INCYTE CORP
Common Stock A - Award 317 29,313,809 0.00

2020-10-02 2020-09-30 4 INCY INCYTE CORP
Common Stock A - Award 317 29,313,809 0.00

2020-09-30 2020-09-29 4 PRLD Prelude Therapeutics Inc
Non-Voting Common Stock C - Conversion 382,884 5,058,149 8.19

2020-09-30 2020-09-29 4 PRLD Prelude Therapeutics Inc
Series C Convertible Preferred Stock C - Conversion -382,884 0 -100.00

2020-09-30 2020-09-29 4 PRLD Prelude Therapeutics Inc
Non-Voting Common Stock C - Conversion 30,349 497,036 6.50

2020-09-30 2020-09-29 4 PRLD Prelude Therapeutics Inc
Series C Convertible Preferred Stock C - Conversion -30,349 0 -100.00

2020-09-30 2020-09-29 4 PRLD Prelude Therapeutics Inc
Series C Convertible Preferred Stock C - Conversion -574,327 0 -100.00

2020-09-30 2020-09-29 4 PRLD Prelude Therapeutics Inc
Series C Convertible Preferred Stock C - Conversion -45,524 0 -100.00

2020-09-30 2020-09-29 4 PRLD Prelude Therapeutics Inc
Non-Voting Common Stock C - Conversion 2,698,424 4,675,265 136.50

2020-09-30 2020-09-29 4 PRLD Prelude Therapeutics Inc
Series B Convertible Preferred Stock C - Conversion -2,698,424 0 -100.00

2020-09-30 2020-09-29 4 PRLD Prelude Therapeutics Inc
Non-Voting Common Stock C - Conversion 247,034 466,687 112.47

2020-09-30 2020-09-29 4 PRLD Prelude Therapeutics Inc
Series B Convertible Preferred Stock C - Conversion -247,034 0 -100.00

2020-09-30 2020-09-29 4 PRLD Prelude Therapeutics Inc
Series B Convertible Preferred Stock C - Conversion -4,047,634 0 -100.00

2020-09-30 2020-09-29 4 PRLD Prelude Therapeutics Inc
Series B Convertible Preferred Stock C - Conversion -370,552 0 -100.00

2020-09-30 2020-09-29 4 PRLD Prelude Therapeutics Inc
Non-Voting Common Stock C - Conversion 1,976,841 1,976,841

2020-09-30 2020-09-29 4 PRLD Prelude Therapeutics Inc
Series A Convertible Preferred Stock C - Conversion -1,976,841 0 -100.00

2020-09-30 2020-09-29 4 PRLD Prelude Therapeutics Inc
Non-Voting Common Stock C - Conversion 219,653 219,653

2020-09-30 2020-09-29 4 PRLD Prelude Therapeutics Inc
Series A Convertible Preferred Stock C - Conversion -219,653 0 -100.00

2020-09-30 2020-09-29 4 PRLD Prelude Therapeutics Inc
Series A Convertible Preferred Stock C - Conversion -2,965,263 0 -100.00

2020-09-30 2020-09-29 4 PRLD Prelude Therapeutics Inc
Series A Convertible Preferred Stock C - Conversion -329,478 0 -100.00

2020-09-30 2020-09-29 4 PRLD Prelude Therapeutics Inc
Common Stock P - Purchase 1,474,319 9,247,763 18.97 19.00 28,012,061 175,707,497

2020-09-30 2020-09-29 4 PRLD Prelude Therapeutics Inc
Common Stock P - Purchase 104,628 870,873 13.65 19.00 1,987,932 16,546,587

2020-09-30 2020-09-29 4 PRLD Prelude Therapeutics Inc
Common Stock C - Conversion 574,327 7,773,444 7.98

2020-09-30 2020-09-29 4 PRLD Prelude Therapeutics Inc
Common Stock C - Conversion 45,524 766,245 6.32

2020-09-30 2020-09-29 4 PRLD Prelude Therapeutics Inc
Common Stock C - Conversion 4,047,634 7,199,117 128.44

2020-09-30 2020-09-29 4 PRLD Prelude Therapeutics Inc
Common Stock C - Conversion 370,552 720,721 105.82

2020-09-30 2020-09-29 4 PRLD Prelude Therapeutics Inc
Common Stock C - Conversion 2,965,263 3,151,483 1,592.34

2020-09-30 2020-09-29 4 PRLD Prelude Therapeutics Inc
Common Stock C - Conversion 329,478 350,169 1,592.37

2020-09-30 2020-09-24 4 PRLD Prelude Therapeutics Inc
Non-Qualified Stock Option (right to buy) A - Award 46,688 46,688

2020-09-30 2020-08-21 4 PRLD Prelude Therapeutics Inc
Series C Preferred Stock P - Purchase 957,211 957,211 14.52 13,898,321 13,898,321

2020-09-30 2020-08-21 4 PRLD Prelude Therapeutics Inc
Series C Preferred Stock P - Purchase 75,873 75,873 14.52 1,101,646 1,101,646

2020-09-30 2020-03-27 4 PRLD Prelude Therapeutics Inc
Series B Preferred Stock P - Purchase 3,373,029 3,373,029 3.93 13,264,099 13,264,099

2020-09-30 2020-03-27 4 PRLD Prelude Therapeutics Inc
Series B Preferred Stock P - Purchase 308,793 308,793 3.93 1,214,298 1,214,298

2020-09-25 2020-09-25 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 7,843 11,324,937 0.07 58.09 455,565 657,814,628

2020-09-25 2020-09-25 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 557 1,027,238 0.05 58.09 32,354 59,667,633

2020-09-25 2020-09-25 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 19,235 11,317,094 0.17 56.92 1,094,854 644,167,859

2020-09-25 2020-09-25 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 1,365 1,026,681 0.13 56.92 77,696 58,438,580

2020-09-25 2020-09-25 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 4,705 11,297,859 0.04 56.76 267,055 641,265,347

2020-09-25 2020-09-25 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 334 1,025,316 0.03 56.76 18,958 58,196,834

2020-09-25 2020-09-25 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 13,153 11,293,154 0.12 55.35 728,057 625,108,824

2020-09-25 2020-09-25 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 933 1,024,982 0.09 55.35 51,644 56,735,726

2020-09-24 2020-09-24 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 29,327 11,280,001 0.26 52.11 1,528,374 587,856,124

2020-09-24 2020-09-24 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 2,081 1,024,049 0.20 52.11 108,451 53,368,211

2020-09-24 2020-09-24 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 4,306 11,250,674 0.04 51.41 221,368 578,388,150

2020-09-24 2020-09-24 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 306 1,021,968 0.03 51.41 15,731 52,538,557

2020-09-24 2020-09-23 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 74,381 11,246,368 0.67 52.44 3,900,235 589,713,428

2020-09-24 2020-09-23 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 5,278 1,021,662 0.52 52.44 276,757 53,571,766

2020-09-24 2020-09-23 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 10,467 11,171,987 0.09 52.40 548,468 585,408,767

2020-09-24 2020-09-23 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 743 1,016,384 0.07 52.40 38,933 53,258,217

2020-09-24 2020-09-23 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 1,120 11,161,520 0.01 51.97 58,206 580,064,194

2020-09-24 2020-09-23 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 80 1,015,641 0.01 51.97 4,158 52,782,863

2020-09-24 2020-09-22 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 22,361 11,160,400 0.20 51.98 1,162,235 580,072,950

2020-09-24 2020-09-22 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 1,587 1,015,561 0.16 51.98 82,486 52,784,799

2020-09-24 2020-09-22 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 36,647 11,138,039 0.33 50.15 1,837,909 558,591,591

2020-09-24 2020-09-22 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 2,601 1,013,974 0.26 50.15 130,445 50,852,520

2020-09-24 2020-09-22 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 10,983 11,101,392 0.10 49.72 546,102 551,988,964

2020-09-24 2020-09-22 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 779 1,011,373 0.08 49.72 38,734 50,287,994

2020-09-24 3 PRLD Prelude Therapeutics Inc
Common Stock 20,691

2020-09-24 3 PRLD Prelude Therapeutics Inc
Common Stock 186,220

2020-09-08 2020-09-08 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 15,172 11,090,409 0.14 47.47 720,200 526,450,625

2020-09-08 2020-09-08 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 1,220 1,010,594 0.12 47.47 57,912 47,971,887

2020-09-08 2020-09-08 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 76,473 11,075,237 0.70 47.39 3,623,857 524,826,686

2020-09-08 2020-09-08 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 6,151 1,009,374 0.61 47.39 291,480 47,831,609

2020-09-08 2020-09-08 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 15,807 10,998,764 0.14 47.04 743,482 517,326,865

2020-09-08 2020-09-08 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 1,272 1,003,223 0.13 47.04 59,829 47,186,594

2020-09-08 2020-09-08 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 185 10,982,957 0.00 45.88 8,487 503,843,152

2020-09-08 2020-09-08 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 15 1,001,951 0.00 45.88 688 45,964,502

2020-09-08 2020-09-04 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 9,101 10,982,772 0.08 47.50 432,281 521,661,901

2020-09-08 2020-09-04 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 712 1,001,936 0.07 47.50 33,819 47,590,157

2020-09-08 2020-09-04 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 26,238 10,973,671 0.24 47.26 1,239,984 518,605,815

2020-09-08 2020-09-04 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 2,054 1,001,224 0.21 47.26 97,070 47,316,945

2020-09-08 2020-09-04 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 29,319 10,947,433 0.27 46.62 1,366,767 510,337,579

2020-09-08 2020-09-04 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 2,295 999,170 0.23 46.62 106,986 46,578,408

2020-09-08 2020-09-04 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 12,132 10,918,114 0.11 45.30 549,535 494,550,167

2020-09-08 2020-09-04 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 950 996,875 0.10 45.30 43,031 45,154,749

2020-09-08 2020-09-03 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 32,088 10,905,982 0.30 49.00 1,572,312 534,393,118

2020-09-08 2020-09-03 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 2,512 995,925 0.25 49.00 123,088 48,800,325

2020-09-08 2020-09-03 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 77,456 10,873,894 0.72 47.60 3,686,658 517,562,558

2020-09-08 2020-09-03 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 6,062 993,413 0.61 47.60 288,532 47,283,280

2020-09-08 2020-09-03 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 2,987 10,796,438 0.03 47.45 141,725 512,260,753

2020-09-08 2020-09-03 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 234 987,351 0.02 47.45 11,103 46,847,040

2020-09-08 2020-09-03 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 2,359 10,793,451 0.02 46.97 110,798 506,947,886

2020-09-08 2020-09-03 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 185 987,117 0.02 46.97 8,689 46,363,010

2020-08-21 2020-08-21 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 83,832 10,791,092 0.78 49.08 4,114,734 529,660,248

2020-08-21 2020-08-21 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 6,645 986,932 0.68 49.08 326,157 48,441,682

2020-08-21 2020-08-21 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 2,286 10,707,260 0.02 48.74 111,430 521,922,177

2020-08-21 2020-08-21 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 181 980,287 0.02 48.74 8,823 47,783,796

2020-08-21 2020-08-21 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 42,714 10,704,974 0.40 47.74 2,039,256 511,077,939

2020-08-21 2020-08-21 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 3,386 980,106 0.35 47.74 161,655 46,792,319

2020-08-21 2020-08-20 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 754 10,662,260 0.01 47.82 36,058 509,896,995

2020-08-21 2020-08-20 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 60 976,720 0.01 47.82 2,869 46,709,290

2020-08-21 2020-08-20 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 41,155 10,661,506 0.39 47.72 1,963,970 508,780,926

2020-08-21 2020-08-20 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 3,262 976,660 0.34 47.72 155,667 46,607,485

2020-08-21 2020-08-20 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 10,640 10,620,351 0.10 46.50 494,716 493,802,778

2020-08-21 2020-08-20 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 843 973,398 0.09 46.50 39,196 45,259,016

2020-08-21 2020-08-20 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 3,576 10,609,711 0.03 46.30 165,575 491,248,717

2020-08-21 2020-08-20 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 283 972,555 0.03 46.30 13,103 45,031,047

2020-08-21 2020-08-19 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 3,585 10,606,135 0.03 46.99 168,447 498,345,162

2020-08-21 2020-08-19 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 284 972,272 0.03 46.99 13,344 45,683,658

2020-07-28 2020-07-24 4 KNSA Kiniksa Pharmaceuticals, Ltd.
Class A1 Common Shares A - Award 1,335,362 11,638,314 12.96 21.00 28,042,602 244,404,594

2020-07-28 2020-07-24 4 KNSA Kiniksa Pharmaceuticals, Ltd.
Class A1 Common Shares A - Award 93,210 1,143,650 8.87 21.00 1,957,410 24,016,650

2020-07-20 2020-07-20 4 BCEL Atreca, Inc.
Class B Common Stock P - Purchase 728,370 6,173,327 13.38 16.00 11,653,920 98,773,232

2020-07-20 2020-07-20 4 BCEL Atreca, Inc.
Class B Common Stock P - Purchase 52,880 542,114 10.81 16.00 846,080 8,673,824

2020-07-20 2020-07-20 4 BCEL Atreca, Inc.
Class B Common Stock P - Purchase 728,370 6,173,327 13.38 16.00 11,653,920 98,773,232

2020-07-20 2020-07-20 4 BCEL Atreca, Inc.
Class B Common Stock P - Purchase 52,880 542,114 10.81 16.00 846,080 8,673,824

2020-07-17 2020-07-15 4 BGNE BeiGene, Ltd.
Ordinary Shares A - Award 13,589,904 18,840,379 258.83 14.23 193,395,206 268,113,665

2020-07-17 2020-07-15 4 BGNE BeiGene, Ltd.
Ordinary Shares A - Award 994,276 1,021,851 3,605.72 14.23 14,149,343 14,541,757

2020-07-06 2020-07-01 4 IGMS IGM Biosciences, Inc.
Common Stock A - Award 223 2,883,650 0.01

2020-07-06 2020-07-01 4 IGMS IGM Biosciences, Inc.
Common Stock A - Award 223 2,883,650 0.01

2020-07-02 2020-06-30 4 KOD Kodiak Sciences Inc.
Non-Qualified Stock Options (right to buy) A - Award 7,106 7,106

2020-07-02 2020-06-30 4 INCY INCYTE CORP
Common Stock A - Award 294 29,313,492 0.00

2020-07-02 2020-06-30 4 INCY INCYTE CORP
Common Stock A - Award 294 29,313,492 0.00

2020-07-02 2020-06-30 4 KNSA Kiniksa Pharmaceuticals, Ltd.
Non-Qualified Share Option (right to buy) A - Award 37,520 37,520

2020-06-25 2020-06-23 4 ACAD ACADIA PHARMACEUTICALS INC
Non-Qualified Stock Options (right to buy) A - Award 11,158 11,158

2020-06-25 2020-06-23 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock A - Award 6,118 38,440,095 0.02

2020-06-25 2020-06-23 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock A - Award 6,118 38,440,095 0.02

2020-06-19 2020-06-17 4 BGNE BeiGene, Ltd.
Share Option (Right to Buy) A - Award 90,766 90,766

2020-06-10 2020-06-08 4 KOD Kodiak Sciences Inc.
Non-Qualified Stock Options (right to buy) A - Award 4,135 4,135

2020-05-28 2020-05-28 4 INCY INCYTE CORP
Common Stock P - Purchase 1 29,313,198 0.00 102.55 103 3,006,068,455

2020-05-28 2020-05-28 4 INCY INCYTE CORP
Common Stock P - Purchase 1 29,313,198 0.00 102.55 103 3,006,068,455

2020-05-28 2020-05-26 4 INCY INCYTE CORP
Non-Qualified Stock Options (right to buy) A - Award 10,514 10,514

2020-05-28 2020-05-26 4 INCY INCYTE CORP
Common Stock A - Award 1,282 29,313,197 0.00

2020-05-28 2020-05-26 4 INCY INCYTE CORP
Common Stock A - Award 1,282 29,313,197 0.00

2020-05-19 2020-05-15 4 SGEN SEATTLE GENETICS INC /WA
Non-Qualified Stock Option (right to buy) A - Award 3,171 3,171

2020-05-19 2020-05-15 4 SGEN SEATTLE GENETICS INC /WA
Common Stock A - Award 1,335 43,290,171 0.00

2020-05-19 2020-05-15 4 SGEN SEATTLE GENETICS INC /WA
Common Stock A - Award 1,335 43,290,171 0.00

2020-05-19 2020-05-15 4 SGEN SEATTLE GENETICS INC /WA
Common Stock S - Sale -1,602,312 43,288,836 -3.57 160.00 -256,369,920 6,926,213,760

2020-05-19 2020-05-15 4 SGEN SEATTLE GENETICS INC /WA
Common Stock S - Sale -147,688 4,082,851 -3.49 160.00 -23,630,080 653,256,160

2020-05-18 2020-05-18 4 KNSA Kiniksa Pharmaceuticals, Ltd.
Class A1 Common Shares A - Award 1,465,603 10,302,952 16.58 18.25 26,747,255 188,028,874

2020-05-18 2020-05-18 4 KNSA Kiniksa Pharmaceuticals, Ltd.
Class A1 Common Shares A - Award 134,397 1,050,440 14.67 18.25 2,452,745 19,170,530

2020-05-18 2020-05-14 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock A - Award 1,189 7,846,213 0.02

2020-05-18 2020-05-14 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock A - Award 1,189 7,846,213 0.02

2020-05-18 2020-05-14 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock A - Award 3,468 7,845,024 0.04

2020-05-18 2020-05-14 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock A - Award 3,468 7,845,024 0.04

2020-05-12 2020-05-08 4 ZYME Zymeworks Inc.
Non-Qualified Stock Option (right to buy) A - Award 9,000 9,000

2020-05-08 2020-05-08 4 SGEN SEATTLE GENETICS INC /WA
Common Stock S - Sale -457,803 44,891,148 -1.01 158.50 -72,561,776 7,115,246,958

2020-05-08 2020-05-08 4 SGEN SEATTLE GENETICS INC /WA
Common Stock S - Sale -42,197 4,230,539 -0.99 158.50 -6,688,224 670,540,432

2020-05-08 2020-05-07 4 SGEN SEATTLE GENETICS INC /WA
Common Stock S - Sale -4,343 45,348,951 -0.01 166.15 -721,610 7,534,941,349

2020-05-08 2020-05-07 4 SGEN SEATTLE GENETICS INC /WA
Common Stock S - Sale -400 4,272,736 -0.01 166.15 -66,462 709,935,168

2020-05-08 2020-05-07 4 SGEN SEATTLE GENETICS INC /WA
Common Stock S - Sale -48,880 45,353,294 -0.11 164.96 -8,063,118 7,481,361,460

2020-05-08 2020-05-07 4 SGEN SEATTLE GENETICS INC /WA
Common Stock S - Sale -4,505 4,273,136 -0.11 164.96 -743,133 704,885,404

2020-05-08 2020-05-07 4 SGEN SEATTLE GENETICS INC /WA
Common Stock S - Sale -84,663 45,402,174 -0.19 164.19 -13,901,157 7,454,764,558

2020-05-08 2020-05-07 4 SGEN SEATTLE GENETICS INC /WA
Common Stock S - Sale -7,805 4,277,641 -0.18 164.19 -1,281,534 702,362,986

2020-05-08 2020-05-07 4 SGEN SEATTLE GENETICS INC /WA
Common Stock S - Sale -16,159 45,486,837 -0.04 163.41 -2,640,610 7,433,195,079

2020-05-08 2020-05-07 4 SGEN SEATTLE GENETICS INC /WA
Common Stock S - Sale -1,489 4,285,446 -0.03 163.41 -243,324 700,302,730

2020-05-08 2020-05-06 4 SGEN SEATTLE GENETICS INC /WA
Common Stock S - Sale -41,072 45,502,996 -0.09 166.62 -6,843,564 7,581,873,004

2020-05-08 2020-05-06 4 SGEN SEATTLE GENETICS INC /WA
Common Stock S - Sale -3,786 4,286,935 -0.09 166.62 -630,837 714,304,543

2020-05-08 2020-05-06 4 SGEN SEATTLE GENETICS INC /WA
Common Stock S - Sale -91,613 45,544,068 -0.20 165.70 -15,180,641 7,546,834,244

2020-05-08 2020-05-06 4 SGEN SEATTLE GENETICS INC /WA
Common Stock S - Sale -8,444 4,290,721 -0.20 165.70 -1,399,205 710,989,633

2020-05-08 2020-05-06 4 SGEN SEATTLE GENETICS INC /WA
Common Stock S - Sale -178,862 45,635,681 -0.39 164.60 -29,440,041 7,511,468,804

2020-05-08 2020-05-06 4 SGEN SEATTLE GENETICS INC /WA
Common Stock S - Sale -16,485 4,299,165 -0.38 164.60 -2,713,372 707,627,082

2020-05-08 2020-05-06 4 SGEN SEATTLE GENETICS INC /WA
Common Stock S - Sale -45,606 45,814,543 -0.10 164.06 -7,482,107 7,516,320,180

2020-05-08 2020-05-06 4 SGEN SEATTLE GENETICS INC /WA
Common Stock S - Sale -4,204 4,315,650 -0.10 164.06 -689,707 708,024,244

2020-05-07 2020-05-05 4 NLTX Neoleukin Therapeutics, Inc.
Non-Qualified Stock Option (right to buy) A - Award 25,000 25,000

2020-04-29 2020-04-28 4 INCY INCYTE CORP
Non-Qualified Stock Options (right to buy) M - Exercise -20,000 0 -100.00

2020-04-29 2020-04-28 4 INCY INCYTE CORP
Non-Qualified Stock Options (right to buy) M - Exercise -20,000 0 -100.00

2020-04-29 2020-04-28 4 INCY INCYTE CORP
Common Stock M - Exercise 20,000 29,311,915 0.07 13.34 266,800 391,020,946

2020-04-29 2020-04-28 4 INCY INCYTE CORP
Common Stock M - Exercise 20,000 29,311,915 0.07 13.34 266,800 391,020,946

2020-04-24 2020-04-23 4 SGEN SEATTLE GENETICS INC /WA
Non-Qualified Stock Options (right to buy) M - Exercise -17,500 0 -100.00

2020-04-24 2020-04-23 4 SGEN SEATTLE GENETICS INC /WA
Non-Qualified Stock Options (right to buy) M - Exercise -17,500 0 -100.00

2020-04-24 2020-04-23 4 SGEN SEATTLE GENETICS INC /WA
Common Stock M - Exercise 17,500 45,860,149 0.04 12.76 223,300 585,175,501

2020-04-24 2020-04-23 4 SGEN SEATTLE GENETICS INC /WA
Common Stock M - Exercise 17,500 45,860,149 0.04 12.76 223,300 585,175,501

2020-04-03 2020-04-01 4 IGMS IGM Biosciences, Inc.
Common Stock A - Award 223 2,883,427 0.01

2020-04-03 2020-04-01 4 IGMS IGM Biosciences, Inc.
Common Stock A - Award 223 2,883,427 0.01

2020-04-01 2020-03-31 4 INCY INCYTE CORP
Common Stock A - Award 392 29,291,915 0.00 73.23 28,706 2,145,046,935

2020-04-01 2020-03-31 4 INCY INCYTE CORP
Common Stock A - Award 392 29,291,915 0.00 73.23 28,706 2,145,046,935

2020-03-18 2020-03-18 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 42,473 38,433,977 0.11 34.47 1,463,896 1,324,684,668

2020-03-18 2020-03-18 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 3,837 3,470,609 0.11 34.47 132,248 119,619,745

2020-03-18 2020-03-18 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 33,464 38,391,504 0.09 33.63 1,125,465 1,291,186,902

2020-03-18 2020-03-18 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 3,023 3,466,772 0.09 33.63 101,670 116,594,823

2020-03-18 2020-03-18 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 2,201 38,358,040 0.01 32.85 72,302 1,260,053,942

2020-03-18 2020-03-18 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 199 3,463,749 0.01 32.85 6,537 113,783,462

2020-03-18 2020-03-18 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 46,225 38,355,839 0.12 32.61 1,507,268 1,250,676,513

2020-03-18 2020-03-18 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 4,175 3,463,550 0.12 32.61 136,135 112,936,668

2020-03-18 2020-03-18 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 275 38,309,614 0.00 31.94 8,782 1,223,417,523

2020-03-18 2020-03-18 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 25 3,459,375 0.00 31.94 798 110,475,141

2020-03-18 2020-03-17 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 93,006 38,309,339 0.24 33.86 3,149,406 1,297,246,161

2020-03-18 2020-03-17 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 8,402 3,459,350 0.24 33.86 284,512 117,141,893

2020-03-18 2020-03-17 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 24,223 38,216,333 0.06 32.32 782,873 1,235,128,953

2020-03-18 2020-03-17 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 2,188 3,450,948 0.06 32.32 70,715 111,532,569

2020-03-18 2020-03-17 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 29,624 38,192,110 0.08 32.19 953,620 1,229,434,575

2020-03-18 2020-03-17 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 2,676 3,448,760 0.08 32.19 86,143 111,018,343

2020-03-18 2020-03-17 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 7,612 38,162,486 0.02 31.83 242,290 1,214,711,929

2020-03-18 2020-03-17 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 688 3,446,084 0.02 31.83 21,899 109,688,854

2020-03-18 2020-03-17 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 43,212 38,154,874 0.11 31.74 1,371,359 1,210,867,819

2020-03-18 2020-03-17 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 3,903 3,445,396 0.11 31.74 123,864 109,341,709

2020-03-18 2020-03-17 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 3,913 38,111,662 0.01 31.00 121,285 1,181,290,020

2020-03-18 2020-03-17 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 353 3,441,493 0.01 31.00 10,941 106,670,796

2020-03-18 2020-03-16 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 631,281 38,107,749 1.68 31.51 19,893,937 1,200,912,359

2020-03-18 2020-03-16 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 57,022 3,441,140 1.68 31.51 1,796,968 108,442,710

2020-03-18 2020-03-16 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 5,503 37,476,468 0.01 31.19 171,613 1,168,714,898

2020-03-18 2020-03-16 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 497 3,384,118 0.01 31.19 15,499 105,534,735

2020-03-18 2020-03-18 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 9,172 10,602,550 0.09 38.38 352,019 406,922,688

2020-03-18 2020-03-18 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 828 971,988 0.09 38.38 31,778 37,304,608

2020-03-18 2020-03-18 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 6,237 10,593,378 0.06 37.75 235,433 399,876,714

2020-03-18 2020-03-18 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 563 971,160 0.06 37.75 21,252 36,659,153

2020-03-18 2020-03-18 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 17,058 10,587,141 0.16 36.69 625,914 388,477,141

2020-03-18 2020-03-18 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 1,542 970,597 0.16 36.69 56,581 35,614,407

2020-03-18 2020-03-17 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 9,172 10,570,083 0.09 38.98 357,570 412,074,686

2020-03-18 2020-03-17 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 828 969,055 0.09 38.98 32,280 37,778,609

2020-03-18 2020-03-16 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 95,934 10,560,911 0.92 39.97 3,834,588 422,131,230

2020-03-18 2020-03-16 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 8,666 968,227 0.90 39.97 346,390 38,701,098

2020-03-18 2020-03-18 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock P - Purchase 14,731 7,841,556 0.19 83.14 1,224,797 651,979,900

2020-03-18 2020-03-18 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock P - Purchase 1,331 994,296 0.13 83.14 110,665 82,669,945

2020-03-18 2020-03-18 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock P - Purchase 1,321 7,826,825 0.02 82.92 109,537 648,995,633

2020-03-18 2020-03-18 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock P - Purchase 119 992,965 0.01 82.92 9,867 82,336,062

2020-03-18 2020-03-18 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock P - Purchase 15,928 7,825,504 0.20 82.13 1,308,149 642,700,035

2020-03-18 2020-03-18 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock P - Purchase 1,439 992,846 0.15 82.13 118,183 81,541,350

2020-03-18 2020-03-18 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock P - Purchase 25,640 7,809,576 0.33 81.79 2,097,003 638,717,107

2020-03-18 2020-03-18 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock P - Purchase 2,314 991,407 0.23 81.79 189,254 81,083,609

2020-03-18 2020-03-18 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock P - Purchase 4,203 7,783,936 0.05 81.47 342,438 634,193,850

2020-03-18 2020-03-18 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock P - Purchase 380 989,093 0.04 81.47 30,960 80,586,055

2020-03-18 2020-03-18 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock P - Purchase 12,815 7,779,733 0.16 81.09 1,039,177 630,863,995

2020-03-18 2020-03-18 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock P - Purchase 1,158 988,713 0.12 81.09 93,903 80,175,429

2020-03-18 2020-03-18 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock P - Purchase 3,298 7,766,918 0.04 80.91 266,845 628,431,432

2020-03-18 2020-03-18 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock P - Purchase 298 987,555 0.03 80.91 24,112 79,904,359

2020-03-18 2020-03-18 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock P - Purchase 10,285 7,763,620 0.13 79.87 821,429 620,054,709

2020-03-18 2020-03-18 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock P - Purchase 929 987,257 0.09 79.87 74,196 78,848,959

2020-03-18 2020-03-18 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock P - Purchase 26,022 7,753,335 0.34 79.72 2,074,362 618,062,527

2020-03-18 2020-03-18 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock P - Purchase 2,351 986,328 0.24 79.72 187,412 78,625,827

2020-03-18 2020-03-18 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock P - Purchase 2,888 7,727,313 0.04 79.29 228,980 612,673,148

2020-03-18 2020-03-18 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock P - Purchase 261 983,977 0.03 79.29 20,694 78,016,289

2020-03-18 2020-03-18 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock P - Purchase 4,191 7,724,425 0.05 79.16 331,760 611,467,028

2020-03-18 2020-03-18 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock P - Purchase 379 983,716 0.04 79.16 30,002 77,871,155

2020-03-18 2020-03-17 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock P - Purchase 565 7,720,234 0.01 78.66 44,443 607,273,606

2020-03-18 2020-03-17 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock P - Purchase 51 983,337 0.01 78.66 4,012 77,349,288

2020-03-18 2020-03-17 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock P - Purchase 65,505 7,719,669 0.86 76.67 5,022,445 591,887,865

2020-03-18 2020-03-17 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock P - Purchase 5,917 983,286 0.61 76.67 453,672 75,391,192

2020-03-18 2020-03-17 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock P - Purchase 27,866 7,654,164 0.37 76.10 2,120,480 582,448,202

2020-03-18 2020-03-17 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock P - Purchase 2,517 977,369 0.26 76.10 191,533 74,373,480

2020-03-18 2020-03-16 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock P - Purchase 62,129 7,626,298 0.82 79.76 4,955,720 608,311,660

2020-03-18 2020-03-16 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock P - Purchase 5,612 974,852 0.58 79.76 447,641 77,759,070

2020-03-18 2020-03-16 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock P - Purchase 133,042 7,564,169 1.79 79.14 10,529,170 598,641,194

2020-03-18 2020-03-16 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock P - Purchase 12,017 969,240 1.26 79.14 951,046 76,707,301

2020-03-18 2020-03-16 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock P - Purchase 7,612 7,431,127 0.10 77.94 593,260 579,163,461

2020-03-18 2020-03-16 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock P - Purchase 688 957,223 0.07 77.94 53,621 74,603,568

2020-03-18 2020-03-16 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock P - Purchase 8,309 7,423,515 0.11 77.89 647,203 578,230,946

2020-03-18 2020-03-16 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock P - Purchase 750 956,535 0.08 77.89 58,419 74,506,233

2020-03-18 2020-03-16 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock P - Purchase 32,228 7,415,206 0.44 75.66 2,438,422 561,046,350

2020-03-18 2020-03-16 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock P - Purchase 2,911 955,785 0.31 75.66 220,251 72,316,222

2020-03-16 2020-03-16 4 ZYME Zymeworks Inc.
Non-Qualified Stock Option (right to buy) A - Award 18,000 18,000

2020-03-16 3 ZYME Zymeworks Inc.
Common Stock 1,876,724

2020-03-16 3 ZYME Zymeworks Inc.
Common Stock 3,248,692

2020-03-16 3 ZYME Zymeworks Inc.
Common Stock 1,876,724

2020-03-16 3 ZYME Zymeworks Inc.
Common Stock 3,248,692

2020-03-16 3 ZYME Zymeworks Inc.
Common Stock 1,876,724

2020-03-16 3 ZYME Zymeworks Inc.
Common Stock 3,248,692

2020-03-16 3 ZYME Zymeworks Inc.
Common Stock 1,876,724

2020-03-16 3 ZYME Zymeworks Inc.
Common Stock 3,248,692

2020-03-16 3 ZYME Zymeworks Inc.
Common Stock 1,876,724

2020-03-16 3 ZYME Zymeworks Inc.
Common Stock 3,248,692

2020-03-16 3 ZYME Zymeworks Inc.
Common Stock 1,876,724

2020-03-16 3 ZYME Zymeworks Inc.
Common Stock 3,248,692

2020-03-16 3 ZYME Zymeworks Inc.
Common Stock 1,876,724

2020-03-16 3 ZYME Zymeworks Inc.
Common Stock 3,248,692

2020-03-16 3 ZYME Zymeworks Inc.
Common Stock 1,876,724

2020-03-16 3 ZYME Zymeworks Inc.
Common Stock 3,248,692

2020-02-26 2020-02-26 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 82,740 10,464,977 0.80 57.82 4,783,944 605,074,505

2020-02-26 2020-02-26 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 7,460 959,561 0.78 57.82 431,330 55,480,857

2020-02-26 2020-02-26 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 8,989 10,382,237 0.09 59.61 535,824 618,873,727

2020-02-26 2020-02-26 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 811 952,101 0.09 59.61 48,343 56,753,693

2020-02-26 2020-02-25 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 14,631 10,373,248 0.14 59.99 877,642 622,240,319

2020-02-26 2020-02-25 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 1,319 951,290 0.14 59.99 79,120 57,063,226

2020-02-26 2020-02-25 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 145,994 10,358,617 1.43 57.68 8,421,518 597,526,463

2020-02-26 2020-02-25 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 13,164 949,971 1.41 57.68 759,352 54,798,127

2020-02-26 2020-02-25 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 14,051 10,212,623 0.14 57.22 803,980 584,353,012

2020-02-26 2020-02-25 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 1,267 936,807 0.14 57.22 72,496 53,602,879

2020-02-26 2020-02-25 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 14,402 10,198,572 0.14 58.80 846,819 599,662,775

2020-02-26 2020-02-25 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 1,298 935,540 0.14 58.80 76,321 55,008,536

2020-02-26 2020-02-24 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 8,623 10,184,170 0.08 60.77 524,043 618,919,508

2020-02-26 2020-02-24 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 777 934,242 0.08 60.77 47,220 56,776,409

2020-02-26 2020-02-24 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 6,788 10,175,547 0.07 58.54 397,393 595,711,118

2020-02-26 2020-02-24 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 612 933,465 0.07 58.54 35,829 54,648,215

2020-02-26 2020-02-24 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 7,122 10,168,759 0.07 58.39 415,826 593,714,180

2020-02-26 2020-02-24 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 642 932,853 0.07 58.39 37,484 54,465,649

2020-02-26 2020-02-24 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 3,577 10,161,637 0.04 57.62 206,108 585,517,589

2020-02-26 2020-02-24 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 323 932,211 0.03 57.62 18,611 53,714,371

2020-02-26 2020-02-24 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 21,301 10,158,060 0.21 56.69 1,207,513 575,841,121

2020-02-26 2020-02-24 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 1,921 931,888 0.21 56.69 108,898 52,826,960

2020-02-26 2020-02-24 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 5,804 10,136,759 0.06 56.62 328,631 573,958,500

2020-02-26 2020-02-24 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 523 929,967 0.06 56.62 29,613 52,656,126

2020-02-26 2020-02-24 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 10,121 10,130,955 0.10 56.25 569,277 569,836,839

2020-02-26 2020-02-24 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 912 929,444 0.10 56.25 51,297 52,278,530

2020-02-26 2020-02-24 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 92 10,120,834 0.00 55.45 5,102 561,225,547

2020-02-26 2020-02-24 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 8 928,532 0.00 55.45 444 51,489,421

2020-02-26 2020-02-24 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 1,813 10,120,742 0.02 55.77 101,117 564,468,192

2020-02-26 2020-02-24 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 164 928,524 0.02 55.77 9,147 51,786,940

2020-02-07 2020-02-05 4 IGMS IGM Biosciences, Inc.
Non-Qualified Stock Option (right to buy) A - Award 10,000 10,000

2020-01-03 2019-12-31 4 INCY INCYTE CORP
Common Stock A - Award 316 29,291,523 0.00 87.32 27,593 2,557,735,788

2020-01-03 2019-12-31 4 INCY INCYTE CORP
Common Stock A - Award 316 29,291,523 0.00 87.32 27,593 2,557,735,788

2019-12-20 2019-12-20 4 NLTX Neoleukin Therapeutics, Inc.
Pre-funded Warrants A - Award 9,765,333 9,765,333

2019-12-20 2019-12-20 4 NLTX Neoleukin Therapeutics, Inc.
Pre-funded Warrants A - Award 1,160,148 1,161,048 128,905.33

2019-12-20 2019-12-20 4 NLTX Neoleukin Therapeutics, Inc.
Common Stock D - Sale to Issuer -9,765,333 3,107,331 -75.86

2019-12-20 2019-12-20 4 NLTX Neoleukin Therapeutics, Inc.
Common Stock D - Sale to Issuer -1,160,148 290,409 -79.98

2019-12-20 2019-12-20 4 NLTX Neoleukin Therapeutics, Inc.
Common Stock P - Purchase 2,767,505 12,872,664 27.39 8.40 23,247,042 108,130,378

2019-12-20 2019-12-20 4 NLTX Neoleukin Therapeutics, Inc.
Common Stock P - Purchase 250,037 1,450,557 20.83 8.40 2,100,311 12,184,679

2019-12-06 2019-12-06 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 1,743,993 10,118,929 20.82 46.00 80,223,678 465,470,734

2019-12-06 2019-12-06 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 158,180 928,360 20.54 46.00 7,276,280 42,704,560

2019-10-15 2019-10-10 4 NLTX Neoleukin Therapeutics, Inc.
Non-Qualified Stock Option (right to buy) A - Award 22,000 22,000

2019-10-03 2019-10-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 370 7,642,042 0.00 67.28 24,894 514,156,586

2019-10-03 2019-10-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 370 7,642,042 0.00 67.28 24,894 514,156,586

2019-10-03 2019-10-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 370 1,217,279 0.03 67.28 24,894 81,898,531

2019-10-03 2019-10-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 370 244,595 0.15 67.28 24,894 16,456,352

2019-10-03 2019-10-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 370 160,223 0.23 67.28 24,894 10,779,803

2019-10-02 2019-09-30 4 INCY INCYTE CORP
Common Stock A - Award 364 29,291,207 0.00 74.23 27,020 2,174,286,296

2019-10-02 2019-09-30 4 INCY INCYTE CORP
Common Stock A - Award 364 29,291,207 0.00 74.23 27,020 2,174,286,296

2019-09-20 2019-09-20 4 IGMS IGM Biosciences, Inc.
Non-Voting Common Stock C - Conversion 2,081,895 2,081,895

2019-09-20 2019-09-20 4 IGMS IGM Biosciences, Inc.
Series C Convertible Preferred C - Conversion -2,081,895 0 -100.00

2019-09-20 2019-09-20 4 IGMS IGM Biosciences, Inc.
Non-Voting Common Stock C - Conversion 187,942 187,942

2019-09-20 2019-09-20 4 IGMS IGM Biosciences, Inc.
Series C Convertible Preferred C - Conversion -187,942 0 -100.00

2019-09-20 2019-09-20 4 IGMS IGM Biosciences, Inc.
Common Stock P - Purchase 2,883,204 2,883,204 16.00 46,131,264 46,131,264

2019-09-20 2019-09-20 4 IGMS IGM Biosciences, Inc.
Common Stock P - Purchase 260,796 260,796 16.00 4,172,736 4,172,736

2019-09-20 2019-09-20 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 1,494,025 37,470,965 4.15 40.00 59,761,000 1,498,838,600

2019-09-20 2019-09-20 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 68,475 3,383,621 2.07 40.00 2,739,000 135,344,840

2019-09-20 2019-09-19 4 KOD Kodiak Sciences Inc.
Common Stock Warrant (right to buy) X - Other -1 138,815 0.00

2019-09-20 2019-09-19 4 KOD Kodiak Sciences Inc.
Common Stock X - Other 1 8,374,936 0.00 0.01 0 83,749

2019-09-19 2019-09-17 4 IGMS IGM Biosciences, Inc.
Non-Qualified Stock Option (right to buy) A - Award 12,100 12,100

2019-08-30 2019-08-29 4 GHDX GENOMIC HEALTH INC
Common Stock G - Gift -95,289 0 -100.00

2019-08-30 2019-08-29 4 GHDX GENOMIC HEALTH INC
Common Stock G - Gift -95,289 0 -100.00

2019-08-30 2019-08-29 4 GHDX GENOMIC HEALTH INC
Common Stock J - Other 8,341 95,289 9.59

2019-08-30 2019-08-29 4 GHDX GENOMIC HEALTH INC
Common Stock J - Other 8,340 95,289 9.59

2019-08-30 2019-08-29 4 GHDX GENOMIC HEALTH INC
Common Stock J - Other -8,866 43,361 -16.98

2019-08-30 2019-08-29 4 GHDX GENOMIC HEALTH INC
Common Stock J - Other -7,815 165,610 -4.51

2019-08-08 2019-08-07 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 50,436 10,105,159 0.50 3.15 159,020 31,860,556

2019-08-08 2019-08-07 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 4,564 1,200,520 0.38 3.15 14,390 3,785,120

2019-08-08 2019-08-07 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 209,382 10,054,723 2.13 3.02 633,255 30,409,504

2019-08-08 2019-08-07 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 18,943 1,195,956 1.61 3.02 57,291 3,617,049

2019-08-08 2019-08-07 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 5,869 9,845,341 0.06 2.96 17,358 29,118,581

2019-08-08 2019-08-07 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 531 1,177,013 0.05 2.96 1,570 3,481,134

2019-08-08 2019-08-06 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 65,568 9,839,472 0.67 2.85 186,666 28,011,993

2019-08-08 2019-08-06 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 5,932 1,176,482 0.51 2.85 16,888 3,349,327

2019-08-08 2019-08-06 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 9,445 9,773,904 0.10 2.83 26,756 27,687,515

2019-08-08 2019-08-06 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 855 1,170,550 0.07 2.83 2,422 3,315,934

2019-07-03 2019-07-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 424 7,641,672 0.01 58.86 24,957 449,788,814

2019-07-03 2019-07-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 424 7,641,672 0.01 58.86 24,957 449,788,814

2019-07-03 2019-07-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 424 1,390,806 0.03 58.86 24,957 81,862,841

2019-07-03 2019-07-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 424 418,122 0.10 58.86 24,957 24,610,661

2019-07-03 2019-07-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 424 333,750 0.13 58.86 24,957 19,644,525

2019-07-03 2019-07-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 424 226,124 0.19 58.86 24,957 13,309,659

2019-07-03 2019-07-01 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 2,964 4,290,995 0.07 2.61 7,736 11,199,497

2019-07-03 2019-07-01 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 2,964 4,290,995 0.07 2.61 7,736 11,199,497

2019-07-02 2019-06-28 4 INCY INCYTE CORP
Common Stock A - Award 310 29,290,843 0.00 84.96 26,338 2,488,550,021

2019-07-02 2019-06-28 4 INCY INCYTE CORP
Common Stock A - Award 310 29,290,843 0.00 84.96 26,338 2,488,550,021

2019-06-28 2019-06-26 4 ACAD ACADIA PHARMACEUTICALS INC
Non-Qualified Stock Option (right to buy) A - Award 30,000 30,000

2019-06-26 2019-06-24 4 BCEL Atreca, Inc.
Class B common stock P - Purchase 1,904,850 5,444,957 53.81 17.00 32,382,450 92,564,269

2019-06-26 2019-06-24 4 BCEL Atreca, Inc.
Class B common stock P - Purchase 95,150 489,234 24.14 17.00 1,617,550 8,316,978

2019-06-26 2019-06-24 4 BCEL Atreca, Inc.
Class B common stock C - Conversion 3,540,107 3,540,107

2019-06-26 2019-06-24 4 BCEL Atreca, Inc.
Series C2 Preferred Stock C - Conversion -3,540,107 0 -100.00

2019-06-26 2019-06-24 4 BCEL Atreca, Inc.
Class B common stock C - Conversion 394,084 394,084

2019-06-26 2019-06-24 4 BCEL Atreca, Inc.
Series C2 Preferred Stock C - Conversion -394,084 0 -100.00

2019-06-26 2019-06-24 4 BCEL Atreca, Inc.
Series B Preferred Stock C - Conversion -920,361 0 -100.00

2019-06-26 2019-06-24 4 BCEL Atreca, Inc.
Series B Preferred Stock C - Conversion -89,878 0 -100.00

2019-06-26 2019-06-24 4 BCEL Atreca, Inc.
Series A Preferred Stock C - Conversion -2,302,669 0 -100.00

2019-06-26 2019-06-24 4 BCEL Atreca, Inc.
Series A Preferred Stock C - Conversion -219,852 0 -100.00

2019-06-26 2019-06-24 4 BCEL Atreca, Inc.
Class A common stock C - Conversion 3,223,030 3,223,030

2019-06-26 2019-06-24 4 BCEL Atreca, Inc.
Class A common stock C - Conversion 309,730 309,730

2019-06-18 2019-06-14 4 GHDX GENOMIC HEALTH INC
Non-Qualified Stock Options (right to buy) A - Award 13,166 13,166

2019-06-18 2019-06-14 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 1,910 7,641,248 0.03

2019-06-18 2019-06-14 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 1,910 7,641,248 0.03

2019-06-18 2019-06-14 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 1,910 1,390,382 0.14

2019-06-18 2019-06-14 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 1,910 417,698 0.46

2019-06-18 2019-06-14 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 1,910 333,326 0.58

2019-06-18 2019-06-14 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 1,910 225,700 0.85

2019-06-07 2019-06-06 4 SGEN SEATTLE GENETICS INC /WA
Common Stock J - Other 74,229 181,733 69.05

2019-06-07 2019-06-06 4 SGEN SEATTLE GENETICS INC /WA
Common Stock J - Other 74,229 181,733 69.05

2019-06-07 2019-06-06 4 SGEN SEATTLE GENETICS INC /WA
Common Stock J - Other -1,002,483 4,302,354 -18.90

2019-06-07 2019-06-06 4 KNSA Kiniksa Pharmaceuticals, Ltd.
Class A Common Shares J - Other 14,840 14,840

2019-06-07 2019-06-06 4 KNSA Kiniksa Pharmaceuticals, Ltd.
Class A Common Shares J - Other 14,840 14,840

2019-06-07 2019-06-06 4 KNSA Kiniksa Pharmaceuticals, Ltd.
Class A Common Shares J - Other -200,423 98,980 -66.94

2019-06-07 2019-06-06 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock J - Other 31,229 102,876 43.59

2019-06-07 2019-06-06 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock J - Other 31,229 102,876 43.59

2019-06-07 2019-06-06 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock J - Other -421,756 3,315,146 -11.29

2019-06-07 2019-06-06 4 IDRA IDERA PHARMACEUTICALS, INC.
Warrants to purchase Common Stock J - Other 880 880

2019-06-07 2019-06-06 4 IDRA IDERA PHARMACEUTICALS, INC.
Warrants to purchase Common Stock J - Other 880 880

2019-06-07 2019-06-06 4 IDRA IDERA PHARMACEUTICALS, INC.
Warrants to purchase Common Stock J - Other 1,660 1,660

2019-06-07 2019-06-06 4 IDRA IDERA PHARMACEUTICALS, INC.
Warrants to purchase Common Stock J - Other 1,660 1,660

2019-06-07 2019-06-06 4 IDRA IDERA PHARMACEUTICALS, INC.
Warrants to purchase Common Stock J - Other 6,256 6,256

2019-06-07 2019-06-06 4 IDRA IDERA PHARMACEUTICALS, INC.
Warrants to purchase Common Stock J - Other 6,256 6,256

2019-06-07 2019-06-06 4 IDRA IDERA PHARMACEUTICALS, INC.
Warrants to purchase Common Stock J - Other -6,009 0 -100.00

2019-06-07 2019-06-06 4 IDRA IDERA PHARMACEUTICALS, INC.
Warrants to purchase Common Stock J - Other -11,337 0 -100.00

2019-06-07 2019-06-06 4 IDRA IDERA PHARMACEUTICALS, INC.
Warrants to purchase Common Stock J - Other -42,724 0 -100.00

2019-06-07 2019-06-06 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock J - Other 21,929 21,929

2019-06-07 2019-06-06 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock J - Other 21,929 21,929

2019-06-07 2019-06-06 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock J - Other -59,267 0 -100.00

2019-06-07 2019-06-06 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock J - Other -178,967 347,757 -33.98

2019-06-07 2019-06-06 4 BGNE BeiGene, Ltd.
Ordinary shares J - Other 43,109 43,109

2019-06-07 2019-06-06 4 BGNE BeiGene, Ltd.
Ordinary shares J - Other 43,109 43,109

2019-06-07 2019-06-06 4 BGNE BeiGene, Ltd.
Ordinary shares J - Other -582,200 18,591 -96.91

2019-06-07 2019-06-06 4 BGNE BeiGene, Ltd.
American Depositary Shares J - Other 13,516 20,618 190.31

2019-06-07 2019-06-06 4 BGNE BeiGene, Ltd.
American Depositary Shares J - Other 13,516 20,618 190.31

2019-06-07 2019-06-06 4 BGNE BeiGene, Ltd.
American Depositary Shares J - Other -182,539 1,028,034 -15.08

2019-06-07 2019-06-05 4 BGNE BeiGene, Ltd.
Shares Option (Right to Buy) A - Award 129,220 129,220

2019-06-07 2019-06-06 4 INCY INCYTE CORP
Common Stock J - Other 220,141 281,190 360.60

2019-06-07 2019-06-06 4 INCY INCYTE CORP
Common Stock J - Other 220,141 281,190 360.60

2019-06-07 2019-06-06 4 INCY INCYTE CORP
Common Stock J - Other -692,706 0 -100.00

2019-06-07 2019-06-06 4 INCY INCYTE CORP
Common Stock J - Other -1,603,238 2,826,766 -36.19

2019-06-05 2019-06-03 4 KOD Kodiak Sciences Inc.
Non-Qualified Stock Option (right to buy) A - Award 24,747 24,747

2019-05-31 2019-05-29 4 KNSA Kiniksa Pharmaceuticals, Ltd.
Non-Qualified Share Option (right to buy) A - Award 37,520 37,520

2019-05-31 2019-05-29 4 KNSA Kiniksa Pharmaceuticals, Ltd.
Non-Qualified Share Option (right to buy) A - Award 37,520 37,520

2019-05-30 2019-05-30 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock S - Sale -22,720 7,382,978 -0.31 120.77 -2,743,928 891,653,328

2019-05-30 2019-05-30 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock S - Sale -2,729 952,874 -0.29 120.77 -329,585 115,080,022

2019-05-30 2019-05-30 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock S - Sale -13,213 7,405,698 -0.18 122.31 -1,616,054 905,775,370

2019-05-30 2019-05-30 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock S - Sale -1,587 955,603 -0.17 122.31 -194,103 116,877,796

2019-05-30 2019-05-30 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock S - Sale -15,355 7,418,911 -0.21 120.12 -1,844,459 891,167,750

2019-05-30 2019-05-30 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock S - Sale -1,845 957,190 -0.19 120.12 -221,623 114,978,716

2019-05-30 2019-05-29 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock S - Sale -35,796 7,434,266 -0.48 122.37 -4,380,432 909,746,742

2019-05-30 2019-05-29 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock S - Sale -4,300 959,035 -0.45 122.37 -526,200 117,359,127

2019-05-30 2019-05-29 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock S - Sale -30,766 7,470,062 -0.41 123.06 -3,786,036 919,259,107

2019-05-30 2019-05-29 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock S - Sale -3,696 963,335 -0.38 123.06 -454,826 118,547,138

2019-05-30 2019-05-29 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock S - Sale -39,732 7,500,828 -0.53 121.37 -4,822,189 910,359,743

2019-05-30 2019-05-29 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock S - Sale -4,772 967,031 -0.49 121.37 -579,168 117,366,522

2019-05-30 2019-05-28 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock S - Sale -71,819 7,540,560 -0.94 127.06 -9,125,258 958,096,767

2019-05-30 2019-05-28 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock S - Sale -8,627 971,803 -0.88 127.06 -1,096,139 123,476,415

2019-05-30 2019-05-28 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock S - Sale -22,886 7,612,379 -0.30 125.05 -2,861,901 951,930,278

2019-05-30 2019-05-28 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock S - Sale -2,749 980,430 -0.28 125.05 -343,763 122,603,066

2019-05-30 2019-05-28 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock S - Sale -15,541 7,635,265 -0.20 126.25 -1,962,085 963,969,004

2019-05-30 2019-05-28 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock S - Sale -1,867 983,179 -0.19 126.25 -235,713 124,128,512

2019-05-22 2019-05-20 4 SGEN SEATTLE GENETICS INC /WA
Non-Qualified Stock Options (right to buy) A - Award 7,038 7,038

2019-05-22 2019-05-20 4 SGEN SEATTLE GENETICS INC /WA
Non-Qualified Stock Options (right to buy) A - Award 7,038 7,038

2019-05-22 2019-05-20 4 SGEN SEATTLE GENETICS INC /WA
Common Stock A - Award 2,963 45,842,649 0.01

2019-05-22 2019-05-20 4 SGEN SEATTLE GENETICS INC /WA
Common Stock A - Award 2,963 45,842,649 0.01

2019-05-17 2019-05-15 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock A - Award 2,726 7,650,806 0.04

2019-05-17 2019-05-15 4 ALXN ALEXION PHARMACEUTICALS, INC.
Common Stock A - Award 2,726 7,650,806 0.04

2019-05-01 2019-04-29 4 SGEN SEATTLE GENETICS INC /WA
Non-Qualified Stock Options (right to buy) M - Exercise -10,000 0 -100.00

2019-05-01 2019-04-29 4 SGEN SEATTLE GENETICS INC /WA
Non-Qualified Stock Options (right to buy) M - Exercise -10,000 0 -100.00

2019-05-01 2019-04-29 4 SGEN SEATTLE GENETICS INC /WA
Common Stock M - Exercise 10,000 45,839,686 0.02 8.38 83,800 384,136,569

2019-05-01 2019-04-29 4 SGEN SEATTLE GENETICS INC /WA
Common Stock M - Exercise 10,000 45,839,686 0.02 8.38 83,800 384,136,569

2019-04-30 2019-04-26 4 INCY INCYTE CORP
Non-Qualified Stock Options (right to buy) A - Award 12,472 12,472

2019-04-30 2019-04-26 4 INCY INCYTE CORP
Non-Qualified Stock Options (right to buy) A - Award 12,472 12,472

2019-04-30 2019-04-26 4 INCY INCYTE CORP
Non-Qualified Stock Options (right to buy) A - Award 12,472 12,472

2019-04-30 2019-04-26 4 INCY INCYTE CORP
Common Stock A - Award 1,520 812,602 0.19

2019-04-30 2019-04-26 4 INCY INCYTE CORP
Common Stock A - Award 1,520 812,602 0.19

2019-04-30 2019-04-26 4 INCY INCYTE CORP
Common Stock A - Award 1,520 812,602 0.19

2019-04-23 2019-04-23 4 HOOK HOOKIPA Pharma Inc.
Class A Common Stock C - Conversion 529,758 529,758

2019-04-23 2019-04-23 4 HOOK HOOKIPA Pharma Inc.
Series D Preferred Stock C - Conversion -529,758 0 -100.00

2019-04-23 2019-04-23 4 HOOK HOOKIPA Pharma Inc.
Class A Common Stock C - Conversion 60,194 60,194

2019-04-23 2019-04-23 4 HOOK HOOKIPA Pharma Inc.
Series D Preferred Stock C - Conversion -60,194 0 -100.00

2019-04-23 2019-04-23 4 HOOK HOOKIPA Pharma Inc.
Class A Common Stock C - Conversion 2,905,359 2,905,359

2019-04-23 2019-04-23 4 HOOK HOOKIPA Pharma Inc.
Series C Preferred Stock C - Conversion -2,905,359 0 -100.00

2019-04-23 2019-04-23 4 HOOK HOOKIPA Pharma Inc.
Class A Common Stock C - Conversion 324,421 324,421

2019-04-23 2019-04-23 4 HOOK HOOKIPA Pharma Inc.
Series C Preferred Stock C - Conversion -324,421 0 -100.00

2019-04-23 2019-04-23 4 HOOK HOOKIPA Pharma Inc.
Common Stock P - Purchase 820,729 820,729 14.00 11,490,206 11,490,206

2019-04-23 2019-04-23 4 HOOK HOOKIPA Pharma Inc.
Common Stock P - Purchase 72,128 72,128 14.00 1,009,792 1,009,792

2019-04-12 2019-04-12 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -9,232 7,639,338 -0.12 65.32 -603,070 499,031,352

2019-04-12 2019-04-12 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,417 1,214,575 -0.12 65.32 -92,564 79,340,776

2019-04-12 2019-04-12 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -244 241,891 -0.10 65.32 -15,939 15,801,263

2019-04-12 2019-04-12 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -142 157,519 -0.09 65.32 -9,276 10,289,755

2019-04-12 2019-04-12 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -11 49,893 -0.02 65.32 -719 3,259,205

2019-04-12 2019-04-12 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -158 171,091 -0.09 65.32 -10,321 11,176,331

2019-04-12 2019-04-12 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -63,775 7,648,570 -0.83 67.13 -4,281,177 513,443,915

2019-04-12 2019-04-12 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -9,791 1,215,992 -0.80 67.13 -657,264 81,628,813

2019-04-12 2019-04-12 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,688 242,135 -0.69 67.13 -113,314 16,254,377

2019-04-12 2019-04-12 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -979 157,661 -0.62 67.13 -65,720 10,583,688

2019-04-12 2019-04-12 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -74 49,904 -0.15 67.13 -4,968 3,350,026

2019-04-12 2019-04-12 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,093 171,249 -0.63 67.13 -73,372 11,495,843

2019-04-12 2019-04-12 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -173,085 7,712,345 -2.19 64.62 -11,184,701 498,369,420

2019-04-12 2019-04-12 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -26,575 1,225,783 -2.12 64.62 -1,717,269 79,209,730

2019-04-12 2019-04-12 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -4,581 243,823 -1.84 64.62 -296,023 15,755,769

2019-04-12 2019-04-12 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -2,656 158,640 -1.65 64.62 -171,630 10,251,269

2019-04-12 2019-04-12 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -202 49,978 -0.40 64.62 -13,053 3,229,563

2019-04-12 2019-04-12 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -2,966 172,342 -1.69 64.62 -191,662 11,136,688

2019-04-12 2019-04-11 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -106,054 7,885,430 -1.33 66.61 -7,063,981 525,227,990

2019-04-12 2019-04-11 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -16,282 1,252,358 -1.28 66.61 -1,084,502 83,416,310

2019-04-12 2019-04-11 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -2,807 248,404 -1.12 66.61 -186,967 16,545,545

2019-04-12 2019-04-11 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,628 161,296 -1.00 66.61 -108,437 10,743,507

2019-04-12 2019-04-11 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -124 50,180 -0.25 66.61 -8,259 3,342,359

2019-04-12 2019-04-11 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,817 175,308 -1.03 66.61 -121,026 11,676,810

2019-04-12 2019-04-11 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -60,618 7,991,484 -0.75 67.42 -4,086,914 538,792,244

2019-04-12 2019-04-11 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -9,307 1,268,640 -0.73 67.42 -627,485 85,532,724

2019-04-12 2019-04-11 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,604 251,211 -0.63 67.42 -108,143 16,936,847

2019-04-12 2019-04-11 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -930 162,924 -0.57 67.42 -62,701 10,984,466

2019-04-12 2019-04-11 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -71 50,304 -0.14 67.42 -4,787 3,391,536

2019-04-12 2019-04-11 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,039 177,125 -0.58 67.42 -70,050 11,941,909

2019-04-10 2019-04-10 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -10,832 8,052,102 -0.13 69.12 -748,735 556,581,420

2019-04-10 2019-04-10 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,663 1,277,947 -0.13 69.12 -114,951 88,334,892

2019-04-10 2019-04-10 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -287 252,815 -0.11 69.12 -19,838 17,475,205

2019-04-10 2019-04-10 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -166 163,854 -0.10 69.12 -11,474 11,325,998

2019-04-10 2019-04-10 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -13 50,375 -0.03 69.12 -899 3,482,046

2019-04-10 2019-04-10 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -185 178,164 -0.10 69.12 -12,788 12,315,141

2019-04-10 2019-04-10 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -102,618 8,062,934 -1.26 68.70 -7,049,918 553,928,404

2019-04-10 2019-04-10 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -15,755 1,279,610 -1.22 68.70 -1,082,378 87,909,975

2019-04-10 2019-04-10 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -2,716 253,102 -1.06 68.70 -186,591 17,388,259

2019-04-10 2019-04-10 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,575 164,020 -0.95 68.70 -108,203 11,268,272

2019-04-10 2019-04-10 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -120 50,388 -0.24 68.70 -8,244 3,461,686

2019-04-10 2019-04-10 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,758 178,349 -0.98 68.70 -120,776 12,252,683

2019-04-10 2019-04-09 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -15,543 8,165,552 -0.19 67.68 -1,051,888 552,611,897

2019-04-10 2019-04-09 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -2,386 1,295,365 -0.18 67.68 -161,475 87,665,122

2019-04-10 2019-04-09 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -411 255,818 -0.16 67.68 -27,815 17,312,739

2019-04-10 2019-04-09 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -239 165,595 -0.14 67.68 -16,175 11,206,807

2019-04-10 2019-04-09 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -18 50,508 -0.04 67.68 -1,218 3,418,179

2019-04-10 2019-04-09 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -266 180,107 -0.15 67.68 -18,002 12,188,921

2019-04-10 2019-04-09 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,813 8,181,095 -0.02 67.87 -123,047 555,244,373

2019-04-10 2019-04-09 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -278 1,297,751 -0.02 67.87 -18,868 88,077,322

2019-04-10 2019-04-09 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -48 256,229 -0.02 67.87 -3,258 17,390,057

2019-04-10 2019-04-09 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -28 165,834 -0.02 67.87 -1,900 11,255,021

2019-04-10 2019-04-09 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -2 50,526 0.00 67.87 -136 3,429,159

2019-04-10 2019-04-09 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -31 180,373 -0.02 67.87 -2,104 12,241,771

2019-04-10 2019-04-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -18,661 8,182,908 -0.23 67.90 -1,267,017 555,590,813

2019-04-10 2019-04-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -2,865 1,298,029 -0.22 67.90 -194,523 88,131,626

2019-04-10 2019-04-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -494 256,277 -0.19 67.90 -33,541 17,400,311

2019-04-10 2019-04-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -286 165,862 -0.17 67.90 -19,418 11,261,449

2019-04-10 2019-04-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -22 50,528 -0.04 67.90 -1,494 3,430,674

2019-04-10 2019-04-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -320 180,404 -0.18 67.90 -21,727 12,248,800

2019-04-05 2019-04-05 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -42,863 8,201,569 -0.52 68.72 -2,945,370 563,578,195

2019-04-05 2019-04-05 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -6,581 1,300,894 -0.50 68.72 -452,219 89,392,102

2019-04-05 2019-04-05 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,134 256,771 -0.44 68.72 -77,924 17,644,250

2019-04-05 2019-04-05 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -658 166,148 -0.39 68.72 -45,215 11,417,009

2019-04-05 2019-04-05 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -50 50,550 -0.10 68.72 -3,436 3,473,589

2019-04-05 2019-04-05 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -734 180,724 -0.40 68.72 -50,437 12,418,612

2019-04-05 2019-04-05 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -21,116 8,244,432 -0.26 68.63 -1,449,147 565,798,055

2019-04-05 2019-04-05 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -3,242 1,307,475 -0.25 68.63 -222,492 89,729,264

2019-04-05 2019-04-05 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -559 257,905 -0.22 68.63 -38,363 17,699,479

2019-04-05 2019-04-05 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -324 166,806 -0.19 68.63 -22,235 11,447,545

2019-04-05 2019-04-05 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -25 50,600 -0.05 68.63 -1,716 3,472,572

2019-04-05 2019-04-05 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -362 181,458 -0.20 68.63 -24,843 12,453,081

2019-04-05 2019-04-04 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -66,784 8,265,548 -0.80 66.64 -4,450,459 550,812,813

2019-04-05 2019-04-04 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -10,253 1,310,717 -0.78 66.64 -683,256 87,345,657

2019-04-05 2019-04-04 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,768 258,464 -0.68 66.64 -117,819 17,223,938

2019-04-05 2019-04-04 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,025 167,130 -0.61 66.64 -68,306 11,137,476

2019-04-05 2019-04-04 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -78 50,625 -0.15 66.64 -5,198 3,373,630

2019-04-05 2019-04-04 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,145 181,820 -0.63 66.64 -76,302 12,116,412

2019-04-05 2019-04-03 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -80,146 8,332,332 -0.95 68.90 -5,521,963 574,087,676

2019-04-05 2019-04-03 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -12,305 1,320,970 -0.92 68.90 -847,800 91,013,248

2019-04-05 2019-04-03 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -2,121 260,232 -0.81 68.90 -146,134 17,929,673

2019-04-05 2019-04-03 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,230 168,155 -0.73 68.90 -84,746 11,585,678

2019-04-05 2019-04-03 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -93 50,703 -0.18 68.90 -6,408 3,493,376

2019-04-05 2019-04-03 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,374 182,965 -0.75 68.90 -94,667 12,606,069

2019-04-03 2019-04-01 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 4,161 89,233 4.89 2.59 10,777 231,113

2019-04-03 2019-04-01 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 4,161 89,233 4.89 2.59 10,777 231,113

2019-04-03 2019-04-01 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 4,161 4,288,031 0.10 2.59 10,777 11,106,000

2019-04-03 2019-04-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 298 8,412,478 0.00 66.84 19,918 562,290,030

2019-04-03 2019-04-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 298 8,412,478 0.00 66.84 19,918 562,290,030

2019-04-03 2019-04-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 298 1,507,172 0.02 66.84 19,918 100,739,376

2019-04-03 2019-04-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 298 436,250 0.07 66.84 19,918 29,158,950

2019-04-03 2019-04-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 298 343,282 0.09 66.84 19,918 22,944,969

2019-04-03 2019-04-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 298 224,693 0.13 66.84 19,918 15,018,480

2019-04-02 2019-03-29 4 INCY INCYTE CORP
Common Stock A - Award 220 811,082 0.03 86.01 18,922 69,761,163

2019-04-02 2019-03-29 4 INCY INCYTE CORP
Common Stock A - Award 220 811,082 0.03 86.01 18,922 69,761,163

2019-04-02 2019-03-29 4 INCY INCYTE CORP
Common Stock A - Award 220 811,082 0.03 86.01 18,922 69,761,163

2019-03-25 2019-03-21 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -46,678 8,412,180 -0.55 74.71 -3,487,122 628,439,478

2019-03-25 2019-03-21 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -7,167 1,332,977 -0.53 74.71 -535,417 99,581,246

2019-03-25 2019-03-21 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,235 262,055 -0.47 74.71 -92,262 19,577,055

2019-03-25 2019-03-21 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -716 169,087 -0.42 74.71 -53,489 12,631,797

2019-03-25 2019-03-21 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -55 50,498 -0.11 74.71 -4,109 3,772,499

2019-03-25 2019-03-21 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -800 184,041 -0.43 74.71 -59,765 13,748,949

2019-03-19 2019-03-19 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -41,281 8,458,858 -0.49 74.34 -3,068,962 628,858,572

2019-03-19 2019-03-19 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -6,338 1,340,144 -0.47 74.34 -471,187 99,630,593

2019-03-19 2019-03-19 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,092 263,290 -0.41 74.34 -81,183 19,573,821

2019-03-19 2019-03-19 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -634 169,803 -0.37 74.34 -47,134 12,623,698

2019-03-19 2019-03-19 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -48 50,553 -0.09 74.34 -3,568 3,758,272

2019-03-19 2019-03-19 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -707 184,841 -0.38 74.34 -52,561 13,741,671

2019-03-19 2019-03-19 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -86,620 8,500,139 -1.01 74.63 -6,464,529 634,373,024

2019-03-19 2019-03-19 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -13,298 1,346,482 -0.98 74.63 -992,442 100,489,163

2019-03-19 2019-03-19 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -2,293 264,382 -0.86 74.63 -171,129 19,731,067

2019-03-19 2019-03-19 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,329 170,437 -0.77 74.63 -99,184 12,719,867

2019-03-19 2019-03-19 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -101 50,601 -0.20 74.63 -7,538 3,776,398

2019-03-19 2019-03-19 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,485 185,548 -0.79 74.63 -110,827 13,847,614

2019-03-19 2019-03-18 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -90,251 8,586,759 -1.04 74.19 -6,695,487 637,029,325

2019-03-19 2019-03-18 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -13,856 1,359,780 -1.01 74.19 -1,027,941 100,878,543

2019-03-19 2019-03-18 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -2,388 266,675 -0.89 74.19 -177,160 19,783,925

2019-03-19 2019-03-18 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,385 171,766 -0.80 74.19 -102,750 12,742,873

2019-03-19 2019-03-18 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -106 50,702 -0.21 74.19 -7,864 3,761,450

2019-03-19 2019-03-18 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,547 187,033 -0.82 74.19 -114,768 13,875,492

2019-03-19 2019-03-15 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -413 8,677,010 0.00 74.56 -30,795 647,001,251

2019-03-19 2019-03-15 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -63 1,373,636 0.00 74.56 -4,698 102,425,168

2019-03-19 2019-03-15 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -11 269,063 0.00 74.56 -820 20,062,683

2019-03-19 2019-03-15 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -6 173,151 0.00 74.56 -447 12,911,004

2019-03-19 2019-03-15 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -7 188,580 0.00 74.56 -522 14,061,468

2019-03-19 2019-03-15 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -42,124 8,677,423 -0.48 74.50 -3,138,238 646,468,014

2019-03-19 2019-03-15 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -6,467 1,373,699 -0.47 74.50 -481,792 102,340,576

2019-03-19 2019-03-15 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,115 269,074 -0.41 74.50 -83,068 20,046,013

2019-03-19 2019-03-15 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -647 173,157 -0.37 74.50 -48,202 12,900,196

2019-03-19 2019-03-15 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -49 50,808 -0.10 74.50 -3,650 3,785,196

2019-03-19 2019-03-15 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -722 188,587 -0.38 74.50 -53,789 14,049,732

2019-03-19 2019-03-15 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -3,068 8,719,547 -0.04 76.57 -234,915 667,649,610

2019-03-19 2019-03-15 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -471 1,380,166 -0.03 76.57 -36,064 105,678,345

2019-03-19 2019-03-15 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -81 270,189 -0.03 76.57 -6,202 20,688,183

2019-03-19 2019-03-15 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -47 173,804 -0.03 76.57 -3,599 13,308,051

2019-03-19 2019-03-15 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -4 50,857 -0.01 76.57 -306 3,894,085

2019-03-19 2019-03-15 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -52 189,309 -0.03 76.57 -3,982 14,495,258

2019-03-19 2019-03-19 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -41,281 8,458,858 -0.49 74.34 -3,068,962 628,858,572

2019-03-19 2019-03-19 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -6,338 1,340,144 -0.47 74.34 -471,187 99,630,593

2019-03-19 2019-03-19 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,092 263,290 -0.41 74.34 -81,183 19,573,821

2019-03-19 2019-03-19 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -634 169,803 -0.37 74.34 -47,134 12,623,698

2019-03-19 2019-03-19 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -48 50,553 -0.09 74.34 -3,568 3,758,272

2019-03-19 2019-03-19 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -707 184,841 -0.38 74.34 -52,561 13,741,671

2019-03-14 2019-03-14 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,648 8,722,615 -0.02 76.03 -125,301 663,197,864

2019-03-14 2019-03-14 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -253 1,380,637 -0.02 76.03 -19,236 104,972,592

2019-03-14 2019-03-14 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -44 270,270 -0.02 76.03 -3,345 20,549,169

2019-03-14 2019-03-14 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -25 173,851 -0.01 76.03 -1,901 13,218,239

2019-03-14 2019-03-14 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -2 50,861 0.00 76.03 -152 3,867,064

2019-03-14 2019-03-14 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -28 189,361 -0.01 76.03 -2,129 14,397,496

2019-03-14 2019-03-14 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -51,987 8,724,263 -0.59 76.50 -3,977,031 667,410,482

2019-03-14 2019-03-14 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -7,982 1,380,890 -0.57 76.50 -610,627 105,638,775

2019-03-14 2019-03-14 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,375 270,314 -0.51 76.50 -105,188 20,679,156

2019-03-14 2019-03-14 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -798 173,876 -0.46 76.50 -61,047 13,301,601

2019-03-14 2019-03-14 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -61 50,863 -0.12 76.50 -4,667 3,891,045

2019-03-14 2019-03-14 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -891 189,389 -0.47 76.50 -68,162 14,488,353

2019-03-14 2019-03-13 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -247 8,776,250 0.00 75.40 -18,624 661,729,250

2019-03-14 2019-03-13 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -39 1,388,872 0.00 75.40 -2,941 104,720,949

2019-03-14 2019-03-13 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -7 271,689 0.00 75.40 -528 20,485,351

2019-03-14 2019-03-13 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -4 174,674 0.00 75.40 -302 13,170,420

2019-03-14 2019-03-13 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -4 174,674 0.00 75.40 -302 13,170,420

2019-03-14 2019-03-13 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1 50,924 0.00 75.40 -75 3,839,670

2019-03-14 2019-03-13 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -63,047 8,776,497 -0.71 75.92 -4,786,390 666,292,344

2019-03-14 2019-03-13 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -9,679 1,388,911 -0.69 75.92 -734,808 105,443,068

2019-03-14 2019-03-13 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,668 271,696 -0.61 75.92 -126,631 20,626,563

2019-03-14 2019-03-13 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -967 174,678 -0.55 75.92 -73,413 13,261,169

2019-03-14 2019-03-13 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -73 50,925 -0.14 75.92 -5,542 3,866,114

2019-03-14 2019-03-13 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,080 190,284 -0.56 75.92 -81,991 14,445,943

2019-03-14 2019-03-13 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -2,832 8,839,544 -0.03 76.05 -215,369 672,232,294

2019-03-14 2019-03-13 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -435 1,398,590 -0.03 76.05 -33,081 106,360,392

2019-03-14 2019-03-13 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -75 273,364 -0.03 76.05 -5,704 20,788,867

2019-03-14 2019-03-13 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -43 175,645 -0.02 76.05 -3,270 13,357,504

2019-03-14 2019-03-13 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -3 50,998 -0.01 76.05 -228 3,878,311

2019-03-14 2019-03-13 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -49 191,364 -0.03 76.05 -3,726 14,552,907

2019-03-14 2019-03-12 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -61,122 8,842,376 -0.69 75.63 -4,622,669 668,750,665

2019-03-14 2019-03-12 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -9,384 1,399,025 -0.67 75.63 -709,714 105,808,541

2019-03-14 2019-03-12 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,618 273,439 -0.59 75.63 -122,370 20,680,246

2019-03-14 2019-03-12 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -938 175,688 -0.53 75.63 -70,941 13,287,319

2019-03-14 2019-03-12 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -71 51,001 -0.14 75.63 -5,370 3,857,216

2019-03-14 2019-03-12 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,047 191,413 -0.54 75.63 -79,185 14,476,603

2019-03-11 2019-03-11 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -3,296 8,903,498 -0.04 74.03 -244,007 659,137,531

2019-03-11 2019-03-11 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -506 1,408,409 -0.04 74.03 -37,460 104,266,349

2019-03-11 2019-03-11 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -87 275,057 -0.03 74.03 -6,441 20,362,827

2019-03-11 2019-03-11 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -51 176,626 -0.03 74.03 -3,776 13,075,852

2019-03-11 2019-03-11 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -4 51,072 -0.01 74.03 -296 3,780,927

2019-03-11 2019-03-11 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -56 192,460 -0.03 74.03 -4,146 14,248,064

2019-03-11 2019-03-11 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -37,107 8,906,794 -0.41 75.08 -2,786,101 668,747,923

2019-03-11 2019-03-11 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -5,697 1,408,915 -0.40 75.08 -427,747 105,785,424

2019-03-11 2019-03-11 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -982 275,144 -0.36 75.08 -73,731 20,658,609

2019-03-11 2019-03-11 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -569 176,677 -0.32 75.08 -42,722 13,265,422

2019-03-11 2019-03-11 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -43 51,076 -0.08 75.08 -3,229 3,834,934

2019-03-11 2019-03-11 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -637 192,516 -0.33 75.08 -47,828 14,454,660

2019-03-11 2019-03-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -18,703 8,943,901 -0.21 73.55 -1,375,551 657,797,981

2019-03-11 2019-03-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -2,872 1,414,612 -0.20 73.55 -211,227 104,040,610

2019-03-11 2019-03-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -495 276,126 -0.18 73.55 -36,406 20,308,267

2019-03-11 2019-03-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -287 177,246 -0.16 73.55 -21,108 13,035,929

2019-03-11 2019-03-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -22 51,119 -0.04 73.55 -1,618 3,759,654

2019-03-11 2019-03-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -321 193,153 -0.17 73.55 -23,609 14,205,843

2019-03-11 2019-03-07 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,647 8,962,604 -0.02 73.72 -121,421 660,745,573

2019-03-11 2019-03-07 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -253 1,417,484 -0.02 73.72 -18,652 104,500,464

2019-03-11 2019-03-07 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -44 276,621 -0.02 73.72 -3,244 20,393,192

2019-03-11 2019-03-07 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -25 177,533 -0.01 73.72 -1,843 13,088,177

2019-03-11 2019-03-07 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -2 51,141 0.00 73.72 -147 3,770,242

2019-03-11 2019-03-07 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -29 193,474 -0.01 73.72 -2,138 14,263,387

2019-03-05 2019-03-05 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -8,486 8,964,251 -0.09 77.04 -653,755 690,598,726

2019-03-05 2019-03-05 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,303 1,417,737 -0.09 77.04 -100,382 109,221,324

2019-03-05 2019-03-05 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -225 276,665 -0.08 77.04 -17,334 21,314,050

2019-03-05 2019-03-05 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -130 177,558 -0.07 77.04 -10,015 13,678,926

2019-03-05 2019-03-05 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -10 51,143 -0.02 77.04 -770 3,940,016

2019-03-05 2019-03-05 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -146 193,503 -0.08 77.04 -11,248 14,907,316

2019-03-05 2019-03-04 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -22,914 8,972,737 -0.25 76.49 -1,752,680 686,320,167

2019-03-05 2019-03-04 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -3,518 1,419,040 -0.25 76.49 -269,090 108,541,660

2019-03-05 2019-03-04 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -607 276,890 -0.22 76.49 -46,429 21,179,178

2019-03-05 2019-03-04 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -352 177,688 -0.20 76.49 -26,924 13,591,266

2019-03-05 2019-03-04 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -27 51,153 -0.05 76.49 -2,065 3,912,667

2019-03-05 2019-03-04 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -393 193,649 -0.20 76.49 -30,060 14,812,115

2019-03-05 2019-03-01 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -58,412 8,995,651 -0.65 77.15 -4,506,626 694,036,064

2019-03-05 2019-03-01 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -8,968 1,422,558 -0.63 77.15 -691,903 109,753,764

2019-03-05 2019-03-01 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,546 277,497 -0.55 77.15 -119,278 21,409,560

2019-03-05 2019-03-01 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -896 178,040 -0.50 77.15 -69,129 13,736,213

2019-03-05 2019-03-01 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -68 51,180 -0.13 77.15 -5,246 3,948,660

2019-03-05 2019-03-01 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,001 194,042 -0.51 77.15 -77,230 14,970,806

2019-03-05 2019-03-01 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -6,909 9,054,063 -0.08 77.64 -536,386 702,919,424

2019-03-05 2019-03-01 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,060 1,431,526 -0.07 77.64 -82,294 111,137,666

2019-03-05 2019-03-01 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -183 279,043 -0.07 77.64 -14,207 21,663,727

2019-03-05 2019-03-01 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -107 178,936 -0.06 77.64 -8,307 13,891,840

2019-03-05 2019-03-01 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -8 51,248 -0.02 77.64 -621 3,978,679

2019-03-05 2019-03-01 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -118 195,043 -0.06 77.64 -9,161 15,142,319

2019-02-28 2019-02-28 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -493 9,060,972 -0.01 76.20 -37,565 690,423,414

2019-02-28 2019-02-28 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -76 1,432,586 -0.01 76.20 -5,791 109,159,472

2019-02-28 2019-02-28 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -13 279,226 0.00 76.20 -991 21,276,323

2019-02-28 2019-02-28 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -8 179,043 0.00 76.20 -610 13,642,629

2019-02-28 2019-02-28 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1 51,256 0.00 76.20 -76 3,905,579

2019-02-28 2019-02-28 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -9 195,161 0.00 76.20 -686 14,870,780

2019-02-28 2019-02-27 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -742 9,061,465 -0.01 76.20 -56,540 690,483,633

2019-02-28 2019-02-27 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -114 1,432,662 -0.01 76.20 -8,687 109,168,844

2019-02-28 2019-02-27 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -20 279,239 -0.01 76.20 -1,524 21,278,012

2019-02-28 2019-02-27 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -11 179,051 -0.01 76.20 -838 13,643,686

2019-02-28 2019-02-27 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1 51,257 0.00 76.20 -76 3,905,783

2019-02-28 2019-02-27 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -13 195,170 -0.01 76.20 -991 14,871,954

2019-02-28 2019-02-27 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -31,482 9,062,207 -0.35 76.66 -2,413,501 694,735,069

2019-02-28 2019-02-27 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -4,833 1,432,776 -0.34 76.66 -370,512 109,840,763

2019-02-28 2019-02-27 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -833 279,259 -0.30 76.66 -63,860 21,408,805

2019-02-28 2019-02-27 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -484 179,062 -0.27 76.66 -37,105 13,727,412

2019-02-28 2019-02-27 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -37 51,258 -0.07 76.66 -2,837 3,929,587

2019-02-28 2019-02-27 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -539 195,183 -0.28 76.66 -41,321 14,963,295

2019-02-28 2019-02-26 4 GHDX GENOMIC HEALTH INC
Non-Qualified Stock Options (right to buy) M - Exercise -8,250 0 -100.00

2019-02-28 2019-02-26 4 GHDX GENOMIC HEALTH INC
Non-Qualified Stock Options (right to buy) M - Exercise -8,250 0 -100.00

2019-02-28 2019-02-26 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -620 9,093,689 -0.01 77.81 -48,239 707,539,019

2019-02-28 2019-02-26 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -95 1,437,609 -0.01 77.81 -7,392 111,853,887

2019-02-28 2019-02-26 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -16 280,092 -0.01 77.81 -1,245 21,792,698

2019-02-28 2019-02-26 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -10 179,546 -0.01 77.81 -778 13,969,666

2019-02-28 2019-02-26 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1 51,295 0.00 77.81 -78 3,991,033

2019-02-28 2019-02-26 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -11 195,722 -0.01 77.81 -856 15,228,248

2019-02-28 2019-02-26 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -6,506 9,094,309 -0.07 78.13 -508,342 710,577,468

2019-02-28 2019-02-26 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -999 1,437,704 -0.07 78.13 -78,056 112,333,996

2019-02-28 2019-02-26 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -172 280,108 -0.06 78.13 -13,439 21,886,043

2019-02-28 2019-02-26 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -100 179,556 -0.06 78.13 -7,813 14,029,482

2019-02-28 2019-02-26 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -8 51,296 -0.02 78.13 -625 4,007,977

2019-02-28 2019-02-26 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -112 195,733 -0.06 78.13 -8,751 15,293,461

2019-02-28 2019-02-26 4 GHDX GENOMIC HEALTH INC
Common Stock M - Exercise 8,250 9,100,815 0.09 17.59 145,118 160,083,336

2019-02-28 2019-02-26 4 GHDX GENOMIC HEALTH INC
Common Stock M - Exercise 8,250 9,100,815 0.09 17.59 145,118 160,083,336

2019-02-27 2019-02-26 4 INCY INCYTE CORP
Non-Qualified Stock Options (right to buy) M - Exercise -20,000 0 -100.00

2019-02-27 2019-02-26 4 INCY INCYTE CORP
Non-Qualified Stock Options (right to buy) M - Exercise -20,000 0 -100.00

2019-02-27 2019-02-26 4 INCY INCYTE CORP
Common Stock M - Exercise 20,000 29,288,793 0.07 2.80 56,000 82,008,620

2019-02-27 2019-02-26 4 INCY INCYTE CORP
Common Stock M - Exercise 20,000 29,288,793 0.07 2.80 56,000 82,008,620

2019-02-06 2019-02-04 4 KNSA Kiniksa Pharmaceuticals, Ltd.
Class A1 Common Shares A - Award 1,818,475 8,837,349 25.91

2019-02-06 2019-02-04 4 KNSA Kiniksa Pharmaceuticals, Ltd.
Class A1 Common Shares A - Award 181,525 916,043 24.71

2019-01-30 2019-01-28 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -13,634 9,092,565 -0.15 70.55 -961,887 641,485,916

2019-01-30 2019-01-28 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -2,093 1,430,453 -0.15 70.55 -147,662 100,919,317

2019-01-30 2019-01-28 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -361 280,280 -0.13 70.55 -25,469 19,773,922

2019-01-30 2019-01-28 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -210 179,656 -0.12 70.55 -14,816 12,674,839

2019-01-30 2019-01-28 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -16 51,304 -0.03 70.55 -1,129 3,619,528

2019-01-30 2019-01-28 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -234 195,845 -0.12 70.55 -16,509 13,816,982

2019-01-30 2019-01-28 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -24,660 9,106,199 -0.27 71.35 -1,759,553 649,750,064

2019-01-30 2019-01-28 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -3,786 1,432,546 -0.26 71.35 -270,141 102,215,738

2019-01-30 2019-01-28 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -653 280,641 -0.23 71.35 -46,593 20,024,437

2019-01-30 2019-01-28 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -378 179,866 -0.21 71.35 -26,971 12,833,889

2019-01-30 2019-01-28 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -29 51,320 -0.06 71.35 -2,069 3,661,810

2019-01-30 2019-01-28 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -423 196,079 -0.22 71.35 -30,182 13,990,727

2019-01-25 2019-01-25 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -75,736 9,130,859 -0.82 72.20 -5,468,397 659,279,065

2019-01-25 2019-01-25 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -11,627 1,436,332 -0.80 72.20 -839,509 103,708,054

2019-01-25 2019-01-25 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -2,004 281,294 -0.71 72.20 -144,696 20,310,383

2019-01-25 2019-01-25 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,162 180,244 -0.64 72.20 -83,900 13,014,230

2019-01-25 2019-01-25 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -89 51,349 -0.17 72.20 -6,426 3,707,572

2019-01-25 2019-01-25 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,298 196,502 -0.66 72.20 -93,720 14,188,113

2019-01-25 2019-01-24 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -65,426 9,206,595 -0.71 72.02 -4,711,967 663,057,131

2019-01-25 2019-01-24 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -10,044 1,447,959 -0.69 72.02 -723,367 104,281,718

2019-01-25 2019-01-24 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,732 283,298 -0.61 72.02 -124,738 20,403,065

2019-01-25 2019-01-24 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,004 181,406 -0.55 72.02 -72,308 13,064,824

2019-01-25 2019-01-24 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -76 51,438 -0.15 72.02 -5,474 3,704,554

2019-01-25 2019-01-24 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,121 197,800 -0.56 72.02 -80,734 14,245,516

2019-01-25 2019-01-23 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,648 9,272,021 -0.02 73.46 -121,054 681,076,303

2019-01-25 2019-01-23 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -253 1,458,003 -0.02 73.46 -18,584 107,097,610

2019-01-25 2019-01-23 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -44 285,030 -0.02 73.46 -3,232 20,936,879

2019-01-25 2019-01-23 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -25 182,410 -0.01 73.46 -1,836 13,398,927

2019-01-25 2019-01-23 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -2 51,514 0.00 73.46 -147 3,783,961

2019-01-25 2019-01-23 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -28 198,921 -0.01 73.46 -2,057 14,611,742

2019-01-25 2019-01-23 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -29,260 9,273,669 -0.31 70.52 -2,063,313 653,946,680

2019-01-25 2019-01-23 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -4,492 1,458,256 -0.31 70.52 -316,760 102,831,109

2019-01-25 2019-01-23 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -774 285,074 -0.27 70.52 -54,580 20,102,421

2019-01-25 2019-01-23 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -450 182,435 -0.25 70.52 -31,732 12,864,678

2019-01-25 2019-01-23 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -34 51,516 -0.07 70.52 -2,398 3,632,728

2019-01-25 2019-01-23 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -502 198,949 -0.25 70.52 -35,399 14,029,187

2019-01-22 2019-01-22 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -42,521 9,302,929 -0.45 71.00 -3,018,995 660,508,889

2019-01-22 2019-01-22 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -6,529 1,462,748 -0.44 71.00 -463,560 103,855,254

2019-01-22 2019-01-22 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,125 285,848 -0.39 71.00 -79,875 20,295,237

2019-01-22 2019-01-22 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -652 182,885 -0.36 71.00 -46,292 12,984,853

2019-01-22 2019-01-22 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -50 51,550 -0.10 71.00 -3,550 3,660,055

2019-01-22 2019-01-22 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -729 199,451 -0.36 71.00 -51,759 14,161,041

2019-01-22 2019-01-22 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -10,547 9,345,450 -0.11 71.61 -755,298 669,251,973

2019-01-22 2019-01-22 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,619 1,469,277 -0.11 71.61 -115,941 105,218,746

2019-01-22 2019-01-22 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -279 286,973 -0.10 71.61 -19,980 20,550,883

2019-01-22 2019-01-22 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -162 183,537 -0.09 71.61 -11,601 13,143,562

2019-01-22 2019-01-22 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -12 51,600 -0.02 71.61 -859 3,695,210

2019-01-22 2019-01-22 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -181 200,180 -0.09 71.61 -12,962 14,335,410

2019-01-22 2019-01-18 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -13,595 9,355,997 -0.15 72.23 -981,964 675,781,792

2019-01-22 2019-01-18 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -2,087 1,470,896 -0.14 72.23 -150,744 106,242,524

2019-01-22 2019-01-18 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -360 287,252 -0.13 72.23 -26,003 20,748,155

2019-01-22 2019-01-18 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -209 183,699 -0.11 72.23 -15,096 13,268,542

2019-01-22 2019-01-18 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -16 51,612 -0.03 72.23 -1,156 3,727,924

2019-01-22 2019-01-18 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -233 200,361 -0.12 72.23 -16,830 14,472,035

2019-01-22 2019-01-18 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -132,363 9,369,592 -1.39 72.79 -9,634,226 681,978,871

2019-01-22 2019-01-18 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -20,322 1,472,983 -1.36 72.79 -1,479,165 107,213,130

2019-01-22 2019-01-18 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -3,503 287,612 -1.20 72.79 -254,971 20,934,242

2019-01-22 2019-01-18 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -2,031 183,908 -1.09 72.79 -147,829 13,386,001

2019-01-22 2019-01-18 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -155 51,628 -0.30 72.79 -11,282 3,757,816

2019-01-22 2019-01-18 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -2,268 200,594 -1.12 72.79 -165,080 14,600,515

2019-01-22 2019-01-17 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -149,754 9,501,955 -1.55 70.79 -10,601,295 672,656,697

2019-01-22 2019-01-17 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -22,991 1,493,305 -1.52 70.79 -1,627,565 105,713,152

2019-01-22 2019-01-17 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -3,963 291,115 -1.34 70.79 -280,546 20,608,438

2019-01-22 2019-01-17 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -2,298 185,939 -1.22 70.79 -162,679 13,162,882

2019-01-22 2019-01-17 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -175 51,783 -0.34 70.79 -12,388 3,665,791

2019-01-22 2019-01-17 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -2,566 202,862 -1.25 70.79 -181,651 14,360,885

2019-01-14 2019-01-14 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -493 9,651,709 -0.01 70.07 -34,545 676,311,658

2019-01-14 2019-01-14 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -76 1,516,296 -0.01 70.07 -5,325 106,249,438

2019-01-14 2019-01-14 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -13 295,078 0.00 70.07 -911 20,676,617

2019-01-14 2019-01-14 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -8 188,237 0.00 70.07 -561 13,190,087

2019-01-14 2019-01-14 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1 51,958 0.00 70.07 -70 3,640,785

2019-01-14 2019-01-14 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -9 205,428 0.00 70.07 -631 14,394,689

2019-01-14 2019-01-11 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -23,462 9,652,202 -0.24 70.22 -1,647,574 677,807,546

2019-01-14 2019-01-11 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -3,602 1,516,372 -0.24 70.22 -252,944 106,484,343

2019-01-14 2019-01-11 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -621 295,091 -0.21 70.22 -43,609 20,722,205

2019-01-14 2019-01-11 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -360 188,245 -0.19 70.22 -25,280 13,219,147

2019-01-14 2019-01-11 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -27 51,959 -0.05 70.22 -1,896 3,648,722

2019-01-14 2019-01-11 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -402 205,437 -0.20 70.22 -28,230 14,426,423

2019-01-14 2019-01-10 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -8,392 9,675,664 -0.09 70.28 -589,772 679,985,347

2019-01-14 2019-01-10 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,288 1,519,974 -0.08 70.28 -90,518 106,820,581

2019-01-14 2019-01-10 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -222 295,712 -0.08 70.28 -15,602 20,782,018

2019-01-14 2019-01-10 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -129 188,605 -0.07 70.28 -9,066 13,254,763

2019-01-14 2019-01-10 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -10 51,986 -0.02 70.28 -703 3,653,467

2019-01-14 2019-01-10 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -144 205,839 -0.07 70.28 -10,120 14,465,933

2019-01-04 2019-01-02 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 3,658 85,072 4.49 3.52 12,876 299,453

2019-01-04 2019-01-02 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 3,658 85,072 4.49 3.52 12,876 299,453

2019-01-04 2019-01-02 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 3,658 85,072 4.49 3.52 12,876 299,453

2019-01-03 2019-01-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 310 295,934 0.10 64.41 19,967 19,061,109

2019-01-03 2019-01-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 310 295,934 0.10 64.41 19,967 19,061,109

2019-01-03 2019-01-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 310 295,934 0.10 64.41 19,967 19,061,109

2019-01-03 2019-01-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 310 1,695,159 0.02 64.41 19,967 109,185,191

2019-01-03 2019-01-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 310 225,893 0.14 64.41 19,967 14,549,768

2019-01-03 2019-01-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 310 362,631 0.09 64.41 19,967 23,357,063

2019-01-02 2018-12-31 4 INCY INCYTE CORP
Common Stock A - Award 298 810,862 0.04 63.59 18,950 51,562,715

2019-01-02 2018-12-31 4 INCY INCYTE CORP
Common Stock A - Award 298 810,862 0.04 63.59 18,950 51,562,715

2019-01-02 2018-12-31 4 INCY INCYTE CORP
Common Stock A - Award 298 29,421,884 0.00 63.59 18,950 1,870,937,604

2018-12-12 2018-12-12 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -15,243 9,683,746 -0.16 73.09 -1,114,047 707,744,323

2018-12-12 2018-12-12 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -2,340 1,520,952 -0.15 73.09 -171,021 111,159,994

2018-12-12 2018-12-12 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -403 295,624 -0.14 73.09 -29,454 21,605,917

2018-12-12 2018-12-12 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -234 188,424 -0.12 73.09 -17,102 13,771,119

2018-12-12 2018-12-12 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -18 51,686 -0.03 73.09 -1,316 3,777,513

2018-12-12 2018-12-12 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -262 205,673 -0.13 73.09 -19,148 15,031,776

2018-12-12 2018-12-11 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -12,627 9,698,989 -0.13 71.81 -906,797 696,524,166

2018-12-12 2018-12-11 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,939 1,523,292 -0.13 71.81 -139,248 109,393,844

2018-12-12 2018-12-11 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -334 296,027 -0.11 71.81 -23,986 21,258,913

2018-12-12 2018-12-11 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -194 188,658 -0.10 71.81 -13,932 13,548,304

2018-12-12 2018-12-11 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -15 51,704 -0.03 71.81 -1,077 3,713,076

2018-12-12 2018-12-11 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -216 205,935 -0.10 71.81 -15,512 14,789,037

2018-12-12 2018-12-11 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -34,794 9,711,616 -0.36 74.88 -2,605,510 727,243,681

2018-12-12 2018-12-11 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -5,342 1,525,231 -0.35 74.88 -400,030 114,215,246

2018-12-12 2018-12-11 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -921 296,361 -0.31 74.88 -68,968 22,192,667

2018-12-12 2018-12-11 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -534 188,852 -0.28 74.88 -39,988 14,141,974

2018-12-12 2018-12-11 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -41 51,719 -0.08 74.88 -3,070 3,872,920

2018-12-12 2018-12-11 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -597 206,151 -0.29 74.88 -44,706 15,437,391

2018-12-12 2018-12-10 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -7,718 9,746,410 -0.08 73.83 -569,813 719,568,679

2018-12-12 2018-12-10 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,185 1,530,573 -0.08 73.83 -87,487 113,000,827

2018-12-12 2018-12-10 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -204 297,282 -0.07 73.83 -15,061 21,948,063

2018-12-12 2018-12-10 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -118 189,386 -0.06 73.83 -8,712 13,982,198

2018-12-12 2018-12-10 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -9 51,760 -0.02 73.83 -664 3,821,394

2018-12-12 2018-12-10 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -132 206,748 -0.06 73.83 -9,745 15,264,019

2018-12-07 2018-12-07 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -84,418 9,754,128 -0.86 76.15 -6,428,768 742,815,864

2018-12-07 2018-12-07 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -12,961 1,531,758 -0.84 76.15 -987,032 116,649,499

2018-12-07 2018-12-07 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -2,234 297,486 -0.75 76.15 -170,128 22,654,749

2018-12-07 2018-12-07 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,296 189,504 -0.68 76.15 -98,696 14,431,488

2018-12-07 2018-12-07 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -99 51,769 -0.19 76.15 -7,539 3,942,416

2018-12-07 2018-12-07 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,447 206,880 -0.69 76.15 -110,195 15,754,740

2018-12-07 2018-12-06 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -76,364 9,838,546 -0.77 75.46 -5,762,481 742,423,568

2018-12-07 2018-12-06 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -11,724 1,544,719 -0.75 75.46 -884,701 116,565,577

2018-12-07 2018-12-06 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -2,021 299,720 -0.67 75.46 -152,506 22,617,081

2018-12-07 2018-12-06 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,172 190,800 -0.61 75.46 -88,440 14,397,902

2018-12-07 2018-12-06 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -89 51,868 -0.17 75.46 -6,716 3,913,996

2018-12-07 2018-12-06 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,309 208,327 -0.62 75.46 -98,778 15,720,501

2018-12-07 2018-12-04 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -2,538 9,914,910 -0.03 77.75 -197,318 770,839,635

2018-12-07 2018-12-04 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -390 1,556,443 -0.03 77.75 -30,321 121,006,439

2018-12-07 2018-12-04 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -67 301,741 -0.02 77.75 -5,209 23,459,005

2018-12-07 2018-12-04 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -39 191,972 -0.02 77.75 -3,032 14,924,959

2018-12-07 2018-12-04 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -3 51,957 -0.01 77.75 -233 4,039,423

2018-12-07 2018-12-04 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -43 209,636 -0.02 77.75 -3,343 16,298,256

2018-12-07 2018-12-04 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -5,493 9,917,448 -0.06 73.81 -405,449 732,025,680

2018-12-07 2018-12-04 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -843 1,556,833 -0.05 73.81 -62,223 114,912,802

2018-12-07 2018-12-04 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -146 301,808 -0.05 73.81 -10,777 22,277,022

2018-12-07 2018-12-04 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -84 192,011 -0.04 73.81 -6,200 14,172,697

2018-12-07 2018-12-04 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -6 51,960 -0.01 73.81 -443 3,835,266

2018-12-07 2018-12-04 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -95 209,679 -0.05 73.81 -7,012 15,476,805

2018-12-07 2018-12-04 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -18,604 9,922,941 -0.19 75.83 -1,410,758 752,465,547

2018-12-07 2018-12-04 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -2,856 1,557,676 -0.18 75.83 -216,573 118,119,973

2018-12-07 2018-12-04 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -492 301,954 -0.16 75.83 -37,309 22,897,444

2018-12-07 2018-12-04 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -286 192,095 -0.15 75.83 -21,688 14,566,737

2018-12-07 2018-12-04 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -21 51,966 -0.04 75.83 -1,592 3,940,629

2018-12-07 2018-12-04 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -319 209,774 -0.15 75.83 -24,190 15,907,351

2018-12-07 2018-12-04 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -371 9,941,545 0.00 77.11 -28,608 766,592,535

2018-12-07 2018-12-04 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -57 1,560,532 0.00 77.11 -4,395 120,332,623

2018-12-07 2018-12-04 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -10 302,446 0.00 77.11 -771 23,321,611

2018-12-07 2018-12-04 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -6 192,381 0.00 77.11 -463 14,834,499

2018-12-07 2018-12-04 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -6 192,381 0.00 77.11 -463 14,834,499

2018-12-07 2018-12-04 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1 51,987 0.00 77.11 -77 4,008,718

2018-12-04 2018-11-30 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock Warrant (right to buy) J - Other 1,569 1,569

2018-12-04 2018-11-30 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock Warrant (right to buy) J - Other 1,569 1,569

2018-12-04 2018-11-30 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock Warrant (right to buy) J - Other -10,731 0 -100.00

2018-12-04 2018-11-30 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock J - Other 71,647 71,647

2018-12-04 2018-11-30 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock J - Other 71,647 71,647

2018-12-04 2018-11-30 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock J - Other -489,977 0 -100.00

2018-12-04 2018-11-30 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 11,178,823 35,976,940 45.08 17.00 190,039,991 611,607,980

2018-12-04 2018-11-30 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 585,882 3,736,902 18.59 17.00 9,959,994 63,527,334

2018-12-03 2018-12-03 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -247 9,941,916 0.00 76.62 -18,925 761,724,749

2018-12-03 2018-12-03 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -38 1,560,589 0.00 76.62 -2,911 119,568,428

2018-12-03 2018-12-03 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -6 302,456 0.00 76.62 -460 23,173,423

2018-12-03 2018-12-03 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -4 192,387 0.00 76.62 -306 14,740,211

2018-12-03 2018-12-03 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -4 192,387 0.00 76.62 -306 14,740,211

2018-12-03 2018-12-03 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1 51,988 0.00 76.62 -77 3,983,191

2018-12-03 2018-12-03 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -32,598 9,942,163 -0.33 77.52 -2,527,147 770,762,210

2018-12-03 2018-12-03 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -5,005 1,560,627 -0.32 77.52 -388,011 120,986,984

2018-12-03 2018-12-03 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -863 302,462 -0.28 77.52 -66,904 23,448,246

2018-12-03 2018-12-03 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -500 192,391 -0.26 77.52 -38,762 14,915,035

2018-12-03 2018-12-03 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -38 51,989 -0.07 77.52 -2,946 4,030,426

2018-12-03 2018-12-03 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -559 210,103 -0.27 77.52 -43,336 16,288,151

2018-12-03 2018-12-03 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -89,047 9,974,761 -0.88 78.05 -6,950,074 778,525,109

2018-12-03 2018-12-03 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -13,671 1,565,632 -0.87 78.05 -1,067,015 122,196,795

2018-12-03 2018-12-03 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -2,357 303,325 -0.77 78.05 -183,963 23,674,365

2018-12-03 2018-12-03 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,367 192,891 -0.70 78.05 -106,694 15,055,046

2018-12-03 2018-12-03 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -104 52,027 -0.20 78.05 -8,117 4,060,681

2018-12-03 2018-12-03 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,526 210,662 -0.72 78.05 -119,104 16,442,064

2018-12-03 2018-12-03 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -44,659 10,063,808 -0.44 80.09 -3,576,721 806,006,357

2018-12-03 2018-12-03 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -6,856 1,579,303 -0.43 80.09 -549,094 126,485,746

2018-12-03 2018-12-03 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,182 305,682 -0.39 80.09 -94,666 24,481,949

2018-12-03 2018-12-03 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -685 194,258 -0.35 80.09 -54,861 15,558,046

2018-12-03 2018-12-03 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -52 52,131 -0.10 80.09 -4,165 4,175,151

2018-12-03 2018-12-03 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -765 212,188 -0.36 80.09 -61,269 16,994,052

2018-12-03 2018-11-30 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -129,121 10,108,467 -1.26 79.07 -10,209,675 799,282,551

2018-12-03 2018-11-30 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -19,824 1,586,159 -1.23 79.07 -1,567,496 125,418,544

2018-12-03 2018-11-30 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -3,417 306,864 -1.10 79.07 -270,184 24,263,921

2018-12-03 2018-11-30 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,981 194,943 -1.01 79.07 -156,639 15,414,260

2018-12-03 2018-11-30 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -151 52,183 -0.29 79.07 -11,940 4,126,141

2018-12-03 2018-11-30 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -2,214 212,953 -1.03 79.07 -175,062 16,838,321

2018-12-03 2018-11-30 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -39,591 10,237,588 -0.39 79.63 -3,152,536 815,194,562

2018-12-03 2018-11-30 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -6,078 1,605,983 -0.38 79.63 -483,977 127,880,572

2018-12-03 2018-11-30 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,048 310,281 -0.34 79.63 -83,450 24,706,931

2018-12-03 2018-11-30 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -608 196,924 -0.31 79.63 -48,414 15,680,586

2018-12-03 2018-11-30 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -46 52,334 -0.09 79.63 -3,663 4,167,231

2018-12-03 2018-11-30 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -678 215,167 -0.31 79.63 -53,988 17,133,232

2018-12-03 2018-11-29 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -30,257 10,277,179 -0.29 77.61 -2,348,376 797,656,054

2018-12-03 2018-11-29 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -4,646 1,612,061 -0.29 77.61 -360,596 125,118,986

2018-12-03 2018-11-29 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -801 311,329 -0.26 77.61 -62,169 24,163,582

2018-12-03 2018-11-29 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -465 197,532 -0.23 77.61 -36,091 15,331,308

2018-12-03 2018-11-29 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -35 52,380 -0.07 77.61 -2,717 4,065,437

2018-12-03 2018-11-29 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -518 215,845 -0.24 77.61 -40,204 16,752,659

2018-12-03 2018-11-29 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -11,994 10,307,436 -0.12 78.80 -945,149 812,244,510

2018-12-03 2018-11-29 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,841 1,616,707 -0.11 78.80 -145,074 127,399,422

2018-12-03 2018-11-29 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -317 312,130 -0.10 78.80 -24,980 24,596,406

2018-12-03 2018-11-29 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -184 197,997 -0.09 78.80 -14,500 15,602,520

2018-12-03 2018-11-29 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -14 52,415 -0.03 78.80 -1,103 4,130,396

2018-12-03 2018-11-29 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -206 216,363 -0.10 78.80 -16,233 17,049,794

2018-11-28 2018-11-28 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -77,976 10,319,430 -0.75 76.81 -5,989,017 792,593,109

2018-11-28 2018-11-28 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -11,972 1,618,548 -0.73 76.81 -919,520 124,314,036

2018-11-28 2018-11-28 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -2,064 312,447 -0.66 76.81 -158,527 23,997,773

2018-11-28 2018-11-28 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,197 198,181 -0.60 76.81 -91,937 15,221,470

2018-11-28 2018-11-28 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -91 52,429 -0.17 76.81 -6,989 4,026,857

2018-11-28 2018-11-28 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,335 216,569 -0.61 76.81 -102,536 16,633,777

2018-11-28 2018-11-28 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -13,595 10,397,406 -0.13 74.01 -1,006,150 769,499,541

2018-11-28 2018-11-28 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -2,087 1,630,520 -0.13 74.01 -154,456 120,672,829

2018-11-28 2018-11-28 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -360 314,511 -0.11 74.01 -26,643 23,276,582

2018-11-28 2018-11-28 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -209 199,378 -0.10 74.01 -15,468 14,755,727

2018-11-28 2018-11-28 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -16 52,520 -0.03 74.01 -1,184 3,886,942

2018-11-28 2018-11-28 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -233 217,904 -0.11 74.01 -17,244 16,126,814

2018-11-28 2018-11-28 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -57,979 10,411,001 -0.55 74.71 -4,331,524 777,790,268

2018-11-28 2018-11-28 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -8,901 1,632,607 -0.54 74.71 -664,980 121,969,620

2018-11-28 2018-11-28 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,534 314,871 -0.48 74.71 -114,603 23,523,540

2018-11-28 2018-11-28 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -890 199,587 -0.44 74.71 -66,491 14,910,845

2018-11-28 2018-11-28 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -68 52,536 -0.13 74.71 -5,080 3,924,886

2018-11-28 2018-11-28 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -994 218,137 -0.45 74.71 -74,260 16,296,688

2018-11-28 2018-11-28 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -56,764 10,468,980 -0.54 75.27 -4,272,831 788,037,813

2018-11-28 2018-11-28 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -8,715 1,641,508 -0.53 75.27 -656,009 123,562,217

2018-11-28 2018-11-28 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,502 316,405 -0.47 75.27 -113,061 23,816,943

2018-11-28 2018-11-28 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -871 200,477 -0.43 75.27 -65,563 15,090,626

2018-11-28 2018-11-28 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -66 52,604 -0.13 75.27 -4,968 3,959,692

2018-11-28 2018-11-28 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -973 219,131 -0.44 75.27 -73,241 16,494,779

2018-11-28 2018-11-27 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -36,652 10,525,744 -0.35 73.76 -2,703,294 776,333,617

2018-11-28 2018-11-27 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -5,627 1,650,223 -0.34 73.76 -415,023 121,713,353

2018-11-28 2018-11-27 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -970 317,907 -0.30 73.76 -71,543 23,447,453

2018-11-28 2018-11-27 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -563 201,348 -0.28 73.76 -41,524 14,850,563

2018-11-28 2018-11-27 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -43 52,670 -0.08 73.76 -3,171 3,884,713

2018-11-28 2018-11-27 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -628 220,104 -0.28 73.76 -46,319 16,233,925

2018-11-28 2018-11-27 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -77,558 10,562,396 -0.73 74.24 -5,758,092 784,177,629

2018-11-28 2018-11-27 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -11,907 1,655,850 -0.71 74.24 -884,004 122,934,278

2018-11-28 2018-11-27 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -2,052 318,877 -0.64 74.24 -152,345 23,674,194

2018-11-28 2018-11-27 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,190 201,911 -0.59 74.24 -88,348 14,990,357

2018-11-28 2018-11-27 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -91 52,713 -0.17 74.24 -6,756 3,913,540

2018-11-28 2018-11-27 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,329 220,732 -0.60 74.24 -98,668 16,387,673

2018-11-28 2018-11-26 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -8,204 10,639,954 -0.08 74.05 -607,484 787,859,866

2018-11-28 2018-11-26 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,260 1,667,757 -0.08 74.05 -93,300 123,492,903

2018-11-28 2018-11-26 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -217 320,929 -0.07 74.05 -16,068 23,763,926

2018-11-28 2018-11-26 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -126 203,101 -0.06 74.05 -9,330 15,039,081

2018-11-28 2018-11-26 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -10 52,804 -0.02 74.05 -740 3,909,994

2018-11-28 2018-11-26 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -141 222,061 -0.06 74.05 -10,441 16,443,017

2018-11-28 2018-11-26 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -24,487 10,648,158 -0.23 74.36 -1,820,848 791,794,899

2018-11-28 2018-11-26 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -3,759 1,669,017 -0.22 74.36 -279,518 124,107,770

2018-11-28 2018-11-26 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -648 321,146 -0.20 74.36 -48,185 23,880,352

2018-11-28 2018-11-26 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -376 203,227 -0.18 74.36 -27,959 15,111,919

2018-11-28 2018-11-26 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -28 52,814 -0.05 74.36 -2,082 3,927,238

2018-11-28 2018-11-26 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -419 222,202 -0.19 74.36 -31,157 16,522,896

2018-11-20 2018-11-16 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -55,365 10,672,645 -0.52 76.35 -4,227,024 814,838,302

2018-11-20 2018-11-16 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -8,499 1,672,776 -0.51 76.35 -648,884 127,713,604

2018-11-20 2018-11-16 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,466 321,794 -0.45 76.35 -111,927 24,568,425

2018-11-20 2018-11-16 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -850 203,603 -0.42 76.35 -64,896 15,544,743

2018-11-20 2018-11-16 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -65 52,842 -0.12 76.35 -4,963 4,034,397

2018-11-20 2018-11-16 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -949 222,621 -0.42 76.35 -72,455 16,996,735

2018-11-20 2018-11-16 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -16,646 10,728,010 -0.15 77.66 -1,292,763 833,159,785

2018-11-20 2018-11-16 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -2,556 1,681,275 -0.15 77.66 -198,504 130,571,347

2018-11-20 2018-11-16 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -440 323,260 -0.14 77.66 -34,171 25,105,050

2018-11-20 2018-11-16 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -255 204,453 -0.12 77.66 -19,804 15,878,249

2018-11-20 2018-11-16 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -19 52,907 -0.04 77.66 -1,476 4,108,869

2018-11-20 2018-11-16 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -285 223,570 -0.13 77.66 -22,134 17,362,916

2018-11-13 2018-11-13 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -38,330 10,744,656 -0.36 79.13 -3,033,110 850,240,746

2018-11-13 2018-11-13 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -5,885 1,683,831 -0.35 79.13 -465,689 133,244,073

2018-11-13 2018-11-13 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,014 323,700 -0.31 79.13 -80,239 25,614,867

2018-11-13 2018-11-13 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -588 204,708 -0.29 79.13 -46,529 16,198,851

2018-11-13 2018-11-13 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -45 52,926 -0.08 79.13 -3,561 4,188,114

2018-11-13 2018-11-13 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -657 223,855 -0.29 79.13 -51,989 17,713,982

2018-11-13 2018-11-13 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -3,296 10,782,986 -0.03 80.09 -263,978 863,613,662

2018-11-13 2018-11-13 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -506 1,689,716 -0.03 80.09 -40,526 135,330,030

2018-11-13 2018-11-13 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -87 324,714 -0.03 80.09 -6,968 26,006,474

2018-11-13 2018-11-13 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -51 205,296 -0.02 80.09 -4,085 16,442,239

2018-11-13 2018-11-13 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -4 52,971 -0.01 80.09 -320 4,242,469

2018-11-13 2018-11-13 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -56 224,512 -0.02 80.09 -4,485 17,981,256

2018-11-13 2018-11-13 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -53,013 10,786,282 -0.49 80.07 -4,244,714 863,650,049

2018-11-13 2018-11-13 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -8,139 1,690,222 -0.48 80.07 -651,684 135,334,892

2018-11-13 2018-11-13 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,403 324,801 -0.43 80.07 -112,337 26,006,589

2018-11-13 2018-11-13 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -814 205,347 -0.39 80.07 -65,176 16,441,991

2018-11-13 2018-11-13 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -62 52,975 -0.12 80.07 -4,964 4,241,671

2018-11-13 2018-11-13 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -908 224,568 -0.40 80.07 -72,703 17,981,003

2018-11-13 2018-11-13 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -99,280 10,839,295 -0.91 78.09 -7,752,428 846,402,609

2018-11-13 2018-11-13 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -15,242 1,698,361 -0.89 78.09 -1,190,194 132,619,066

2018-11-13 2018-11-13 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -2,628 326,204 -0.80 78.09 -205,211 25,472,129

2018-11-13 2018-11-13 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,524 206,161 -0.73 78.09 -119,004 16,098,391

2018-11-13 2018-11-13 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -115 53,037 -0.22 78.09 -8,980 4,141,474

2018-11-13 2018-11-13 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,702 225,476 -0.75 78.09 -132,903 17,606,632

2018-11-13 2018-11-13 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -15,014 10,938,575 -0.14 81.26 -1,220,038 888,868,604

2018-11-13 2018-11-13 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -2,305 1,713,603 -0.13 81.26 -187,304 139,247,380

2018-11-13 2018-11-13 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -397 328,832 -0.12 81.26 -32,260 26,720,888

2018-11-13 2018-11-13 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -230 207,685 -0.11 81.26 -18,690 16,876,483

2018-11-13 2018-11-13 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -18 53,152 -0.03 81.26 -1,463 4,319,132

2018-11-13 2018-11-13 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -257 227,178 -0.11 81.26 -20,884 18,460,484

2018-11-13 2018-11-12 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -46,511 10,953,589 -0.42 81.16 -3,774,912 889,011,904

2018-11-13 2018-11-12 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -7,140 1,715,908 -0.41 81.16 -579,495 139,266,010

2018-11-13 2018-11-12 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,231 329,229 -0.37 81.16 -99,910 26,720,785

2018-11-13 2018-11-12 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -714 207,915 -0.34 81.16 -57,949 16,874,735

2018-11-13 2018-11-12 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -54 53,170 -0.10 81.16 -4,383 4,315,368

2018-11-13 2018-11-12 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -796 227,435 -0.35 81.16 -64,605 18,459,011

2018-11-13 2018-11-12 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -7,533 11,000,100 -0.07 80.51 -606,473 885,604,851

2018-11-13 2018-11-12 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,156 1,723,048 -0.07 80.51 -93,068 138,720,527

2018-11-13 2018-11-12 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -199 330,460 -0.06 80.51 -16,021 26,604,938

2018-11-13 2018-11-12 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -116 208,629 -0.06 80.51 -9,339 16,796,470

2018-11-13 2018-11-12 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -9 53,224 -0.02 80.51 -725 4,285,000

2018-11-13 2018-11-12 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -129 228,231 -0.06 80.51 -10,386 18,374,604

2018-11-13 2018-11-12 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -11,877 11,007,633 -0.11 80.38 -954,711 884,828,765

2018-11-13 2018-11-12 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,824 1,724,204 -0.11 80.38 -146,619 138,597,035

2018-11-13 2018-11-12 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -314 330,659 -0.09 80.38 -25,240 26,579,429

2018-11-13 2018-11-12 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -182 208,745 -0.09 80.38 -14,630 16,779,591

2018-11-13 2018-11-12 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -14 53,233 -0.03 80.38 -1,125 4,279,039

2018-11-13 2018-11-12 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -204 228,360 -0.09 80.38 -16,398 18,356,308

2018-11-13 2018-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -19,367 11,019,510 -0.18 85.11 -1,648,296 937,853,967

2018-11-13 2018-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -2,973 1,726,028 -0.17 85.11 -253,028 146,899,654

2018-11-13 2018-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -513 330,973 -0.15 85.11 -43,661 28,168,616

2018-11-13 2018-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -297 208,927 -0.14 85.11 -25,277 17,781,464

2018-11-13 2018-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -23 53,247 -0.04 85.11 -1,957 4,531,772

2018-11-13 2018-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -332 228,564 -0.15 85.11 -28,256 19,452,739

2018-11-13 2018-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -112,010 11,038,877 -1.00 82.06 -9,191,025 905,799,468

2018-11-13 2018-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -17,198 1,729,001 -0.98 82.06 -1,411,189 141,873,869

2018-11-13 2018-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -2,964 331,486 -0.89 82.06 -243,212 27,200,216

2018-11-13 2018-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,720 209,224 -0.82 82.06 -141,135 17,167,959

2018-11-13 2018-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -129 53,270 -0.24 82.06 -10,585 4,371,091

2018-11-13 2018-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,919 228,896 -0.83 82.06 -157,464 18,782,153

2018-11-13 2018-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -8,157 11,150,887 -0.07 82.55 -673,321 920,452,198

2018-11-13 2018-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,252 1,746,199 -0.07 82.55 -103,347 144,140,346

2018-11-13 2018-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -216 334,450 -0.06 82.55 -17,830 27,607,242

2018-11-13 2018-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -125 210,944 -0.06 82.55 -10,318 17,412,415

2018-11-13 2018-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -9 53,399 -0.02 82.55 -743 4,407,831

2018-11-13 2018-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -140 230,815 -0.06 82.55 -11,556 19,052,670

2018-11-13 2018-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -4,120 11,159,044 -0.04 83.90 -345,678 936,271,689

2018-11-13 2018-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -633 1,747,451 -0.04 83.90 -53,110 146,615,508

2018-11-13 2018-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -109 334,666 -0.03 83.90 -9,145 28,079,314

2018-11-13 2018-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -63 211,069 -0.03 83.90 -5,286 17,709,217

2018-11-13 2018-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -5 53,408 -0.01 83.90 -420 4,481,065

2018-11-13 2018-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -71 230,955 -0.03 83.90 -5,957 19,377,702

2018-11-13 2018-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -62,929 11,163,164 -0.56 83.20 -5,235,598 928,758,500

2018-11-13 2018-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -9,661 1,748,084 -0.55 83.20 -803,781 145,437,967

2018-11-13 2018-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,665 334,775 -0.49 83.20 -138,526 27,852,778

2018-11-13 2018-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -966 211,132 -0.46 83.20 -80,370 17,565,866

2018-11-13 2018-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -74 53,413 -0.14 83.20 -6,157 4,443,881

2018-11-13 2018-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,078 231,026 -0.46 83.20 -89,688 19,221,017

2018-11-13 2018-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -17,602 11,226,093 -0.16 85.87 -1,511,565 964,036,246

2018-11-13 2018-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -2,702 1,757,745 -0.15 85.87 -232,033 150,945,649

2018-11-13 2018-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -466 336,440 -0.14 85.87 -40,018 28,891,650

2018-11-13 2018-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -270 212,098 -0.13 85.87 -23,186 18,213,831

2018-11-13 2018-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -21 53,487 -0.04 85.87 -1,803 4,593,175

2018-11-13 2018-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -302 232,104 -0.13 85.87 -25,934 19,931,838

2018-11-13 2018-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -4,120 11,243,695 -0.04 82.00 -337,840 921,982,990

2018-11-13 2018-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -633 1,760,447 -0.04 82.00 -51,906 144,356,654

2018-11-13 2018-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -109 336,906 -0.03 82.00 -8,938 27,626,292

2018-11-13 2018-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -63 212,368 -0.03 82.00 -5,166 17,414,176

2018-11-13 2018-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -5 53,508 -0.01 82.00 -410 4,387,656

2018-11-13 2018-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -71 232,406 -0.03 82.00 -5,822 19,057,292

2018-11-13 2018-11-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,565 11,247,815 -0.01 83.85 -131,227 943,138,286

2018-11-13 2018-11-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -240 1,761,080 -0.01 83.85 -20,124 147,667,967

2018-11-13 2018-11-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -42 337,015 -0.01 83.85 -3,522 28,258,977

2018-11-13 2018-11-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -24 212,431 -0.01 83.85 -2,012 17,812,509

2018-11-13 2018-11-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -2 53,513 0.00 83.85 -168 4,487,108

2018-11-13 2018-11-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -27 232,477 -0.01 83.85 -2,264 19,493,382

2018-11-13 2018-11-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -9,301 11,249,380 -0.08 84.84 -789,121 954,426,648

2018-11-13 2018-11-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -1,428 1,761,320 -0.08 84.84 -121,155 149,434,968

2018-11-13 2018-11-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -246 337,057 -0.07 84.84 -20,871 28,596,792

2018-11-13 2018-11-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -143 212,455 -0.07 84.84 -12,132 18,025,235

2018-11-13 2018-11-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -11 53,515 -0.02 84.84 -933 4,540,352

2018-11-13 2018-11-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -159 232,504 -0.07 84.84 -13,490 19,726,244

2018-11-13 2018-11-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -21,423 11,258,681 -0.19 89.34 -1,913,901 1,005,834,798

2018-11-13 2018-11-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -3,289 1,762,748 -0.19 89.34 -293,835 157,481,438

2018-11-13 2018-11-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -567 337,303 -0.17 89.34 -50,655 30,134,178

2018-11-13 2018-11-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -329 212,598 -0.15 89.34 -29,392 18,993,208

2018-11-13 2018-11-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -25 53,526 -0.05 89.34 -2,233 4,781,938

2018-11-13 2018-11-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -367 232,663 -0.16 89.34 -32,787 20,785,787

2018-11-13 2018-11-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -30,555 11,280,104 -0.27 85.15 -2,601,670 960,468,143

2018-11-13 2018-11-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -4,692 1,766,037 -0.26 85.15 -399,510 150,372,929

2018-11-13 2018-11-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -809 337,870 -0.24 85.15 -68,884 28,768,651

2018-11-13 2018-11-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -470 212,927 -0.22 85.15 -40,019 18,130,117

2018-11-13 2018-11-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -37 53,551 -0.07 85.15 -3,150 4,559,712

2018-11-13 2018-11-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -522 233,030 -0.22 85.15 -44,447 19,841,829

2018-11-13 2018-11-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -36,174 11,310,659 -0.32 85.78 -3,102,970 970,217,018

2018-11-13 2018-11-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -5,554 1,770,729 -0.31 85.78 -476,417 151,891,363

2018-11-13 2018-11-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -957 338,679 -0.28 85.78 -82,091 29,051,546

2018-11-13 2018-11-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -555 213,397 -0.26 85.78 -47,607 18,304,981

2018-11-13 2018-11-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -42 53,588 -0.08 85.78 -3,603 4,596,725

2018-11-13 2018-11-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -620 233,552 -0.26 85.78 -53,183 20,033,857

2018-11-13 2018-11-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -3,663 11,346,833 -0.03 87.30 -319,780 990,579,656

2018-11-13 2018-11-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -562 1,776,283 -0.03 87.30 -49,063 155,069,684

2018-11-13 2018-11-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -97 339,636 -0.03 87.30 -8,468 29,650,257

2018-11-13 2018-11-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -56 213,952 -0.03 87.30 -4,889 18,678,031

2018-11-13 2018-11-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -4 53,630 -0.01 87.30 -349 4,681,904

2018-11-13 2018-11-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -63 234,172 -0.03 87.30 -5,500 20,443,239

2018-11-13 2018-11-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -4,306 11,350,496 -0.04 88.38 -380,544 1,003,104,624

2018-11-13 2018-11-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -661 1,776,845 -0.04 88.38 -58,416 157,029,388

2018-11-13 2018-11-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -114 339,733 -0.03 88.38 -10,075 30,024,040

2018-11-13 2018-11-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -66 214,008 -0.03 88.38 -5,833 18,913,043

2018-11-13 2018-11-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -5 53,634 -0.01 88.38 -442 4,739,926

2018-11-13 2018-11-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -74 234,235 -0.03 88.38 -6,540 20,700,612

2018-11-13 2018-11-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -15,798 11,354,802 -0.14 83.94 -1,326,160 953,176,583

2018-11-13 2018-11-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -2,425 1,777,506 -0.14 83.94 -203,566 149,212,386

2018-11-13 2018-11-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -418 339,847 -0.12 83.94 -35,089 28,528,388

2018-11-13 2018-11-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -242 214,074 -0.11 83.94 -20,315 17,970,399

2018-11-13 2018-11-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -18 53,639 -0.03 83.94 -1,511 4,502,715

2018-11-13 2018-11-08 4 GHDX GENOMIC HEALTH INC
Common Stock S - Sale -271 234,309 -0.12 83.94 -22,749 19,669,022

2018-10-11 2018-10-09 4 KOD Kodiak Sciences Inc.
Secured Bridge Notes 30% 12/1/2020 C - Conversion -3,660,993 0 -100.00

2018-10-11 2018-10-09 4 KOD Kodiak Sciences Inc.
Secured Bridge Notes 30% 12/1/2020 C - Conversion -294,948 0 -100.00

2018-10-11 2018-10-09 4 KOD Kodiak Sciences Inc.
Series B Redeemable Convertible Preferred Shares C - Conversion -4,627,208 0 -100.00

2018-10-11 2018-10-09 4 KOD Kodiak Sciences Inc.
Series B Redeemable Convertible Preferred Shares C - Conversion -372,792 0 -100.00

2018-10-11 2018-10-09 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 2,248,102 8,374,935 36.69 10.00 22,481,020 83,749,350

2018-10-11 2018-10-09 4 KOD Kodiak Sciences Inc.
Common Stock P - Purchase 251,898 770,180 48.60 10.00 2,518,980 7,701,800

2018-10-11 2018-10-09 4 KOD Kodiak Sciences Inc.
Common Stock J - Other 767,427 6,126,833 14.32

2018-10-11 2018-10-09 4 KOD Kodiak Sciences Inc.
Common Stock J - Other 86,501 518,282 20.03

2018-10-11 2018-10-09 4 KOD Kodiak Sciences Inc.
Common Stock C - Conversion 732,198 5,359,406 15.82 5.00 3,660,990 26,797,030

2018-10-11 2018-10-09 4 KOD Kodiak Sciences Inc.
Common Stock C - Conversion 58,989 431,781 15.82 5.00 294,945 2,158,905

2018-10-11 2018-10-09 4 KOD Kodiak Sciences Inc.
Common Stock C - Conversion 4,627,208 4,627,208

2018-10-11 2018-10-09 4 KOD Kodiak Sciences Inc.
Common Stock C - Conversion 372,792 372,792

2018-10-03 2018-10-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 284 340,265 0.08 70.18 19,931 23,879,798

2018-10-03 2018-10-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 284 340,265 0.08 70.18 19,931 23,879,798

2018-10-03 2018-10-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 284 11,544,497 0.00 70.18 19,931 810,192,799

2018-10-03 2018-10-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 284 1,953,828 0.01 70.18 19,931 137,119,649

2018-10-03 2018-10-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 284 227,554 0.12 70.18 19,931 15,969,740

2018-10-03 2018-10-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 284 388,213 0.07 70.18 19,931 27,244,788

2018-10-03 2018-10-01 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 2,340 81,414 2.96 8.71 20,381 709,116

2018-10-03 2018-10-01 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 2,340 81,414 2.96 8.71 20,381 709,116

2018-10-03 2018-10-01 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 2,340 4,280,212 0.05 8.71 20,381 37,280,647

2018-10-02 2018-09-28 4 INCY INCYTE CORP
Common Stock A - Award 275 810,564 0.03 69.08 18,997 55,993,761

2018-10-02 2018-09-28 4 INCY INCYTE CORP
Common Stock A - Award 275 810,564 0.03 69.08 18,997 55,993,761

2018-10-02 2018-09-28 4 INCY INCYTE CORP
Common Stock A - Award 275 1,269,837 0.02 69.08 18,997 87,720,340

2018-09-24 2018-09-20 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 131,007 24,798,117 0.53 19.09 2,501,238 473,455,569

2018-09-24 2018-09-20 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 14,555 3,151,020 0.46 19.09 277,890 60,160,534

2018-09-24 2018-09-20 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 38,207 24,667,110 0.16 19.01 726,353 468,946,428

2018-09-24 2018-09-20 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 4,245 3,136,465 0.14 19.01 80,702 59,627,336

2018-09-24 2018-09-20 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 920,495 24,628,903 3.88 18.64 17,154,897 458,999,014

2018-09-24 2018-09-20 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 102,267 3,132,220 3.38 18.64 1,905,909 58,373,931

2018-08-06 2018-08-02 4 BGNE BeiGene, Ltd.
Ordinary shares P - Purchase 5,231,900 5,250,491 28,142.11 108.00 565,045,200 567,053,028

2018-08-06 2018-08-02 4 BGNE BeiGene, Ltd.
Ordinary shares P - Purchase 582,200 600,791 3,131.62 108.00 62,877,600 64,885,428

2018-07-05 2018-07-02 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 16,383 632,599 2.66 1.32 21,626 835,031

2018-07-05 2018-07-02 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 16,383 632,599 2.66 1.32 21,626 835,031

2018-07-05 2018-07-02 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 16,383 34,222,983 0.05 1.32 21,626 45,174,338

2018-07-03 2018-06-29 4 INCY INCYTE CORP
Common Stock A - Award 283 810,289 0.03 67.00 18,961 54,289,363

2018-07-03 2018-06-29 4 INCY INCYTE CORP
Common Stock A - Award 283 810,289 0.03 67.00 18,961 54,289,363

2018-07-03 2018-06-29 4 INCY INCYTE CORP
Common Stock A - Award 283 810,289 0.03 67.00 18,961 54,289,363

2018-07-03 2018-07-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 396 339,981 0.12 50.40 19,958 17,135,042

2018-07-03 2018-07-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 396 339,981 0.12 50.40 19,958 17,135,042

2018-07-03 2018-07-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 396 339,981 0.12 50.40 19,958 17,135,042

2018-07-03 2018-07-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 396 1,953,544 0.02 50.40 19,958 98,458,618

2018-07-03 2018-07-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 396 227,270 0.17 50.40 19,958 11,454,408

2018-07-03 2018-07-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 396 387,929 0.10 50.40 19,958 19,551,622

2018-06-21 2018-06-20 4 IDRA IDERA PHARMACEUTICALS, INC.
Non-Qualified Stock Option (right to buy) A - Award 100,000 100,000

2018-06-11 2018-06-07 4 GHDX GENOMIC HEALTH INC
Non-Qualified Stock Options (right to buy) A - Award 20,000 20,000

2018-06-08 2018-06-06 4 ACAD ACADIA PHARMACEUTICALS INC
Non-Qualified Stock Option (right to buy) A - Award 30,000 30,000

2018-06-08 2018-06-06 4 BGNE BeiGene, Ltd.
Share Option (Right to Buy) A - Award 34,884 34,884

2018-06-08 2018-06-06 4 BGNE BeiGene, Ltd.
Ordinary shares A - Award 18,580 73,180,602 0.03

2018-06-08 2018-06-06 4 BGNE BeiGene, Ltd.
Ordinary shares A - Award 18,580 73,180,602 0.03

2018-05-31 2018-05-29 4 KNSA Kiniksa Pharmaceuticals, Ltd.
Class B1 Common Shares C - Conversion 14,658,102 14,658,102

2018-05-31 2018-05-29 4 KNSA Kiniksa Pharmaceuticals, Ltd.
Series A Preferred C - Conversion -14,658,102 0 -100.00

2018-05-31 2018-05-29 4 KNSA Kiniksa Pharmaceuticals, Ltd.
Class B1 Common Shares C - Conversion 1,399,516 1,399,516

2018-05-31 2018-05-29 4 KNSA Kiniksa Pharmaceuticals, Ltd.
Series A Preferred C - Conversion -1,399,516 0 -100.00

2018-05-31 2018-05-29 4 KNSA Kiniksa Pharmaceuticals, Ltd.
Class A1 Common Shares C - Conversion 3,284,771 7,018,874 87.97

2018-05-31 2018-05-29 4 KNSA Kiniksa Pharmaceuticals, Ltd.
Series B Preferred C - Conversion -3,284,771 0 -100.00

2018-05-31 2018-05-29 4 KNSA Kiniksa Pharmaceuticals, Ltd.
Class A1 Common Shares C - Conversion 313,621 734,518 74.51

2018-05-31 2018-05-29 4 KNSA Kiniksa Pharmaceuticals, Ltd.
Series B Preferred C - Conversion -313,621 0 -100.00

2018-05-31 2018-05-29 4 KNSA Kiniksa Pharmaceuticals, Ltd.
Class A1 Common Shares C - Conversion 3,734,103 3,734,103

2018-05-31 2018-05-29 4 KNSA Kiniksa Pharmaceuticals, Ltd.
Series C Preferred C - Conversion -3,734,103 0 -100.00

2018-05-31 2018-05-29 4 KNSA Kiniksa Pharmaceuticals, Ltd.
Class A1 Common Shares C - Conversion 420,897 420,897

2018-05-31 2018-05-29 4 KNSA Kiniksa Pharmaceuticals, Ltd.
Series C Preferred C - Conversion -420,897 0 -100.00

2018-05-31 2018-05-29 4 KNSA Kiniksa Pharmaceuticals, Ltd.
Class A Common Shares P - Purchase 2,700,597 2,700,597 18.00 48,610,746 48,610,746

2018-05-31 2018-05-29 4 KNSA Kiniksa Pharmaceuticals, Ltd.
Class A Common Shares P - Purchase 299,403 299,403 18.00 5,389,254 5,389,254

2018-05-31 2018-02-09 4 KNSA Kiniksa Pharmaceuticals, Ltd.
Series C Preferred P - Purchase 3,734,103 3,734,103

2018-05-31 2018-02-09 4 KNSA Kiniksa Pharmaceuticals, Ltd.
Series C Preferred P - Purchase 420,897 420,897

2018-05-18 2018-05-18 4 SGEN SEATTLE GENETICS INC /WA
Non-Qualified Stock Options (right to buy) A - Award 9,260 9,260

2018-05-18 2018-05-18 4 SGEN SEATTLE GENETICS INC /WA
Non-Qualified Stock Options (right to buy) A - Award 9,260 9,260

2018-05-18 2018-05-18 4 SGEN SEATTLE GENETICS INC /WA
Common Stock A - Award 3,700 45,829,686 0.01 56.77 210,049 2,601,751,274

2018-05-18 2018-05-18 4 SGEN SEATTLE GENETICS INC /WA
Common Stock A - Award 3,700 45,829,686 0.01 56.77 210,049 2,601,751,274

2018-05-11 2018-05-09 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock A - Award 2,174 7,648,080 0.03

2018-05-11 2018-05-09 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock A - Award 2,174 7,648,080 0.03

2018-05-09 2018-05-07 4 AQXP AQUINOX PHARMACEUTICALS, INC
Non-Qualified Stock Option (right to buy) A - Award 30,000 30,000

2018-05-08 2018-05-08 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 126,399 45,825,986 0.28 54.02 6,828,339 2,475,615,998

2018-05-08 2018-05-07 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 129,715 45,699,587 0.28 53.70 6,966,305 2,454,282,610

2018-05-08 2018-05-04 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 204,537 45,569,872 0.45 52.68 10,775,582 2,400,748,453

2018-05-03 2018-05-02 4 INCY INCYTE CORP
Non-Qualified Stock Options (right to buy) M - Exercise -20,000 0 -100.00

2018-05-03 2018-05-02 4 INCY INCYTE CORP
Non-Qualified Stock Options (right to buy) M - Exercise -20,000 0 -100.00

2018-05-03 2018-05-02 4 INCY INCYTE CORP
Non-Qualified Stock Options (right to buy) M - Exercise -20,000 0 -100.00

2018-05-03 2018-05-02 4 INCY INCYTE CORP
Common Stock M - Exercise 20,000 810,006 2.53 9.92 198,400 8,035,260

2018-05-03 2018-05-02 4 INCY INCYTE CORP
Common Stock M - Exercise 20,000 810,006 2.53 9.92 198,400 8,035,260

2018-05-03 2018-05-02 4 INCY INCYTE CORP
Common Stock M - Exercise 20,000 810,006 2.53 9.92 198,400 8,035,260

2018-05-03 2018-05-01 4 INCY INCYTE CORP
Non-Qualified Stock Options (right to buy) A - Award 15,000 15,000

2018-05-02 2018-05-02 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 9,105 45,365,335 0.02 54.42 495,488 2,468,749,775

2018-05-02 2018-05-02 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 21,442 45,356,230 0.05 52.26 1,120,576 2,370,352,865

2018-05-02 2018-05-02 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 37,400 45,334,788 0.08 52.33 1,957,022 2,372,224,385

2018-05-02 2018-05-02 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 2,000 45,297,388 0.00 51.88 103,750 2,349,802,002

2018-05-02 2018-05-01 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 5,951 45,295,388 0.01 52.33 311,418 2,370,321,243

2018-05-02 2018-05-01 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 37,963 45,289,437 0.08 52.06 1,976,213 2,357,600,519

2018-05-02 2018-05-01 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 57,270 45,251,474 0.13 51.37 2,941,708 2,324,369,113

2018-05-02 2018-05-01 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 10,500 45,194,204 0.02 51.36 539,280 2,321,174,317

2018-05-02 2018-05-01 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 22,700 45,183,704 0.05 51.30 1,164,424 2,317,752,317

2018-05-02 2018-05-01 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 72,533 45,161,004 0.16 51.26 3,717,693 2,314,736,292

2018-05-02 2018-05-01 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 100,000 45,088,471 0.22 51.14 5,114,000 2,305,824,407

2018-05-02 2018-05-01 4 SGEN SEATTLE GENETICS INC /WA
Common Stock M - Exercise 10,000 44,988,471 0.02 10.08 100,800 453,483,788

2018-05-02 2018-05-01 4 SGEN SEATTLE GENETICS INC /WA
Common Stock M - Exercise 10,000 44,988,471 0.02 10.08 100,800 453,483,788

2018-05-02 2018-04-30 4 SGEN SEATTLE GENETICS INC /WA
Non-Qualified Stock Options (right to buy) M - Exercise -10,000 0 -100.00

2018-05-02 2018-04-30 4 SGEN SEATTLE GENETICS INC /WA
Non-Qualified Stock Options (right to buy) M - Exercise -10,000 0 -100.00

2018-05-02 2018-04-30 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 168,097 44,978,471 0.38 51.25 8,614,786 2,305,097,162

2018-05-02 2018-04-30 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 52,700 44,810,374 0.12 51.07 2,691,173 2,288,282,078

2018-05-02 2018-04-30 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 248,121 44,757,674 0.56 51.03 12,661,069 2,283,885,637

2018-05-02 2018-04-30 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 154,218 44,509,553 0.35 50.90 7,849,897 2,265,594,110

2018-04-04 2018-04-02 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 13,349 616,216 2.21 1.62 21,625 998,270

2018-04-04 2018-04-02 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 13,349 616,216 2.21 1.62 21,625 998,270

2018-04-04 2018-04-02 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 13,349 616,216 2.21 1.62 21,625 998,270

2018-04-03 2018-04-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 638 339,585 0.19 31.29 19,963 10,625,615

2018-04-03 2018-04-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 638 1,382,967 0.05 31.29 19,963 43,273,037

2018-04-03 2018-04-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 638 1,382,967 0.05 31.29 19,963 43,273,037

2018-04-03 2018-04-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 638 1,382,967 0.05 31.29 19,963 43,273,037

2018-04-03 2018-04-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 638 1,382,967 0.05 31.29 19,963 43,273,037

2018-04-03 2018-04-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 638 339,585 0.19 31.29 19,963 10,625,615

2018-04-02 2018-03-29 4 INCY INCYTE CORP
Common Stock A - Award 228 790,006 0.03 83.33 18,999 65,831,200

2018-04-02 2018-03-29 4 INCY INCYTE CORP
Common Stock A - Award 228 1,249,279 0.02 83.33 18,999 104,102,419

2018-04-02 2018-03-29 4 INCY INCYTE CORP
Common Stock A - Award 228 790,006 0.03 83.33 18,999 65,831,200

2018-03-29 2018-03-28 4 NVTA Invitae Corp
Common Stock P - Purchase 999,514 7,480,182 15.42 4.50 4,497,813 33,660,819

2018-03-29 2018-03-28 4 NVTA Invitae Corp
Common Stock P - Purchase 111,597 845,858 15.20 4.50 502,186 3,806,361

2018-03-15 2018-03-15 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock Warrant (right to buy) M - Exercise -439,036 0 -100.00

2018-03-15 2018-03-15 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock Warrant (right to buy) M - Exercise -17,626,445 0 -100.00

2018-03-15 2018-03-15 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock Warrant (right to buy) M - Exercise -2,250,846 0 -100.00

2018-03-15 2018-03-15 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock M - Exercise 439,036 602,867 267.98 0.47 206,347 283,347

2018-03-15 2018-03-15 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock M - Exercise 17,626,445 34,193,251 106.40 0.47 8,284,429 16,070,828

2018-03-15 2018-03-15 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock M - Exercise 2,250,846 4,102,796 121.54 0.47 1,057,898 1,928,314

2018-03-12 2018-03-09 4 GHDX GENOMIC HEALTH INC
Non-Qualified Stock Options (right to buy) M - Exercise -8,250 0 -100.00

2018-03-12 2018-03-09 4 GHDX GENOMIC HEALTH INC
Non-Qualified Stock Options (right to buy) M - Exercise -8,250 0 -100.00

2018-03-12 2018-03-09 4 GHDX GENOMIC HEALTH INC
Non-Qualified Stock Options (right to buy) M - Exercise -8,250 0 -100.00

2018-03-12 2018-03-09 4 GHDX GENOMIC HEALTH INC
Non-Qualified Stock Options (right to buy) M - Exercise -8,250 0 -100.00

2018-03-12 2018-03-09 4 GHDX GENOMIC HEALTH INC
Non-Qualified Stock Options (right to buy) M - Exercise -8,250 0 -100.00

2018-03-12 2018-03-09 4 GHDX GENOMIC HEALTH INC
Non-Qualified Stock Options (right to buy) M - Exercise -8,250 0 -100.00

2018-03-12 2018-03-09 4 GHDX GENOMIC HEALTH INC
Common Stock M - Exercise 8,250 338,947 2.49 18.50 152,625 6,270,520

2018-03-12 2018-03-09 4 GHDX GENOMIC HEALTH INC
Common Stock M - Exercise 8,250 338,947 2.49 18.50 152,625 6,270,520

2018-03-12 2018-03-09 4 GHDX GENOMIC HEALTH INC
Common Stock M - Exercise 8,250 1,382,329 0.60 18.50 152,625 25,573,086

2018-03-12 2018-03-09 4 GHDX GENOMIC HEALTH INC
Common Stock M - Exercise 8,250 1,382,329 0.60 18.50 152,625 25,573,086

2018-03-12 2018-03-09 4 GHDX GENOMIC HEALTH INC
Common Stock M - Exercise 8,250 1,382,329 0.60 18.50 152,625 25,573,086

2018-03-12 2018-03-09 4 GHDX GENOMIC HEALTH INC
Common Stock M - Exercise 8,250 338,947 2.49 18.50 152,625 6,270,520

2018-02-05 2018-02-01 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 3,456,543 44,355,335 8.45 52.00 179,740,236 2,306,477,420

2018-02-05 2018-02-01 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 389,610 5,278,174 7.97 52.00 20,259,720 274,465,048

2018-01-22 2018-01-18 4 BGNE BeiGene, Ltd.
American Depositary Shares P - Purchase 1,645,148 5,121,404 47.33 101.00 166,159,948 517,261,804

2018-01-22 2018-01-18 4 BGNE BeiGene, Ltd.
American Depositary Shares P - Purchase 335,050 708,025 89.83 101.00 33,840,050 71,510,525

2018-01-19 2018-01-19 4 BLCM BELLICUM PHARMACEUTICALS, INC
Common Stock S - Sale -4,136 58,131 -6.64 7.91 -32,715 459,799

2018-01-19 2018-01-19 4 BLCM BELLICUM PHARMACEUTICALS, INC
Common Stock S - Sale -265,708 3,734,776 -6.64 7.91 -2,101,671 29,540,958

2018-01-19 2018-01-19 4 BLCM BELLICUM PHARMACEUTICALS, INC
Common Stock S - Sale -25,517 358,671 -6.64 7.91 -201,832 2,836,980

2018-01-19 2018-01-18 4 BLCM BELLICUM PHARMACEUTICALS, INC
Common Stock S - Sale -4,548 62,267 -6.81 8.12 -36,910 505,340

2018-01-19 2018-01-18 4 BLCM BELLICUM PHARMACEUTICALS, INC
Common Stock S - Sale -292,168 4,000,484 -6.81 8.12 -2,371,148 32,466,728

2018-01-19 2018-01-18 4 BLCM BELLICUM PHARMACEUTICALS, INC
Common Stock S - Sale -28,058 384,188 -6.81 8.12 -227,710 3,117,955

2018-01-19 2018-01-17 4 BLCM BELLICUM PHARMACEUTICALS, INC
Common Stock S - Sale -3,649 66,815 -5.18 8.63 -31,476 576,340

2018-01-19 2018-01-17 4 BLCM BELLICUM PHARMACEUTICALS, INC
Common Stock S - Sale -234,437 4,292,652 -5.18 8.63 -2,022,230 37,027,987

2018-01-19 2018-01-17 4 BLCM BELLICUM PHARMACEUTICALS, INC
Common Stock S - Sale -22,514 412,246 -5.18 8.63 -194,204 3,555,993

2018-01-04 2018-01-02 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 9,333 163,831 6.04 2.21 20,626 362,067

2018-01-04 2018-01-02 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 9,333 163,831 6.04 2.21 20,626 362,067

2018-01-04 2018-01-02 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 9,333 163,831 6.04 2.21 20,626 362,067

2018-01-03 2018-01-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 584 330,697 0.18 34.20 19,973 11,309,837

2018-01-03 2018-01-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 584 330,697 0.18 34.20 19,973 11,309,837

2018-01-03 2018-01-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 584 1,374,079 0.04 34.20 19,973 46,993,502

2018-01-03 2018-01-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 584 1,374,079 0.04 34.20 19,973 46,993,502

2018-01-03 2018-01-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 584 1,374,079 0.04 34.20 19,973 46,993,502

2018-01-03 2018-01-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 584 330,697 0.18 34.20 19,973 11,309,837

2018-01-03 2017-12-29 4 INCY INCYTE CORP
Common Stock A - Award 200 789,778 0.03 94.71 18,942 74,799,874

2018-01-03 2017-12-29 4 INCY INCYTE CORP
Common Stock A - Award 200 789,778 0.03 94.71 18,942 74,799,874

2018-01-03 2017-12-29 4 INCY INCYTE CORP
Common Stock A - Award 200 789,778 0.03 94.71 18,942 74,799,874

2017-11-29 2017-11-27 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock Warrant (right to buy) M - Exercise -39,378 0 -100.00

2017-11-29 2017-11-27 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock F - Taxes -1,941 489,977 -0.39 28.00 -54,348 13,719,356

2017-11-29 2017-11-27 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock M - Exercise 39,378 491,918 8.70 1.38 54,342 678,847

2017-11-20 2017-11-16 4 MRTX Mirati Therapeutics, Inc.
Common Stock Warrants (right to buy) P - Purchase 1,618,684 1,618,684 13.00 21,041,273 21,041,273

2017-11-20 2017-11-16 4 MRTX Mirati Therapeutics, Inc.
Common Stock Warrants (right to buy) P - Purchase 304,392 304,392 13.00 3,956,792 3,956,792

2017-11-13 2017-11-08 4 MRTX Mirati Therapeutics, Inc.
Common Stock Warrants (right to buy) X - Other -5,996 0 -100.00

2017-11-13 2017-11-08 4 MRTX Mirati Therapeutics, Inc.
Common Stock Warrants (right to buy) X - Other -249,801 0 -100.00

2017-11-13 2017-11-08 4 MRTX Mirati Therapeutics, Inc.
Common Stock Warrants (right to buy) X - Other -24,466 0 -100.00

2017-11-13 2017-11-08 4 MRTX Mirati Therapeutics, Inc.
Common Stock X - Other 5,996 35,999 19.98 7.86 47,129 282,952

2017-11-13 2017-11-08 4 MRTX Mirati Therapeutics, Inc.
Common Stock X - Other 249,801 2,372,218 11.77 7.86 1,963,436 18,645,633

2017-11-13 2017-11-08 4 MRTX Mirati Therapeutics, Inc.
Common Stock X - Other 24,466 141,244 20.95 7.86 192,303 1,110,178

2017-10-30 2017-10-26 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock P - Purchase 7,204,652 16,557,473 77.03 1.50 10,806,978 24,836,210

2017-10-30 2017-10-26 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock P - Purchase 795,348 1,842,617 75.94 1.50 1,193,022 2,763,926

2017-10-16 2017-10-13 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock Warrant (right to buy) M - Exercise -1,426,590 0 -100.00

2017-10-16 2017-10-13 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock F - Taxes -55,457 23,708,408 -0.23 35.40 -1,963,178 839,277,643

2017-10-16 2017-10-13 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock M - Exercise 1,426,590 23,763,865 6.39 1.38 1,968,694 32,794,134

2017-10-16 2017-10-13 4 BGNE BeiGene, Ltd.
American Depositary Shares J - Other 7,102 7,102

2017-10-16 2017-10-13 4 BGNE BeiGene, Ltd.
American Depositary Shares J - Other 7,102 7,102

2017-10-16 2017-10-13 4 BGNE BeiGene, Ltd.
American Depositary Shares J - Other -49,200 0 -100.00

2017-10-06 2017-10-05 4 RYTM RHYTHM PHARMACEUTICALS, INC.
Series A Convertible Prefered C - Conversion -9,913,242 0 -100.00

2017-10-06 2017-10-05 4 RYTM RHYTHM PHARMACEUTICALS, INC.
Series A Convertible Prefered C - Conversion -760,829 0 -100.00

2017-10-06 2017-10-05 4 RYTM RHYTHM PHARMACEUTICALS, INC.
Common Stock P - Purchase 797,191 1,878,242 73.74 17.00 13,552,247 31,930,114

2017-10-06 2017-10-05 4 RYTM RHYTHM PHARMACEUTICALS, INC.
Common Stock P - Purchase 87,809 170,778 105.83 17.00 1,492,753 2,903,226

2017-10-06 2017-10-05 4 RYTM RHYTHM PHARMACEUTICALS, INC.
Common Stock C - Conversion 1,081,051 1,081,051

2017-10-06 2017-10-05 4 RYTM RHYTHM PHARMACEUTICALS, INC.
Common Stock C - Conversion 82,969 82,969

2017-10-04 2017-10-02 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 9,045 154,498 6.22 2.28 20,623 352,255

2017-10-04 2017-10-02 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 9,045 154,498 6.22 2.28 20,623 352,255

2017-10-04 2017-10-02 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 9,045 154,498 6.22 2.28 20,623 352,255

2017-10-03 2017-10-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 622 330,113 0.19 32.09 19,960 10,593,326

2017-10-03 2017-10-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 622 330,113 0.19 32.09 19,960 10,593,326

2017-10-03 2017-10-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 622 1,373,495 0.05 32.09 19,960 44,075,455

2017-10-03 2017-10-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 622 1,373,495 0.05 32.09 19,960 44,075,455

2017-10-03 2017-10-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 622 1,373,495 0.05 32.09 19,960 44,075,455

2017-10-03 2017-10-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 622 330,113 0.19 32.09 19,960 10,593,326

2017-10-03 2017-09-29 4 INCY INCYTE CORP
Common Stock A - Award 162 789,578 0.02 116.74 18,912 92,175,336

2017-10-03 2017-09-29 4 INCY INCYTE CORP
Common Stock A - Award 162 789,578 0.02 116.74 18,912 92,175,336

2017-10-03 2017-09-29 4 INCY INCYTE CORP
Common Stock A - Award 162 789,578 0.02 116.74 18,912 92,175,336

2017-09-08 2017-09-08 4 INCY INCYTE CORP
Common Stock P - Purchase 2,029 789,416 0.26 132.00 267,828 104,202,912

2017-09-08 2017-09-08 4 INCY INCYTE CORP
Common Stock P - Purchase 85,402 29,247,347 0.29 132.00 11,273,064 3,860,649,804

2017-09-08 2017-09-08 4 INCY INCYTE CORP
Common Stock P - Purchase 12,569 4,386,818 0.29 132.00 1,659,108 579,059,976

2017-08-14 2017-08-11 4 BGNE BeiGene, Ltd.
American Depositary Shares P - Purchase 158,279 3,476,256 4.77 71.00 11,237,809 246,814,176

2017-08-14 2017-08-11 4 BGNE BeiGene, Ltd.
American Depositary Shares P - Purchase 17,777 372,975 5.00 71.00 1,262,167 26,481,225

2017-08-02 2017-07-31 4 NVTA Invitae Corp
Series A Convertible Preferred P - Purchase 3,109,063 3,109,063 8.50 26,427,036 26,427,036

2017-08-02 2017-07-31 4 NVTA Invitae Corp
Series A Convertible Preferred P - Purchase 349,760 349,760 8.50 2,972,960 2,972,960

2017-07-06 2017-07-03 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 11,787 145,453 8.82 1.75 20,627 254,543

2017-07-06 2017-07-03 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 11,787 145,453 8.82 1.75 20,627 254,543

2017-07-06 2017-07-03 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 11,787 145,453 8.82 1.75 20,627 254,543

2017-07-05 2017-07-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 614 1,372,873 0.04 32.55 19,986 44,687,016

2017-07-05 2017-07-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 614 1,372,873 0.04 32.55 19,986 44,687,016

2017-07-05 2017-07-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 614 1,372,873 0.04 32.55 19,986 44,687,016

2017-07-05 2017-07-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 614 1,372,873 0.04 32.55 19,986 44,687,016

2017-07-05 2017-07-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 614 1,372,873 0.04 32.55 19,986 44,687,016

2017-07-05 2017-07-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 614 329,491 0.19 32.55 19,986 10,724,932

2017-07-05 2017-06-30 4 INCY INCYTE CORP
Common Stock A - Award 150 1,246,660 0.01 125.91 18,886 156,966,961

2017-07-05 2017-06-30 4 INCY INCYTE CORP
Common Stock A - Award 150 1,246,660 0.01 125.91 18,886 156,966,961

2017-07-05 2017-06-30 4 INCY INCYTE CORP
Common Stock A - Award 150 787,387 0.02 125.91 18,886 99,139,897

2017-06-20 2017-06-16 4 GHDX GENOMIC HEALTH INC
Non-Qualified Stock Options (right to buy) A - Award 20,000 20,000

2017-06-16 2017-06-14 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock P - Purchase 22,560 7,317,906 0.31 117.95 2,660,914 863,134,572

2017-06-16 2017-06-14 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock P - Purchase 2,564 647,367 0.40 117.95 302,419 76,355,837

2017-06-16 2017-06-14 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock P - Purchase 197,126 7,295,346 2.78 117.51 23,163,488 857,246,927

2017-06-16 2017-06-14 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock P - Purchase 22,399 644,803 3.60 117.51 2,632,017 75,768,221

2017-06-16 2017-06-14 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock P - Purchase 32,172 7,098,220 0.46 117.22 3,771,228 832,059,027

2017-06-16 2017-06-14 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock P - Purchase 3,656 622,404 0.59 117.22 428,559 72,958,695

2017-06-16 2017-06-14 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock P - Purchase 65,264 7,066,048 0.93 117.01 7,636,802 826,826,541

2017-06-16 2017-06-14 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock P - Purchase 7,416 618,748 1.21 117.01 867,776 72,402,178

2017-06-16 2017-06-14 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock P - Purchase 898 7,000,784 0.01 116.96 105,030 818,811,697

2017-06-16 2017-06-14 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock P - Purchase 102 611,332 0.02 116.96 11,930 71,501,391

2017-06-16 2017-06-14 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock P - Purchase 31,974 6,999,886 0.46 116.71 3,731,542 816,925,196

2017-06-16 2017-06-14 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock P - Purchase 3,634 611,230 0.60 116.71 424,108 71,333,903

2017-06-16 2017-06-14 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock P - Purchase 12,726 6,967,912 0.18 116.37 1,480,897 810,840,590

2017-06-16 2017-06-14 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock P - Purchase 1,446 607,596 0.24 116.37 168,268 70,704,610

2017-06-16 2017-06-14 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock P - Purchase 385,774 6,955,186 5.87 116.37 44,891,517 809,356,911

2017-06-16 2017-06-14 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock P - Purchase 43,835 606,150 7.80 116.37 5,100,965 70,536,100

2017-06-16 2017-06-14 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock P - Purchase 1,976 6,569,412 0.03 116.18 229,562 763,202,753

2017-06-16 2017-06-14 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock P - Purchase 224 562,315 0.04 116.18 26,023 65,327,058

2017-06-16 2017-06-14 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock P - Purchase 169,897 6,567,436 2.66 115.77 19,668,568 760,296,304

2017-06-16 2017-06-14 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock P - Purchase 19,305 562,091 3.56 115.77 2,234,894 65,071,926

2017-06-16 2017-06-14 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock P - Purchase 207,814 6,397,539 3.36 115.71 24,046,636 740,273,952

2017-06-16 2017-06-14 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock P - Purchase 23,614 542,786 4.55 115.71 2,732,430 62,807,016

2017-06-16 2017-06-14 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock P - Purchase 18,678 6,189,725 0.30 115.06 2,149,048 712,175,522

2017-06-16 2017-06-14 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock P - Purchase 2,122 519,172 0.41 115.06 244,152 59,734,736

2017-06-16 2017-06-14 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock P - Purchase 64,455 6,171,047 1.06 114.33 7,369,301 705,551,231

2017-06-16 2017-06-14 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock P - Purchase 7,324 517,050 1.44 114.33 837,371 59,115,619

2017-06-16 2017-06-15 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock P - Purchase 160,000 980,146 19.51 117.71 18,832,960 115,369,065

2017-06-16 2017-06-15 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock P - Purchase 103,200 820,146 14.39 117.63 12,139,416 96,473,774

2017-06-16 2017-06-15 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock P - Purchase 32,008 716,946 4.67 117.60 3,764,067 84,311,201

2017-06-16 2017-06-15 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock P - Purchase 300 684,938 0.04 116.75 35,025 79,966,512

2017-06-16 2017-06-15 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock P - Purchase 3,747 7,645,906 0.05 116.75 437,462 892,659,526

2017-06-16 2017-06-15 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock P - Purchase 426 684,638 0.06 116.75 49,736 79,931,486

2017-06-16 2017-06-15 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock P - Purchase 44,898 7,642,159 0.59 117.50 5,275,484 897,948,333

2017-06-16 2017-06-15 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock P - Purchase 5,102 684,212 0.75 117.50 599,481 80,394,431

2017-06-16 2017-06-15 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock P - Purchase 5,373 7,597,261 0.07 117.21 629,790 890,504,591

2017-06-16 2017-06-15 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock P - Purchase 611 679,110 0.09 117.21 71,618 79,601,132

2017-06-16 2017-06-15 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock P - Purchase 217,305 7,591,888 2.95 117.05 25,434,638 888,598,604

2017-06-16 2017-06-15 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock P - Purchase 24,692 678,499 3.78 117.05 2,890,095 79,415,458

2017-06-16 2017-06-15 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock P - Purchase 8,950 7,374,583 0.12 116.95 1,046,720 862,471,494

2017-06-16 2017-06-15 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock P - Purchase 1,017 653,807 0.16 116.95 118,940 76,463,971

2017-06-16 2017-06-15 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock P - Purchase 39,473 7,365,633 0.54 116.65 4,604,506 859,197,407

2017-06-16 2017-06-15 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock P - Purchase 4,485 652,790 0.69 116.65 523,173 76,147,627

2017-06-16 2017-06-15 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock P - Purchase 4,310 7,326,160 0.06 116.54 502,277 853,773,836

2017-06-16 2017-06-15 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock P - Purchase 490 648,305 0.08 116.54 57,103 75,551,974

2017-06-16 2017-06-14 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock P - Purchase 3,944 7,321,850 0.05 118.00 465,392 863,978,300

2017-06-16 2017-06-14 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock P - Purchase 448 647,815 0.07 118.00 52,864 76,442,170

2017-06-14 2017-06-13 4 ACAD ACADIA PHARMACEUTICALS INC
Non-Qualified Stock Option (right to buy) A - Award 30,000 30,000

2017-06-09 2017-06-07 4/A IDRA IDERA PHARMACEUTICALS, INC.
Non-Qualified Stock Option (right to buy) A - Award 100,000 100,000

2017-06-08 2017-06-07 4 IDRA IDERA PHARMACEUTICALS, INC.
Non-Qualified Stock Option (right to buy) A - Award 100,000 100,000

2017-06-01 2017-05-31 4 GHDX GENOMIC HEALTH INC
Non-Qualified Stock Options (right to buy) M - Exercise -8,250 0 -100.00

2017-06-01 2017-05-31 4 GHDX GENOMIC HEALTH INC
Non-Qualified Stock Options (right to buy) M - Exercise -8,250 0 -100.00

2017-06-01 2017-05-31 4 GHDX GENOMIC HEALTH INC
Non-Qualified Stock Options (right to buy) M - Exercise -8,250 0 -100.00

2017-06-01 2017-05-31 4 GHDX GENOMIC HEALTH INC
Non-Qualified Stock Options (right to buy) M - Exercise -8,250 0 -100.00

2017-06-01 2017-05-31 4 GHDX GENOMIC HEALTH INC
Non-Qualified Stock Options (right to buy) M - Exercise -8,250 0 -100.00

2017-06-01 2017-05-31 4 GHDX GENOMIC HEALTH INC
Non-Qualified Stock Options (right to buy) M - Exercise -8,250 0 -100.00

2017-06-01 2017-05-31 4 GHDX GENOMIC HEALTH INC
Common Stock M - Exercise 8,250 328,877 2.57 18.13 149,572 5,962,540

2017-06-01 2017-05-31 4 GHDX GENOMIC HEALTH INC
Common Stock M - Exercise 8,250 1,372,259 0.60 18.13 149,572 24,879,056

2017-06-01 2017-05-31 4 GHDX GENOMIC HEALTH INC
Common Stock M - Exercise 8,250 1,372,259 0.60 18.13 149,572 24,879,056

2017-06-01 2017-05-31 4 GHDX GENOMIC HEALTH INC
Common Stock M - Exercise 8,250 1,372,259 0.60 18.13 149,572 24,879,056

2017-06-01 2017-05-31 4 GHDX GENOMIC HEALTH INC
Common Stock M - Exercise 8,250 1,372,259 0.60 18.13 149,572 24,879,056

2017-06-01 2017-05-31 4 GHDX GENOMIC HEALTH INC
Common Stock M - Exercise 8,250 328,877 2.57 18.13 149,572 5,962,540

2017-05-31 2017-05-26 4 INCY INCYTE CORP
Non-Qualified Stock Options (right to buy) A - Award 15,000 15,000

2017-05-23 2017-05-19 4 SGEN SEATTLE GENETICS INC /WA
Non-Qualified Stock Options (right to buy) A - Award 9,260 9,260

2017-05-23 2017-05-19 4 SGEN SEATTLE GENETICS INC /WA
Non-Qualified Stock Options (right to buy) A - Award 9,260 9,260

2017-05-23 2017-05-19 4 SGEN SEATTLE GENETICS INC /WA
Common Stock A - Award 3,700 40,898,792 0.01 66.60 246,420 2,723,859,547

2017-05-23 2017-05-19 4 SGEN SEATTLE GENETICS INC /WA
Common Stock A - Award 3,700 40,898,792 0.01 66.60 246,420 2,723,859,547

2017-05-17 2017-05-15 4 SGEN SEATTLE GENETICS INC /WA
Non-Qualified Stock Options (right to buy) M - Exercise -10,000 0 -100.00

2017-05-17 2017-05-15 4 SGEN SEATTLE GENETICS INC /WA
Non-Qualified Stock Options (right to buy) M - Exercise -10,000 0 -100.00

2017-05-17 2017-05-15 4 SGEN SEATTLE GENETICS INC /WA
Common Stock M - Exercise 10,000 40,895,092 0.02 10.20 102,000 417,129,938

2017-05-17 2017-05-15 4 SGEN SEATTLE GENETICS INC /WA
Common Stock M - Exercise 10,000 40,895,092 0.02 10.20 102,000 417,129,938

2017-05-12 2017-05-10 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock A - Award 2,030 6,559,338 0.03

2017-05-12 2017-05-10 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock A - Award 2,030 6,106,592 0.03

2017-05-09 2017-05-08 4 AQXP AQUINOX PHARMACEUTICALS, INC
Non-Qualified Stock Option (right to buy) A - Award 36,000 36,000

2017-04-28 2017-04-27 4 INCY INCYTE CORP
Non-Qualified Stock Options (right M - Exercise -20,000 0 -100.00

2017-04-28 2017-04-27 4 INCY INCYTE CORP
Non-Qualified Stock Options (right M - Exercise -20,000 0 -100.00

2017-04-28 2017-04-27 4 INCY INCYTE CORP
Non-Qualified Stock Options (right M - Exercise -20,000 0 -100.00

2017-04-28 2017-04-27 4 INCY INCYTE CORP
Common Stock M - Exercise 20,000 787,237 2.61 7.26 145,200 5,715,341

2017-04-28 2017-04-27 4 INCY INCYTE CORP
Common Stock M - Exercise 20,000 787,237 2.61 7.26 145,200 5,715,341

2017-04-28 2017-04-27 4 INCY INCYTE CORP
Common Stock M - Exercise 20,000 787,237 2.61 7.26 145,200 5,715,341

2017-04-21 2017-04-19 4 BGNE BeiGene, Ltd.
Share Option (right to buy) A - Award 399,984 399,984

2017-04-05 2017-04-03 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 8,487 133,666 6.78 2.43 20,623 324,808

2017-04-05 2017-04-03 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 8,487 133,666 6.78 2.43 20,623 324,808

2017-04-05 2017-04-03 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 8,487 133,666 6.78 2.43 20,623 324,808

2017-04-04 2017-03-31 4 INCY INCYTE CORP
Common Stock A - Award 142 767,237 0.02 133.67 18,981 102,556,570

2017-04-04 2017-03-31 4 INCY INCYTE CORP
Common Stock A - Award 142 1,226,510 0.01 133.67 18,981 163,947,592

2017-04-04 2017-03-31 4 INCY INCYTE CORP
Common Stock A - Award 142 767,237 0.02 133.67 18,981 102,556,570

2017-04-04 2017-04-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 634 320,627 0.20 31.49 19,965 10,096,544

2017-04-04 2017-04-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 634 1,364,009 0.05 31.49 19,965 42,952,643

2017-04-04 2017-04-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 634 1,364,009 0.05 31.49 19,965 42,952,643

2017-04-04 2017-04-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 634 1,364,009 0.05 31.49 19,965 42,952,643

2017-04-04 2017-04-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 634 1,364,009 0.05 31.49 19,965 42,952,643

2017-04-04 2017-04-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 634 320,627 0.20 31.49 19,965 10,096,544

2017-03-28 2017-03-24 4 BLCM BELLICUM PHARMACEUTICALS, INC
Common Stock P - Purchase 151,177 4,527,089 3.45 12.00 1,814,124 54,325,068

2017-03-28 2017-03-24 4 BLCM BELLICUM PHARMACEUTICALS, INC
Common Stock P - Purchase 15,489 434,760 3.69 12.00 185,868 5,217,120

2017-02-22 2017-02-17 4 INCY INCYTE CORP
1.25% Convertible Senior Note due 2020 D - Sale to Issuer -6,050,000 0 -100.00

2017-02-22 2017-02-17 4 INCY INCYTE CORP
0.375% Convertible Senior Note due 2018 D - Sale to Issuer -5,674,000 0 -100.00

2017-02-22 2017-02-17 4 INCY INCYTE CORP
1.25% Convertible Senior Note due 2020 D - Sale to Issuer -243,450,000 0 -100.00

2017-02-22 2017-02-17 4 INCY INCYTE CORP
0.375% Convertible Senior Note due 2018 D - Sale to Issuer -228,326,000 0 -100.00

2017-02-22 2017-02-17 4 INCY INCYTE CORP
0.375% Convertible Senior Note due 2018 D - Sale to Issuer -25,000,000 0 -100.00

2017-02-22 2017-02-17 4 INCY INCYTE CORP
1.25% Convertible Senior Note due 2020 D - Sale to Issuer -25,000,000 0 -100.00

2017-02-22 2017-02-17 4 INCY INCYTE CORP
Common Stock A - Award 121,672 767,095 18.85

2017-02-22 2017-02-17 4 INCY INCYTE CORP
Common Stock A - Award 111,514 645,423 20.89

2017-02-22 2017-02-17 4 INCY INCYTE CORP
Common Stock A - Award 4,896,067 29,141,653 20.19

2017-02-22 2017-02-17 4 INCY INCYTE CORP
Common Stock A - Award 4,487,412 24,245,586 22.71

2017-02-22 2017-02-17 4 INCY INCYTE CORP
Common Stock A - Award 502,779 4,353,957 13.06

2017-02-22 2017-02-17 4 INCY INCYTE CORP
Common Stock A - Award 491,338 3,851,178 14.62

2017-01-09 2017-01-09 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 32,051 9,764,459 0.33 17.76 569,226 173,416,792

2017-01-09 2017-01-09 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 3,389 1,169,695 0.29 17.76 60,189 20,773,783

2017-01-09 2017-01-09 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 235,169 9,732,408 2.48 17.60 4,138,880 171,286,488

2017-01-09 2017-01-09 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 24,871 1,166,306 2.18 17.60 437,720 20,526,519

2017-01-09 2017-01-09 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 35,360 9,497,239 0.37 16.31 576,555 154,855,331

2017-01-09 2017-01-09 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 3,739 1,141,435 0.33 16.31 60,966 18,611,440

2017-01-09 2017-01-09 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 5,006 9,461,879 0.05 15.62 78,207 147,819,151

2017-01-09 2017-01-09 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 529 1,137,696 0.05 15.62 8,264 17,773,770

2017-01-09 2017-01-09 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 15,148 9,456,873 0.16 15.13 229,189 143,082,488

2017-01-09 2017-01-09 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 1,602 1,137,167 0.14 15.13 24,238 17,205,337

2017-01-09 2017-01-09 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 9,143 9,441,725 0.10 16.20 148,089 152,927,620

2017-01-09 2017-01-09 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 967 1,135,565 0.09 16.20 15,662 18,392,746

2017-01-09 2017-01-09 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 8,671 9,432,582 0.09 15.35 133,078 144,766,552

2017-01-09 2017-01-09 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 917 1,134,598 0.08 15.35 14,074 17,413,243

2017-01-09 2017-01-09 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 2,442 9,423,911 0.03 16.85 41,156 158,823,999

2017-01-09 2017-01-09 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 258 1,133,681 0.02 16.85 4,348 19,106,266

2017-01-09 2017-01-09 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 11,305 9,421,469 0.12 15.32 173,204 144,346,327

2017-01-09 2017-01-09 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 1,195 1,133,423 0.11 15.32 18,309 17,365,174

2017-01-09 2017-01-09 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 5,697 9,410,164 0.06 16.74 95,365 157,521,440

2017-01-09 2017-01-09 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 603 1,132,228 0.05 16.74 10,094 18,952,931

2017-01-05 2017-01-03 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 14,169 125,179 12.76 1.50 21,254 187,768

2017-01-05 2017-01-03 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 14,169 125,179 12.76 1.50 21,254 187,768

2017-01-05 2017-01-03 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 14,169 125,179 12.76 1.50 21,254 187,768

2017-01-04 2016-12-30 4 INCY INCYTE CORP
Common Stock A - Award 189 993,182 0.02 100.27 18,951 99,586,359

2017-01-04 2016-12-30 4 INCY INCYTE CORP
Common Stock A - Award 189 993,182 0.02 100.27 18,951 99,586,359

2017-01-04 2016-12-30 4 INCY INCYTE CORP
Common Stock A - Award 189 533,909 0.04 100.27 18,951 53,535,055

2017-01-04 2017-01-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 680 14,045,614 0.00 29.39 19,985 412,800,595

2017-01-04 2017-01-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 680 14,045,614 0.00 29.39 19,985 412,800,595

2017-01-04 2017-01-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 680 14,045,614 0.00 29.39 19,985 412,800,595

2017-01-04 2017-01-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 680 14,045,614 0.00 29.39 19,985 412,800,595

2017-01-04 2017-01-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 680 1,363,375 0.05 29.39 19,985 40,069,591

2017-01-04 2017-01-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 680 319,993 0.21 29.39 19,985 9,404,594

2016-11-21 2016-11-18 4 BGNE BeiGene, Ltd.
American Depositary Shares P - Purchase 1,594,671 3,317,977 92.54 32.00 51,029,472 106,175,264

2016-11-21 2016-11-18 4 BGNE BeiGene, Ltd.
American Depositary Shares P - Purchase 165,824 355,198 87.56 32.00 5,306,368 11,366,336

2016-11-18 2016-11-17 4 NVTA Invitae Corp
Common Stock P - Purchase 664,259 6,480,668 11.42 6.00 3,985,554 38,884,008

2016-11-18 2016-11-17 4 NVTA Invitae Corp
Common Stock P - Purchase 69,074 734,261 10.38 6.00 414,444 4,405,566

2016-11-09 2016-11-08 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 294,178 40,885,092 0.72 59.46 17,493,177 2,431,215,642

2016-11-09 2016-11-08 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 32,122 4,874,864 0.66 59.46 1,910,122 289,881,838

2016-11-09 2016-11-07 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 50,667 40,590,914 0.12 58.74 2,976,321 2,384,423,943

2016-11-09 2016-11-07 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 5,533 4,842,742 0.11 58.74 325,024 284,476,225

2016-11-03 2016-11-03 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 18,616 40,540,247 0.05 55.99 1,042,351 2,269,937,618

2016-11-03 2016-11-03 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 2,039 4,837,209 0.04 55.99 114,168 270,845,974

2016-11-03 2016-11-03 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 16,854 40,521,631 0.04 56.42 950,861 2,286,129,117

2016-11-03 2016-11-03 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 1,846 4,835,170 0.04 56.42 104,147 272,788,203

2016-11-03 2016-11-03 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 143,016 40,504,777 0.35 56.48 8,078,001 2,287,839,420

2016-11-03 2016-11-03 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 15,662 4,833,324 0.33 56.48 884,640 273,001,606

2016-11-03 2016-11-03 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 361 40,361,761 0.00 56.49 20,393 2,280,035,879

2016-11-03 2016-11-03 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 39 4,817,662 0.00 56.49 2,203 272,149,726

2016-11-03 2016-11-03 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 456 40,361,400 0.00 56.55 25,788 2,282,558,254

2016-11-03 2016-11-03 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 50 4,817,623 0.00 56.55 2,828 272,451,034

2016-11-03 2016-11-03 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 341,438 40,360,944 0.85 56.91 19,430,383 2,296,840,421

2016-11-03 2016-11-03 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 37,392 4,817,573 0.78 56.91 2,127,885 274,156,035

2016-11-03 2016-11-02 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 95,280 40,019,506 0.24 55.84 5,320,673 2,234,789,264

2016-11-03 2016-11-02 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 10,434 4,780,181 0.22 55.84 582,661 266,937,257

2016-11-03 2016-11-02 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 3,335 39,924,226 0.01 55.87 186,336 2,230,686,279

2016-11-03 2016-11-02 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 365 4,769,747 0.01 55.87 20,394 266,500,074

2016-11-03 2016-11-02 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 6,289 39,920,891 0.02 56.12 352,915 2,240,208,704

2016-11-03 2016-11-02 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 689 4,769,382 0.01 56.12 38,664 267,639,594

2016-11-03 2016-11-02 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 26,381 39,914,602 0.07 56.13 1,480,758 2,240,394,636

2016-11-03 2016-11-02 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 2,889 4,768,693 0.06 56.13 162,159 267,665,307

2016-11-03 2016-11-02 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 289,278 39,888,221 0.73 56.26 16,274,202 2,244,031,537

2016-11-03 2016-11-02 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 31,679 4,765,804 0.67 56.26 1,782,197 268,114,601

2016-11-03 2016-11-01 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 2,884 39,598,943 0.01 51.83 149,479 2,052,425,095

2016-11-03 2016-11-01 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 316 4,734,125 0.01 51.83 16,378 245,371,119

2016-11-03 2016-11-01 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 2,434 39,596,059 0.01 53.33 129,815 2,111,812,251

2016-11-03 2016-11-01 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 266 4,733,809 0.01 53.33 14,187 252,472,496

2016-11-03 2016-11-01 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 32,717 39,593,625 0.08 53.66 1,755,578 2,124,574,121

2016-11-03 2016-11-01 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 3,583 4,733,543 0.08 53.66 192,262 253,999,551

2016-11-03 2016-11-01 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 40,332 39,560,908 0.10 54.37 2,192,976 2,151,049,207

2016-11-03 2016-11-01 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 4,417 4,729,960 0.09 54.37 240,166 257,182,588

2016-11-03 2016-11-01 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 924 39,520,576 0.00 54.51 50,365 2,154,183,605

2016-11-03 2016-11-01 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 101 4,725,543 0.00 54.51 5,505 257,579,425

2016-11-03 2016-11-01 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 1,803 39,519,652 0.00 54.61 98,455 2,158,021,973

2016-11-03 2016-11-01 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 197 4,725,442 0.00 54.61 10,757 258,038,903

2016-11-03 2016-11-01 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 85,353 39,517,849 0.22 54.93 4,688,039 2,170,529,712

2016-11-03 2016-11-01 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 9,347 4,725,245 0.20 54.93 513,387 259,535,499

2016-10-11 2016-10-07 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock P - Purchase 2,928,596 9,309,333 45.90 2.00 5,857,192 18,618,666

2016-10-11 2016-10-07 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock P - Purchase 321,404 1,003,781 47.10 2.00 642,808 2,007,562

2016-10-05 2016-10-03 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 8,299 111,010 8.08 2.56 21,245 284,186

2016-10-05 2016-10-03 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 8,299 111,010 8.08 2.56 21,245 284,186

2016-10-05 2016-10-03 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 8,299 111,010 8.08 2.56 21,245 284,186

2016-10-04 2016-09-30 4 INCY INCYTE CORP
Common Stock A - Award 201 992,993 0.02 94.29 18,952 93,629,310

2016-10-04 2016-09-30 4 INCY INCYTE CORP
Common Stock A - Award 201 992,993 0.02 94.29 18,952 93,629,310

2016-10-04 2016-09-30 4 INCY INCYTE CORP
Common Stock A - Award 201 533,720 0.04 94.29 18,952 50,324,459

2016-10-04 2016-09-30 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 690 1,362,695 0.05 28.92 19,955 39,409,139

2016-10-04 2016-09-30 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 690 1,362,695 0.05 28.92 19,955 39,409,139

2016-10-04 2016-09-30 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 690 1,362,695 0.05 28.92 19,955 39,409,139

2016-10-04 2016-09-30 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 690 1,362,695 0.05 28.92 19,955 39,409,139

2016-10-04 2016-09-30 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 690 1,362,695 0.05 28.92 19,955 39,409,139

2016-10-04 2016-09-30 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 690 319,313 0.22 28.92 19,955 9,234,532

2016-09-21 2016-09-20 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 12,550 1,131,625 1.12 13.15 165,029 14,880,529

2016-09-21 2016-09-20 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 2,476,348 9,404,467 35.74 12.25 30,335,263 115,204,721

2016-09-21 2016-09-20 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 294,707 1,119,075 35.75 12.25 3,610,161 13,708,669

2016-09-13 2016-09-13 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 24,339 39,432,496 0.06 51.55 1,254,571 2,032,575,609

2016-09-13 2016-09-13 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 2,730 4,715,898 0.06 51.55 140,720 243,084,264

2016-09-13 2016-09-13 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 58,541 39,408,157 0.15 51.41 3,009,341 2,025,803,896

2016-09-13 2016-09-13 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 6,565 4,713,168 0.14 51.41 337,478 242,283,700

2016-09-13 2016-09-13 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 899 39,349,616 0.00 50.64 45,523 1,992,546,505

2016-09-13 2016-09-13 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 101 4,706,603 0.00 50.64 5,114 238,328,256

2016-09-13 2016-09-13 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 21,804 39,348,717 0.06 50.42 1,099,388 1,984,017,399

2016-09-13 2016-09-13 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 2,445 4,706,502 0.05 50.42 123,280 237,308,420

2016-09-13 2016-09-13 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 21,290 39,326,913 0.05 50.41 1,073,191 1,982,398,896

2016-09-13 2016-09-13 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 2,388 4,704,057 0.05 50.41 120,375 237,123,046

2016-09-13 2016-09-13 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 90 39,305,623 0.00 50.00 4,500 1,965,281,150

2016-09-13 2016-09-13 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 10 4,701,669 0.00 50.00 500 235,083,450

2016-09-13 2016-09-12 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 899 39,305,533 0.00 49.84 44,802 1,958,791,237

2016-09-13 2016-09-12 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 101 4,701,659 0.00 49.84 5,033 234,307,176

2016-09-13 2016-09-12 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 8,380 39,304,634 0.02 50.99 427,266 2,004,001,791

2016-09-13 2016-09-12 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 940 4,701,558 0.02 50.99 47,927 239,715,517

2016-09-13 2016-09-12 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 2,338 39,296,254 0.01 50.48 118,029 1,983,788,861

2016-09-13 2016-09-12 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 262 4,700,618 0.01 50.48 13,227 237,300,828

2016-09-13 2016-09-12 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 33,241 39,293,916 0.08 51.25 1,703,751 2,013,990,018

2016-09-13 2016-09-12 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 3,728 4,700,356 0.08 51.25 191,077 240,914,397

2016-09-13 2016-09-09 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 23,440 39,260,675 0.06 50.33 1,179,656 1,975,856,286

2016-09-13 2016-09-09 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 2,637 4,696,628 0.06 50.33 132,711 236,365,319

2016-09-13 2016-09-09 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 170,652 39,237,235 0.44 50.38 8,597,226 1,976,720,891

2016-09-13 2016-09-09 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 19,201 4,693,991 0.41 50.38 967,321 236,477,164

2016-09-13 2016-09-09 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 7,944 39,066,583 0.02 51.05 405,541 1,994,349,062

2016-09-13 2016-09-09 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 894 4,674,790 0.02 51.05 45,639 238,648,030

2016-09-13 2016-09-09 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 28,271 39,058,639 0.07 50.55 1,428,963 1,974,226,720

2016-09-13 2016-09-09 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 3,181 4,673,896 0.07 50.55 160,784 236,243,008

2016-09-08 2016-09-08 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 33,893 39,030,368 0.09 50.48 1,710,844 1,970,167,110

2016-09-08 2016-09-08 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 3,813 4,670,715 0.08 50.48 192,472 235,767,418

2016-09-08 2016-09-08 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 48,036 38,996,475 0.12 50.10 2,406,829 1,953,906,681

2016-09-08 2016-09-08 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 5,405 4,666,902 0.12 50.10 270,816 233,833,725

2016-09-08 2016-09-08 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 101,290 38,948,439 0.26 50.05 5,069,433 1,949,318,739

2016-09-08 2016-09-08 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 11,397 4,661,497 0.25 50.05 570,405 233,301,865

2016-09-08 2016-09-08 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 5,581 38,847,149 0.01 49.46 276,030 1,921,337,258

2016-09-08 2016-09-08 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 628 4,650,100 0.01 49.46 31,060 229,988,831

2016-09-08 2016-09-08 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 944 38,841,568 0.00 49.18 46,427 1,910,267,156

2016-09-08 2016-09-08 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 106 4,649,472 0.00 49.18 5,213 228,665,682

2016-09-08 2016-09-07 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 13,825 38,840,624 0.04 48.61 672,033 1,888,042,733

2016-09-08 2016-09-07 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 1,556 4,649,366 0.03 48.61 75,637 226,005,681

2016-09-08 2016-09-07 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 12,955 38,826,799 0.03 48.95 634,191 1,900,703,822

2016-09-08 2016-09-07 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 1,457 4,647,810 0.03 48.95 71,325 227,526,102

2016-09-08 2016-09-07 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 548 38,813,844 0.00 47.27 25,904 1,834,718,762

2016-09-08 2016-09-07 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 62 4,646,353 0.00 47.27 2,931 219,631,712

2016-09-08 2016-09-07 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 11,681 38,813,296 0.03 48.16 562,550 1,869,225,047

2016-09-08 2016-09-07 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 1,314 4,646,291 0.03 48.16 63,281 223,762,587

2016-09-08 2016-09-07 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 8,598 38,801,615 0.02 48.44 416,460 1,879,426,065

2016-09-08 2016-09-07 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 967 4,644,977 0.02 48.44 46,838 224,987,822

2016-09-08 2016-09-07 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 5,930 38,793,017 0.02 48.29 286,332 1,873,132,464

2016-09-08 2016-09-07 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 667 4,644,010 0.01 48.29 32,206 224,237,416

2016-09-08 2016-09-06 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 84,331 4,643,343 1.85 46.17 3,893,638 214,387,325

2016-09-08 2016-09-06 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 3,600 4,559,012 0.08 45.10 162,369 205,623,295

2016-09-08 2016-09-06 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 35,263 4,555,412 0.78 45.39 1,600,457 206,753,296

2016-09-08 2016-09-06 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 8,360 4,520,149 0.19 46.10 385,414 208,388,813

2016-09-08 2016-09-06 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 2,735 4,511,789 0.06 44.98 123,025 202,948,842

2016-09-08 2016-09-06 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 9,074 4,509,054 0.20 45.80 415,623 206,531,357

2016-08-16 2016-08-16 4 BCRX BIOCRYST PHARMACEUTICALS INC
Common Stock S - Sale -850 9,418,390 -0.01 4.29 -3,645 40,392,649

2016-08-16 2016-08-16 4 BCRX BIOCRYST PHARMACEUTICALS INC
Common Stock S - Sale -140 1,551,387 -0.01 4.29 -600 6,653,433

2016-08-16 2016-08-15 4 BCRX BIOCRYST PHARMACEUTICALS INC
Common Stock S - Sale -343,583 9,419,240 -3.52 4.83 -1,658,681 45,472,323

2016-08-16 2016-08-15 4 BCRX BIOCRYST PHARMACEUTICALS INC
Common Stock S - Sale -56,417 1,551,527 -3.51 4.83 -272,359 7,490,152

2016-08-16 2016-08-12 4 BCRX BIOCRYST PHARMACEUTICALS INC
Common Stock S - Sale -296,856 9,762,823 -2.95 5.25 -1,559,711 51,294,848

2016-08-16 2016-08-12 4 BCRX BIOCRYST PHARMACEUTICALS INC
Common Stock S - Sale -48,744 1,607,944 -2.94 5.25 -256,106 8,448,299

2016-08-16 2016-08-12 4 BCRX BIOCRYST PHARMACEUTICALS INC
Common Stock S - Sale -2,834,561 10,059,679 -21.98 5.00 -14,172,805 50,298,395

2016-08-16 2016-08-12 4 BCRX BIOCRYST PHARMACEUTICALS INC
Common Stock S - Sale -465,439 1,656,688 -21.93 5.00 -2,327,195 8,283,440

2016-08-15 2016-08-15 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 89,896 11,348,958 0.80 27.02 2,428,621 306,602,314

2016-08-15 2016-08-15 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 10,104 1,758,289 0.58 27.02 272,969 47,501,760

2016-08-12 2016-08-10 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 1,169,877 22,337,275 5.53 33.00 38,605,941 737,130,075

2016-08-12 2016-08-10 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 133,153 3,029,953 4.60 33.00 4,394,049 99,988,449

2016-07-06 2016-07-01 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 13,038 102,711 14.54 1.63 21,252 167,419

2016-07-06 2016-07-01 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 13,038 102,711 14.54 1.63 21,252 167,419

2016-07-06 2016-07-01 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 13,038 102,711 14.54 1.63 21,252 167,419

2016-07-06 2016-07-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 746 13,937,394 0.01 26.74 19,948 372,685,916

2016-07-06 2016-07-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 746 13,937,394 0.01 26.74 19,948 372,685,916

2016-07-06 2016-07-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 746 1,362,005 0.05 26.74 19,948 36,420,014

2016-07-06 2016-07-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 746 1,362,005 0.05 26.74 19,948 36,420,014

2016-07-06 2016-07-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 746 318,623 0.23 26.74 19,948 8,519,979

2016-07-06 2016-07-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 746 318,623 0.23 26.74 19,948 8,519,979

2016-07-05 2016-06-30 4 INCY INCYTE CORP
Common Stock A - Award 237 23,803,844 0.00 79.98 18,955 1,903,831,443

2016-07-05 2016-06-30 4 INCY INCYTE CORP
Common Stock A - Award 237 533,519 0.04 79.98 18,955 42,670,850

2016-07-05 2016-06-30 4 INCY INCYTE CORP
Common Stock A - Award 237 533,519 0.04 79.98 18,955 42,670,850

2016-06-15 2016-06-13 4 IDRA IDERA PHARMACEUTICALS, INC.
Non-Qualified Stock Option (right to buy) A - Award 70,000 70,000

2016-06-13 2016-06-10 4 ACAD ACADIA PHARMACEUTICALS INC
Non-Qualified Stock Option (right to buy) A - Award 26,500 26,500

2016-06-13 2016-06-10 4 GHDX GENOMIC HEALTH INC
Non-Qualified Stock Options (right to buy) A - Award 20,000 20,000

2016-06-09 2016-06-09 4 MRTX Mirati Therapeutics, Inc.
Common Stock S - Sale -2,318 30,003 -7.17 9.56 -22,157 286,787

2016-06-09 2016-06-09 4 MRTX Mirati Therapeutics, Inc.
Common Stock S - Sale -158,684 2,122,417 -6.96 9.56 -1,516,797 20,287,335

2016-06-09 2016-06-09 4 MRTX Mirati Therapeutics, Inc.
Common Stock S - Sale -9,056 116,778 -7.20 9.56 -86,563 1,116,234

2016-06-09 2016-06-09 4 MRTX Mirati Therapeutics, Inc.
Common Stock S - Sale -5,111 32,321 -13.65 9.40 -48,043 303,817

2016-06-09 2016-06-09 4 MRTX Mirati Therapeutics, Inc.
Common Stock S - Sale -349,919 2,281,101 -13.30 9.40 -3,289,239 21,442,349

2016-06-09 2016-06-09 4 MRTX Mirati Therapeutics, Inc.
Common Stock S - Sale -19,970 125,834 -13.70 9.40 -187,718 1,182,840

2016-06-09 2016-06-08 4 MRTX Mirati Therapeutics, Inc.
Common Stock S - Sale -2,154 37,432 -5.44 9.21 -19,844 344,839

2016-06-09 2016-06-08 4 MRTX Mirati Therapeutics, Inc.
Common Stock S - Sale -147,529 2,631,020 -5.31 9.21 -1,359,096 24,238,009

2016-06-09 2016-06-08 4 MRTX Mirati Therapeutics, Inc.
Common Stock S - Sale -8,417 145,804 -5.46 9.21 -77,541 1,343,205

2016-06-09 2016-06-07 4 MRTX Mirati Therapeutics, Inc.
Common Stock S - Sale -4,201 39,586 -9.59 9.44 -39,648 373,605

2016-06-09 2016-06-07 4 MRTX Mirati Therapeutics, Inc.
Common Stock S - Sale -275,506 2,778,549 -9.02 9.44 -2,600,171 26,223,390

2016-06-09 2016-06-07 4 MRTX Mirati Therapeutics, Inc.
Common Stock S - Sale -16,493 154,221 -9.66 9.44 -155,658 1,455,507

2016-05-31 2016-05-27 4 INCY INCYTE CORP
Non-Qualified Stock Options (right to buy) A - Award 15,000 15,000

2016-05-24 2016-05-20 4 SGEN SEATTLE GENETICS INC /WA
Non-Qualified Stock Options (right to buy) A - Award 9,260 9,260

2016-05-24 2016-05-20 4 SGEN SEATTLE GENETICS INC /WA
Non-Qualified Stock Options (right to buy) A - Award 9,260 9,260

2016-05-24 2016-05-20 4 SGEN SEATTLE GENETICS INC /WA
Common Stock A - Award 3,700 38,787,087 0.01 38.82 143,634 1,505,714,717

2016-05-24 2016-05-20 4 SGEN SEATTLE GENETICS INC /WA
Common Stock A - Award 3,700 38,787,087 0.01 38.82 143,634 1,505,714,717

2016-05-19 2016-05-17 4 GHDX GENOMIC HEALTH INC
Common Stock M - Exercise 8,250 13,932,918 0.06 10.73 88,522 149,500,210

2016-05-19 2016-05-17 4 GHDX GENOMIC HEALTH INC
Common Stock M - Exercise 8,250 13,932,918 0.06 10.73 88,522 149,500,210

2016-05-19 2016-05-17 4 GHDX GENOMIC HEALTH INC
Common Stock M - Exercise 8,250 13,932,918 0.06 10.73 88,522 149,500,210

2016-05-19 2016-05-17 4 GHDX GENOMIC HEALTH INC
Common Stock M - Exercise 8,250 13,932,918 0.06 10.73 88,522 149,500,210

2016-05-19 2016-05-17 4 GHDX GENOMIC HEALTH INC
Common Stock M - Exercise 8,250 13,932,918 0.06 10.73 88,522 149,500,210

2016-05-19 2016-05-17 4 GHDX GENOMIC HEALTH INC
Non-Qualified Stock Options (right to buy) M - Exercise -8,250 0 -100.00

2016-05-19 2016-05-17 4 GHDX GENOMIC HEALTH INC
Non-Qualified Stock Options (right to buy) M - Exercise -8,250 0 -100.00

2016-05-19 2016-05-17 4 GHDX GENOMIC HEALTH INC
Non-Qualified Stock Options (right to buy) M - Exercise -8,250 0 -100.00

2016-05-19 2016-05-17 4 GHDX GENOMIC HEALTH INC
Non-Qualified Stock Options (right to buy) M - Exercise -8,250 0 -100.00

2016-05-19 2016-05-17 4 GHDX GENOMIC HEALTH INC
Non-Qualified Stock Options (right to buy) M - Exercise -8,250 0 -100.00

2016-05-19 2016-05-17 4 GHDX GENOMIC HEALTH INC
Non-Qualified Stock Options (right to buy) M - Exercise -8,250 0 -100.00

2016-05-19 2016-05-17 4 GHDX GENOMIC HEALTH INC
Common Stock M - Exercise 8,250 317,877 2.66 10.73 88,522 3,410,820

2016-05-13 2016-05-11 4 ALXN ALEXION PHARMACEUTICALS INC
Non-Qualified Stock Option (right to buy) A - Award 2,294 2,294

2016-05-13 2016-05-11 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock A - Award 835 6,104,562 0.01

2016-05-13 2016-05-11 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock A - Award 835 6,104,562 0.01

2016-05-11 2016-05-11 4 NTLA Intellia Therapeutics, Inc.
Series B Preferred Stock C - Conversion -1,232,130 0 -100.00

2016-05-11 2016-05-11 4 NTLA Intellia Therapeutics, Inc.
Series B Preferred Stock C - Conversion -101,204 0 -100.00

2016-05-11 2016-05-11 4 NTLA Intellia Therapeutics, Inc.
Common Stock P - Purchase 179,531 976,214 22.53 18.00 3,231,558 17,571,852

2016-05-11 2016-05-11 4 NTLA Intellia Therapeutics, Inc.
Common Stock P - Purchase 20,469 85,906 31.28 18.00 368,442 1,546,308

2016-05-11 2016-05-11 4 NTLA Intellia Therapeutics, Inc.
Common Stock C - Conversion 796,683 796,683

2016-05-11 2016-05-11 4 NTLA Intellia Therapeutics, Inc.
Common Stock C - Conversion 65,437 65,437

2016-04-05 2016-04-01 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 10,788 7,110,113 0.15 1.97 21,252 14,006,923

2016-04-05 2016-04-01 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 10,788 89,673 13.68 1.97 21,252 176,656

2016-04-05 2016-04-01 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 10,788 89,673 13.68 1.97 21,252 176,656

2016-04-05 2016-04-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 784 13,883,418 0.01 25.48 19,976 353,749,491

2016-04-05 2016-04-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 784 13,883,418 0.01 25.48 19,976 353,749,491

2016-04-05 2016-04-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 784 13,883,418 0.01 25.48 19,976 353,749,491

2016-04-05 2016-04-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 784 13,883,418 0.01 25.48 19,976 353,749,491

2016-04-05 2016-04-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 784 309,627 0.25 25.48 19,976 7,889,296

2016-04-05 2016-04-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 784 309,627 0.25 25.48 19,976 7,889,296

2016-04-04 2016-03-31 4 INCY INCYTE CORP
Common Stock A - Award 262 533,282 0.05 72.47 18,987 38,646,947

2016-04-04 2016-03-31 4 INCY INCYTE CORP
Common Stock A - Award 262 533,282 0.05 72.47 18,987 38,646,947

2016-04-04 2016-03-31 4 INCY INCYTE CORP
Common Stock A - Award 262 533,282 0.05 72.47 18,987 38,646,947

2016-04-01 2016-03-30 4 MRTX Mirati Therapeutics, Inc.
Common Stock X - Other 137 3,268,830 0.00 6.74 923 22,031,914

2016-04-01 2016-03-30 4 MRTX Mirati Therapeutics, Inc.
Common Stock Warrants (right to buy) X - Other -3,479 0 -100.00

2016-04-01 2016-03-30 4 MRTX Mirati Therapeutics, Inc.
Common Stock Warrants (right to buy) X - Other -310,003 0 -100.00

2016-04-01 2016-03-30 4 MRTX Mirati Therapeutics, Inc.
Common Stock Warrants (right to buy) X - Other -137 0 -100.00

2016-04-01 2016-03-30 4 MRTX Mirati Therapeutics, Inc.
Common Stock Warrants (right to buy) X - Other -137 0 -100.00

2016-04-01 2016-03-30 4 MRTX Mirati Therapeutics, Inc.
Common Stock X - Other 3,479 43,787 8.63 6.74 23,448 295,124

2016-04-01 2016-03-30 4 MRTX Mirati Therapeutics, Inc.
Common Stock X - Other 310,003 3,054,055 11.30 6.74 2,089,420 20,584,331

2016-04-01 2016-03-30 4 MRTX Mirati Therapeutics, Inc.
Common Stock X - Other 137 137 6.74 923 923

2016-04-01 2016-04-01 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 262,253 21,167,398 1.25 28.55 7,486,904 604,295,345

2016-04-01 2016-04-01 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 28,647 2,896,800 1.00 28.55 817,826 82,699,005

2016-04-01 2016-04-01 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 10,818 20,905,145 0.05 27.82 300,959 581,585,315

2016-04-01 2016-04-01 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 1,182 2,868,153 0.04 27.82 32,883 79,792,590

2016-04-01 2016-03-31 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 318,969 20,894,327 1.55 27.72 8,840,959 579,134,330

2016-04-01 2016-03-31 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 34,844 2,866,971 1.23 27.72 965,782 79,464,695

2016-04-01 2016-03-31 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 60,587 20,575,358 0.30 27.56 1,669,705 567,032,176

2016-04-01 2016-03-31 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 6,618 2,832,127 0.23 27.56 182,384 78,050,022

2016-04-01 2016-03-31 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 28,433 20,514,771 0.14 26.55 755,024 544,759,487

2016-04-01 2016-03-31 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 3,106 2,825,509 0.11 26.55 82,478 75,029,979

2016-04-01 2016-03-31 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 180,122 20,486,338 0.89 26.49 4,772,224 542,773,234

2016-04-01 2016-03-31 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 19,676 2,822,403 0.70 26.49 521,304 74,777,874

2016-04-01 2016-03-31 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 13,433 20,306,216 0.07 26.28 353,086 533,748,888

2016-04-01 2016-03-31 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 1,467 2,802,727 0.05 26.28 38,560 73,669,679

2016-04-01 2016-03-31 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 14,775 20,292,783 0.07 25.61 378,343 519,637,294

2016-04-01 2016-03-31 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 1,614 2,801,260 0.06 25.61 41,330 71,731,865

2016-04-01 2016-03-30 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 16,057 2,799,646 0.58 26.35 423,057 73,762,833

2016-04-01 2016-03-30 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 37,882 2,783,589 1.38 25.98 983,985 72,303,724

2016-04-01 2016-03-30 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 408,607 2,745,707 17.48 25.92 10,593,014 71,181,630

2016-03-21 2016-03-17 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 92,140 38,783,387 0.24 31.73 2,923,547 1,230,573,599

2016-03-21 2016-03-17 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 10,034 4,496,280 0.22 31.73 318,373 142,664,267

2016-03-21 2016-03-17 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 19,741 38,691,247 0.05 32.41 639,713 1,253,801,466

2016-03-21 2016-03-17 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 2,150 4,486,246 0.05 32.41 69,671 145,378,148

2016-03-17 2016-03-17 4 INCY INCYTE CORP
Common Stock M - Exercise 20,000 206,421,153 0.01 3.86 77,200 796,785,651

2016-03-17 2016-03-17 4 INCY INCYTE CORP
Non-Qualified Stock Options (right to buy) M - Exercise -20,000 0 -100.00

2016-03-17 2016-03-17 4 INCY INCYTE CORP
Non-Qualified Stock Options (right to buy) M - Exercise -20,000 0 -100.00

2016-03-17 2016-03-17 4 INCY INCYTE CORP
Non-Qualified Stock Options (right to buy) M - Exercise -20,000 0 -100.00

2016-03-17 2016-03-17 4 INCY INCYTE CORP
Common Stock P - Purchase 90,179 19,757,285 0.46 62.59 5,644,024 1,236,547,221

2016-03-17 2016-03-17 4 INCY INCYTE CORP
Common Stock P - Purchase 9,821 3,358,951 0.29 62.59 614,666 210,226,330

2016-03-17 2016-03-17 4 INCY INCYTE CORP
Common Stock P - Purchase 127,964 19,667,106 0.65 61.38 7,854,149 1,207,123,699

2016-03-17 2016-03-17 4 INCY INCYTE CORP
Common Stock P - Purchase 13,936 3,349,130 0.42 61.38 855,361 205,562,231

2016-03-17 2016-03-17 4 INCY INCYTE CORP
Common Stock P - Purchase 24,431 19,539,142 0.13 61.03 1,490,975 1,192,434,758

2016-03-17 2016-03-17 4 INCY INCYTE CORP
Common Stock P - Purchase 2,660 3,335,194 0.08 61.03 162,334 203,540,219

2016-03-17 2016-03-17 4 INCY INCYTE CORP
Common Stock P - Purchase 20,659 19,514,711 0.11 60.95 1,259,178 1,189,433,344

2016-03-17 2016-03-17 4 INCY INCYTE CORP
Common Stock P - Purchase 2,250 3,332,534 0.07 60.95 137,139 203,119,947

2016-03-17 2016-03-17 4 INCY INCYTE CORP
Common Stock P - Purchase 97,484 19,494,052 0.50 60.85 5,931,960 1,186,224,761

2016-03-17 2016-03-17 4 INCY INCYTE CORP
Common Stock P - Purchase 10,616 3,330,284 0.32 60.85 645,990 202,649,780

2016-03-17 2016-03-17 4 INCY INCYTE CORP
Common Stock M - Exercise 20,000 533,020 3.90 3.86 77,200 2,057,457

2016-03-17 2016-03-17 4 INCY INCYTE CORP
Common Stock M - Exercise 20,000 533,020 3.90 3.86 77,200 2,057,457

2016-03-17 2016-03-15 4 INCY INCYTE CORP
Common Stock P - Purchase 1,182 19,376,568 0.01 65.29 77,176 1,265,142,628

2016-03-17 2016-03-15 4 INCY INCYTE CORP
Common Stock P - Purchase 129 3,299,668 0.00 65.29 8,423 215,443,243

2016-03-17 2016-03-15 4 INCY INCYTE CORP
Common Stock P - Purchase 179,176 19,375,386 0.93 65.80 11,789,387 1,274,857,773

2016-03-17 2016-03-15 4 INCY INCYTE CORP
Common Stock P - Purchase 19,513 3,299,539 0.59 65.80 1,283,912 217,102,407

2016-03-17 2016-03-15 4 INCY INCYTE CORP
Common Stock P - Purchase 180,358 19,196,210 0.95 67.15 12,110,607 1,288,979,431

2016-03-17 2016-03-15 4 INCY INCYTE CORP
Common Stock P - Purchase 19,642 3,280,026 0.60 67.15 1,318,913 220,245,874

2016-03-16 2016-03-16 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 198,484 38,671,506 0.52 31.60 6,272,531 1,222,104,667

2016-03-16 2016-03-16 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 21,616 4,484,096 0.48 31.60 683,113 141,707,299

2016-03-16 2016-03-16 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 32,810 38,473,022 0.09 31.86 1,045,205 1,225,608,131

2016-03-16 2016-03-16 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 3,573 4,462,480 0.08 31.86 113,823 142,158,102

2016-03-16 2016-03-16 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 8,627 38,440,212 0.02 31.50 271,712 1,210,693,697

2016-03-16 2016-03-16 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 940 4,458,907 0.02 31.50 29,606 140,435,505

2016-03-16 2016-03-16 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 273,381 38,431,585 0.72 31.89 8,719,077 1,225,717,756

2016-03-16 2016-03-16 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 29,772 4,457,967 0.67 31.89 949,533 142,180,171

2016-03-16 2016-03-15 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 145,272 38,158,204 0.38 31.74 4,611,296 1,211,236,790

2016-03-16 2016-03-15 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 15,821 4,428,195 0.36 31.74 502,198 140,561,980

2016-03-16 2016-03-15 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 63,560 38,012,932 0.17 31.50 2,002,401 1,197,563,211

2016-03-16 2016-03-15 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 6,922 4,412,374 0.16 31.50 218,071 139,007,872

2016-03-16 2016-03-15 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 387,336 37,949,372 1.03 32.31 12,514,051 1,226,068,311

2016-03-16 2016-03-15 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 42,182 4,405,452 0.97 32.31 1,362,816 142,331,343

2016-03-16 2016-03-14 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 107,260 37,562,036 0.29 33.77 3,622,063 1,268,432,394

2016-03-16 2016-03-14 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 11,681 4,363,270 0.27 33.77 394,456 147,343,265

2016-03-16 2016-03-16 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 128,975 6,928,119 1.90 8.16 1,051,920 56,505,739

2016-03-16 2016-03-16 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 14,046 824,368 1.73 8.16 114,559 6,723,545

2016-03-16 2016-03-16 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 185,413 6,799,144 2.80 7.91 1,466,320 53,770,350

2016-03-16 2016-03-16 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 20,192 810,322 2.56 7.91 159,686 6,408,351

2016-03-16 2016-03-16 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 11,840 6,613,731 0.18 7.70 91,160 50,921,099

2016-03-16 2016-03-16 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 1,289 790,130 0.16 7.70 9,924 6,083,448

2016-03-16 2016-03-15 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 68,132 6,601,891 1.04 8.03 546,807 52,984,797

2016-03-16 2016-03-15 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 7,420 788,841 0.95 8.03 59,551 6,331,001

2016-03-16 2016-03-15 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 30,986 6,533,759 0.48 7.88 244,126 51,476,874

2016-03-16 2016-03-15 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 3,374 781,421 0.43 7.88 26,582 6,156,503

2016-03-11 2016-03-11 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 4,874 37,454,776 0.01 32.34 157,646 1,211,448,511

2016-03-11 2016-03-11 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 547 4,351,589 0.01 32.34 17,692 140,749,100

2016-03-11 2016-03-11 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 147,831 37,449,902 0.40 33.15 4,900,997 1,241,565,366

2016-03-11 2016-03-11 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 16,608 4,351,042 0.38 33.15 550,600 144,248,790

2016-03-11 2016-03-11 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 23,289 37,302,071 0.06 32.96 767,582 1,229,438,958

2016-03-11 2016-03-11 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 2,616 4,334,434 0.06 32.96 86,221 142,858,610

2016-03-11 2016-03-10 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 95,682 37,278,782 0.26 32.41 3,100,652 1,208,048,754

2016-03-11 2016-03-10 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 10,749 4,331,818 0.25 32.41 348,330 140,376,028

2016-03-11 2016-03-10 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 165,237 37,183,100 0.45 32.30 5,337,915 1,201,185,172

2016-03-11 2016-03-10 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 18,563 4,321,069 0.43 32.30 599,670 139,590,406

2016-03-11 2016-03-09 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 36,589 37,017,863 0.10 31.15 1,139,842 1,153,202,679

2016-03-11 2016-03-09 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 4,111 4,302,506 0.10 31.15 128,068 134,034,248

2016-03-11 2016-03-09 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 97,272 36,981,274 0.26 32.12 3,124,484 1,187,879,200

2016-03-11 2016-03-09 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 10,927 4,298,395 0.25 32.12 350,987 138,069,176

2016-03-11 2016-03-09 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 53,734 36,884,002 0.15 32.47 1,744,598 1,197,523,958

2016-03-11 2016-03-09 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 6,037 4,287,468 0.14 32.47 196,005 139,202,510

2016-03-08 2016-03-08 4 SGEN SEATTLE GENETICS INC /WA
Common Stock M - Exercise 10,000 286,671,473 0.00 4.18 41,800 1,198,286,757

2016-03-08 2016-03-08 4 SGEN SEATTLE GENETICS INC /WA
Non-Qualified Stock Options (right to buy) M - Exercise -10,000 0 -100.00

2016-03-08 2016-03-08 4 SGEN SEATTLE GENETICS INC /WA
Non-Qualified Stock Options (right to buy) M - Exercise -10,000 0 -100.00

2016-03-08 2016-03-08 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 88,732 36,830,268 0.24

2016-03-08 2016-03-08 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 9,968 4,281,431 0.23

2016-03-08 2016-03-08 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 48,996 36,741,536 0.13

2016-03-08 2016-03-08 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 5,504 4,271,463 0.13

2016-03-08 2016-03-08 4 SGEN SEATTLE GENETICS INC /WA
Common Stock M - Exercise 10,000 36,692,540 0.03 4.18 41,800 153,374,817

2016-03-08 2016-03-07 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 14,157 36,682,540 0.04 33.72 477,445 1,237,118,662

2016-03-08 2016-03-07 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 1,590 4,255,959 0.04 33.72 53,623 143,532,217

2016-03-08 2016-03-07 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 40,921 36,668,383 0.11 33.68 1,378,043 1,234,833,465

2016-03-08 2016-03-07 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 4,597 4,254,369 0.11 33.68 154,807 143,268,854

2016-03-08 2016-03-04 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 218,550 36,627,462 0.60 32.49 7,101,280 1,190,125,135

2016-03-08 2016-03-04 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 23,908 4,249,772 0.57 32.49 776,835 138,086,567

2016-03-08 2016-03-04 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 41,104 36,408,912 0.11 31.68 1,302,257 1,153,507,150

2016-03-08 2016-03-04 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 4,496 4,225,864 0.11 31.68 142,442 133,883,823

2016-03-02 2016-03-02 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 59,492 36,367,808 0.16 32.24 1,918,022 1,172,498,130

2016-03-02 2016-03-02 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 6,508 4,221,368 0.15 32.24 209,818 136,096,904

2016-03-02 2016-03-02 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 301,066 36,308,316 0.84 32.76 9,862,139 1,189,366,031

2016-03-02 2016-03-02 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 32,934 4,214,860 0.79 32.76 1,078,832 138,067,855

2016-03-02 2016-03-01 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 21,814 36,007,250 0.06 31.24 681,563 1,125,021,321

2016-03-02 2016-03-01 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 2,386 4,181,926 0.06 31.24 74,549 130,661,351

2016-03-02 2016-02-29 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 172,462 35,985,436 0.48 30.34 5,232,928 1,091,888,092

2016-03-02 2016-02-29 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 18,866 4,179,540 0.45 30.34 572,442 126,817,692

2016-03-02 2016-02-29 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 54,439 35,812,974 0.15 30.55 1,663,024 1,094,029,055

2016-03-02 2016-02-29 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 5,955 4,160,674 0.14 30.55 181,916 127,101,934

2016-02-26 2016-02-25 4 INCY INCYTE CORP
Common Stock P - Purchase 6,022 19,015,852 0.03 74.00 445,628 1,407,173,048

2016-02-26 2016-02-25 4 INCY INCYTE CORP
Common Stock P - Purchase 678 3,260,384 0.02 74.00 50,172 241,268,416

2016-02-26 2016-02-24 4 INCY INCYTE CORP
Common Stock P - Purchase 20,492 19,009,830 0.11 69.70 1,428,282 1,324,975,646

2016-02-26 2016-02-24 4 INCY INCYTE CORP
Common Stock P - Purchase 2,308 3,259,706 0.07 69.70 160,866 227,199,878

2016-02-26 2016-02-24 4 INCY INCYTE CORP
Common Stock P - Purchase 23,157 18,989,338 0.12 70.50 1,632,684 1,338,843,276

2016-02-26 2016-02-24 4 INCY INCYTE CORP
Common Stock P - Purchase 2,608 3,257,398 0.08 70.50 183,877 229,662,846

2016-02-26 2016-02-24 4 INCY INCYTE CORP
Common Stock P - Purchase 8,111 18,966,181 0.04 71.96 583,702 1,364,886,043

2016-02-26 2016-02-24 4 INCY INCYTE CORP
Common Stock P - Purchase 914 3,254,790 0.03 71.96 65,775 234,228,359

2016-02-26 2016-02-26 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 39,815 35,758,535 0.11 30.13 1,199,793 1,077,554,845

2016-02-26 2016-02-26 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 4,485 4,154,719 0.11 30.13 135,152 125,199,133

2016-02-26 2016-02-25 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 128,255 35,718,720 0.36 29.86 3,830,118 1,066,678,851

2016-02-26 2016-02-25 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 14,447 4,150,234 0.35 29.86 431,435 123,939,683

2016-02-26 2016-02-24 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 67,407 35,590,465 0.19 28.52 1,922,670 1,015,157,510

2016-02-26 2016-02-24 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 7,593 4,135,787 0.18 28.52 216,577 117,966,293

2016-02-26 2016-02-24 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 4,134 35,523,058 0.01 28.46 117,674 1,011,163,846

2016-02-26 2016-02-24 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 466 4,128,194 0.01 28.46 13,265 117,509,042

2016-02-26 2016-02-24 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 43,056 35,518,924 0.12 29.77 1,281,975 1,057,561,755

2016-02-26 2016-02-24 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 4,850 4,127,728 0.12 29.77 144,407 122,901,450

2016-02-22 2016-02-22 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 218,768 35,475,868 0.62 30.21 6,610,053 1,071,899,804

2016-02-22 2016-02-22 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 24,643 4,122,878 0.60 30.21 744,586 124,572,346

2016-02-22 2016-02-19 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 456,849 35,257,100 1.31 29.20 13,339,991 1,029,507,320

2016-02-22 2016-02-19 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 49,677 4,098,235 1.23 29.20 1,450,568 119,668,462

2016-02-22 2016-02-18 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 226,865 34,800,251 0.66 29.94 6,791,816 1,041,839,474

2016-02-22 2016-02-18 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 24,669 4,048,558 0.61 29.94 738,533 121,204,515

2016-02-17 2016-02-17 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 726,291 34,573,386 2.15 31.25 22,694,197 1,080,304,220

2016-02-17 2016-02-17 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 78,976 4,023,889 2.00 31.25 2,467,739 125,733,252

2016-02-17 2016-02-16 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 902 33,847,095 0.00 29.50 26,609 998,489,302

2016-02-17 2016-02-16 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 98 3,944,913 0.00 29.50 2,891 116,374,934

2016-02-17 2016-02-16 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 106,444 33,846,193 0.32 29.19 3,107,590 988,126,066

2016-02-17 2016-02-16 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 11,575 3,944,815 0.29 29.19 337,927 115,167,296

2016-02-17 2016-02-16 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 151,144 33,739,749 0.45 30.27 4,574,645 1,021,194,235

2016-02-17 2016-02-12 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 16,435 3,933,240 0.42 30.27 497,435 119,046,588

2016-02-17 2016-02-12 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 631 33,588,605 0.00 27.93 17,626 938,227,145

2016-02-17 2016-02-12 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 69 3,916,805 0.00 27.93 1,927 109,407,722

2016-02-17 2016-02-12 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 72,073 33,587,974 0.22 27.28 1,966,043 916,229,549

2016-02-17 2016-02-12 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 7,909 3,916,736 0.20 27.28 215,746 106,842,683

2016-02-17 2016-02-12 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 87,049 33,515,901 0.26 28.07 2,443,831 940,932,108

2016-02-17 2016-02-12 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 9,551 3,908,827 0.24 28.07 268,137 109,737,191

2016-02-16 2016-02-16 4 INCY INCYTE CORP
Common Stock P - Purchase 15,187 18,958,070 0.08 69.45 1,054,742 1,316,643,649

2016-02-16 2016-02-16 4 INCY INCYTE CORP
Common Stock P - Purchase 1,651 3,253,876 0.05 69.45 114,662 225,982,664

2016-02-16 2016-02-16 4 INCY INCYTE CORP
Common Stock P - Purchase 8,250 18,942,883 0.04 70.86 584,597 1,342,296,478

2016-02-16 2016-02-16 4 INCY INCYTE CORP
Common Stock P - Purchase 897 3,252,225 0.03 70.86 63,562 230,453,314

2016-02-16 2016-02-16 4 INCY INCYTE CORP
Common Stock P - Purchase 67,373 18,934,633 0.36 69.54 4,684,923 1,316,659,468

2016-02-16 2016-02-16 4 INCY INCYTE CORP
Common Stock P - Purchase 7,326 3,251,328 0.23 69.54 509,429 226,087,920

2016-02-16 2016-02-16 4 INCY INCYTE CORP
Common Stock P - Purchase 124,057 18,867,260 0.66 70.21 8,710,228 1,324,698,625

2016-02-16 2016-02-16 4 INCY INCYTE CORP
Common Stock P - Purchase 13,490 3,244,002 0.42 70.21 947,153 227,766,246

2016-02-16 2016-02-16 4 INCY INCYTE CORP
Common Stock P - Purchase 397,079 18,743,203 2.16 71.10 28,233,945 1,332,718,580

2016-02-16 2016-02-16 4 INCY INCYTE CORP
Common Stock P - Purchase 43,178 3,230,512 1.35 71.10 3,070,133 229,702,648

2016-02-16 2016-02-12 4 INCY INCYTE CORP
Common Stock P - Purchase 149,927 18,346,124 0.82 67.94 10,186,595 1,246,503,545

2016-02-16 2016-02-12 4 INCY INCYTE CORP
Common Stock P - Purchase 16,450 3,187,334 0.52 67.94 1,117,674 216,559,265

2016-02-16 2016-02-12 4 INCY INCYTE CORP
Common Stock P - Purchase 38,117 18,196,197 0.21 63.98 2,438,547 1,164,107,162

2016-02-16 2016-02-12 4 INCY INCYTE CORP
Common Stock P - Purchase 4,183 3,170,884 0.13 63.98 267,609 202,858,255

2016-02-16 2016-02-12 4 INCY INCYTE CORP
Common Stock P - Purchase 168,055 18,158,080 0.93 64.87 10,902,350 1,177,981,834

2016-02-16 2016-02-12 4 INCY INCYTE CORP
Common Stock P - Purchase 18,441 3,166,701 0.59 64.87 1,196,336 205,435,611

2016-02-16 2016-02-12 4 INCY INCYTE CORP
Common Stock P - Purchase 541,340 17,990,025 3.10 65.80 35,621,958 1,183,803,012

2016-02-16 2016-02-12 4 INCY INCYTE CORP
Common Stock P - Purchase 59,401 3,148,260 1.92 65.80 3,908,782 207,165,897

2016-02-16 2016-02-12 4 INCY INCYTE CORP
Common Stock P - Purchase 49,021 17,448,685 0.28 66.68 3,268,823 1,163,514,958

2016-02-16 2016-02-12 4 INCY INCYTE CORP
Common Stock P - Purchase 5,379 3,088,859 0.17 66.68 358,683 205,971,605

2016-02-16 2016-02-12 4 INCY INCYTE CORP
Common Stock P - Purchase 72,894 17,399,664 0.42 67.68 4,933,706 1,177,666,678

2016-02-16 2016-02-12 4 INCY INCYTE CORP
Common Stock P - Purchase 7,999 3,083,480 0.26 67.68 541,399 208,700,102

2016-02-16 2016-02-11 4 INCY INCYTE CORP
Common Stock P - Purchase 6,939 17,326,770 0.04 60.85 422,220 1,054,288,905

2016-02-16 2016-02-11 4 INCY INCYTE CORP
Common Stock P - Purchase 761 3,075,481 0.02 60.85 46,305 187,135,023

2016-02-16 2016-02-11 4 INCY INCYTE CORP
Common Stock P - Purchase 57,865 17,319,831 0.34 61.73 3,572,047 1,069,165,292

2016-02-16 2016-02-11 4 INCY INCYTE CORP
Common Stock P - Purchase 6,349 3,074,720 0.21 61.73 391,928 189,804,618

2016-02-16 2016-02-11 4 INCY INCYTE CORP
Common Stock P - Purchase 136,793 17,261,966 0.80 58.13 7,952,133 1,003,482,965

2016-02-16 2016-02-11 4 INCY INCYTE CORP
Common Stock P - Purchase 15,010 3,068,371 0.49 58.13 872,570 178,372,384

2016-02-16 2016-02-11 4 INCY INCYTE CORP
Common Stock P - Purchase 114,908 17,125,173 0.68 59.01 6,780,526 1,010,527,346

2016-02-16 2016-02-11 4 INCY INCYTE CORP
Common Stock P - Purchase 12,609 3,053,361 0.41 59.01 744,036 180,173,642

2016-02-16 2016-02-11 4 INCY INCYTE CORP
Common Stock P - Purchase 65,309 17,010,265 0.39 60.40 3,944,513 1,027,380,882

2016-02-16 2016-02-11 4 INCY INCYTE CORP
Common Stock P - Purchase 7,166 3,040,752 0.24 60.40 432,810 183,654,427

2016-02-16 2016-02-11 4 INCY INCYTE CORP
Common Stock P - Purchase 113,546 16,944,956 0.67 61.40 6,971,475 1,040,383,019

2016-02-16 2016-02-11 4 INCY INCYTE CORP
Common Stock P - Purchase 12,459 3,033,586 0.41 61.40 764,955 186,255,507

2016-02-16 2016-02-11 4 INCY INCYTE CORP
Common Stock P - Purchase 289,755 16,831,410 1.75 62.56 18,126,986 1,052,967,960

2016-02-16 2016-02-11 4 INCY INCYTE CORP
Common Stock P - Purchase 31,795 3,021,127 1.06 62.56 1,989,086 189,000,799

2016-02-16 2016-02-11 4 INCY INCYTE CORP
Common Stock P - Purchase 176,647 16,541,655 1.08 63.37 11,194,368 1,048,267,836

2016-02-16 2016-02-11 4 INCY INCYTE CORP
Common Stock P - Purchase 19,383 2,989,332 0.65 63.37 1,228,328 189,438,154

2016-02-16 2016-02-11 4 INCY INCYTE CORP
Common Stock P - Purchase 235,734 16,365,008 1.46 64.46 15,195,814 1,054,916,236

2016-02-16 2016-02-11 4 INCY INCYTE CORP
Common Stock P - Purchase 25,869 2,969,949 0.88 64.46 1,667,560 191,447,961

2016-02-09 2016-02-05 4 BCRX BIOCRYST PHARMACEUTICALS INC
Common Stock P - Purchase 45,000 12,894,240 0.35 6.33 284,656 81,565,094

2016-02-09 2016-02-08 4 BGNE BeiGene, Ltd.
Ordinary stock warrant (right to buy) X - Other -56,853 0 -100.00

2016-02-09 2016-02-08 4 BGNE BeiGene, Ltd.
Ordinary stock warrant (right to buy) X - Other -2,296,890 0 -100.00

2016-02-09 2016-02-08 4 BGNE BeiGene, Ltd.
Ordinary stock warrant (right to buy) X - Other -238,850 0 -100.00

2016-02-09 2016-02-08 4 BGNE BeiGene, Ltd.
Series A-2 Preferred shares C - Conversion -26,292,961 0 -100.00

2016-02-09 2016-02-08 4 BGNE BeiGene, Ltd.
Series A-2 Preferred shares C - Conversion -1,912,167 0 -100.00

2016-02-09 2016-02-08 4 BGNE BeiGene, Ltd.
Series A Preferred shares C - Conversion -582,747 0 -100.00

2016-02-09 2016-02-08 4 BGNE BeiGene, Ltd.
Series A Preferred shares C - Conversion -44,572,171 0 -100.00

2016-02-09 2016-02-08 4 BGNE BeiGene, Ltd.
Series A Preferred shares C - Conversion -4,382,118 0 -100.00

2016-02-09 2016-02-08 4 BGNE BeiGene, Ltd.
American Depositary Shares P - Purchase 1,723,306 1,723,306 24.00 41,359,344 41,359,344

2016-02-09 2016-02-08 4 BGNE BeiGene, Ltd.
American Depositary Shares P - Purchase 189,374 189,374 24.00 4,544,976 4,544,976

2016-02-09 2016-02-08 4 BGNE BeiGene, Ltd.
Ordinary shares X - Other 56,853 639,600 9.76 0.68 38,376 431,730

2016-02-09 2016-02-08 4 BGNE BeiGene, Ltd.
Ordinary shares X - Other 2,296,890 73,162,022 3.24 0.68 1,550,401 49,384,365

2016-02-09 2016-02-08 4 BGNE BeiGene, Ltd.
Ordinary shares X - Other 238,850 6,533,135 3.79 0.68 161,224 4,409,866

2016-02-09 2016-02-08 4 BGNE BeiGene, Ltd.
Ordinary shares C - Conversion 26,292,961 70,865,132 58.99

2016-02-09 2016-02-08 4 BGNE BeiGene, Ltd.
Ordinary shares C - Conversion 1,912,167 6,294,285 43.64

2016-02-09 2016-02-08 4 BGNE BeiGene, Ltd.
Ordinary shares C - Conversion 582,747 582,747

2016-02-09 2016-02-08 4 BGNE BeiGene, Ltd.
Ordinary shares C - Conversion 44,572,171 44,572,171

2016-02-09 2016-02-08 4 BGNE BeiGene, Ltd.
Ordinary shares C - Conversion 4,382,118 4,382,118

2016-02-04 2016-02-04 4 BCRX BIOCRYST PHARMACEUTICALS INC
Common Stock P - Purchase 24,800 12,849,240 0.19 6.65 164,915 85,444,876

2016-02-04 2016-02-03 4 BCRX BIOCRYST PHARMACEUTICALS INC
Common Stock P - Purchase 91,187 12,824,440 0.72 6.29 573,311 80,629,819

2016-02-04 2016-02-02 4 BCRX BIOCRYST PHARMACEUTICALS INC
Common Stock P - Purchase 91,728 12,733,253 0.73 6.52 598,360 83,061,556

2016-01-29 2016-01-28 4 BCRX BIOCRYST PHARMACEUTICALS INC
Common Stock P - Purchase 25,000 12,641,525 0.20 6.88 172,015 86,981,277

2016-01-29 2016-01-27 4 BCRX BIOCRYST PHARMACEUTICALS INC
Common Stock P - Purchase 63,345 12,616,525 0.50 6.98 441,971 88,028,018

2016-01-26 2016-01-26 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 3,581 6,502,773 0.06 11.00 39,377 71,504,492

2016-01-26 2016-01-26 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 395 778,047 0.05 11.00 4,343 8,555,405

2016-01-26 2016-01-26 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 66,345 6,499,192 1.03 10.80 716,745 70,212,721

2016-01-26 2016-01-26 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 7,318 777,652 0.95 10.80 79,059 8,401,208

2016-01-26 2016-01-25 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 2,522 6,432,847 0.04 11.20 28,257 72,075,548

2016-01-26 2016-01-25 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 278 770,334 0.04 11.20 3,115 8,631,053

2016-01-26 2016-01-25 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 4,503 6,430,325 0.07 10.98 49,423 70,576,032

2016-01-26 2016-01-25 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 497 770,056 0.06 10.98 5,455 8,451,750

2016-01-26 2016-01-25 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 2,833 6,425,822 0.04 11.23 31,822 72,178,688

2016-01-26 2016-01-25 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 312 769,559 0.04 11.23 3,505 8,644,148

2016-01-26 2016-01-22 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 25,650 6,422,989 0.40 10.69 274,219 68,666,891

2016-01-26 2016-01-22 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 2,810 769,247 0.37 10.69 30,041 8,223,866

2016-01-26 2016-01-22 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 156 6,397,339 0.00 10.60 1,654 67,811,793

2016-01-26 2016-01-22 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 17 766,437 0.00 10.60 180 8,124,232

2016-01-26 2016-01-22 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 4,021 6,397,183 0.06 10.69 42,999 68,409,556

2016-01-26 2016-01-22 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 440 766,420 0.06 10.69 4,705 8,195,866

2016-01-26 2016-01-22 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 17,221 6,393,162 0.27 10.78 185,666 68,927,237

2016-01-26 2016-01-22 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 1,887 765,980 0.25 10.78 20,345 8,258,337

2016-01-25 2016-01-22 4 BCRX BIOCRYST PHARMACEUTICALS INC
Common Stock P - Purchase 3,200 12,553,180 0.03 7.00 22,389 87,829,579

2016-01-25 2016-01-21 4 BCRX BIOCRYST PHARMACEUTICALS INC
Common Stock P - Purchase 103,600 12,549,980 0.83 7.29 755,368 91,504,414

2016-01-20 2016-01-20 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 1,734 6,375,941 0.03 8.90 15,433 56,745,875

2016-01-20 2016-01-20 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 190 764,093 0.02 8.90 1,691 6,800,428

2016-01-20 2016-01-20 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 27,996 6,374,207 0.44 8.96 250,766 57,095,047

2016-01-20 2016-01-20 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 3,067 763,903 0.40 8.96 27,472 6,842,432

2016-01-20 2016-01-20 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 13,789 6,346,211 0.22 8.96 123,493 56,836,031

2016-01-20 2016-01-20 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 1,511 760,836 0.20 8.96 13,532 6,813,971

2016-01-20 2016-01-20 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 57,453 6,332,422 0.92 9.89 567,934 62,597,258

2016-01-20 2016-01-20 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 6,294 759,325 0.84 9.89 62,217 7,506,079

2016-01-20 2016-01-19 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 14,313 6,274,969 0.23 9.15 131,017 57,439,184

2016-01-20 2016-01-19 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 1,568 753,031 0.21 9.15 14,353 6,893,020

2016-01-20 2016-01-19 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 10,123 6,260,656 0.16 9.21 93,282 57,691,319

2016-01-20 2016-01-19 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 1,109 751,463 0.15 9.21 10,219 6,924,656

2016-01-20 2016-01-19 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 45,903 6,250,533 0.74 9.08 416,602 56,727,962

2016-01-20 2016-01-19 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 5,029 750,354 0.67 9.08 45,642 6,809,988

2016-01-20 2016-01-20 4 BCRX BIOCRYST PHARMACEUTICALS INC
Comon Stock P - Purchase 1,325 12,446,380 0.01 6.94 9,197 86,396,547

2016-01-20 2016-01-20 4 BCRX BIOCRYST PHARMACEUTICALS INC
Comon Stock P - Purchase 51,370 12,445,055 0.41 6.87 352,974 85,512,462

2016-01-20 2016-01-19 4 BCRX BIOCRYST PHARMACEUTICALS INC
Common Stock P - Purchase 92,200 12,393,685 0.75 7.12 656,750 88,281,458

2016-01-20 2016-01-15 4 BCRX BIOCRYST PHARMACEUTICALS INC
Common Stock P - Purchase 25,000 12,301,485 0.20 7.49 187,332 92,178,718

2016-01-20 2016-01-15 4 BCRX BIOCRYST PHARMACEUTICALS INC
Common Stock P - Purchase 175,000 12,276,485 1.45 7.45 1,303,890 91,469,634

2016-01-15 2016-01-15 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 47,193 6,204,630 0.77 8.56 403,930 53,106,049

2016-01-15 2016-01-15 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 5,196 745,325 0.70 8.56 44,473 6,379,311

2016-01-15 2016-01-15 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 4,949 6,157,437 0.08 8.95 44,308 55,126,918

2016-01-15 2016-01-15 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 545 740,129 0.07 8.95 4,879 6,626,301

2016-01-15 2016-01-15 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 3,279 6,152,488 0.05 8.82 28,937 54,295,091

2016-01-15 2016-01-15 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 361 739,584 0.05 8.82 3,186 6,526,755

2016-01-15 2016-01-15 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 20,851 6,149,209 0.34 8.10 168,891 49,807,978

2016-01-15 2016-01-15 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 2,296 739,223 0.31 8.10 18,597 5,987,632

2016-01-15 2016-01-14 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 2,998 6,128,358 0.05 8.08 24,213 49,495,071

2016-01-15 2016-01-14 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 330 736,927 0.04 8.08 2,665 5,951,717

2016-01-15 2016-01-14 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 12,706 6,125,360 0.21 7.91 100,517 48,457,723

2016-01-15 2016-01-14 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 1,399 736,597 0.19 7.91 11,067 5,827,219

2016-01-15 2016-01-14 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 90,550 6,112,654 1.50 8.17 739,947 49,950,775

2016-01-15 2016-01-14 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 9,970 735,198 1.37 8.17 81,472 6,007,817

2016-01-15 2016-01-15 4/A AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 47,193 6,204,630 0.77 8.56 403,930 53,106,049

2016-01-15 2016-01-15 4/A AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 5,196 745,325 0.70 8.56 44,473 6,379,311

2016-01-15 2016-01-15 4/A AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 4,949 6,157,437 0.08 8.95 44,308 55,126,918

2016-01-15 2016-01-15 4/A AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 545 740,129 0.07 8.95 4,879 6,626,301

2016-01-15 2016-01-15 4/A AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 3,279 6,152,488 0.05 8.82 28,937 54,295,091

2016-01-15 2016-01-15 4/A AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 361 739,584 0.05 8.82 3,186 6,526,755

2016-01-15 2016-01-15 4/A AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 20,851 6,149,209 0.34 8.10 168,891 49,807,978

2016-01-15 2016-01-15 4/A AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 2,296 739,223 0.31 8.10 18,597 5,987,632

2016-01-15 2016-01-14 4/A AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 2,998 6,128,358 0.05 8.08 24,213 49,495,071

2016-01-15 2016-01-14 4/A AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 330 736,927 0.04 8.08 2,665 5,951,717

2016-01-15 2016-01-14 4/A AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 12,706 6,125,360 0.21 7.91 100,517 48,457,723

2016-01-15 2016-01-14 4/A AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 1,399 736,597 0.19 7.91 11,067 5,827,219

2016-01-15 2016-01-14 4/A AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 90,550 6,112,654 1.50 8.17 739,947 49,950,775

2016-01-15 2016-01-14 4/A AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 9,970 735,198 1.37 8.17 81,472 6,007,817

2016-01-08 2016-01-07 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 1,801,161 20,278,008 9.75 29.00 52,233,669 588,062,232

2016-01-08 2016-01-07 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 785,045 2,337,100 50.58 29.00 22,766,305 67,775,900

2016-01-08 2016-01-07 4/A ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 1,801,161 20,278,008 9.75 29.00 52,233,669 588,062,232

2016-01-08 2016-01-07 4/A ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 785,045 2,337,100 50.58 29.00 22,766,305 67,775,900

2016-01-06 2016-01-04 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 7,082 78,885 9.86 3.00 21,246 236,655

2016-01-06 2016-01-04 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 7,082 78,885 9.86 3.00 21,246 236,655

2016-01-06 2016-01-04 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 7,082 6,348,612 0.11 3.00 21,246 19,045,836

2016-01-05 2015-12-31 4 INCY INCYTE CORP
Common Stock A - Award 175 513,020 0.03 108.45 18,979 55,637,019

2016-01-05 2015-12-31 4 INCY INCYTE CORP
Common Stock A - Award 175 513,020 0.03 108.45 18,979 55,637,019

2016-01-05 2015-12-31 4 INCY INCYTE CORP
Common Stock A - Award 175 666,111 0.03 108.45 18,979 72,239,738

2016-01-05 2016-01-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 568 308,843 0.18 35.20 19,994 10,871,274

2016-01-05 2016-01-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 568 308,843 0.18 35.20 19,994 10,871,274

2016-01-05 2016-01-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 568 482,740 0.12 35.20 19,994 16,992,448

2016-01-05 2016-01-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 568 11,423,179 0.00 35.20 19,994 402,095,901

2016-01-05 2016-01-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 568 196,132 0.29 35.20 19,994 6,903,846

2016-01-05 2016-01-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 568 356,791 0.16 35.20 19,994 12,559,043

2015-12-24 3 BLCM BELLICUM PHARMACEUTICALS, INC
Common Stock 5,284,918

2015-12-24 3 BLCM BELLICUM PHARMACEUTICALS, INC
Common Stock 9,241,559

2015-12-24 3 BLCM BELLICUM PHARMACEUTICALS, INC
Common Stock 4,936,111

2015-12-24 3 BLCM BELLICUM PHARMACEUTICALS, INC
Common Stock 5,284,918

2015-12-24 3 BLCM BELLICUM PHARMACEUTICALS, INC
Common Stock 9,241,559

2015-12-24 3 BLCM BELLICUM PHARMACEUTICALS, INC
Common Stock 4,936,111

2015-12-24 3 BLCM BELLICUM PHARMACEUTICALS, INC
Common Stock 5,284,918

2015-12-24 3 BLCM BELLICUM PHARMACEUTICALS, INC
Common Stock 9,241,559

2015-12-24 3 BLCM BELLICUM PHARMACEUTICALS, INC
Common Stock 4,936,111

2015-12-24 3 BLCM BELLICUM PHARMACEUTICALS, INC
Common Stock 5,284,918

2015-12-24 3 BLCM BELLICUM PHARMACEUTICALS, INC
Common Stock 9,241,559

2015-12-24 3 BLCM BELLICUM PHARMACEUTICALS, INC
Common Stock 4,936,111

2015-12-24 3 BLCM BELLICUM PHARMACEUTICALS, INC
Common Stock 5,284,918

2015-12-24 3 BLCM BELLICUM PHARMACEUTICALS, INC
Common Stock 9,241,559

2015-12-24 3 BLCM BELLICUM PHARMACEUTICALS, INC
Common Stock 4,936,111

2015-12-15 2015-12-11 4 ACAD ACADIA PHARMACEUTICALS INC
Non-Qualified Stock Option (right to buy) A - Award 15,000 15,000

2015-11-20 2015-11-20 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 150,000 33,428,852 0.45 44.00 6,600,000 1,470,869,488

2015-11-20 2015-11-20 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 31,647 33,278,852 0.10 43.87 1,388,259 1,459,843,401

2015-11-20 2015-11-19 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 57,461 33,247,205 0.17 43.93 2,524,015 1,460,406,753

2015-11-20 2015-11-19 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 75,612 33,189,744 0.23 43.93 3,321,363 1,457,905,971

2015-11-20 2015-11-18 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 4,000 33,114,132 0.01 43.00 172,000 1,423,907,676

2015-11-20 2015-11-18 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 10,638 33,110,132 0.03 43.84 466,321 1,451,395,880

2015-11-10 2015-11-10 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 9,400 33,099,494 0.03 44.00 413,600 1,456,377,736

2015-11-10 2015-11-09 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 800 33,090,094 0.00 43.00 34,400 1,422,874,042

2015-11-10 2015-11-09 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 407,800 33,089,294 1.25 43.71 17,823,388 1,446,207,301

2015-11-10 2015-11-09 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 98,700 32,681,494 0.30 44.00 4,342,800 1,437,985,736

2015-11-10 2015-11-06 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 196,490 32,582,794 0.61 41.31 8,117,179 1,346,024,545

2015-11-10 2015-11-06 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 221,434 32,386,304 0.69 42.51 9,412,318 1,376,618,715

2015-11-06 3 BCRX BIOCRYST PHARMACEUTICALS INC
Common Stock 14,293,989

2015-11-06 3 BCRX BIOCRYST PHARMACEUTICALS INC
Common Stock 14,293,989

2015-11-06 3 BCRX BIOCRYST PHARMACEUTICALS INC
Common Stock 16,392,657

2015-11-06 3 BCRX BIOCRYST PHARMACEUTICALS INC
Common Stock 26,372,015

2015-11-06 3 BCRX BIOCRYST PHARMACEUTICALS INC
Common Stock 14,293,989

2015-11-06 3 BCRX BIOCRYST PHARMACEUTICALS INC
Common Stock 14,293,989

2015-11-06 3 BCRX BIOCRYST PHARMACEUTICALS INC
Common Stock 16,392,657

2015-11-06 3 BCRX BIOCRYST PHARMACEUTICALS INC
Common Stock 26,372,015

2015-11-06 3 BCRX BIOCRYST PHARMACEUTICALS INC
Common Stock 14,293,989

2015-11-06 3 BCRX BIOCRYST PHARMACEUTICALS INC
Common Stock 14,293,989

2015-11-06 3 BCRX BIOCRYST PHARMACEUTICALS INC
Common Stock 16,392,657

2015-11-06 3 BCRX BIOCRYST PHARMACEUTICALS INC
Common Stock 26,372,015

2015-11-06 3 BCRX BIOCRYST PHARMACEUTICALS INC
Common Stock 14,293,989

2015-11-06 3 BCRX BIOCRYST PHARMACEUTICALS INC
Common Stock 14,293,989

2015-11-06 3 BCRX BIOCRYST PHARMACEUTICALS INC
Common Stock 16,392,657

2015-11-06 3 BCRX BIOCRYST PHARMACEUTICALS INC
Common Stock 26,372,015

2015-11-06 3 BCRX BIOCRYST PHARMACEUTICALS INC
Common Stock 14,293,989

2015-11-06 3 BCRX BIOCRYST PHARMACEUTICALS INC
Common Stock 14,293,989

2015-11-06 3 BCRX BIOCRYST PHARMACEUTICALS INC
Common Stock 16,392,657

2015-11-06 3 BCRX BIOCRYST PHARMACEUTICALS INC
Common Stock 26,372,015

2015-10-05 2015-10-01 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 6,945 71,803 10.71 3.06 21,252 219,717

2015-10-05 2015-10-01 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 6,945 71,803 10.71 3.06 21,252 219,717

2015-10-05 2015-10-01 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 6,945 71,803 10.71 3.06 21,252 219,717

2015-10-05 2015-10-01 4 INCY INCYTE CORP
Common Stock A - Award 172 512,845 0.03 110.33 18,977 56,582,189

2015-10-05 2015-10-01 4 INCY INCYTE CORP
Common Stock A - Award 172 972,118 0.02 110.33 18,977 107,253,779

2015-10-05 2015-10-01 4 INCY INCYTE CORP
Common Stock A - Award 172 16,282,190 0.00 110.33 18,977 1,796,414,023

2015-10-05 2015-10-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 936 308,275 0.30 21.34 19,974 6,578,588

2015-10-05 2015-10-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 936 308,275 0.30 21.34 19,974 6,578,588

2015-10-05 2015-10-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 936 11,422,611 0.01 21.34 19,974 243,758,519

2015-10-05 2015-10-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 936 1,911,734 0.05 21.34 19,974 40,796,404

2015-10-05 2015-10-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 936 195,564 0.48 21.34 19,974 4,173,336

2015-10-05 2015-10-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 936 356,223 0.26 21.34 19,974 7,601,799

2015-09-18 2015-09-16 4 INCY INCYTE CORP
4.75% Convertible Senior Notes due 2015 M - Exercise -892,000 0 -100.00

2015-09-18 2015-09-16 4 INCY INCYTE CORP
4.75% Convertible Senior Notes due 2015 M - Exercise -31,967,000 0 -100.00

2015-09-18 2015-09-16 4 INCY INCYTE CORP
4.75% Convertible Senior Notes due 2015 M - Exercise -7,587,000 0 -100.00

2015-09-18 2015-09-16 4 INCY INCYTE CORP
4.75% Convertible Senior Notes due 2015 M - Exercise -65,000 0 -100.00

2015-09-18 2015-09-16 4 INCY INCYTE CORP
4.75% Convertible Senior Notes due 2015 M - Exercise -64,000 0 -100.00

2015-09-18 2015-09-16 4 INCY INCYTE CORP
Common Stock M - Exercise 101,652 512,673 24.73

2015-09-18 2015-09-16 4 INCY INCYTE CORP
Common Stock M - Exercise 3,642,962 16,128,927 29.18

2015-09-18 2015-09-16 4 INCY INCYTE CORP
Common Stock M - Exercise 864,614 2,943,733 41.59

2015-09-18 2015-09-16 4 INCY INCYTE CORP
Common Stock M - Exercise 7,406 61,049 13.81

2015-09-18 2015-09-16 4 INCY INCYTE CORP
Common Stock M - Exercise 7,292 58,632 14.20

2015-09-16 2015-09-16 4 MRTX Mirati Therapeutics, Inc.
Common Stock Warrants (right to buy) J - Other 137 137

2015-09-16 2015-09-16 4 MRTX Mirati Therapeutics, Inc.
Common Stock Warrants (right to buy) J - Other 137 137

2015-09-16 2015-09-16 4 MRTX Mirati Therapeutics, Inc.
Common Stock Warrants (right to buy) J - Other -274 0 -100.00

2015-09-16 2015-09-16 4 MRTX Mirati Therapeutics, Inc.
Common Stock P - Purchase 139,220 2,744,052 5.34 45.00 6,264,900 123,482,340

2015-09-16 2015-09-16 4 MRTX Mirati Therapeutics, Inc.
Common Stock P - Purchase 10,780 170,714 6.74 45.00 485,100 7,682,130

2015-09-15 2015-09-15 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 346,000 32,164,870 1.09 48.44 16,761,728 1,558,204,612

2015-09-15 2015-09-15 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 50,000 31,818,870 0.16 47.40 2,370,000 1,508,214,438

2015-09-15 2015-09-15 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 160,453 31,768,870 0.51 48.60 7,798,690 1,544,100,511

2015-09-15 2015-09-15 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 33,320 31,608,417 0.11 47.98 1,598,614 1,516,495,987

2015-09-15 2015-09-15 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 14,386 31,575,097 0.05 47.54 683,847 1,500,941,181

2015-09-15 2015-09-15 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 1,600 31,560,711 0.01 47.24 75,577 1,490,798,589

2015-09-15 2015-09-15 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 20,500 31,559,111 0.06 46.31 949,351 1,461,496,119

2015-09-15 2015-09-14 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 1,950 31,538,611 0.01 44.68 87,130 1,409,201,909

2015-09-15 2015-09-14 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 89,843 31,536,661 0.29 45.28 4,067,696 1,427,841,249

2015-09-15 2015-09-14 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 212,983 31,446,818 0.68 46.81 9,969,500 1,471,990,959

2015-09-15 2015-09-14 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 9,818 31,233,835 0.03 46.74 458,905 1,459,906,929

2015-09-15 2015-09-14 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 2,331 31,224,017 0.01 45.63 106,368 1,424,814,344

2015-09-15 2015-09-14 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 3,513 31,221,686 0.01 45.43 159,601 1,418,448,028

2015-09-15 2015-09-11 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 13,897 31,218,173 0.04 45.00 625,359 1,404,805,298

2015-09-15 2015-09-11 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 40,649 31,204,276 0.13 42.14 1,713,148 1,315,101,092

2015-09-15 2015-09-11 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 8,063 31,163,627 0.03 44.40 357,971 1,383,565,315

2015-09-15 2015-09-11 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 15,391 31,155,564 0.05 40.67 625,950 1,267,093,672

2015-09-15 2015-09-11 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 191,321 31,140,173 0.62 41.06 7,856,214 1,278,708,924

2015-09-15 2015-09-11 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 88,640 30,948,852 0.29 42.44 3,761,802 1,313,441,425

2015-09-15 2015-09-11 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 183,073 30,860,212 0.60 43.28 7,923,253 1,335,605,287

2015-09-15 2015-09-11 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 274,814 30,677,139 0.90 44.63 12,265,553 1,369,188,203

2015-09-15 2015-09-11 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 3,100 30,402,325 0.01 40.55 125,706 1,232,823,399

2015-09-15 2015-09-11 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 11,300 30,399,225 0.04 41.13 464,823 1,250,466,041

2015-09-15 2015-09-11 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 43,612 30,387,925 0.14 43.60 1,901,322 1,324,801,095

2015-09-15 2015-09-11 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 3,338,927 30,344,313 12.36 41.00 136,896,007 1,244,116,833

2015-09-11 2015-09-10 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 2,213,469 6,022,104 58.12 15.50 34,308,770 93,342,612

2015-09-11 2015-09-10 4 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock P - Purchase 266,563 725,228 58.12 15.50 4,131,726 11,241,034

2015-08-27 3 NVTA Invitae Corp
Common Stock 7,220,154

2015-08-27 3 NVTA Invitae Corp
Common Stock 12,371,376

2015-08-27 3 NVTA Invitae Corp
Common Stock 6,628,338

2015-08-27 3 NVTA Invitae Corp
Common Stock 7,220,154

2015-08-27 3 NVTA Invitae Corp
Common Stock 12,371,376

2015-08-27 3 NVTA Invitae Corp
Common Stock 6,628,338

2015-08-27 3 NVTA Invitae Corp
Common Stock 7,220,154

2015-08-27 3 NVTA Invitae Corp
Common Stock 12,371,376

2015-08-27 3 NVTA Invitae Corp
Common Stock 6,628,338

2015-08-27 3 NVTA Invitae Corp
Common Stock 7,220,154

2015-08-27 3 NVTA Invitae Corp
Common Stock 12,371,376

2015-08-27 3 NVTA Invitae Corp
Common Stock 6,628,338

2015-08-27 3 NVTA Invitae Corp
Common Stock 7,220,154

2015-08-27 3 NVTA Invitae Corp
Common Stock 12,371,376

2015-08-27 3 NVTA Invitae Corp
Common Stock 6,628,338

2015-08-10 3 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock 4,725,965

2015-08-10 3 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock 8,075,935

2015-08-10 3 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock 4,725,965

2015-08-10 3 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock 8,075,935

2015-08-10 3 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock 4,725,965

2015-08-10 3 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock 8,075,935

2015-08-10 3 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock 4,725,965

2015-08-10 3 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock 8,075,935

2015-08-10 3 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock 4,725,965

2015-08-10 3 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock 8,075,935

2015-08-10 3 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock 4,725,965

2015-08-10 3 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock 8,075,935

2015-08-10 3 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock 4,725,965

2015-08-10 3 AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock 8,075,935

2015-08-10 3/A AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock 2,260

2015-08-10 3/A AQXP AQUINOX PHARMACEUTICALS, INC
Common Stock 2,260

2015-07-24 2015-07-22 4 ALXN ALEXION PHARMACEUTICALS INC
Non-Qualified Stock Option (right to buy) A - Award 2,329 2,329

2015-07-24 2015-07-22 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock A - Award 696 6,103,727 0.01

2015-07-24 2015-07-22 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock A - Award 696 6,103,727 0.01

2015-07-23 2015-07-22 4 XOMA XOMA Corp
Common Stock S - Sale -229,436 90,538 -71.70 1.09 -250,659 98,913

2015-07-23 2015-07-22 4 XOMA XOMA Corp
Common Stock S - Sale -9,411,311 3,153,539 -74.90 1.09 -10,281,857 3,445,241

2015-07-23 2015-07-22 4 XOMA XOMA Corp
Common Stock S - Sale -1,359,253 467,436 -74.41 1.09 -1,484,984 510,674

2015-07-06 2015-07-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 730 307,339 0.24 27.34 19,958 8,402,648

2015-07-06 2015-07-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 730 1,350,721 0.05 27.34 19,958 36,928,712

2015-07-06 2015-07-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 730 481,236 0.15 27.34 19,958 13,156,992

2015-07-06 2015-07-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 730 11,421,675 0.01 27.34 19,958 312,268,594

2015-07-06 2015-07-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 730 194,628 0.38 27.34 19,958 5,321,130

2015-07-06 2015-07-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 730 355,287 0.21 27.34 19,958 9,713,547

2015-07-06 2015-07-01 4 INCY INCYTE CORP
Common Stock A - Award 182 826,200 0.02 104.21 18,966 86,098,302

2015-07-06 2015-07-01 4 INCY INCYTE CORP
Common Stock A - Award 182 411,021 0.04 104.21 18,966 42,832,498

2015-07-06 2015-07-01 4 INCY INCYTE CORP
Common Stock A - Award 182 549,414 0.03 104.21 18,966 57,254,433

2015-07-06 2015-07-01 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 5,260 64,858 8.83 3.66 19,252 237,380

2015-07-06 2015-07-01 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 5,260 64,858 8.83 3.66 19,252 237,380

2015-07-06 2015-07-01 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 5,260 64,858 8.83 3.66 19,252 237,380

2015-06-24 2015-06-22 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock A - Award 6,103,033 6,103,033

2015-06-24 2015-06-22 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock A - Award 506,166 506,166

2015-06-24 2015-06-22 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock A - Award 94,412 94,412

2015-06-24 2015-06-22 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock A - Award 66,154 66,154

2015-06-24 2015-06-22 4 ALXN ALEXION PHARMACEUTICALS INC
Common Stock A - Award 65,811 65,811

2015-06-23 2015-06-22 4 GEVA SYNAGEVA BIOPHARMA CORP
Non-Qualified Stock Option (right to buy) D - Sale to Issuer -2,250 0 -100.00

2015-06-23 2015-06-22 4 GEVA SYNAGEVA BIOPHARMA CORP
Non-Qualified Stock Option (right to buy) D - Sale to Issuer -2,250 0 -100.00

2015-06-23 2015-06-22 4 GEVA SYNAGEVA BIOPHARMA CORP
Non-Qualified Stock Option (right to buy) D - Sale to Issuer -2,250 0 -100.00

2015-06-23 2015-06-22 4 GEVA SYNAGEVA BIOPHARMA CORP
Non-Qualified Stock Option (right to buy) D - Sale to Issuer -2,500 0 -100.00

2015-06-23 2015-06-22 4 GEVA SYNAGEVA BIOPHARMA CORP
Non-Qualified Stock Option (right to buy) D - Sale to Issuer -2,500 0 -100.00

2015-06-23 2015-06-22 4 GEVA SYNAGEVA BIOPHARMA CORP
Non-Qualified Stock Option (right to buy) D - Sale to Issuer -2,500 0 -100.00

2015-06-23 2015-06-22 4 GEVA SYNAGEVA BIOPHARMA CORP
Non-Qualified Stock Option (right to buy) D - Sale to Issuer -3,000 0 -100.00

2015-06-23 2015-06-22 4 GEVA SYNAGEVA BIOPHARMA CORP
Non-Qualified Stock Option (right to buy) D - Sale to Issuer -3,000 0 -100.00

2015-06-23 2015-06-22 4 GEVA SYNAGEVA BIOPHARMA CORP
Non-Qualified Stock Option (right to buy) D - Sale to Issuer -15,000 0 -100.00

2015-06-23 2015-06-22 4 GEVA SYNAGEVA BIOPHARMA CORP
Non-Qualified Stock Option (right to buy) D - Sale to Issuer -7,500 0 -100.00

2015-06-23 2015-06-22 4 GEVA SYNAGEVA BIOPHARMA CORP
Non-Qualified Stock Option (right to buy) D - Sale to Issuer -7,500 0 -100.00

2015-06-23 2015-06-22 4 GEVA SYNAGEVA BIOPHARMA CORP
Non-Qualified Stock Option (right to buy) D - Sale to Issuer -7,500 0 -100.00

2015-06-23 2015-06-22 4 GEVA SYNAGEVA BIOPHARMA CORP
Non-Qualified Stock Option (right to buy) D - Sale to Issuer -2,250 0 -100.00

2015-06-23 2015-06-22 4 GEVA SYNAGEVA BIOPHARMA CORP
Non-Qualified Stock Option (right to buy) D - Sale to Issuer -2,750 0 -100.00

2015-06-23 2015-06-22 4 GEVA SYNAGEVA BIOPHARMA CORP
Non-Qualified Stock Option (right to buy) D - Sale to Issuer -2,750 0 -100.00

2015-06-23 2015-06-22 4 GEVA SYNAGEVA BIOPHARMA CORP
Non-Qualified Stock Option (right to buy) D - Sale to Issuer -2,750 0 -100.00

2015-06-23 2015-06-22 4 GEVA SYNAGEVA BIOPHARMA CORP
Comon Stock D - Sale to Issuer -9,184,771 0 -100.00

2015-06-23 2015-06-22 4 GEVA SYNAGEVA BIOPHARMA CORP
Comon Stock D - Sale to Issuer -12,250 0 -100.00

2015-06-23 2015-06-22 4 GEVA SYNAGEVA BIOPHARMA CORP
Comon Stock D - Sale to Issuer -12,250 0 -100.00

2015-06-23 2015-06-22 4 GEVA SYNAGEVA BIOPHARMA CORP
Comon Stock D - Sale to Issuer -12,250 0 -100.00

2015-06-23 2015-06-22 4 GEVA SYNAGEVA BIOPHARMA CORP
Comon Stock D - Sale to Issuer -12,250 0 -100.00

2015-06-23 2015-06-22 4 GEVA SYNAGEVA BIOPHARMA CORP
Comon Stock D - Sale to Issuer -12,250 0 -100.00

2015-06-23 2015-06-22 4 GEVA SYNAGEVA BIOPHARMA CORP
Comon Stock D - Sale to Issuer -680,187 0 -100.00

2015-06-23 2015-06-22 4 GEVA SYNAGEVA BIOPHARMA CORP
Comon Stock D - Sale to Issuer -143,462 0 -100.00

2015-06-23 2015-06-22 4 GEVA SYNAGEVA BIOPHARMA CORP
Comon Stock D - Sale to Issuer -200,526 0 -100.00

2015-06-23 2014-06-04 4 GEVA SYNAGEVA BIOPHARMA CORP
Non-Qualified Stock Option (right to buy) D - Sale to Issuer -7,500 0 -100.00

2015-06-23 2013-06-06 4 GEVA SYNAGEVA BIOPHARMA CORP
Non-Qualified Stock Option (right to buy) D - Sale to Issuer -7,500 0 -100.00

2015-06-23 2012-06-27 4 GEVA SYNAGEVA BIOPHARMA CORP
Non-Qualified Stock Option (right to buy) D - Sale to Issuer -7,500 0 -100.00

2015-06-23 2011-12-20 4 GEVA SYNAGEVA BIOPHARMA CORP
Non-Qualified Stock Option (right to buy) D - Sale to Issuer -15,000 0 -100.00

2015-06-22 2015-06-22 4 GEVA SYNAGEVA BIOPHARMA CORP
Common Stock J - Other 21,196 100,523 26.72

2015-06-22 2015-06-22 4 GEVA SYNAGEVA BIOPHARMA CORP
Common Stock J - Other -211,614 12,250 -94.53

2015-06-22 2015-06-22 4 GEVA SYNAGEVA BIOPHARMA CORP
Common Stock J - Other 497 79,327 0.63

2015-06-22 2015-06-22 4 GEVA SYNAGEVA BIOPHARMA CORP
Common Stock J - Other -100,490 12,250 -89.13

2015-06-22 2015-06-22 4 GEVA SYNAGEVA BIOPHARMA CORP
Common Stock J - Other 40,449 78,830 105.39

2015-06-22 2015-06-22 4 GEVA SYNAGEVA BIOPHARMA CORP
Common Stock J - Other -1,068,128 680,187 -61.09

2015-06-22 2015-06-22 4 GEVA SYNAGEVA BIOPHARMA CORP
Common Stock J - Other 5,543 38,381 16.88

2015-06-22 2015-06-22 4 GEVA SYNAGEVA BIOPHARMA CORP
Common Stock J - Other -55,479 12,250 -81.91

2015-06-22 2015-06-22 4 GEVA SYNAGEVA BIOPHARMA CORP
Common Stock J - Other 12,500 32,838 61.46

2015-06-22 2015-06-22 4 GEVA SYNAGEVA BIOPHARMA CORP
Common Stock J - Other -165,213 12,250 -93.10

2015-06-22 2015-06-22 4 GEVA SYNAGEVA BIOPHARMA CORP
Common Stock J - Other 19,318 20,338 1,893.92

2015-06-22 2015-06-22 4 GEVA SYNAGEVA BIOPHARMA CORP
Common Stock J - Other -206,800 12,250 -94.41

2015-06-17 2015-06-15 4 ACAD ACADIA PHARMACEUTICALS INC
Non-Qualified Stock Option (right to buy) A - Award 12,500 12,500

2015-06-16 2015-06-12 4 GHDX GENOMIC HEALTH INC
Non-Qualified Stock Options (right to buy) A - Award 20,000 20,000

2015-06-10 2015-06-08 4 IDRA IDERA PHARMACEUTICALS, INC.
Non-Qualified Stock Option (right to buy) A - Award 70,000 70,000

2015-05-27 2015-05-22 4 INCY INCYTE CORP
Non-Qualified Stock Options (right to buy) A - Award 15,000 15,000

2015-05-21 2015-05-21 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 198,802 27,005,386 0.74 43.27 8,602,242 1,168,533,854

2015-05-21 2015-05-21 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 57,202 26,816,266 0.21 43.29 2,476,343 1,160,908,335

2015-05-21 2015-05-21 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 16,300 26,759,064 0.06 43.67 711,775 1,168,493,400

2015-05-21 2015-05-21 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 90,155 26,742,764 0.34 43.62 3,932,723 1,166,567,503

2015-05-21 2015-05-20 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 150,000 26,652,609 0.57 42.93 6,439,500 1,144,196,504

2015-05-21 2015-05-20 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 9,200 26,492,927 0.03 40.95 376,718 1,084,821,778

2015-05-21 2015-05-20 4 SGEN SEATTLE GENETICS INC /WA
Common Stoc P - Purchase 52,381 26,483,727 0.20 41.54 2,176,038 1,100,200,229

2015-05-21 2015-05-20 4 SGEN SEATTLE GENETICS INC /WA
Common Stoc P - Purchase 139,683 26,431,346 0.53 42.68 5,961,908 1,128,134,781

2015-05-21 2015-05-20 4 SGEN SEATTLE GENETICS INC /WA
Common Stoc P - Purchase 13,352 26,291,663 0.05 42.97 573,749 1,129,779,051

2015-05-21 2015-05-20 4 SGEN SEATTLE GENETICS INC /WA
Common Stoc P - Purchase 2,300 26,278,311 0.01 42.15 96,949 1,107,675,482

2015-05-21 2015-05-20 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 7,382 26,276,011 0.03 41.24 304,410 1,083,538,610

2015-05-21 2015-05-19 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 4,500 26,268,629 0.02 41.07 184,815 1,078,852,593

2015-05-21 2015-05-19 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 89,100 26,264,129 0.34 40.57 3,614,475 1,065,443,789

2015-05-21 2015-05-19 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 120,529 26,175,029 0.46 41.09 4,951,958 1,075,406,301

2015-05-18 2015-05-15 4 SGEN SEATTLE GENETICS INC /WA
Non-Qualified Stock Options (right to buy) A - Award 9,260 9,260

2015-05-18 2015-05-15 4 SGEN SEATTLE GENETICS INC /WA
Non-Qualified Stock Options (right to buy) A - Award 9,260 9,260

2015-05-18 2015-05-15 4 SGEN SEATTLE GENETICS INC /WA
Common Stock A - Award 3,700 26,054,500 0.01 39.94 147,778 1,040,616,730

2015-05-18 2015-05-15 4 SGEN SEATTLE GENETICS INC /WA
Common Stock A - Award 3,700 26,054,500 0.01 39.94 147,778 1,040,616,730

2015-05-12 2015-05-11 4 INCY INCYTE CORP
Non-Qualified Stock Options (right to buy) M - Exercise -20,000 0 -100.00

2015-05-12 2015-05-11 4 INCY INCYTE CORP
Non-Qualified Stock Options (right to buy) M - Exercise -20,000 0 -100.00

2015-05-12 2015-05-11 4 INCY INCYTE CORP
Non-Qualified Stock Options (right to buy) M - Exercise -20,000 0 -100.00

2015-05-12 2015-05-11 4 INCY INCYTE CORP
Common Stock M - Exercise 20,000 410,839 5.12 7.68 153,600 3,155,244

2015-05-12 2015-05-11 4 INCY INCYTE CORP
Common Stock M - Exercise 20,000 410,839 5.12 7.68 153,600 3,155,244

2015-05-12 2015-05-11 4 INCY INCYTE CORP
Common Stock M - Exercise 20,000 410,839 5.12 7.68 153,600 3,155,244

2015-05-12 2015-05-11 4 SGEN SEATTLE GENETICS INC /WA
Non-Qualified Stock Options (right to buy) M - Exercise -10,000 0 -100.00

2015-05-12 2015-05-11 4 SGEN SEATTLE GENETICS INC /WA
Non-Qualified Stock Options (right to buy) M - Exercise -10,000 0 -100.00

2015-05-12 2015-05-11 4 SGEN SEATTLE GENETICS INC /WA
Common Stock M - Exercise 10,000 26,050,800 0.04 5.11 51,100 133,119,588

2015-05-12 2015-05-11 4 SGEN SEATTLE GENETICS INC /WA
Common Stock M - Exercise 10,000 26,050,800 0.04 5.11 51,100 133,119,588

2015-05-07 2015-05-07 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 1,100 26,040,800 0.00 37.07 40,777 965,332,456

2015-05-07 2015-05-07 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 46,617 26,039,700 0.18 37.15 1,732,013 967,481,618

2015-05-07 2015-05-06 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 8,334 25,993,083 0.03 35.85 298,745 931,761,050

2015-05-07 2015-05-06 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 129,118 25,984,749 0.50 36.40 4,700,515 945,969,590

2015-05-07 2015-05-06 4 SGEN SEATTLE GENETICS INC /WA
Common Stoc P - Purchase 137,800 25,855,631 0.54 36.25 4,995,250 937,266,624

2015-05-07 2015-05-06 4 SGEN SEATTLE GENETICS INC /WA
Common Stoc P - Purchase 155,731 25,717,831 0.61 36.67 5,710,048 942,972,563

2015-05-07 2015-05-06 4 SGEN SEATTLE GENETICS INC /WA
Common Stoc P - Purchase 23,012 25,562,100 0.09 35.91 826,437 918,019,366

2015-05-07 2015-05-05 4 SGEN SEATTLE GENETICS INC /WA
Common Stoc P - Purchase 354,300 25,539,088 1.41 34.76 12,315,078 887,710,606

2015-05-07 2015-05-05 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 59,973 25,184,788 0.24 34.61 2,075,833 871,716,030

2015-05-07 2015-05-05 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 4,330 25,124,815 0.02 33.99 147,177 853,992,462

2015-05-07 2015-05-05 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 90,397 25,120,485 0.36 34.56 3,123,949 868,116,233

2015-05-07 2015-05-05 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 21,952 25,030,088 0.09 34.52 757,888 864,158,782

2015-04-02 2015-04-01 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 5,470 59,598 10.11 3.52 19,254 209,785

2015-04-02 2015-04-01 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 5,470 59,598 10.11 3.52 19,254 209,785

2015-04-02 2015-04-01 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 5,470 59,598 10.11 3.52 19,254 209,785

2015-04-02 2015-04-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 656 306,609 0.21 30.43 19,962 9,330,112

2015-04-02 2015-04-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 656 1,349,991 0.05 30.43 19,962 41,080,226

2015-04-02 2015-04-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 656 1,349,991 0.05 30.43 19,962 41,080,226

2015-04-02 2015-04-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 656 1,349,991 0.05 30.43 19,962 41,080,226

2015-04-02 2015-04-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 656 1,349,991 0.05 30.43 19,962 41,080,226

2015-04-02 2015-04-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 656 306,609 0.21 30.43 19,962 9,330,112

2015-03-11 2015-03-10 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 2,880 25,008,136 0.01 34.72 99,986 868,217,461

2015-03-11 2015-03-10 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 6,439 25,005,256 0.03 34.47 221,935 861,863,660

2015-03-11 2015-03-09 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 158,771 24,998,817 0.64 34.69 5,507,401 867,151,464

2015-03-11 2015-03-09 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 116,946 24,840,046 0.47 34.62 4,049,208 860,076,657

2015-03-05 2015-03-04 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 19,600 24,723,100 0.08 34.82 682,537 860,939,928

2015-03-05 2015-03-04 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 4,021 24,703,500 0.02 34.79 139,882 859,380,417

2015-03-05 2015-03-03 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 213,820 24,699,479 0.87 34.76 7,432,169 858,529,191

2015-03-05 2015-03-03 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 211,400 24,485,659 0.87 34.92 7,382,532 855,090,632

2015-02-26 2015-02-25 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 1,000 24,274,259 0.00 35.60 35,595 864,042,249

2015-02-26 2015-02-25 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 62,650 24,273,259 0.26 34.46 2,159,163 836,551,171

2015-02-26 2015-02-24 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 163,054 24,210,609 0.68 33.80 5,510,818 818,258,058

2015-02-26 2015-02-24 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 4,995 24,047,555 0.02 33.60 167,830 807,985,824

2015-02-26 2015-02-24 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 49,416 24,042,560 0.21 33.65 1,662,843 809,029,740

2015-02-17 2015-02-13 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock P - Purchase 4,898,409 6,323,855 343.64 3.75 18,369,034 23,714,456

2015-02-17 2015-02-13 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock P - Purchase 434,924 625,495 228.22 3.75 1,630,965 2,345,606

2015-02-02 2015-01-29 4 MRTX Mirati Therapeutics, Inc.
Common Stock P - Purchase 390,935 2,604,832 17.66 20.00 7,818,700 52,096,640

2015-02-02 2015-01-29 4 MRTX Mirati Therapeutics, Inc.
Common Stock P - Purchase 34,065 159,934 27.06 20.00 681,300 3,198,680

2015-01-09 2015-01-07 4 GEVA SYNAGEVA BIOPHARMA CORP
Common Stock P - Purchase 1,000,000 9,184,771 12.22 94.19 94,190,000 865,113,580

2015-01-06 2015-01-06 4 XOMA XOMA Corp
Common Stock S - Sale -21,441 345,074 -5.85 3.86 -82,762 1,331,986

2015-01-06 2015-01-06 4 XOMA XOMA Corp
Common Stock S - Sale -859,988 12,589,950 -6.39 3.86 -3,319,554 48,597,207

2015-01-06 2015-01-06 4 XOMA XOMA Corp
Common Stock S - Sale -118,571 1,851,789 -6.02 3.86 -457,684 7,147,906

2015-01-06 2015-01-05 4 XOMA XOMA Corp
Common Stock S - Sale -21,548 366,515 -5.55 3.81 -82,130 1,396,972

2015-01-06 2015-01-05 4 XOMA XOMA Corp
Common Stock S - Sale -863,100 13,449,938 -6.03 3.81 -3,289,706 51,264,439

2015-01-06 2015-01-05 4 XOMA XOMA Corp
Common Stock S - Sale -118,652 1,970,360 -5.68 3.81 -452,242 7,510,027

2015-01-06 2015-01-02 4 XOMA XOMA Corp
Common Stock S - Sale -4,554 388,063 -1.16 3.55 -16,184 1,379,059

2015-01-06 2015-01-02 4 XOMA XOMA Corp
Common Stock S - Sale -182,454 14,313,038 -1.26 3.55 -648,387 50,864,243

2015-01-06 2015-01-02 4 XOMA XOMA Corp
Common Stock S - Sale -25,092 2,089,012 -1.19 3.55 -89,169 7,423,722

2015-01-06 2015-01-02 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 3,927 54,128 7.82 4.90 19,242 265,227

2015-01-06 2015-01-02 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 3,927 54,128 7.82 4.90 19,242 265,227

2015-01-06 2015-01-02 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 3,927 1,425,446 0.28 4.90 19,242 6,984,685

2015-01-05 2015-01-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 624 305,953 0.20 31.97 19,949 9,781,317

2015-01-05 2015-01-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 624 1,349,335 0.05 31.97 19,949 43,138,240

2015-01-05 2015-01-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 624 11,420,289 0.01 31.97 19,949 365,106,639

2015-01-05 2015-01-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 624 1,909,412 0.03 31.97 19,949 61,043,902

2015-01-05 2015-01-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 624 193,242 0.32 31.97 19,949 6,177,947

2015-01-05 2015-01-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 624 353,901 0.18 31.97 19,949 11,314,215

2014-12-30 2014-12-30 4 XOMA XOMA Corp
Common Stock S - Sale -8,415 392,617 -2.10 3.65 -30,711 1,432,856

2014-12-30 2014-12-30 4 XOMA XOMA Corp
Common Stock S - Sale -337,123 14,495,492 -2.27 3.65 -1,230,330 52,901,298

2014-12-30 2014-12-30 4 XOMA XOMA Corp
Common Stock S - Sale -46,362 2,114,104 -2.15 3.65 -169,198 7,715,423

2014-12-30 2014-12-29 4 XOMA XOMA Corp
Common Stock S - Sale -4,746 401,032 -1.17 3.68 -17,447 1,474,274

2014-12-30 2014-12-29 4 XOMA XOMA Corp
Common Stock S - Sale -190,117 14,832,615 -1.27 3.68 -698,908 54,527,659

2014-12-30 2014-12-29 4 XOMA XOMA Corp
Common Stock S - Sale -26,137 2,160,466 -1.20 3.68 -96,085 7,942,305

2014-12-30 2014-12-26 4 XOMA XOMA Corp
Common Stock S - Sale -2,825 405,778 -0.69 3.71 -10,482 1,505,680

2014-12-30 2014-12-26 4 XOMA XOMA Corp
Common Stock S - Sale -112,855 15,022,732 -0.75 3.71 -418,760 55,743,349

2014-12-30 2014-12-26 4 XOMA XOMA Corp
Common Stock S - Sale -15,420 2,186,603 -0.70 3.71 -57,217 8,113,609

2014-12-19 2014-12-19 4 XOMA XOMA Corp
Common Stock S - Sale -16,182 408,603 -3.81 4.21 -68,102 1,719,606

2014-12-19 2014-12-19 4 XOMA XOMA Corp
Common Stock S - Sale -647,781 15,135,587 -4.10 4.21 -2,726,186 63,698,118

2014-12-19 2014-12-19 4 XOMA XOMA Corp
Common Stock S - Sale -88,937 2,202,023 -3.88 4.21 -374,291 9,267,214

2014-12-19 2014-12-18 4 XOMA XOMA Corp
Common Stock S - Sale -3,558 424,785 -0.83 4.29 -15,260 1,821,903

2014-12-19 2014-12-18 4 XOMA XOMA Corp
Common Stock S - Sale -142,543 15,783,368 -0.90 4.29 -611,367 67,694,865

2014-12-19 2014-12-18 4 XOMA XOMA Corp
Common Stock S - Sale -19,599 2,290,960 -0.85 4.29 -84,060 9,825,927

2014-12-19 2014-12-17 4 XOMA XOMA Corp
Common Stock S - Sale -14,753 428,343 -3.33 4.31 -63,571 1,845,730

2014-12-19 2014-12-17 4 XOMA XOMA Corp
Common Stock S - Sale -590,638 15,925,911 -3.58 4.31 -2,545,059 68,624,750

2014-12-19 2014-12-17 4 XOMA XOMA Corp
Common Stock S - Sale -81,109 2,310,559 -3.39 4.31 -349,499 9,956,199

2014-12-17 2014-12-16 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 3,900 23,993,144 0.02 31.97 124,679 767,036,821

2014-12-17 2014-12-16 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 500 23,989,244 0.00 30.80 15,400 738,868,715

2014-12-17 2014-12-16 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 49,685 23,988,744 0.21 31.82 1,581,096 763,379,407

2014-12-17 2014-12-16 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 1,855,894 23,939,059 8.40 31.94 59,276,698 764,606,363

2014-12-17 2014-12-15 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 597,000 22,083,165 2.78 31.75 18,954,631 701,136,072

2014-12-17 2014-12-15 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 305,532 21,486,165 1.44 31.68 9,680,415 680,763,355

2014-12-17 2014-12-15 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 70,867 21,180,633 0.34 31.41 2,226,244 665,376,877

2014-12-16 2014-12-16 4 XOMA XOMA Corp
Common Stock S - Sale -6,874 443,096 -1.53 4.27 -29,358 1,892,419

2014-12-16 2014-12-16 4 XOMA XOMA Corp
Common Stock S - Sale -274,734 16,516,549 -1.64 4.27 -1,173,361 70,540,529

2014-12-16 2014-12-16 4 XOMA XOMA Corp
Common Stock S - Sale -37,592 2,391,668 -1.55 4.27 -160,552 10,214,575

2014-12-16 2014-12-15 4 XOMA XOMA Corp
Common Stock S - Sale -9,908 449,970 -2.15 4.45 -44,093 2,002,456

2014-12-16 2014-12-15 4 XOMA XOMA Corp
Common Stock S - Sale -396,496 16,791,283 -2.31 4.45 -1,764,486 74,724,568

2014-12-16 2014-12-15 4 XOMA XOMA Corp
Common Stock S - Sale -54,396 2,429,260 -2.19 4.45 -242,073 10,810,693

2014-12-16 2014-12-12 4 XOMA XOMA Corp
Common Stock S - Sale -5,457 459,878 -1.17 4.71 -25,724 2,167,865

2014-12-16 2014-12-12 4 XOMA XOMA Corp
Common Stock S - Sale -218,383 17,187,779 -1.25 4.71 -1,029,457 81,023,190

2014-12-16 2014-12-12 4 XOMA XOMA Corp
Common Stock S - Sale -29,960 2,483,656 -1.19 4.71 -141,231 11,707,954

2014-12-10 2014-12-09 4 XOMA XOMA Corp
Common Stock S - Sale -8,429 465,335 -1.78 4.62 -38,907 2,147,940

2014-12-10 2014-12-09 4 XOMA XOMA Corp
Common Stock S - Sale -337,541 17,406,162 -1.90 4.62 -1,558,056 80,345,103

2014-12-10 2014-12-09 4 XOMA XOMA Corp
Common Stock S - Sale -46,383 2,513,616 -1.81 4.62 -214,099 11,602,600

2014-12-10 2014-12-10 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 100,000 21,109,766 0.48 34.95 3,495,000 737,786,322

2014-12-10 2014-12-10 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 354,000 21,009,766 1.71 34.27 12,131,651 720,008,883

2014-12-10 2014-12-10 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 14,772 20,655,766 0.07 34.53 510,114 713,295,239

2014-12-10 2014-12-10 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 185,378 20,640,994 0.91 34.33 6,364,935 708,706,465

2014-12-10 2014-12-09 4 SGEN SEATTLE GENETICS INC /WA
Common Stock J - Other 30,507 107,504 39.62

2014-12-10 2014-12-09 4 SGEN SEATTLE GENETICS INC /WA
Common Stock J - Other 30,507 3,993,087 0.77

2014-12-10 2014-12-09 4 SGEN SEATTLE GENETICS INC /WA
Common Stock J - Other -399,208 0 -100.00

2014-12-10 2014-12-09 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 5,500 20,455,616 0.03 33.90 186,438 693,400,380

2014-12-10 2014-12-09 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 80,430 20,450,116 0.39 34.64 2,786,393 708,467,684

2014-12-10 2014-12-09 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 42,500 20,369,686 0.21 33.28 1,414,515 677,958,148

2014-12-10 2014-12-08 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 185,528 20,327,186 0.92 33.31 6,180,420 677,151,416

2014-12-10 2014-12-08 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 216,284 20,141,658 1.09 32.56 7,043,267 655,911,079

2014-12-10 2014-12-08 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 38,614 19,925,374 0.19 33.00 1,274,254 657,533,357

2014-12-10 2014-12-08 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 24,890 19,886,760 0.13 33.06 822,744 657,360,829

2014-12-04 2014-12-04 4 XOMA XOMA Corp
Common Stock S - Sale -28,086 473,764 -5.60 4.55 -127,671 2,153,589

2014-12-04 2014-12-04 4 XOMA XOMA Corp
Common Stock S - Sale -1,122,584 17,743,703 -5.95 4.55 -5,102,930 80,657,551

2014-12-04 2014-12-04 4 XOMA XOMA Corp
Common Stock S - Sale -153,618 2,559,999 -5.66 4.55 -698,301 11,636,987

2014-12-04 2014-12-03 4 XOMA XOMA Corp
Common Stock S - Sale -11,965 501,850 -2.33 4.84 -57,913 2,429,054

2014-12-04 2014-12-03 4 XOMA XOMA Corp
Common Stock S - Sale -486,800 18,866,287 -2.52 4.84 -2,356,209 91,316,602

2014-12-04 2014-12-03 4 XOMA XOMA Corp
Common Stock S - Sale -69,153 2,713,617 -2.49 4.84 -334,714 13,134,449

2014-12-04 2014-12-02 4 XOMA XOMA Corp
Common Stock S - Sale -10,534 513,815 -2.01 5.36 -56,453 2,753,586

2014-12-04 2014-12-02 4 XOMA XOMA Corp
Common Stock S - Sale -428,583 19,353,087 -2.17 5.36 -2,296,819 103,715,129

2014-12-04 2014-12-02 4 XOMA XOMA Corp
Common Stock S - Sale -60,883 2,782,770 -2.14 5.36 -326,278 14,913,143

2014-11-10 2014-11-10 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 98,076 19,861,870 0.50 36.57 3,586,737 726,368,448

2014-11-10 2014-11-10 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 10,639 19,763,794 0.05 36.75 390,999 726,349,075

2014-11-10 2014-11-10 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 69,397 19,753,155 0.35 35.88 2,490,291 708,836,041

2014-11-10 2014-11-10 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 63,137 19,683,758 0.32 36.74 2,319,502 723,134,028

2014-11-10 2014-11-07 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 25,505 19,620,621 0.13 35.91 915,851 704,550,993

2014-11-10 2014-11-07 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 22,839 19,595,116 0.12 35.55 811,963 696,637,726

2014-11-10 2014-11-07 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 13,116 19,572,277 0.07 35.56 466,413 696,001,913

2014-11-10 2014-11-07 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 17,098 19,559,161 0.09 34.91 596,816 682,724,250

2014-11-10 2014-11-07 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 104,140 19,542,063 0.54 35.98 3,746,947 703,121,473

2014-11-10 2014-11-07 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 29,006 19,437,923 0.15 35.28 1,023,471 685,863,225

2014-11-10 2014-11-06 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 13,500 19,408,917 0.07 34.26 462,530 664,978,610

2014-11-10 2014-11-06 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 25,769 19,395,417 0.13 34.58 890,989 670,615,938

2014-11-10 2014-11-06 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 866,669 19,369,648 4.68 33.79 29,287,172 654,554,641

2014-11-10 2014-11-06 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 4,394 18,502,979 0.02 33.71 148,139 623,807,584

2014-11-10 2014-11-06 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 38,166 18,498,585 0.21 34.83 1,329,390 644,339,013

2014-11-10 2014-11-06 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 252,474 18,460,419 1.39 34.41 8,686,949 635,173,175

2014-10-03 2014-10-01 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 8,914 50,201 21.59 2.16 19,254 108,434

2014-10-03 2014-10-01 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 8,914 50,201 21.59 2.16 19,254 108,434

2014-10-03 2014-10-01 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 8,914 1,421,519 0.63 2.16 19,254 3,070,481

2014-10-03 2014-10-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 700 305,329 0.23 28.54 19,978 8,714,090

2014-10-03 2014-10-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 700 305,329 0.23 28.54 19,978 8,714,090

2014-10-03 2014-10-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 700 1,348,711 0.05 28.54 19,978 38,492,212

2014-10-03 2014-10-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 700 11,419,665 0.01 28.54 19,978 325,917,239

2014-10-03 2014-10-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 700 192,618 0.36 28.54 19,978 5,497,318

2014-10-03 2014-10-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 700 353,277 0.20 28.54 19,978 10,082,526

2014-09-16 2014-09-12 4 XOMA XOMA Corp
Non-Qualified Stock Option (right to buy) A - Award 7,000 7,000

2014-09-16 2014-09-12 4 XOMA XOMA Corp
Common Shares A - Award 5,500 524,349 1.06

2014-09-16 2014-09-12 4 XOMA XOMA Corp
Common Shares A - Award 5,500 524,349 1.06

2014-09-16 2014-09-12 4 XOMA XOMA Corp
Common Shares A - Award 5,500 524,349 1.06

2014-07-03 2014-07-01 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 6,182 41,287 17.61 2.83 17,495 116,842

2014-07-03 2014-07-01 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 6,182 41,287 17.61 2.83 17,495 116,842

2014-07-03 2014-07-01 4 IDRA IDERA PHARMACEUTICALS, INC.
Common Stock A - Award 6,182 1,412,605 0.44 2.83 17,495 3,997,672

2014-07-03 2014-07-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 716 304,629 0.24 27.86 19,948 8,486,964

2014-07-03 2014-07-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 716 1,348,011 0.05 27.86 19,948 37,555,586

2014-07-03 2014-07-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 716 11,418,965 0.01 27.86 19,948 318,132,365

2014-07-03 2014-07-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 716 1,908,088 0.04 27.86 19,948 53,159,332

2014-07-03 2014-07-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 716 191,918 0.37 27.86 19,948 5,346,835

2014-07-03 2014-07-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 716 352,577 0.20 27.86 19,948 9,822,795

2014-06-24 2014-06-20 4 GEVA SYNAGEVA BIOPHARMA CORP
Non-Qualified Stock Options (right to buy) M - Exercise -4,250 0 -100.00

2014-06-24 2014-06-20 4 GEVA SYNAGEVA BIOPHARMA CORP
Non-Qualified Stock Options (right to buy) M - Exercise -4,250 0 -100.00

2014-06-24 2014-06-20 4 GEVA SYNAGEVA BIOPHARMA CORP
Non-Qualified Stock Options (right to buy) M - Exercise -4,250 0 -100.00

2014-06-24 2014-06-20 4 GEVA SYNAGEVA BIOPHARMA CORP
Non-Qualified Stock Options (right to buy) M - Exercise -4,250 0 -100.00

2014-06-24 2014-06-20 4 GEVA SYNAGEVA BIOPHARMA CORP
Non-Qualified Stock Options (right to buy) M - Exercise -4,250 0 -100.00

2014-06-24 2014-06-20 4 GEVA SYNAGEVA BIOPHARMA CORP
Non-Qualified Stock Options (right to buy) M - Exercise -4,250 0 -100.00

2014-06-24 2014-06-20 4 GEVA SYNAGEVA BIOPHARMA CORP
Non-Qualified Stock Options (right to buy) M - Exercise -4,250 0 -100.00

2014-06-24 2014-06-20 4 GEVA SYNAGEVA BIOPHARMA CORP
Common Stock M - Exercise 4,250 223,864 1.94 60.45 256,912 13,532,579

2014-06-24 2014-06-20 4 GEVA SYNAGEVA BIOPHARMA CORP
Common Stock M - Exercise 4,250 223,864 1.94 60.45 256,912 13,532,579

2014-06-24 2014-06-20 4 GEVA SYNAGEVA BIOPHARMA CORP
Common Stock M - Exercise 4,250 223,864 1.94 60.45 256,912 13,532,579

2014-06-24 2014-06-20 4 GEVA SYNAGEVA BIOPHARMA CORP
Common Stock M - Exercise 4,250 257,722 1.68 60.45 256,912 15,579,295

2014-06-24 2014-06-20 4 GEVA SYNAGEVA BIOPHARMA CORP
Common Stock M - Exercise 4,250 1,893,297 0.22 60.45 256,912 114,449,804

2014-06-24 2014-06-20 4 GEVA SYNAGEVA BIOPHARMA CORP
Common Stock M - Exercise 4,250 212,711 2.04 60.45 256,912 12,858,380

2014-06-24 2014-06-20 4 GEVA SYNAGEVA BIOPHARMA CORP
Common Stock M - Exercise 4,250 322,445 1.34 60.45 256,912 19,491,800

2014-06-16 2014-06-13 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 670 416,208 0.16 39.80 26,668 16,566,494

2014-06-16 2014-06-13 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 27,046 18,207,945 0.15 39.80 1,076,523 724,738,118

2014-06-16 2014-06-13 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 1,471 415,538 0.36 39.93 58,731 16,590,770

2014-06-16 2014-06-13 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 59,400 18,180,899 0.33 39.93 2,371,604 725,890,573

2014-06-16 2014-06-12 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 1,938 414,067 0.47 39.99 77,503 16,559,036

2014-06-16 2014-06-12 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 78,262 18,121,499 0.43 39.99 3,129,791 724,700,491

2014-06-16 2014-06-12 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 1,155 412,129 0.28 39.84 46,021 16,421,239

2014-06-16 2014-06-12 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 46,653 18,043,237 0.26 39.84 1,858,884 718,930,974

2014-06-11 2014-06-09 4 IDRA IDERA PHARMACEUTICALS, INC.
Non-Qualified Stock Option (right to buy) A - Award 70,000 70,000

2014-06-10 2014-06-06 4 ACAD ACADIA PHARMACEUTICALS INC
Non-Qualified Stock Option (right to buy) A - Award 12,500 12,500

2014-06-10 2014-06-06 4 GHDX GENOMIC HEALTH INC
Non-Qualified Stock Options (right to buy) A - Award 20,000 20,000

2014-06-09 2014-06-09 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 5,534 410,974 1.36 38.96 215,578 16,009,574

2014-06-09 2014-06-09 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 223,466 17,996,584 1.26 38.96 8,705,163 701,060,529

2014-06-09 2014-06-09 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 534 405,440 0.13 38.56 20,591 15,633,847

2014-06-09 2014-06-09 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 21,559 17,773,118 0.12 38.56 831,319 685,334,985

2014-06-09 2014-06-06 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 477 404,906 0.12 37.52 17,895 15,190,413

2014-06-09 2014-06-06 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 19,223 17,751,559 0.11 37.52 721,168 665,965,712

2014-06-09 2014-06-06 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 3,757 404,429 0.94 37.40 140,504 15,124,795

2014-06-09 2014-06-06 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 151,530 17,732,336 0.86 37.40 5,666,904 663,152,128

2014-06-09 2014-06-05 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 2,411 400,672 0.61 37.67 90,826 15,093,995

2014-06-09 2014-06-05 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 97,254 17,580,806 0.56 37.67 3,663,724 662,298,849

2014-06-09 2014-06-05 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 496 398,261 0.12 37.63 18,667 14,988,274

2014-06-09 2014-06-05 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 20,011 17,483,552 0.11 37.63 753,100 657,981,241

2014-06-06 2014-06-04 4 GEVA SYNAGEVA BIOPHARMA CORP
Non-Qualified Stock Options (right to buy) A - Award 15,000 15,000

2014-06-04 2014-06-04 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 1,534 397,765 0.39 36.04 55,281 14,334,377

2014-06-04 2014-06-04 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 61,878 17,463,541 0.36 36.04 2,229,916 629,338,866

2014-06-04 2014-06-04 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 572 396,231 0.14 36.39 20,817 14,419,995

2014-06-04 2014-06-04 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 23,058 17,401,663 0.13 36.39 839,147 633,296,981

2014-06-04 2014-06-03 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 19 395,659 0.00 35.27 670 13,956,001

2014-06-04 2014-06-03 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 781 17,378,605 0.00 35.27 27,548 612,992,058

2014-06-04 2014-06-03 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 2,137 395,640 0.54 34.38 73,479 13,603,725

2014-06-04 2014-06-03 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 86,201 17,377,824 0.50 34.38 2,963,944 597,520,838

2014-06-04 2014-06-03 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 270 393,503 0.07 35.11 9,481 13,817,386

2014-06-04 2014-06-03 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 10,896 17,291,623 0.06 35.11 382,600 607,174,592

2014-06-04 2014-06-02 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 1,809 393,233 0.46 34.05 61,604 13,391,196

2014-06-04 2014-06-02 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 72,980 17,280,727 0.42 34.05 2,485,268 588,479,605

2014-06-04 2014-06-02 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 480 391,424 0.12 34.21 16,421 13,391,046

2014-06-04 2014-06-02 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 19,348 17,207,747 0.11 34.21 661,916 588,695,953

2014-05-29 2014-05-28 4 INCY INCYTE CORP
Non-Qualified Stock Options (right to buy) A - Award 15,000 15,000

2014-05-27 2014-05-22 4 XOMA XOMA Corp
Non-Qualified Stock Option (right to buy) A - Award 11,600 11,600

2014-05-27 2014-05-22 4 XOMA XOMA Corp
Common Shares A - Award 8,400 518,849 1.65

2014-05-27 2014-05-22 4 XOMA XOMA Corp
Common Shares A - Award 8,400 518,849 1.65

2014-05-27 2014-05-22 4 XOMA XOMA Corp
Common Shares A - Award 8,400 518,849 1.65

2014-05-23 2014-05-21 4 INCY INCYTE CORP
Non-Qualified Stock Options (right to buy) M - Exercise -10,000 0 -100.00

2014-05-23 2014-05-21 4 INCY INCYTE CORP
Non-Qualified Stock Options (right to buy) M - Exercise -10,000 0 -100.00

2014-05-23 2014-05-21 4 INCY INCYTE CORP
Non-Qualified Stock Options (right to buy) M - Exercise -10,000 0 -100.00

2014-05-23 2014-05-21 4 INCY INCYTE CORP
Common Stock M - Exercise 10,000 390,839 2.63 7.02 70,200 2,743,690

2014-05-23 2014-05-21 4 INCY INCYTE CORP
Common Stock M - Exercise 10,000 390,839 2.63 7.02 70,200 2,743,690

2014-05-23 2014-05-21 4 INCY INCYTE CORP
Common Stock M - Exercise 10,000 390,839 2.63 7.02 70,200 2,743,690

2014-05-16 2014-05-16 4 SGEN SEATTLE GENETICS INC /WA
Non-Qualified Stock Options (right to buy) A - Award 8,750 8,750

2014-05-16 2014-05-16 4 SGEN SEATTLE GENETICS INC /WA
Non-Qualified Stock Options (right to buy) A - Award 8,750 8,750

2014-05-16 2014-05-16 4 SGEN SEATTLE GENETICS INC /WA
Non-Qualified Stock Options (right to buy) A - Award 8,750 8,750

2014-05-16 2014-05-16 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 1,151 390,944 0.30 34.08 39,232 13,325,287

2014-05-16 2014-05-16 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 46,460 17,188,399 0.27 34.08 1,583,584 585,864,861

2014-05-16 2014-05-16 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 2,921 389,793 0.76 34.03 99,415 13,266,449

2014-05-16 2014-05-16 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 117,879 17,141,939 0.69 34.03 4,011,965 583,419,037

2014-05-16 2014-05-16 4 SGEN SEATTLE GENETICS INC /WA
Common Stock A - Award 3,500 386,872 0.91

2014-05-16 2014-05-16 4 SGEN SEATTLE GENETICS INC /WA
Common Stock A - Award 3,500 386,872 0.91

2014-05-16 2014-05-16 4 SGEN SEATTLE GENETICS INC /WA
Common Stock A - Award 3,500 17,178,061 0.02

2014-05-16 2014-05-15 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 505 383,372 0.13 34.26 17,304 13,136,012

2014-05-16 2014-05-15 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 20,395 17,020,560 0.12 34.26 698,822 583,199,276

2014-05-16 2014-05-15 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 7 382,867 0.00 34.10 239 13,055,765

2014-05-16 2014-05-15 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 293 17,000,165 0.00 34.10 9,991 579,705,626

2014-05-16 2014-05-14 4 SGEN SEATTLE GENETICS INC /WA
Non-Qualified Stock Options (right to buy) M - Exercise -10,000 0 -100.00

2014-05-16 2014-05-14 4 SGEN SEATTLE GENETICS INC /WA
Non-Qualified Stock Options (right to buy) M - Exercise -10,000 0 -100.00

2014-05-16 2014-05-14 4 SGEN SEATTLE GENETICS INC /WA
Non-Qualified Stock Options (right to buy) M - Exercise -10,000 0 -100.00

2014-05-16 2014-05-14 4 SGEN SEATTLE GENETICS INC /WA
Common Stock M - Exercise 10,000 382,860 2.68 7.26 72,600 2,779,564

2014-05-16 2014-05-14 4 SGEN SEATTLE GENETICS INC /WA
Common Stock M - Exercise 10,000 382,860 2.68 7.26 72,600 2,779,564

2014-05-16 2014-05-14 4 SGEN SEATTLE GENETICS INC /WA
Common Stock M - Exercise 10,000 382,860 2.68 7.26 72,600 2,779,564

2014-05-16 2014-05-09 4/A SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 746 372,860 0.20 34.60 25,815 12,902,522

2014-05-16 2014-05-09 4/A SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 30,122 16,989,872 0.18 34.60 1,042,348 587,920,929

2014-05-16 2014-05-09 4/A SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 740 372,114 0.20 33.73 24,964 12,553,191

2014-05-16 2014-05-09 4/A SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 29,865 16,959,750 0.18 33.73 1,007,490 572,133,774

2014-05-16 2014-05-09 4/A SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 1,069 371,374 0.29 34.31 36,673 12,740,319

2014-05-16 2014-05-09 4/A SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 43,131 16,929,885 0.26 34.31 1,479,648 580,794,942

2014-05-16 2014-05-09 4/A SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 783 370,305 0.21 33.92 26,559 12,560,486

2014-05-16 2014-05-09 4/A SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 31,617 16,886,754 0.19 33.92 1,072,427 572,786,875

2014-05-16 2014-05-08 4/A SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 329 369,522 0.09 34.74 11,430 12,837,564

2014-05-16 2014-05-08 4/A SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 13,271 16,855,137 0.08 34.74 461,048 585,564,315

2014-05-16 2014-05-08 4/A SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 2,933 369,193 0.80 33.77 99,060 12,469,235

2014-05-16 2014-05-08 4/A SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 118,389 16,841,866 0.71 33.77 3,998,506 568,822,235

2014-05-16 2014-05-08 4/A SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 839 366,260 0.23 33.72 28,295 12,352,009

2014-05-16 2014-05-08 4/A SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 33,868 16,723,477 0.20 34.72 1,176,056 580,717,722

2014-05-16 2014-05-08 4/A SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 1,534 365,421 0.42 33.98 52,118 12,415,252

2014-05-16 2014-05-08 4/A SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 61,892 16,689,609 0.37 33.98 2,102,793 567,032,804

2014-05-16 2014-05-07 4/A SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 623 363,887 0.17 34.01 21,190 12,376,779

2014-05-16 2014-05-07 4/A SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 25,156 16,627,717 0.15 34.01 855,623 565,553,550

2014-05-16 2014-05-07 4/A SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 1,228 363,264 0.34 33.40 41,020 12,134,580

2014-05-16 2014-05-07 4/A SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 49,553 16,602,561 0.30 33.40 1,655,283 554,596,928

2014-05-16 2014-05-07 4/A SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 984 362,036 0.27 33.54 33,007 12,143,991

2014-05-16 2014-05-07 4/A SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 39,710 16,553,008 0.24 33.54 1,332,016 555,247,479

2014-05-09 2013-05-09 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 746 372,860 0.20 34.60 25,815 12,902,522

2014-05-09 2013-05-09 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 30,122 16,989,872 0.18 34.60 1,042,348 587,920,929

2014-05-09 2013-05-09 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 740 372,114 0.20 33.73 24,964 12,553,191

2014-05-09 2013-05-09 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 29,865 16,959,750 0.18 33.73 1,007,490 572,133,774

2014-05-09 2013-05-09 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 1,069 371,374 0.29 34.31 36,673 12,740,319

2014-05-09 2013-05-09 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 43,131 16,929,885 0.26 34.31 1,479,648 580,794,942

2014-05-09 2013-05-09 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 783 370,305 0.21 33.92 26,559 12,560,486

2014-05-09 2013-05-09 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 31,617 16,886,754 0.19 33.92 1,072,427 572,786,875

2014-05-09 2013-05-08 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 329 369,522 0.09 34.74 11,430 12,837,564

2014-05-09 2013-05-08 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 13,271 16,855,137 0.08 34.74 461,048 585,564,315

2014-05-09 2013-05-08 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 2,933 369,193 0.80 33.77 99,060 12,469,235

2014-05-09 2013-05-08 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 118,389 16,841,866 0.71 33.77 3,998,506 568,822,235

2014-05-09 2013-05-08 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 839 366,260 0.23 33.72 28,295 12,352,009

2014-05-09 2013-05-08 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 33,868 16,723,477 0.20 34.72 1,176,056 580,717,722

2014-05-09 2013-05-08 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 1,534 365,421 0.42 33.98 52,118 12,415,252

2014-05-09 2013-05-08 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 61,892 16,689,609 0.37 33.98 2,102,793 567,032,804

2014-05-09 2013-05-07 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 623 363,887 0.17 34.01 21,190 12,376,779

2014-05-09 2013-05-07 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 25,156 16,627,717 0.15 34.01 855,623 565,553,550

2014-05-09 2013-05-07 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 1,228 363,264 0.34 33.40 41,020 12,134,580

2014-05-09 2013-05-07 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 49,553 16,602,561 0.30 33.40 1,655,283 554,596,928

2014-05-09 2013-05-07 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 984 362,036 0.27 33.54 33,007 12,143,991

2014-05-09 2013-05-07 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 39,710 16,553,008 0.24 33.54 1,332,016 555,247,479

2014-04-25 2014-04-23 4 GEVA SYNAGEVA BIOPHARMA CORP
Non-Qualified Stock Options (right to buy) M - Exercise 8,000 0 -100.00 65.10 520,800

2014-04-25 2014-04-23 4 GEVA SYNAGEVA BIOPHARMA CORP
Non-Qualified Stock Options (right to buy) M - Exercise 8,000 0 -100.00 65.10 520,800

2014-04-25 2014-04-23 4 GEVA SYNAGEVA BIOPHARMA CORP
Non-Qualified Stock Options (right to buy) M - Exercise 8,000 0 -100.00 65.10 520,800

2014-04-25 2014-04-23 4 GEVA SYNAGEVA BIOPHARMA CORP
Non-Qualified Stock Options (right to buy) M - Exercise 8,000 0 -100.00 65.10 520,800

2014-04-25 2014-04-23 4 GEVA SYNAGEVA BIOPHARMA CORP
Non-Qualified Stock Options (right to buy) M - Exercise 8,000 0 -100.00 65.10 520,800

2014-04-25 2014-04-23 4 GEVA SYNAGEVA BIOPHARMA CORP
Non-Qualified Stock Options (right to buy) M - Exercise 8,000 0 -100.00 65.10 520,800

2014-04-25 2014-04-23 4 GEVA SYNAGEVA BIOPHARMA CORP
Non-Qualified Stock Options (right to buy) M - Exercise 8,000 0 -100.00 65.10 520,800

2014-04-25 2014-04-23 4 GEVA SYNAGEVA BIOPHARMA CORP
Common Stock M - Exercise 8,000 219,614 3.78 65.10 520,800 14,296,871

2014-04-25 2014-04-23 4 GEVA SYNAGEVA BIOPHARMA CORP
Common Stock M - Exercise 8,000 219,614 3.78 65.10 520,800 14,296,871

2014-04-25 2014-04-23 4 GEVA SYNAGEVA BIOPHARMA CORP
Common Stock M - Exercise 8,000 219,614 3.78 65.10 520,800 14,296,871

2014-04-25 2014-04-23 4 GEVA SYNAGEVA BIOPHARMA CORP
Common Stock M - Exercise 8,000 253,472 3.26 65.10 520,800 16,501,027

2014-04-25 2014-04-23 4 GEVA SYNAGEVA BIOPHARMA CORP
Common Stock M - Exercise 8,000 1,889,047 0.43 65.10 520,800 122,976,960

2014-04-25 2014-04-23 4 GEVA SYNAGEVA BIOPHARMA CORP
Common Stock M - Exercise 8,000 208,461 3.99 65.10 520,800 13,570,811

2014-04-25 2014-04-23 4 GEVA SYNAGEVA BIOPHARMA CORP
Common Stock M - Exercise 8,000 318,195 2.58 65.10 520,800 20,714,494

2014-04-03 2014-04-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 752 303,913 0.25 26.57 19,981 8,074,968

2014-04-03 2014-04-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 752 303,913 0.25 26.57 19,981 8,074,968

2014-04-03 2014-04-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 752 1,347,295 0.06 26.57 19,981 35,797,628

2014-04-03 2014-04-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 752 11,418,249 0.01 26.57 19,981 303,382,876

2014-04-03 2014-04-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 752 1,907,372 0.04 26.57 19,981 50,678,874

2014-04-03 2014-04-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 752 191,202 0.39 26.57 19,981 5,080,237

2014-03-19 2014-03-17 4 IDRA IDERA PHARMACEUTICALS, INC.
Non-Qualified Stock Option (right to buy) A - Award 80,000 80,000

2014-03-12 2014-03-10 4 IDP IDERA PHARMACEUTICALS, INC.
Non-Qualified Stock Option (right to buy) A - Award 60,000 60,000

2014-03-12 3 IDP IDERA PHARMACEUTICALS, INC.
Common Stock 1,784,624

2014-03-12 3 IDP IDERA PHARMACEUTICALS, INC.
Common Stock 3,019,499

2014-03-12 3 IDP IDERA PHARMACEUTICALS, INC.
Common Stock 1,648,181

2014-03-12 3 IDP IDERA PHARMACEUTICALS, INC.
Common Stock 1,784,624

2014-03-12 3 IDP IDERA PHARMACEUTICALS, INC.
Common Stock 3,019,499

2014-03-12 3 IDP IDERA PHARMACEUTICALS, INC.
Common Stock 1,648,181

2014-03-12 3 IDP IDERA PHARMACEUTICALS, INC.
Common Stock 1,784,624

2014-03-12 3 IDP IDERA PHARMACEUTICALS, INC.
Common Stock 3,019,499

2014-03-12 3 IDP IDERA PHARMACEUTICALS, INC.
Common Stock 1,648,181

2014-03-12 3 IDP IDERA PHARMACEUTICALS, INC.
Common Stock 1,784,624

2014-03-12 3 IDP IDERA PHARMACEUTICALS, INC.
Common Stock 3,019,499

2014-03-12 3 IDP IDERA PHARMACEUTICALS, INC.
Common Stock 1,648,181

2014-03-12 3 IDP IDERA PHARMACEUTICALS, INC.
Common Stock 1,784,624

2014-03-12 3 IDP IDERA PHARMACEUTICALS, INC.
Common Stock 3,019,499

2014-03-12 3 IDP IDERA PHARMACEUTICALS, INC.
Common Stock 1,648,181

2014-03-12 3 IDP IDERA PHARMACEUTICALS, INC.
Common Stock 1,784,624

2014-03-12 3 IDP IDERA PHARMACEUTICALS, INC.
Common Stock 3,019,499

2014-03-12 3 IDP IDERA PHARMACEUTICALS, INC.
Common Stock 1,648,181

2014-03-12 3 IDP IDERA PHARMACEUTICALS, INC.
Common Stock 1,784,624

2014-03-12 3 IDP IDERA PHARMACEUTICALS, INC.
Common Stock 3,019,499

2014-03-12 3 IDP IDERA PHARMACEUTICALS, INC.
Common Stock 1,648,181

2014-03-12 3 IDP IDERA PHARMACEUTICALS, INC.
Common Stock 1,784,624

2014-03-12 3 IDP IDERA PHARMACEUTICALS, INC.
Common Stock 3,019,499

2014-03-12 3 IDP IDERA PHARMACEUTICALS, INC.
Common Stock 1,648,181

2014-03-07 2014-03-06 4 GEVA SYNAGEVA BIOPHARMA CORP
Common Stock P - Purchase 9,031 211,614 4.46 105.75 955,028 22,378,180

2014-03-07 2014-03-06 4 GEVA SYNAGEVA BIOPHARMA CORP
Common Stock P - Purchase 365,969 8,172,521 4.69 105.75 38,701,222 864,244,096

2014-03-07 2014-03-05 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 11,738 452,540 2.66 28.50 334,533 12,897,390

2014-03-07 2014-03-05 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 475,644 18,476,847 2.64 28.50 13,555,854 526,590,140

2014-03-07 2014-03-05 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 38,934 1,552,055 2.57 28.50 1,109,619 44,233,568

2014-01-03 2014-01-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 682 303,161 0.23 29.27 19,962 8,873,522

2014-01-03 2014-01-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 682 303,161 0.23 29.27 19,962 8,873,522

2014-01-03 2014-01-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 682 11,243,600 0.01 29.27 19,962 329,100,172

2014-01-03 2014-01-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 682 1,732,723 0.04 29.27 19,962 50,716,802

2014-01-03 2014-01-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 682 16,553 4.30 29.27 19,962 484,506

2014-01-03 2014-01-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 682 177,212 0.39 29.27 19,962 5,186,995

2013-12-16 2013-12-16 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 639 361,052 0.18 39.91 25,504 14,410,344

2013-12-16 2013-12-16 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 25,596 16,513,298 0.16 39.91 1,021,590 659,080,401

2013-12-16 2013-12-16 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 1,280 360,413 0.36 39.92 51,100 14,388,372

2013-12-16 2013-12-16 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 51,244 16,487,702 0.31 39.92 2,045,758 658,220,390

2013-12-16 2013-12-13 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 1,063 359,133 0.30 39.65 42,153 14,241,383

2013-12-16 2013-12-13 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 42,646 16,436,458 0.26 39.65 1,691,123 651,786,098

2013-12-16 2013-12-12 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 2,486 358,070 0.70 39.70 98,694 14,215,379

2013-12-16 2013-12-12 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 99,775 16,393,812 0.61 39.70 3,961,068 650,834,336

2013-12-16 2013-12-12 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 1,377 355,584 0.39 39.54 54,442 14,058,725

2013-12-16 2013-12-12 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 55,256 16,294,037 0.34 39.54 2,184,656 644,217,341

2013-12-16 2013-12-12 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 3,056 354,207 0.87 39.53 120,798 14,001,201

2013-12-16 2013-12-12 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 122,660 16,238,781 0.76 39.53 4,848,541 641,891,407

2013-12-05 2013-12-05 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 5,492 351,151 1.59 43.98 241,512 15,441,935

2013-12-05 2013-12-05 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 219,958 16,116,121 1.38 43.98 9,672,697 708,709,644

2013-12-05 2013-12-05 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 553 345,659 0.16 44.00 24,332 15,208,823

2013-12-05 2013-12-05 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 22,147 15,896,163 0.14 44.00 974,457 699,423,224

2013-12-05 2013-12-05 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 2,863 345,106 0.84 44.05 126,102 15,200,366

2013-12-05 2013-12-05 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 114,663 15,874,016 0.73 44.05 5,050,389 699,178,972

2013-12-05 2013-12-04 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 170 342,243 0.05 43.42 7,382 14,861,800

2013-12-05 2013-12-04 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 6,814 15,759,353 0.04 43.42 295,896 684,345,176

2013-12-05 2013-12-04 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 2,512 342,073 0.74 42.95 107,883 14,691,043

2013-12-05 2013-12-04 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 100,626 15,752,539 0.64 42.95 4,321,595 676,525,868

2013-12-05 2013-12-04 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 340 339,561 0.10 43.72 14,864 14,845,233

2013-12-05 2013-12-04 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 13,632 15,651,913 0.09 43.72 595,976 684,284,419

2013-12-05 2013-12-04 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 1,011 339,221 0.30 43.01 43,479 14,588,403

2013-12-05 2013-12-04 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 40,471 15,638,281 0.26 43.01 1,740,480 672,533,657

2013-12-05 2013-12-04 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 1,818 338,210 0.54 43.20 78,547 14,612,329

2013-12-05 2013-12-04 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 72,807 15,597,810 0.47 43.20 3,145,619 673,901,821

2013-12-05 2013-12-04 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 455 336,392 0.14 43.64 19,858 14,681,829

2013-12-05 2013-12-04 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 18,232 15,525,003 0.12 43.64 795,736 677,588,756

2013-12-05 2013-12-04 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 290 335,937 0.09 42.65 12,369 14,328,721

2013-12-05 2013-12-04 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 11,617 15,506,771 0.07 42.65 495,500 661,410,303

2013-12-05 2013-12-03 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 3,551 335,647 1.07 42.56 151,129 14,284,968

2013-12-05 2013-12-03 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 142,220 15,495,154 0.93 42.56 6,052,812 659,466,007

2013-12-05 2013-12-03 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 2,632 332,096 0.80 42.41 111,631 14,085,188

2013-12-05 2013-12-03 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 105,414 15,352,934 0.69 42.41 4,470,924 651,163,990

2013-12-05 2013-12-03 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 2,816 329,464 0.86 42.31 119,144 13,939,556

2013-12-05 2013-12-03 4 SGEN SEATTLE GENETICS INC /WA
Common Stock P - Purchase 112,797 15,247,520 0.75 42.31 4,772,419 645,119,522

2013-11-13 2013-11-08 4 INCY INCYTE CORP
4.75% Convertible Senior Note due 2015 D - Sale to Issuer -127,000 892,000 -12.46 432.60 -54,940,390 385,880,538

2013-11-13 2013-11-08 4 INCY INCYTE CORP
4.75% Convertible Senior Note due 2015 D - Sale to Issuer -4,567,000 31,967,000 -12.50 432.60 -1,975,691,050 13,828,972,150

2013-11-13 2013-11-08 4 INCY INCYTE CORP
4.75% Convertible Senior Note due 2015 D - Sale to Issuer -1,084,000 7,587,000 -12.50 432.60 -468,940,026 3,282,147,580

2013-11-13 2013-11-08 4 INCY INCYTE CORP
4.75% Convertible Senior Note due 2015 D - Sale to Issuer -2,459,000 1,019,000 -70.70 425.88 -1,047,233,756 433,969,580

2013-11-13 2013-11-08 4 INCY INCYTE CORP
4.75% Convertible Senior Note due 2015 D - Sale to Issuer -88,153,000 36,534,000 -70.70 425.88 -37,542,414,519 15,559,023,199

2013-11-13 2013-11-08 4 INCY INCYTE CORP
4.75% Convertible Senior Note due 2015 D - Sale to Issuer -20,922,000 8,671,000 -70.70 425.88 -8,910,217,424 3,692,787,271

2013-11-13 2013-11-08 4 INCY INCYTE CORP
1.25% Convertible Senior Note due 2020 P - Purchase 170,000 6,050,000 2.89 104.52 17,768,043 632,333,295

2013-11-13 2013-11-08 4 INCY INCYTE CORP
1.25% Convertible Senior Note due 2020 P - Purchase 6,830,000 243,450,000 2.89 104.52 713,857,257 25,444,882,755

2013-11-13 2013-11-08 4 INCY INCYTE CORP
1.25% Convertible Senior Note due 2020 P - Purchase 242,000 5,880,000 4.29 104.25 25,228,500 612,990,000

2013-11-13 2013-11-08 4 INCY INCYTE CORP
1.25% Convertible Senior Note due 2020 P - Purchase 9,758,000 236,620,000 4.30 104.25 1,017,271,500 24,667,635,000

2013-11-13 2013-11-08 4 INCY INCYTE CORP
1.25% Convertible Senior Note due 2020 P - Purchase 61,000 5,638,000 1.09 103.75 6,328,750 584,942,500

2013-11-13 2013-11-08 4 INCY INCYTE CORP
1.25% Convertible Senior Note due 2020 P - Purchase 2,439,000 226,862,000 1.09 103.75 253,046,250 23,536,932,500

2013-11-13 2013-11-08 4 INCY INCYTE CORP
1.25% Convertible Senior Note due 2020 P - Purchase 121,000 5,577,000 2.22 104.75 12,674,750 584,190,750

2013-11-13 2013-11-08 4 INCY INCYTE CORP
1.25% Convertible Senior Note due 2020 P - Purchase 4,879,000 224,423,000 2.22 104.75 511,075,250 23,508,309,250

2013-11-13 2013-11-08 4 INCY INCYTE CORP
0.375% Convertible Senior Note due 2018 P - Purchase 5,456,000 5,456,000 100.00 545,600,000 545,600,000

2013-11-13 2013-11-08 4 INCY INCYTE CORP
1.25% Convertible Senior Note due 2020 P - Purchase 5,456,000 5,456,000 100.00 545,600,000 545,600,000

2013-11-13 2013-11-08 4 INCY INCYTE CORP
0.375% Convertible Senior Note due 2018 P - Purchase 219,544,000 219,544,000 100.00 21,954,400,000 21,954,400,000

2013-11-13 2013-11-08 4 INCY INCYTE CORP
1.25% Convertible Senior Note due 2020 P - Purchase 219,544,000 219,544,000 100.00 21,954,400,000 21,954,400,000

2013-11-13 2013-11-08 4 INCY INCYTE CORP
0.375% Convertible Senior Note due 2018 P - Purchase 25,000,000 25,000,000 100.00 2,500,000,000 2,500,000,000

2013-11-13 2013-11-08 4 INCY INCYTE CORP
1.25% Convertible Senior Note due 2020 P - Purchase 25,000,000 25,000,000 100.00 2,500,000,000 2,500,000,000

2013-11-13 2013-11-08 4 INCY INCYTE CORP
0.375% Convertible Senior Note due 2018 P - Purchase 133,000 5,674,000 2.40 104.09 13,844,090 590,611,767

2013-11-13 2013-11-08 4 INCY INCYTE CORP
0.375% Convertible Senior Note due 2018 P - Purchase 5,367,000 228,326,000 2.41 104.09 558,655,860 23,766,658,833

2013-11-13 2013-11-08 4 INCY INCYTE CORP
0.375% Convertible Senior Note due 2018 P - Purchase 85,000 5,541,000 1.56 104.12 8,850,625 576,956,625

2013-11-13 2013-11-08 4 INCY INCYTE CORP
0.375% Convertible Senior Note due 2018 P - Purchase 3,415,000 222,959,000 1.56 104.12 355,586,875 23,215,605,875

2013-10-28 2013-10-24 4 MRTX Mirati Therapeutics, Inc.
Common Stock P - Purchase 8,721 40,308 27.61 17.50 152,618 705,390

2013-10-28 2013-10-24 4 MRTX Mirati Therapeutics, Inc.
Common Stock P - Purchase 346,965 2,213,897 18.58 17.50 6,071,888 38,743,198

2013-10-28 2013-10-24 4 MRTX Mirati Therapeutics, Inc.
Common Stock P - Purchase 44,314 125,869 54.34 17.50 775,495 2,202,708

2013-10-02 2013-10-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 658 302,479 0.22 30.33 19,957 9,174,188

2013-10-02 2013-10-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 658 11,242,918 0.01 30.33 19,957 340,997,703

2013-10-02 2013-10-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 658 1,732,041 0.04 30.33 19,957 52,532,804

2013-10-02 2013-10-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 658 15,871 4.33 30.33 19,957 481,367

2013-10-02 2013-10-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 658 176,530 0.37 30.33 19,957 5,354,155

2013-10-02 2013-10-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 658 196,794 0.34 30.33 19,957 5,968,762

2013-09-27 2013-09-25 4 GEVA SYNAGEVA BIOPHARMA CORP
Common Stock P - Purchase 25,663 202,583 14.51 56.63 1,453,296 11,472,275

2013-09-27 2013-09-25 4 GEVA SYNAGEVA BIOPHARMA CORP
Common Stock P - Purchase 1,024,337 7,806,552 15.10 56.63 58,008,204 442,085,040

2013-08-21 2013-08-19 4 XOMA XOMA Corp
Common Stock A - Award 21,410 510,449 4.38 3.62 77,504 1,847,825

2013-08-21 2013-08-19 4 XOMA XOMA Corp
Common Stock A - Award 1,854,058 19,767,770 10.35 3.62 6,711,690 71,559,327

2013-08-21 2013-08-19 4 XOMA XOMA Corp
Common Stock A - Award 882,323 2,829,753 45.31 3.62 3,194,009 10,243,706

2013-08-21 2013-08-19 4/A XOMA XOMA Corp
Common Stock P - Purchase 21,410 510,449 4.38 3.62 77,504 1,847,825

2013-08-21 2013-08-19 4/A XOMA XOMA Corp
Common Stock P - Purchase 1,854,058 19,767,770 10.35 3.62 6,711,690 71,559,327

2013-08-21 2013-08-19 4/A XOMA XOMA Corp
Common Stock P - Purchase 882,323 2,829,753 45.31 3.62 3,194,009 10,243,706

2013-08-02 2013-08-01 4 BCRX BIOCRYST PHARMACEUTICALS INC
Common Stock P - Purchase 24,705 145,533 20.45 4.40 108,702 640,345

2013-08-02 2013-08-01 4 BCRX BIOCRYST PHARMACEUTICALS INC
Common Stock P - Purchase 991,161 4,832,285 25.80 4.40 4,361,108 21,262,054

2013-08-02 2013-08-01 4 BCRX BIOCRYST PHARMACEUTICALS INC
Common Stock P - Purchase 120,498 1,642,513 7.92 4.40 530,191 7,227,057

2013-07-29 2013-07-25 4 GHDX GENOMIC HEALTH INC
Non-Qualified Stock Option (right to buy) A - Award 3,030 3,030

2013-07-29 2013-07-25 4 GHDX GENOMIC HEALTH INC
Non-Qualified Stock Option (right to buy) A - Award 3,030 3,030

2013-07-29 2013-07-25 4 GHDX GENOMIC HEALTH INC
Non-Qualified Stock Option (right to buy) A - Award 3,030 3,030

2013-07-29 2013-07-25 4 GHDX GENOMIC HEALTH INC
Non-Qualified Stock Option (right to buy) A - Award 3,030 3,030

2013-07-29 2013-07-25 4 GHDX GENOMIC HEALTH INC
Non-Qualified Stock Option (right to buy) A - Award 3,030 3,030

2013-07-29 2013-07-25 4 GHDX GENOMIC HEALTH INC
Non-Qualified Stock Option (right to buy) A - Award 3,030 3,030

2013-07-11 3 MYG Mirati Therapeutics, Inc.
Common Stock 81,555

2013-07-11 3 MYG Mirati Therapeutics, Inc.
Common Stock 1,866,932

2013-07-11 3 MYG Mirati Therapeutics, Inc.
Common Stock 31,587

2013-07-03 2013-07-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 606 301,821 0.20 32.85 19,907 9,914,820

2013-07-03 2013-07-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 606 301,821 0.20 32.85 19,907 9,914,820

2013-07-03 2013-07-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 606 301,821 0.20 32.85 19,907 9,914,820

2013-07-03 2013-07-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 606 1,731,383 0.04 32.85 19,907 56,875,932

2013-07-03 2013-07-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 606 15,213 4.15 32.85 19,907 499,747

2013-07-03 2013-07-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 606 175,872 0.35 32.85 19,907 5,777,395

2013-06-13 2013-06-11 4 INCY INCYTE CORP
Non-Qualified Stock Options (right to buy) M - Exercise -10,000 10,000 -50.00 4.44 -44,400 44,400

2013-06-13 2013-06-11 4 INCY INCYTE CORP
Non-Qualified Stock Options (right to buy) M - Exercise -10,000 10,000 -50.00 4.44 -44,400 44,400

2013-06-13 2013-06-11 4 INCY INCYTE CORP
Non-Qualified Stock Options (right to buy) M - Exercise -10,000 10,000 -50.00 4.44 -44,400 44,400

2013-06-13 2013-06-11 4 INCY INCYTE CORP
Common Stock M - Exercise 10,000 380,839 2.70 4.44 44,400 1,690,925

2013-06-13 2013-06-11 4 INCY INCYTE CORP
Common Stock M - Exercise 10,000 380,839 2.70 4.44 44,400 1,690,925

2013-06-13 2013-06-11 4 INCY INCYTE CORP
Common Stock M - Exercise 10,000 12,455,783 0.08 4.44 44,400 55,303,677

2013-06-11 2013-06-07 4 GHDX GENOMIC HEALTH INC
Non-Qualified Stock Option (right to buy) A - Award 16,500 16,500

2013-06-11 2013-06-07 4 GHDX GENOMIC HEALTH INC
Non-Qualified Stock Option (right to buy) A - Award 16,500 16,500

2013-06-11 2013-06-07 4 GHDX GENOMIC HEALTH INC
Non-Qualified Stock Option (right to buy) A - Award 16,500 16,500

2013-06-11 2013-06-07 4 GHDX GENOMIC HEALTH INC
Non-Qualified Stock Option (right to buy) A - Award 16,500 16,500

2013-06-11 2013-06-07 4 GHDX GENOMIC HEALTH INC
Non-Qualified Stock Option (right to buy) A - Award 16,500 16,500

2013-06-11 2013-06-07 4 GHDX GENOMIC HEALTH INC
Non-Qualified Stock Option (right to buy) A - Award 16,500 16,500

2013-06-11 2013-06-07 4 ACAD ACADIA PHARMACEUTICALS INC
Non-Qualified Stock Option (right to buy) A - Award 12,500 12,500

2013-06-11 2013-06-07 4 ACAD ACADIA PHARMACEUTICALS INC
Non-Qualified Stock Option (right to buy) A - Award 12,500 12,500

2013-06-11 2013-06-07 4 ACAD ACADIA PHARMACEUTICALS INC
Non-Qualified Stock Option (right to buy) A - Award 12,500 12,500

2013-06-10 2013-06-06 4 GEVA SYNAGEVA BIOPHARMA CORP
Non-Qualified Stock Option (right to buy) A - Award 15,000 15,000

2013-06-10 2013-06-06 4 GEVA SYNAGEVA BIOPHARMA CORP
Non-Qualified Stock Option (right to buy) A - Award 15,000 15,000

2013-06-10 2013-06-06 4 GEVA SYNAGEVA BIOPHARMA CORP
Non-Qualified Stock Option (right to buy) A - Award 15,000 15,000

2013-06-10 2013-06-06 4 GEVA SYNAGEVA BIOPHARMA CORP
Non-Qualified Stock Option (right to buy) A - Award 15,000 15,000

2013-06-10 2013-06-06 4 GEVA SYNAGEVA BIOPHARMA CORP
Non-Qualified Stock Option (right to buy) A - Award 15,000 15,000

2013-06-10 2013-06-06 4 GEVA SYNAGEVA BIOPHARMA CORP
Non-Qualified Stock Option (right to buy) A - Award 15,000 15,000

2013-06-10 2013-06-06 4 GEVA SYNAGEVA BIOPHARMA CORP
Non-Qualified Stock Option (right to buy) A - Award 15,000 15,000

2013-06-05 2013-06-05 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stoc P - Purchase 5,437 440,802 1.25 14.46 78,641 6,375,804

2013-06-05 2013-06-05 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stoc P - Purchase 217,986 18,001,203 1.23 14.46 3,152,971 260,371,200

2013-06-05 2013-06-05 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stoc P - Purchase 26,577 1,513,121 1.79 14.46 384,412 21,885,933

2013-06-05 2013-06-05 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stoc P - Purchase 3,790 435,365 0.88 14.55 55,145 6,334,648

2013-06-05 2013-06-05 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stoc P - Purchase 151,980 17,783,217 0.86 14.55 2,211,339 258,749,364

2013-06-05 2013-06-05 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stoc P - Purchase 18,530 1,486,544 1.26 14.55 269,615 21,629,513

2013-06-05 2013-06-05 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stoc P - Purchase 4,312 431,575 1.01 14.58 62,885 6,294,003

2013-06-05 2013-06-05 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stoc P - Purchase 172,893 17,631,237 0.99 14.58 2,521,437 257,130,434

2013-06-05 2013-06-05 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stoc P - Purchase 21,080 1,468,014 1.46 14.58 307,427 21,409,223

2013-06-05 2013-06-05 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stoc P - Purchase 5,437 427,263 1.29 14.46 78,600 6,176,728

2013-06-05 2013-06-05 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stoc P - Purchase 217,986 17,458,344 1.26 14.46 3,151,315 252,386,550

2013-06-05 2013-06-05 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stoc P - Purchase 26,577 1,446,934 1.87 14.46 384,210 20,917,601

2013-06-05 2013-06-04 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 2,775 421,826 0.66 14.42 40,004 6,081,001

2013-06-05 2013-06-04 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 111,266 17,240,358 0.65 14.42 1,604,000 248,535,277

2013-06-05 2013-06-04 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 13,566 1,420,357 0.96 14.42 195,566 20,475,724

2013-06-05 2013-06-04 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 11,552 419,051 2.83 14.45 166,955 6,056,335

2013-06-05 2013-06-04 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 463,197 17,129,092 2.78 14.45 6,694,355 247,558,202

2013-06-05 2013-06-04 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 56,475 1,406,791 4.18 14.45 816,205 20,331,647

2013-06-05 2013-06-04 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 890 407,499 0.22 14.50 12,903 5,907,798

2013-06-05 2013-06-04 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 35,702 16,665,895 0.21 14.50 517,597 241,617,146

2013-06-05 2013-06-04 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 4,353 1,350,316 0.32 14.50 63,108 19,576,476

2013-06-05 2013-06-03 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 5,189 406,609 1.29 14.00 72,641 5,692,119

2013-06-05 2013-06-03 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 208,063 16,630,193 1.27 14.00 2,912,674 232,806,072

2013-06-05 2013-06-03 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 25,368 1,345,963 1.92 14.00 355,127 18,842,136

2013-06-05 2013-06-03 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 11,511 401,420 2.95 14.08 162,100 5,652,877

2013-06-05 2013-06-03 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 461,548 16,422,130 2.89 14.08 6,499,611 231,259,719

2013-06-05 2013-06-03 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 56,274 1,320,595 4.45 14.08 792,462 18,596,883

2013-06-05 2013-06-05 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 4,735 301,215 1.60 35.82 169,584 10,788,015

2013-06-05 2013-06-05 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 189,886 11,241,654 1.72 35.82 6,800,767 402,619,838

2013-06-05 2013-06-05 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 23,152 1,730,777 1.36 35.82 829,189 61,987,778

2013-06-05 2013-06-04 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 3,558 296,480 1.21 36.62 130,294 10,857,098

2013-06-05 2013-06-04 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 142,702 11,051,768 1.31 36.62 5,225,747 404,715,744

2013-06-05 2013-06-04 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 17,399 1,707,625 1.03 36.62 637,151 62,533,228

2013-06-03 2013-06-03 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 2,790 292,922 0.96 36.69 102,356 10,746,400

2013-06-03 2013-06-03 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 111,907 10,909,066 1.04 36.69 4,105,521 400,219,813

2013-06-03 2013-06-03 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 13,644 1,690,226 0.81 36.69 500,556 62,009,152

2013-06-03 2013-05-31 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 1,114 290,132 0.39 36.75 40,942 10,662,989

2013-06-03 2013-05-31 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 44,627 10,797,159 0.42 36.75 1,640,140 396,819,347

2013-06-03 2013-05-31 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 5,501 1,676,582 0.33 36.75 202,174 61,618,077

2013-05-29 2013-05-29 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 1,021 289,018 0.35 36.82 37,595 10,642,105

2013-05-29 2013-05-29 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 40,933 10,752,532 0.38 36.82 1,507,219 395,925,432

2013-05-29 2013-05-29 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 5,046 1,671,081 0.30 36.82 185,802 61,531,876

2013-05-29 2013-05-28 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 1,613 287,997 0.56 36.93 59,574 10,636,852

2013-05-29 2013-05-28 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 64,679 10,711,599 0.61 36.93 2,388,848 395,621,126

2013-05-29 2013-05-28 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 7,974 1,666,035 0.48 36.93 294,511 61,533,170

2013-05-24 2013-05-23 4 XOMA XOMA Corp
Non-Qualified Stock Option (right to buy) A - Award 11,600 11,600

2013-05-24 2013-05-23 4 XOMA XOMA Corp
Non-Qualified Stock Option (right to buy) A - Award 11,600 11,600

2013-05-24 2013-05-23 4 XOMA XOMA Corp
Non-Qualified Stock Option (right to buy) A - Award 11,600 11,600

2013-05-24 2013-05-23 4 XOMA XOMA Corp
Common Shares A - Award 8,400 489,039 1.75

2013-05-24 2013-05-23 4 XOMA XOMA Corp
Common Shares A - Award 8,400 489,039 1.75

2013-05-24 2013-05-23 4 XOMA XOMA Corp
Common Shares A - Award 8,400 1,947,430 0.43

2013-05-24 2013-05-24 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 1,358 286,384 0.48 36.93 50,154 10,576,877

2013-05-24 2013-05-24 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 54,399 10,646,920 0.51 36.93 2,009,091 393,217,373

2013-05-24 2013-05-24 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 6,760 1,658,061 0.41 36.93 249,664 61,236,338

2013-05-24 2013-05-23 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 332 285,026 0.12 36.99 12,280 10,542,371

2013-05-24 2013-05-23 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 13,313 10,592,521 0.13 36.99 492,413 391,789,811

2013-05-24 2013-05-23 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 1,655 1,651,301 0.10 36.99 61,214 61,077,331

2013-05-24 2013-05-23 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 35 284,694 0.01 36.18 1,266 10,300,969

2013-05-24 2013-05-23 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 1,392 10,579,208 0.01 36.18 50,366 382,783,251

2013-05-24 2013-05-23 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 173 1,649,646 0.01 36.18 6,260 59,688,481

2013-05-21 2013-05-17 4 SGEN SEATTLE GENETICS INC /WA
Non-Qualified Stock Option (right to buy) A - Award 8,750 8,750

2013-05-21 2013-05-17 4 SGEN SEATTLE GENETICS INC /WA
Non-Qualified Stock Option (right to buy) A - Award 8,750 8,750

2013-05-21 2013-05-17 4 SGEN SEATTLE GENETICS INC /WA
Non-Qualified Stock Option (right to buy) A - Award 8,750 8,750

2013-05-21 2013-05-17 4 SGEN SEATTLE GENETICS INC /WA
Common Stock A - Award 3,500 326,648 1.08

2013-05-21 2013-05-17 4 SGEN SEATTLE GENETICS INC /WA
Common Stock A - Award 3,500 326,648 1.08

2013-05-21 2013-05-17 4 SGEN SEATTLE GENETICS INC /WA
Common Stock A - Award 3,500 326,648 1.08

2013-05-17 2013-05-15 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 43,184 389,909 12.45 12.50 539,800 4,873,862

2013-05-17 2013-05-15 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 1,730,970 15,960,582 12.16 12.50 21,637,125 199,507,275

2013-05-17 2013-05-15 4 ACAD ACADIA PHARMACEUTICALS INC
Common Stock P - Purchase 218,846 1,264,321 20.93 12.50 2,735,575 15,804,012

2013-05-16 2013-05-16 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 418 284,659 0.15 36.54 15,273 10,401,212

2013-05-16 2013-05-16 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 16,768 10,577,816 0.16 36.54 612,689 386,504,934

2013-05-16 2013-05-16 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 2,120 1,649,473 0.13 36.54 77,463 60,270,424

2013-05-16 2013-05-15 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 1,129 284,241 0.40 36.41 41,111 10,350,295

2013-05-16 2013-05-15 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 45,279 10,561,048 0.43 36.41 1,648,780 384,567,890

2013-05-16 2013-05-15 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 5,725 1,647,353 0.35 36.41 208,469 59,986,383

2013-05-14 2013-05-14 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 589 283,112 0.21 35.53 20,928 10,059,507

2013-05-14 2013-05-14 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 23,610 10,515,769 0.23 35.53 838,908 373,645,253

2013-05-14 2013-05-14 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 2,985 1,641,628 0.18 35.53 106,063 58,330,162

2013-05-14 2013-05-13 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 3,516 282,523 1.26 34.02 119,609 9,610,980

2013-05-14 2013-05-13 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 140,962 10,492,159 1.36 34.02 4,795,302 356,926,462

2013-05-14 2013-05-13 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 17,822 1,638,643 1.10 34.02 606,276 55,744,013

2013-05-14 2013-05-13 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 1,104 279,007 0.40 34.74 38,358 9,694,098

2013-05-14 2013-05-13 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 44,244 10,351,197 0.43 34.74 1,537,258 359,652,340

2013-05-14 2013-05-13 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 5,594 1,620,821 0.35 34.74 194,364 56,315,426

2013-04-03 2013-04-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 714 277,903 0.26 27.99 19,985 7,778,505

2013-04-03 2013-04-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 714 277,903 0.26 27.99 19,985 7,778,505

2013-04-03 2013-04-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 714 10,306,953 0.01 27.99 19,985 288,491,614

2013-04-03 2013-04-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 714 1,615,227 0.04 27.99 19,985 45,210,204

2013-04-03 2013-04-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 714 14,607 5.14 27.99 19,985 408,850

2013-04-03 2013-04-01 4 GHDX GENOMIC HEALTH INC
Common Stock A - Award 714 175,266 0.41 27.99 19,985 4,905,695

2013-02-21 2013-02-21 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 612 277,189 0.22 27.63 16,912 7,659,813

2013-02-21 2013-02-21 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 24,508 10,306,239 0.24 27.64 677,325 284,832,497

2013-02-21 2013-02-21 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 3,080 1,614,513 0.19 27.64 85,122 44,620,134

2013-02-21 2013-02-20 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 453 276,577 0.16 27.97 12,672 7,736,744

2013-02-21 2013-02-20 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 18,151 10,281,731 0.18 27.97 507,742 287,612,918

2013-02-21 2013-02-20 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 2,281 1,611,433 0.14 27.97 63,807 45,076,938

2013-02-14 2013-02-14 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 758 276,124 0.28 28.43 21,551 7,850,509

2013-02-14 2013-02-14 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 30,102 10,263,580 0.29 28.43 855,833 291,804,869

2013-02-14 2013-02-14 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 3,940 1,609,152 0.25 28.43 112,019 45,749,961

2013-02-14 2013-02-13 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 375 275,366 0.14 28.58 10,718 7,870,098

2013-02-14 2013-02-13 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 14,878 10,233,478 0.15 28.58 425,221 292,477,918

2013-02-14 2013-02-13 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 1,947 1,605,212 0.12 28.58 55,646 45,877,762

2013-02-11 2013-02-11 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 1,742 274,991 0.64 28.23 49,180 7,763,463

2013-02-11 2013-02-11 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 69,187 10,218,600 0.68 28.23 1,953,267 288,488,450

2013-02-11 2013-02-11 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 9,055 1,603,265 0.57 28.23 255,638 45,262,897

2013-02-11 2013-02-08 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 788 273,249 0.29 27.96 22,033 7,640,288

2013-02-11 2013-02-08 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 31,584 10,149,413 0.31 27.96 883,117 283,786,722

2013-02-11 2013-02-08 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 4,004 1,594,210 0.25 27.96 111,955 44,575,546

2013-01-23 2013-01-18 4 ACAD ACADIA PHARMACEUTICALS INC
Stock Options (right to buy) A - Award 15,000 15,000

2013-01-08 2013-01-04 4 GEVA SYNAGEVA BIOPHARMA CORP
Common Stock P - Purchase 20,099 176,920 12.82 47.53 955,305 8,409,008

2013-01-08 2013-01-04 4 GEVA SYNAGEVA BIOPHARMA CORP
Common Stock P - Purchase 839,621 6,782,215 14.13 47.53 39,907,186 322,358,679

2012-12-21 3 ACAD ACADIA PHARMACEUTICALS INC
Common Stock 1,045,475

2012-12-21 3 ACAD ACADIA PHARMACEUTICALS INC
Common Stock 14,229,612

2012-12-21 3 ACAD ACADIA PHARMACEUTICALS INC
Common Stock 346,725

2012-11-23 2012-11-21 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 6 271,806 0.00 27.54 165 7,485,537

2012-11-23 2012-11-21 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 268 10,117,174 0.00 27.54 7,381 278,626,972

2012-11-23 2012-11-21 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 26 1,589,551 0.00 27.54 716 43,776,235

2012-11-23 2012-11-20 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 4,859 271,800 1.82 26.83 130,352 7,291,551

2012-11-23 2012-11-20 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 202,311 10,116,906 2.04 26.83 5,427,377 271,405,226

2012-11-23 2012-11-20 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 21,830 1,589,525 1.39 26.83 585,631 42,642,028

2012-11-14 2012-11-14 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 2,223 266,941 0.84 27.32 60,725 7,291,894

2012-11-14 2012-11-14 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 92,592 9,914,595 0.94 27.32 2,529,289 270,832,034

2012-11-14 2012-11-14 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 8,352 1,567,695 0.54 27.32 228,147 42,823,940

2012-11-14 2012-11-13 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 2,231 264,718 0.85 27.99 62,450 7,409,960

2012-11-14 2012-11-13 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 92,917 9,822,003 0.96 27.99 2,600,923 274,936,526

2012-11-14 2012-11-13 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 8,691 1,559,343 0.56 27.99 243,278 43,648,973

2012-11-14 2012-11-12 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 4,298 262,487 1.66 27.94 120,075 7,333,204

2012-11-14 2012-11-12 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 178,978 9,729,086 1.87 27.94 5,000,180 271,805,367

2012-11-14 2012-11-12 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 16,724 1,550,652 1.09 27.94 467,225 43,321,185

2012-11-14 2012-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 143 258,189 0.06 27.86 3,983 7,192,010

2012-11-14 2012-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 24 258,046 0.01 26.68 640 6,884,693

2012-11-14 2012-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 79 258,022 0.03 27.16 2,146 7,008,187

2012-11-14 2012-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 9,905 257,943 3.99 27.84 275,793 7,182,113

2012-11-14 2012-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 651 248,038 0.26 26.91 17,516 6,673,735

2012-11-14 2012-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 324 247,387 0.13 25.83 8,367 6,388,868

2012-11-14 2012-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 5,972 9,550,108 0.06 27.86 166,354 266,023,988

2012-11-14 2012-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 980 9,544,136 0.01 26.68 26,146 254,638,503

2012-11-14 2012-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 3,298 9,543,156 0.03 27.16 89,578 259,203,569

2012-11-14 2012-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 412,596 9,539,858 4.52 27.84 11,488,241 265,625,898

2012-11-14 2012-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 27,125 9,127,262 0.30 26.91 729,828 245,579,024

2012-11-14 2012-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 13,447 9,100,137 0.15 25.83 347,274 235,014,678

2012-11-14 2012-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 585 1,533,928 0.04 27.86 16,296 42,728,485

2012-11-14 2012-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 96 1,533,343 0.01 26.68 2,561 40,909,745

2012-11-14 2012-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 323 1,533,247 0.02 27.16 8,773 41,644,828

2012-11-14 2012-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 40,412 1,532,924 2.71 27.84 1,125,224 42,682,429

2012-11-14 2012-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 2,657 1,492,512 0.18 26.91 71,490 40,157,677

2012-11-14 2012-11-09 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 1,316 1,489,855 0.09 25.83 33,986 38,476,101

2012-10-31 2012-10-29 4 XOMA XOMA Corp
Common Stock P - Purchase 103,608 463,839 28.76 3.00 310,824 1,391,517

2012-10-31 2012-10-29 4 XOMA XOMA Corp
Common Stock P - Purchase 4,282,419 17,888,512 31.47 3.00 12,847,257 53,665,536

2012-10-31 2012-10-29 4 XOMA XOMA Corp
Common Stock P - Purchase 336,639 1,922,230 21.23 3.00 1,009,917 5,766,690

2012-07-13 2012-07-13 4 GEVA SYNAGEVA BIOPHARMA CORP
Common Stock P - Purchase 21,082 156,821 15.53 41.20 868,578 6,461,025

2012-07-13 2012-07-13 4 GEVA SYNAGEVA BIOPHARMA CORP
Common Stock P - Purchase 864,918 5,942,594 17.03 41.20 35,634,622 244,834,873

2012-06-21 2012-06-19 4 RDEA Ardea Biosciences, Inc./DE
Stock Option (Right to Buy) D - Sale to Issuer -12,500 0 -100.00

2012-06-21 2012-06-19 4 RDEA Ardea Biosciences, Inc./DE
Stock Option (Right to Buy) D - Sale to Issuer -12,500 0 -100.00

2012-06-21 2012-06-19 4 RDEA Ardea Biosciences, Inc./DE
Stock Option (Right to Buy) D - Sale to Issuer -25,000 0 -100.00

2012-06-21 2012-06-19 4 RDEA Ardea Biosciences, Inc./DE
Warrants D - Sale to Issuer -4,023 0 -100.00

2012-06-21 2012-06-19 4 RDEA Ardea Biosciences, Inc./DE
Warrants D - Sale to Issuer -147,292 0 -100.00

2012-06-21 2012-06-19 4 RDEA Ardea Biosciences, Inc./DE
Warrants D - Sale to Issuer -46,195 0 -100.00

2012-06-21 2012-06-19 4 RDEA Ardea Biosciences, Inc./DE
Warrants D - Sale to Issuer -998 0 -100.00

2012-06-21 2012-06-19 4 RDEA Ardea Biosciences, Inc./DE
Warrants D - Sale to Issuer -205 0 -100.00

2012-06-21 2012-06-19 4 RDEA Ardea Biosciences, Inc./DE
Common Stock D - Sale to Issuer -116,454 0 -100.00 32.00 -3,726,528

2012-06-21 2012-06-19 4 RDEA Ardea Biosciences, Inc./DE
Common Stock D - Sale to Issuer -4,922,226 0 -100.00 32.00 -157,511,232

2012-06-21 2012-06-19 4 RDEA Ardea Biosciences, Inc./DE
Common Stock D - Sale to Issuer -1,646,964 0 -100.00 32.00 -52,702,848

2012-06-21 2012-06-19 4 RDEA Ardea Biosciences, Inc./DE
Common Stock D - Sale to Issuer -99,636 0 -100.00 32.00 -3,188,352

2012-06-21 2012-06-19 4 RDEA Ardea Biosciences, Inc./DE
Common Stock D - Sale to Issuer -65,882 0 -100.00 32.00 -2,108,224

2012-06-21 2012-06-19 4 RDEA Ardea Biosciences, Inc./DE
Common Stock D - Sale to Issuer -60,827 0 -100.00 32.00 -1,946,464

2012-06-21 2012-06-19 4 RDEA Ardea Biosciences, Inc./DE
Common Stock D - Sale to Issuer -2,302 0 -100.00 32.00 -73,664

2012-05-23 2012-05-22 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 380 247,063 0.15 32.94 12,518 8,138,922

2012-05-23 2012-05-22 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 17,026 9,086,690 0.19 32.94 560,882 299,340,103

2012-05-23 2012-05-21 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 2,732 246,683 1.12 32.21 87,992 7,945,166

2012-05-23 2012-05-21 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 546 243,951 0.22 32.04 17,493 7,815,922

2012-05-23 2012-05-21 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 122,268 9,069,664 1.37 32.21 3,938,008 292,115,738

2012-05-23 2012-05-21 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 24,454 8,947,396 0.27 32.04 783,479 286,664,726

2012-05-16 2012-05-16 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 517 243,405 0.21 34.46 17,815 8,387,176

2012-05-16 2012-05-16 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 23,104 8,922,942 0.26 34.46 796,111 307,464,059

2012-05-16 2012-05-15 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 1,972 242,888 0.82 34.25 67,541 8,318,914

2012-05-16 2012-05-15 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 540 240,916 0.22 33.11 17,882 7,977,668

2012-05-16 2012-05-15 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 555 240,376 0.23 34.47 19,129 8,285,160

2012-05-16 2012-05-15 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 88,028 8,899,838 1.00 34.25 3,014,959 304,819,452

2012-05-16 2012-05-15 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 24,136 8,811,810 0.27 33.11 799,237 291,793,395

2012-05-16 2012-05-15 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 24,769 8,787,674 0.28 34.47 853,726 302,889,154

2012-05-16 2012-05-14 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 3,212 239,821 1.36 33.92 108,951 8,134,728

2012-05-16 2012-05-14 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 897 236,609 0.38 33.67 30,198 7,965,513

2012-05-16 2012-05-14 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 370 235,712 0.16 32.59 12,058 7,681,501

2012-05-16 2012-05-14 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 175 235,342 0.07 31.53 5,517 7,419,863

2012-05-16 2012-05-14 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 143,388 8,762,905 1.66 33.92 4,863,721 297,237,738

2012-05-16 2012-05-14 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 40,073 8,619,517 0.47 33.67 1,349,070 290,178,626

2012-05-16 2012-05-14 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 16,526 8,579,444 0.19 32.59 538,558 279,591,211

2012-05-16 2012-05-14 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 7,797 8,562,918 0.09 31.53 245,824 269,971,679

2012-05-11 2012-05-11 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 627 235,167 0.27 30.22 18,946 7,105,877

2012-05-11 2012-05-11 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 26,033 8,555,121 0.31 30.22 786,621 258,504,103

2012-05-11 2012-05-10 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 214 234,540 0.09 29.98 6,415 7,030,829

2012-05-11 2012-05-10 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 8,867 8,529,088 0.10 29.98 265,807 255,677,324

2012-05-11 2012-05-10 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 1,402 234,326 0.60 29.86 41,861 6,996,599

2012-05-11 2012-05-10 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 58,198 8,520,221 0.69 29.86 1,737,699 254,400,167

2012-05-11 2012-05-09 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 460 232,924 0.20 29.90 13,752 6,963,379

2012-05-11 2012-05-09 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 19,087 8,462,023 0.23 29.90 570,615 252,976,409

2012-05-08 2012-05-08 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 116 232,464 0.05 28.50 3,306 6,624,620

2012-05-08 2012-05-08 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 1,737 232,348 0.75 28.90 50,196 6,714,416

2012-05-08 2012-05-08 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 172 230,611 0.07 28.41 4,886 6,550,529

2012-05-08 2012-05-08 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 4,811 8,442,936 0.06 28.50 137,101 240,601,724

2012-05-08 2012-05-08 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 72,073 8,438,125 0.86 28.90 2,082,773 243,845,780

2012-05-08 2012-05-08 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 7,124 8,366,052 0.09 28.41 202,358 237,638,544

2012-05-08 2012-05-07 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 536 230,439 0.23 28.28 15,159 6,517,184

2012-05-08 2012-05-07 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 754 229,903 0.33 28.25 21,300 6,494,530

2012-05-08 2012-05-07 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 22,241 8,358,928 0.27 28.28 629,011 236,403,858

2012-05-08 2012-05-07 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 31,273 8,336,687 0.38 28.25 883,431 235,503,071

2012-05-08 2012-05-07 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 722 1,488,539 0.05 28.28 20,419 42,098,265

2012-05-08 2012-05-07 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 1,014 1,487,817 0.07 28.25 28,644 42,029,342

2012-05-08 2012-05-04 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 5 229,149 0.00 28.00 140 6,416,172

2012-05-08 2012-05-04 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 369 229,144 0.16 27.99 10,330 6,414,863

2012-05-08 2012-05-04 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 935 228,775 0.41 28.03 26,208 6,412,540

2012-05-08 2012-05-04 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 188 8,305,414 0.00 28.00 5,264 232,551,592

2012-05-08 2012-05-04 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 14,078 8,305,226 0.17 27.99 394,112 232,503,971

2012-05-08 2012-05-04 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 35,727 8,291,148 0.43 28.03 1,001,424 232,400,049

2012-05-08 2012-05-04 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 7 1,486,803 0.00 28.00 196 41,630,484

2012-05-08 2012-05-04 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 514 1,486,796 0.03 27.99 14,389 41,622,705

2012-05-08 2012-05-04 4 GHDX GENOMIC HEALTH INC
Common Stock P - Purchase 1,305 1,486,282 0.09 28.03 36,579 41,660,336

2012-04-24 3 RDEA Ardea Biosciences, Inc./DE
Common Stock 0

2012-04-23 3 GEVA SYNAGEVA BIOPHARMA CORP
Common Stock 0

2012-04-23 3 BCRX BIOCRYST PHARMACEUTICALS INC
Common Stock 0

2012-04-23 3 INCY INCYTE CORP
Common Stock 0

2012-04-23 3 XOMA XOMA Corp
Common Stock 0

2012-04-23 3 SGEN SEATTLE GENETICS INC /WA
Common Stock 0

2012-04-23 3 GHDX GENOMIC HEALTH INC
Common Stock 0

P

Compra de mercado aberto ou privada de ativo não-derivativo ou derivativo

S

Venda de mercado aberto ou privada de ativo não-derivativo ou derivativo

A

Concessão, premiação, ou outra aquisição de ativos da empresa (como uma opção)

C

Conversão de derivativo

D

Venda ou transferência de ativos de volta para a empresa

F

Pagamento do preço de exercício ou responsabilidade fiscal utilizando parte dos ativos recebidos da empresa

G

Doação de ativos pelo ou para o insider

K

Swaps de capital e transações de hedge similares

M

Exercício ou conversão de ativo derivativo recebido da empresa (como uma opção)

V

Uma transação voluntariamente reportada no Formulário 4

J

Outro (acompanhado de uma nota explicativa descrevendo a transação)

Data de Negociação	Ticker	Insider	Ações Reportadas	Preço Reportado	Ações Ajustadas	Preço Ajustado	Base de Custos	Dias para Máx	Preço em Máx	Lucro Máx ($)	Retorno Máx (%)
2016-02-05	BCRX	BAKER BROS. ADVISORS LP	45,000	6.3257	45,000	6.3257	284,656	336	7.13	36,194	12.71
2016-02-04	BCRX	BAKER BROS. ADVISORS LP	24,800	6.6498	24,800	6.6498	164,915
2016-02-03	BCRX	BAKER BROS. ADVISORS LP	91,187	6.2872	91,187	6.2872	573,311
2016-02-02	BCRX	BAKER BROS. ADVISORS LP	91,728	6.5232	91,728	6.5232	598,360
2016-01-28	BCRX	BAKER BROS. ADVISORS LP	25,000	6.8806	25,000	6.8806	172,015
2016-01-27	BCRX	BAKER BROS. ADVISORS LP	63,345	6.9772	63,345	6.9772	441,971
2016-01-22	BCRX	BAKER BROS. ADVISORS LP	3,200	6.9966	3,200	6.9966	22,389
2016-01-21	BCRX	BAKER BROS. ADVISORS LP	103,600	7.2912	103,600	7.2912	755,368
2016-01-20	BCRX	BAKER BROS. ADVISORS LP	51,370	6.8712	51,370	6.8712	352,974
2016-01-20	BCRX	BAKER BROS. ADVISORS LP	1,325	6.9415	1,325	6.9415	9,197
2016-01-19	BCRX	BAKER BROS. ADVISORS LP	92,200	7.1231	92,200	7.1231	656,750
2016-01-15	BCRX	BAKER BROS. ADVISORS LP	175,000	7.4508	175,000	7.4508	1,303,890
2016-01-15	BCRX	BAKER BROS. ADVISORS LP	25,000	7.4933	25,000	7.4933	187,332
2013-08-01	BCRX	BAKER FELIX	120,498	4.4000	120,498	4.4000	530,191
2013-08-01	BCRX	BAKER FELIX	991,161	4.4000	991,161	4.4000	4,361,108
2013-08-01	BCRX	BAKER FELIX	24,705	4.4000	24,705	4.4000	108,702

Data de Negociação	Ticker	Insider	Ações Reportadas	Preço Reportado	Ações Ajustadas	Preço Ajustado	Base de Custos	Dias para Mín	Preço em Mín	Máxima Perda Evitada ($)	Máxima Perda Evitada (%)
2016-08-16	BCRX	BAKER BROS. ADVISORS LP	140	4.2887	140	4.2887	600	79	3.76	-74	-12.27
2016-08-16	BCRX	BAKER BROS. ADVISORS LP	850	4.2887	850	4.2887	3,645
2016-08-15	BCRX	BAKER BROS. ADVISORS LP	56,417	4.8276	56,417	4.8276	272,359
2016-08-15	BCRX	BAKER BROS. ADVISORS LP	343,583	4.8276	343,583	4.8276	1,658,681
2016-08-12	BCRX	BAKER BROS. ADVISORS LP	465,439	5.0000	465,439	5.0000	2,327,195
2016-08-12	BCRX	BAKER BROS. ADVISORS LP	2,834,561	5.0000	2,834,561	5.0000	14,172,805
2016-08-12	BCRX	BAKER BROS. ADVISORS LP	48,744	5.2541	48,744	5.2541	256,106
2016-08-12	BCRX	BAKER BROS. ADVISORS LP	296,856	5.2541	296,856	5.2541	1,559,711

Data de Negociação	Ticker	Insider	Ações Reportadas	Preço Reportado	Ações Ajustadas	Preço Ajustado	Base de Custos	Dias para Máx	Preço em Máx	Lucro Máx ($)	Retorno Máx (%)
2024-12-16	BCYC	BAKER BROS. ADVISORS LP	42,369	15.3418	42,369	15.3418	650,017	2	15.3150	-1,135	-0.17
2024-12-16	BCYC	BAKER BROS. ADVISORS LP	457,631	15.3418	457,631	15.3418	7,020,883
2024-12-13	BCYC	BAKER BROS. ADVISORS LP	2,809	13.4979	2,809	13.4979	37,916
2024-12-13	BCYC	BAKER BROS. ADVISORS LP	30,241	13.4979	30,241	13.4979	408,190
2024-12-13	BCYC	BAKER BROS. ADVISORS LP	5,573	13.6288	5,573	13.6288	75,953
2024-12-13	BCYC	BAKER BROS. ADVISORS LP	59,995	13.6288	59,995	13.6288	817,660
2024-12-13	BCYC	BAKER BROS. ADVISORS LP	22,722	13.7242	22,722	13.7242	311,841
2024-12-13	BCYC	BAKER BROS. ADVISORS LP	244,587	13.7242	244,587	13.7242	3,356,761
2024-12-13	BCYC	BAKER BROS. ADVISORS LP	52,656	13.8040	52,656	13.8040	726,863
2024-12-13	BCYC	BAKER BROS. ADVISORS LP	566,814	13.8040	566,814	13.8040	7,824,300

Data de Negociação	Ticker	Insider	Ações Reportadas	Preço Reportado	Ações Ajustadas	Preço Ajustado	Base de Custos	Dias para Máx	Preço em Máx	Lucro Máx ($)	Retorno Máx (%)
2025-09-08	CELC	BAKER BROS. ADVISORS LP	13,976	56.2200	13,976	56.2200	785,731	238	144.9800	1,240,510	157.88
2025-09-08	CELC	BAKER BROS. ADVISORS LP	151,524	56.2200	151,524	56.2200	8,518,679
2025-09-08	CELC	BAKER BROS. ADVISORS LP	388	58.0236	388	58.0236	22,513
2025-09-08	CELC	BAKER BROS. ADVISORS LP	4,212	58.0236	4,212	58.0236	244,395

Data de Negociação	Ticker	Insider	Ações Reportadas	Preço Reportado	Ações Ajustadas	Preço Ajustado	Base de Custos	Dias para Máx	Preço em Máx	Lucro Máx ($)	Retorno Máx (%)
2025-03-17	IMCR	BAKER BROS. ADVISORS LP	60,110	29.7416	60,110	29.7416	1,787,768	262	40.2150	629,557	35.21
2025-03-17	IMCR	BAKER BROS. ADVISORS LP	646,290	29.7416	646,290	29.7416	19,221,699
2025-03-17	IMCR	BAKER BROS. ADVISORS LP	8,589	29.5603	8,589	29.5603	253,893
2025-03-17	IMCR	BAKER BROS. ADVISORS LP	92,349	29.5603	92,349	29.5603	2,729,864

Data de Negociação	Ticker	Insider	Ações Reportadas	Preço Reportado	Ações Ajustadas	Preço Ajustado	Base de Custos	Dias para Máx	Preço em Máx	Lucro Máx ($)	Retorno Máx (%)
2024-12-30	KALA	BAKER BROS. ADVISORS LP	30,620	6.4400	612	322.0000	197,193	263	19.6300	-185,178	-93.91
2024-12-30	KALA	BAKER BROS. ADVISORS LP	279,939	6.4400	5,599	322.0000	1,802,807

Data de Negociação	Ticker	Insider	Ações Reportadas	Preço Reportado	Ações Ajustadas	Preço Ajustado	Base de Custos	Dias para Mín	Preço em Mín	Máxima Perda Evitada ($)	Máxima Perda Evitada (%)
2025-10-01	KALA	BAKER BROS. ADVISORS LP	50,640	1.3838	1,013	69.1900	70,076	219	0.0793	-69,995	-99.89
2025-10-01	KALA	BAKER BROS. ADVISORS LP	462,967	1.3838	9,259	69.1900	640,654
2025-09-30	KALA	BAKER BROS. ADVISORS LP	21,376	1.5959	428	79.7950	34,114
2025-09-30	KALA	BAKER BROS. ADVISORS LP	195,425	1.5959	3,908	79.7950	311,879

Data de Negociação	Ticker	Insider	Ações Reportadas	Preço Reportado	Ações Ajustadas	Preço Ajustado	Base de Custos	Dias para Máx	Preço em Máx	Lucro Máx ($)	Retorno Máx (%)
2018-05-29	KNSA	BAKER BROS. ADVISORS LP	299,403	18.0000	299,403	18.0000	5,389,254	114	30.93	3,871,281	71.83
2018-05-29	KNSA	BAKER BROS. ADVISORS LP	2,700,597	18.0000	2,700,597	18.0000	48,610,746

Data de Negociação	Ticker	Insider	Ações Reportadas	Preço Reportado	Ações Ajustadas	Preço Ajustado	Base de Custos	Dias para Máx	Preço em Máx	Lucro Máx ($)	Retorno Máx (%)
2025-12-18	KOD	BAKER BROS. ADVISORS LP	217,428	23.0000	217,428	23.0000	5,000,844	123	46.4400	5,096,512	101.91
2025-12-18	KOD	BAKER BROS. ADVISORS LP	2,391,268	23.0000	2,391,268	23.0000	54,999,164
2022-06-06	KOD	BAKER BROS. ADVISORS LP	11,945	7.7488	11,945	7.7488	92,559
2022-06-06	KOD	BAKER BROS. ADVISORS LP	101,315	7.7488	101,315	7.7488	785,070
2022-06-06	KOD	BAKER BROS. ADVISORS LP	20,108	7.7808	20,108	7.7808	156,456
2022-06-06	KOD	BAKER BROS. ADVISORS LP	170,549	7.7808	170,549	7.7808	1,327,008
2022-06-03	KOD	BAKER BROS. ADVISORS LP	1,550	7.9333	1,550	7.9333	12,297
2022-06-03	KOD	BAKER BROS. ADVISORS LP	13,155	7.9333	13,155	7.9333	104,363
2022-06-03	KOD	BAKER BROS. ADVISORS LP	9,224	7.9527	9,224	7.9527	73,356
2022-06-03	KOD	BAKER BROS. ADVISORS LP	78,271	7.9527	78,271	7.9527	622,466
2022-06-02	KOD	BAKER BROS. ADVISORS LP	1,247	7.5144	1,247	7.5144	9,370
2022-06-02	KOD	BAKER BROS. ADVISORS LP	10,585	7.5144	10,585	7.5144	79,540
2022-06-02	KOD	BAKER BROS. ADVISORS LP	16,278	7.6793	16,278	7.6793	125,004
2022-06-02	KOD	BAKER BROS. ADVISORS LP	138,122	7.6793	138,122	7.6793	1,060,680
2022-05-27	KOD	BAKER BROS. ADVISORS LP	42	6.6350	42	6.6350	279
2022-05-27	KOD	BAKER BROS. ADVISORS LP	358	6.6350	358	6.6350	2,375
2022-05-27	KOD	BAKER BROS. ADVISORS LP	6,026	6.7806	6,026	6.7806	40,860
2022-05-27	KOD	BAKER BROS. ADVISORS LP	51,082	6.7806	51,082	6.7806	346,367
2022-05-27	KOD	BAKER BROS. ADVISORS LP	10,386	6.9200	10,386	6.9200	71,871
2022-05-27	KOD	BAKER BROS. ADVISORS LP	88,046	6.9200	88,046	6.9200	609,278
2022-05-26	KOD	BAKER BROS. ADVISORS LP	3,432	6.7064	3,432	6.7064	23,016
2022-05-26	KOD	BAKER BROS. ADVISORS LP	29,090	6.7064	29,090	6.7064	195,089
2022-05-26	KOD	BAKER BROS. ADVISORS LP	6,299	6.7512	6,299	6.7512	42,526
2022-05-26	KOD	BAKER BROS. ADVISORS LP	53,401	6.7512	53,401	6.7512	360,521
2022-05-26	KOD	BAKER BROS. ADVISORS LP	116	6.7550	116	6.7550	784
2022-05-26	KOD	BAKER BROS. ADVISORS LP	984	6.7550	984	6.7550	6,647
2022-05-25	KOD	BAKER BROS. ADVISORS LP	5,688	6.5335	5,688	6.5335	37,163
2022-05-25	KOD	BAKER BROS. ADVISORS LP	48,222	6.5335	48,222	6.5335	315,058
2022-05-25	KOD	BAKER BROS. ADVISORS LP	4,984	6.6036	4,984	6.6036	32,912
2022-05-25	KOD	BAKER BROS. ADVISORS LP	42,250	6.6036	42,250	6.6036	279,002
2022-05-18	KOD	BAKER BROS. ADVISORS LP	1,115	5.9537	1,115	5.9537	6,638
2022-05-18	KOD	BAKER BROS. ADVISORS LP	9,157	5.9537	9,157	5.9537	54,518
2022-05-18	KOD	BAKER BROS. ADVISORS LP	22,266	5.9686	22,266	5.9686	132,897
2022-05-18	KOD	BAKER BROS. ADVISORS LP	182,827	5.9686	182,827	5.9686	1,091,221
2022-05-18	KOD	BAKER BROS. ADVISORS LP	912	5.9689	912	5.9689	5,444
2022-05-18	KOD	BAKER BROS. ADVISORS LP	7,489	5.9689	7,489	5.9689	44,701
2022-05-17	KOD	BAKER BROS. ADVISORS LP	989	5.9866	989	5.9866	5,921
2022-05-17	KOD	BAKER BROS. ADVISORS LP	8,118	5.9866	8,118	5.9866	48,599
2022-05-17	KOD	BAKER BROS. ADVISORS LP	11,043	5.9877	11,043	5.9877	66,122
2022-05-17	KOD	BAKER BROS. ADVISORS LP	90,674	5.9877	90,674	5.9877	542,929
2022-05-16	KOD	BAKER BROS. ADVISORS LP	11,410	5.7101	11,410	5.7101	65,152
2022-05-16	KOD	BAKER BROS. ADVISORS LP	93,690	5.7101	93,690	5.7101	534,979
2022-05-16	KOD	BAKER BROS. ADVISORS LP	1,846	5.7475	1,846	5.7475	10,610
2022-05-16	KOD	BAKER BROS. ADVISORS LP	15,154	5.7475	15,154	5.7475	87,098
2022-02-17	KOD	BAKER BROS. ADVISORS LP	426	53.8186	426	53.8186	22,927
2022-02-17	KOD	BAKER BROS. ADVISORS LP	5,174	53.8186	5,174	53.8186	278,457
2022-02-17	KOD	BAKER BROS. ADVISORS LP	22,403	54.5737	22,403	54.5737	1,222,615
2022-02-17	KOD	BAKER BROS. ADVISORS LP	271,997	54.5737	271,997	54.5737	14,843,883
2022-02-16	KOD	BAKER BROS. ADVISORS LP	1,961	53.7325	1,961	53.7325	105,369
2022-02-16	KOD	BAKER BROS. ADVISORS LP	23,804	53.7325	23,804	53.7325	1,279,048
2022-02-16	KOD	BAKER BROS. ADVISORS LP	5,281	54.2616	5,281	54.2616	286,556
2022-02-16	KOD	BAKER BROS. ADVISORS LP	64,119	54.2616	64,119	54.2616	3,479,200
2022-02-15	KOD	BAKER BROS. ADVISORS LP	441	54.1550	441	54.1550	23,882
2022-02-15	KOD	BAKER BROS. ADVISORS LP	5,359	54.1550	5,359	54.1550	290,217
2022-01-31	KOD	BAKER BROS. ADVISORS LP	2,307	57.2205	2,307	57.2205	132,008
2022-01-31	KOD	BAKER BROS. ADVISORS LP	27,841	57.2205	27,841	57.2205	1,593,076
2022-01-28	KOD	BAKER BROS. ADVISORS LP	1,851	49.7011	1,851	49.7011	91,997
2022-01-28	KOD	BAKER BROS. ADVISORS LP	22,395	49.7011	22,395	49.7011	1,113,056
2022-01-28	KOD	BAKER BROS. ADVISORS LP	1,414	50.5555	1,414	50.5555	71,485
2022-01-28	KOD	BAKER BROS. ADVISORS LP	17,119	50.5555	17,119	50.5555	865,460
2022-01-28	KOD	BAKER BROS. ADVISORS LP	953	51.6136	953	51.6136	49,188
2022-01-28	KOD	BAKER BROS. ADVISORS LP	11,526	51.6136	11,526	51.6136	594,898
2022-01-27	KOD	BAKER BROS. ADVISORS LP	86,479	52.0415	86,479	52.0415	4,500,497
2022-01-27	KOD	BAKER BROS. ADVISORS LP	117,291	51.5881	117,291	51.5881	6,050,820
2022-01-27	KOD	BAKER BROS. ADVISORS LP	4,465	51.6713	4,465	51.6713	230,712
2022-01-27	KOD	BAKER BROS. ADVISORS LP	54,024	51.6713	54,024	51.6713	2,791,490
2022-01-25	KOD	BAKER BROS. ADVISORS LP	5,500	58.8971	5,500	58.8971	323,934
2022-01-24	KOD	BAKER BROS. ADVISORS LP	19,750	56.3873	19,750	56.3873	1,113,649
2022-01-24	KOD	BAKER BROS. ADVISORS LP	1,200	56.5950	1,200	56.5950	67,914
2022-01-24	KOD	BAKER BROS. ADVISORS LP	116,083	56.8650	116,083	56.8650	6,601,060
2022-01-24	KOD	BAKER BROS. ADVISORS LP	25,900	57.5876	25,900	57.5876	1,491,519
2022-01-24	KOD	BAKER BROS. ADVISORS LP	132,367	58.1258	132,367	58.1258	7,693,938
2022-01-24	KOD	BAKER BROS. ADVISORS LP	9,350	58.7559	9,350	58.7559	549,368
2022-01-24	KOD	BAKER BROS. ADVISORS LP	57,547	58.8709	57,547	58.8709	3,387,844
2022-01-21	KOD	BAKER BROS. ADVISORS LP	102,207	56.5742	102,207	56.5742	5,782,279
2022-01-21	KOD	BAKER BROS. ADVISORS LP	31,207	57.5285	31,207	57.5285	1,795,292
2021-09-30	KOD	BAKER BROS. ADVISORS LP	86,932	95.8286	86,932	95.8286	8,330,572
2021-09-16	KOD	BAKER BROS. ADVISORS LP	1,153	94.5918	1,153	94.5918	109,064
2021-09-15	KOD	BAKER BROS. ADVISORS LP	30,285	94.3842	30,285	94.3842	2,858,425
2021-09-15	KOD	BAKER BROS. ADVISORS LP	400	94.4775	400	94.4775	37,791
2021-09-07	KOD	BAKER BROS. ADVISORS LP	5,300	92.8829	5,300	92.8829	492,279
2021-09-07	KOD	BAKER BROS. ADVISORS LP	52,201	93.3497	52,201	93.3497	4,872,948
2021-08-19	KOD	BAKER BROS. ADVISORS LP	2,968	86.9385	2,968	86.9385	258,033
2021-08-19	KOD	BAKER BROS. ADVISORS LP	4,649	87.0710	4,649	87.0710	404,793
2021-08-19	KOD	BAKER BROS. ADVISORS LP	2,396	87.4821	2,396	87.4821	209,607
2021-08-19	KOD	BAKER BROS. ADVISORS LP	73,635	87.6141	73,635	87.6141	6,451,464
2021-08-18	KOD	BAKER BROS. ADVISORS LP	12,898	87.7890	12,898	87.7890	1,132,303
2021-08-18	KOD	BAKER BROS. ADVISORS LP	8,186	87.9134	8,186	87.9134	719,659
2021-08-18	KOD	BAKER BROS. ADVISORS LP	1,100	88.1650	1,100	88.1650	96,982
2021-08-18	KOD	BAKER BROS. ADVISORS LP	400	89.6563	400	89.6563	35,863
2021-08-17	KOD	BAKER BROS. ADVISORS LP	400	84.8025	400	84.8025	33,921
2021-08-17	KOD	BAKER BROS. ADVISORS LP	7,764	85.9522	7,764	85.9522	667,333
2021-08-13	KOD	BAKER BROS. ADVISORS LP	21,595	88.5870	21,595	88.5870	1,913,036
2021-08-13	KOD	BAKER BROS. ADVISORS LP	16,269	88.7588	16,269	88.7588	1,444,017
2021-08-13	KOD	BAKER BROS. ADVISORS LP	400	88.8150	400	88.8150	35,526
2021-08-12	KOD	BAKER BROS. ADVISORS LP	300	85.5800	300	85.5800	25,674
2021-08-12	KOD	BAKER BROS. ADVISORS LP	4,600	86.4447	4,600	86.4447	397,646
2021-08-12	KOD	BAKER BROS. ADVISORS LP	6,086	88.0109	6,086	88.0109	535,634
2021-08-11	KOD	BAKER BROS. ADVISORS LP	3,723	84.3903	3,723	84.3903	314,185
2021-08-11	KOD	BAKER BROS. ADVISORS LP	600	85.7229	600	85.7229	51,434
2021-08-11	KOD	BAKER BROS. ADVISORS LP	44,700	86.0734	44,700	86.0734	3,847,481
2021-08-11	KOD	BAKER BROS. ADVISORS LP	4,500	87.9978	4,500	87.9978	395,990
2021-06-30	KOD	BAKER BROS. ADVISORS LP	4,603	89.7392	4,603	89.7392	413,070
2021-06-30	KOD	BAKER BROS. ADVISORS LP	22,353	90.2041	22,353	90.2041	2,016,332
2021-06-30	KOD	BAKER BROS. ADVISORS LP	7,009	91.6359	7,009	91.6359	642,276
2021-06-30	KOD	BAKER BROS. ADVISORS LP	121,612	92.7459	121,612	92.7459	11,279,014
2021-06-29	KOD	BAKER BROS. ADVISORS LP	7,079	89.8709	7,079	89.8709	636,196
2021-06-29	KOD	BAKER BROS. ADVISORS LP	3,847	89.8956	3,847	89.8956	345,828
2021-06-29	KOD	BAKER BROS. ADVISORS LP	11,731	90.3911	11,731	90.3911	1,060,378
2021-06-29	KOD	BAKER BROS. ADVISORS LP	1,200	90.3950	1,200	90.3950	108,474
2021-06-29	KOD	BAKER BROS. ADVISORS LP	30,221	90.7037	30,221	90.7037	2,741,157
2021-06-28	KOD	BAKER BROS. ADVISORS LP	5,200	90.2731	5,200	90.2731	469,420
2021-06-28	KOD	BAKER BROS. ADVISORS LP	10,170	90.7617	10,170	90.7617	923,046
2021-06-28	KOD	BAKER BROS. ADVISORS LP	22,445	91.7974	22,445	91.7974	2,060,393
2021-06-28	KOD	BAKER BROS. ADVISORS LP	10,459	91.8678	10,459	91.8678	960,845
2020-11-20	KOD	BAKER BROS. ADVISORS LP	116,158	108.0000	116,158	108.0000	12,545,064
2020-11-20	KOD	BAKER BROS. ADVISORS LP	1,411,619	108.0000	1,411,619	108.0000	152,454,852
2020-09-25	KOD	BAKER BROS. ADVISORS LP	933	55.3529	933	55.3529	51,644
2020-09-25	KOD	BAKER BROS. ADVISORS LP	13,153	55.3529	13,153	55.3529	728,057
2020-09-25	KOD	BAKER BROS. ADVISORS LP	334	56.7599	334	56.7599	18,958
2020-09-25	KOD	BAKER BROS. ADVISORS LP	4,705	56.7599	4,705	56.7599	267,055
2020-09-25	KOD	BAKER BROS. ADVISORS LP	1,365	56.9199	1,365	56.9199	77,696
2020-09-25	KOD	BAKER BROS. ADVISORS LP	19,235	56.9199	19,235	56.9199	1,094,854
2020-09-25	KOD	BAKER BROS. ADVISORS LP	557	58.0855	557	58.0855	32,354
2020-09-25	KOD	BAKER BROS. ADVISORS LP	7,843	58.0855	7,843	58.0855	455,565
2020-09-24	KOD	BAKER BROS. ADVISORS LP	306	51.4092	306	51.4092	15,731
2020-09-24	KOD	BAKER BROS. ADVISORS LP	4,306	51.4092	4,306	51.4092	221,368
2020-09-24	KOD	BAKER BROS. ADVISORS LP	2,081	52.1149	2,081	52.1149	108,451
2020-09-24	KOD	BAKER BROS. ADVISORS LP	29,327	52.1149	29,327	52.1149	1,528,374
2020-09-23	KOD	BAKER BROS. ADVISORS LP	80	51.9700	80	51.9700	4,158
2020-09-23	KOD	BAKER BROS. ADVISORS LP	1,120	51.9700	1,120	51.9700	58,206
2020-09-23	KOD	BAKER BROS. ADVISORS LP	743	52.3997	743	52.3997	38,933
2020-09-23	KOD	BAKER BROS. ADVISORS LP	10,467	52.3997	10,467	52.3997	548,468
2020-09-23	KOD	BAKER BROS. ADVISORS LP	5,278	52.4359	5,278	52.4359	276,757
2020-09-23	KOD	BAKER BROS. ADVISORS LP	74,381	52.4359	74,381	52.4359	3,900,235
2020-09-22	KOD	BAKER BROS. ADVISORS LP	779	49.7225	779	49.7225	38,734
2020-09-22	KOD	BAKER BROS. ADVISORS LP	10,983	49.7225	10,983	49.7225	546,102
2020-09-22	KOD	BAKER BROS. ADVISORS LP	2,601	50.1517	2,601	50.1517	130,445
2020-09-22	KOD	BAKER BROS. ADVISORS LP	36,647	50.1517	36,647	50.1517	1,837,909
2020-09-22	KOD	BAKER BROS. ADVISORS LP	1,587	51.9760	1,587	51.9760	82,486
2020-09-22	KOD	BAKER BROS. ADVISORS LP	22,361	51.9760	22,361	51.9760	1,162,235
2020-09-08	KOD	BAKER BROS. ADVISORS LP	15	45.8750	15	45.8750	688
2020-09-08	KOD	BAKER BROS. ADVISORS LP	185	45.8750	185	45.8750	8,487
2020-09-08	KOD	BAKER BROS. ADVISORS LP	1,272	47.0350	1,272	47.0350	59,829
2020-09-08	KOD	BAKER BROS. ADVISORS LP	15,807	47.0350	15,807	47.0350	743,482
2020-09-08	KOD	BAKER BROS. ADVISORS LP	6,151	47.3874	6,151	47.3874	291,480
2020-09-08	KOD	BAKER BROS. ADVISORS LP	76,473	47.3874	76,473	47.3874	3,623,857
2020-09-08	KOD	BAKER BROS. ADVISORS LP	1,220	47.4690	1,220	47.4690	57,912
2020-09-08	KOD	BAKER BROS. ADVISORS LP	15,172	47.4690	15,172	47.4690	720,200
2020-09-04	KOD	BAKER BROS. ADVISORS LP	950	45.2963	950	45.2963	43,031
2020-09-04	KOD	BAKER BROS. ADVISORS LP	12,132	45.2963	12,132	45.2963	549,535
2020-09-04	KOD	BAKER BROS. ADVISORS LP	2,295	46.6171	2,295	46.6171	106,986
2020-09-04	KOD	BAKER BROS. ADVISORS LP	29,319	46.6171	29,319	46.6171	1,366,767
2020-09-04	KOD	BAKER BROS. ADVISORS LP	2,054	47.2591	2,054	47.2591	97,070
2020-09-04	KOD	BAKER BROS. ADVISORS LP	26,238	47.2591	26,238	47.2591	1,239,984
2020-09-04	KOD	BAKER BROS. ADVISORS LP	712	47.4982	712	47.4982	33,819
2020-09-04	KOD	BAKER BROS. ADVISORS LP	9,101	47.4982	9,101	47.4982	432,281
2020-09-03	KOD	BAKER BROS. ADVISORS LP	185	46.9681	185	46.9681	8,689
2020-09-03	KOD	BAKER BROS. ADVISORS LP	2,359	46.9681	2,359	46.9681	110,798
2020-09-03	KOD	BAKER BROS. ADVISORS LP	234	47.4472	234	47.4472	11,103
2020-09-03	KOD	BAKER BROS. ADVISORS LP	2,987	47.4472	2,987	47.4472	141,725
2020-09-03	KOD	BAKER BROS. ADVISORS LP	6,062	47.5968	6,062	47.5968	288,532
2020-09-03	KOD	BAKER BROS. ADVISORS LP	77,456	47.5968	77,456	47.5968	3,686,658
2020-09-03	KOD	BAKER BROS. ADVISORS LP	2,512	49.0000	2,512	49.0000	123,088
2020-09-03	KOD	BAKER BROS. ADVISORS LP	32,088	49.0000	32,088	49.0000	1,572,312
2020-08-21	KOD	BAKER BROS. ADVISORS LP	3,386	47.7421	3,386	47.7421	161,655
2020-08-21	KOD	BAKER BROS. ADVISORS LP	42,714	47.7421	42,714	47.7421	2,039,256
2020-08-21	KOD	BAKER BROS. ADVISORS LP	181	48.7447	181	48.7447	8,823
2020-08-21	KOD	BAKER BROS. ADVISORS LP	2,286	48.7447	2,286	48.7447	111,430
2020-08-21	KOD	BAKER BROS. ADVISORS LP	6,645	49.0831	6,645	49.0831	326,157
2020-08-21	KOD	BAKER BROS. ADVISORS LP	83,832	49.0831	83,832	49.0831	4,114,734
2020-08-20	KOD	BAKER BROS. ADVISORS LP	283	46.3018	283	46.3018	13,103
2020-08-20	KOD	BAKER BROS. ADVISORS LP	3,576	46.3018	3,576	46.3018	165,575
2020-08-20	KOD	BAKER BROS. ADVISORS LP	843	46.4959	843	46.4959	39,196
2020-08-20	KOD	BAKER BROS. ADVISORS LP	10,640	46.4959	10,640	46.4959	494,716
2020-08-20	KOD	BAKER BROS. ADVISORS LP	3,262	47.7213	3,262	47.7213	155,667
2020-08-20	KOD	BAKER BROS. ADVISORS LP	41,155	47.7213	41,155	47.7213	1,963,970
2020-08-20	KOD	BAKER BROS. ADVISORS LP	60	47.8226	60	47.8226	2,869
2020-08-20	KOD	BAKER BROS. ADVISORS LP	754	47.8226	754	47.8226	36,058
2020-08-19	KOD	BAKER BROS. ADVISORS LP	284	46.9865	284	46.9865	13,344
2020-08-19	KOD	BAKER BROS. ADVISORS LP	3,585	46.9865	3,585	46.9865	168,447
2020-03-18	KOD	BAKER BROS. ADVISORS LP	1,542	36.6933	1,542	36.6933	56,581
2020-03-18	KOD	BAKER BROS. ADVISORS LP	17,058	36.6933	17,058	36.6933	625,914
2020-03-18	KOD	BAKER BROS. ADVISORS LP	563	37.7478	563	37.7478	21,252
2020-03-18	KOD	BAKER BROS. ADVISORS LP	6,237	37.7478	6,237	37.7478	235,433
2020-03-18	KOD	BAKER BROS. ADVISORS LP	828	38.3797	828	38.3797	31,778
2020-03-18	KOD	BAKER BROS. ADVISORS LP	9,172	38.3797	9,172	38.3797	352,019
2020-03-17	KOD	BAKER BROS. ADVISORS LP	828	38.9850	828	38.9850	32,280
2020-03-17	KOD	BAKER BROS. ADVISORS LP	9,172	38.9850	9,172	38.9850	357,570
2020-03-16	KOD	BAKER BROS. ADVISORS LP	8,666	39.9711	8,666	39.9711	346,390
2020-03-16	KOD	BAKER BROS. ADVISORS LP	95,934	39.9711	95,934	39.9711	3,834,588
2020-02-26	KOD	BAKER BROS. ADVISORS LP	811	59.6089	811	59.6089	48,343
2020-02-26	KOD	BAKER BROS. ADVISORS LP	8,989	59.6089	8,989	59.6089	535,824
2020-02-26	KOD	BAKER BROS. ADVISORS LP	7,460	57.8190	7,460	57.8190	431,330
2020-02-26	KOD	BAKER BROS. ADVISORS LP	82,740	57.8190	82,740	57.8190	4,783,944
2020-02-25	KOD	BAKER BROS. ADVISORS LP	1,298	58.7987	1,298	58.7987	76,321
2020-02-25	KOD	BAKER BROS. ADVISORS LP	14,402	58.7987	14,402	58.7987	846,819
2020-02-25	KOD	BAKER BROS. ADVISORS LP	1,267	57.2187	1,267	57.2187	72,496
2020-02-25	KOD	BAKER BROS. ADVISORS LP	14,051	57.2187	14,051	57.2187	803,980
2020-02-25	KOD	BAKER BROS. ADVISORS LP	13,164	57.6840	13,164	57.6840	759,352
2020-02-25	KOD	BAKER BROS. ADVISORS LP	145,994	57.6840	145,994	57.6840	8,421,518
2020-02-25	KOD	BAKER BROS. ADVISORS LP	1,319	59.9851	1,319	59.9851	79,120
2020-02-25	KOD	BAKER BROS. ADVISORS LP	14,631	59.9851	14,631	59.9851	877,642
2020-02-24	KOD	BAKER BROS. ADVISORS LP	164	55.7734	164	55.7734	9,147
2020-02-24	KOD	BAKER BROS. ADVISORS LP	1,813	55.7734	1,813	55.7734	101,117
2020-02-24	KOD	BAKER BROS. ADVISORS LP	8	55.4525	8	55.4525	444
2020-02-24	KOD	BAKER BROS. ADVISORS LP	92	55.4525	92	55.4525	5,102
2020-02-24	KOD	BAKER BROS. ADVISORS LP	912	56.2471	912	56.2471	51,297
2020-02-24	KOD	BAKER BROS. ADVISORS LP	10,121	56.2471	10,121	56.2471	569,277
2020-02-24	KOD	BAKER BROS. ADVISORS LP	523	56.6215	523	56.6215	29,613
2020-02-24	KOD	BAKER BROS. ADVISORS LP	5,804	56.6215	5,804	56.6215	328,631
2020-02-24	KOD	BAKER BROS. ADVISORS LP	1,921	56.6881	1,921	56.6881	108,898
2020-02-24	KOD	BAKER BROS. ADVISORS LP	21,301	56.6881	21,301	56.6881	1,207,513
2020-02-24	KOD	BAKER BROS. ADVISORS LP	323	57.6204	323	57.6204	18,611
2020-02-24	KOD	BAKER BROS. ADVISORS LP	3,577	57.6204	3,577	57.6204	206,108
2020-02-24	KOD	BAKER BROS. ADVISORS LP	642	58.3861	642	58.3861	37,484
2020-02-24	KOD	BAKER BROS. ADVISORS LP	7,122	58.3861	7,122	58.3861	415,826
2020-02-24	KOD	BAKER BROS. ADVISORS LP	612	58.5434	612	58.5434	35,829
2020-02-24	KOD	BAKER BROS. ADVISORS LP	6,788	58.5434	6,788	58.5434	397,393
2020-02-24	KOD	BAKER BROS. ADVISORS LP	777	60.7727	777	60.7727	47,220
2020-02-24	KOD	BAKER BROS. ADVISORS LP	8,623	60.7727	8,623	60.7727	524,043
2019-12-06	KOD	BAKER BROS. ADVISORS LP	158,180	46.0000	158,180	46.0000	7,276,280
2019-12-06	KOD	BAKER BROS. ADVISORS LP	1,743,993	46.0000	1,743,993	46.0000	80,223,678
2018-10-09	KOD	BAKER BROS. ADVISORS LP	251,898	10.0000	251,898	10.0000	2,518,980
2018-10-09	KOD	BAKER BROS. ADVISORS LP	2,248,102	10.0000	2,248,102	10.0000	22,481,020

Data de Negociação	Ticker	Insider	Ações Reportadas	Preço Reportado	Ações Ajustadas	Preço Ajustado	Base de Custos	Dias para Máx	Preço em Máx	Lucro Máx ($)	Retorno Máx (%)
2025-12-11	KYMR	BAKER BROS. ADVISORS LP	167,192	86.0000	167,192	86.0000	14,378,512	77	95.0300	1,509,744	10.50
2025-12-11	KYMR	BAKER BROS. ADVISORS LP	1,838,621	86.0000	1,838,621	86.0000	158,121,406
2025-06-30	KYMR	BAKER BROS. ADVISORS LP	55,191	44.0000	55,191	44.0000	2,428,404
2025-06-30	KYMR	BAKER BROS. ADVISORS LP	600,309	44.0000	600,309	44.0000	26,413,596
2024-08-20	KYMR	BAKER BROS. ADVISORS LP	1	46.4100	1	46.4100	46

Data de Negociação	Ticker	Insider	Ações Reportadas	Preço Reportado	Ações Ajustadas	Preço Ajustado	Base de Custos	Dias para Máx	Preço em Máx	Lucro Máx ($)	Retorno Máx (%)
2025-08-20	MDGL	BAKER BROS. ADVISORS LP	480	380.4365	480	380.4365	182,610	124	602.8300	106,749	58.46
2025-08-20	MDGL	BAKER BROS. ADVISORS LP	5,209	380.4365	5,209	380.4365	1,981,694
2025-08-20	MDGL	BAKER BROS. ADVISORS LP	176	380.7800	176	380.7800	67,017
2025-08-20	MDGL	BAKER BROS. ADVISORS LP	1,919	380.7800	1,919	380.7800	730,717
2025-08-20	MDGL	BAKER BROS. ADVISORS LP	873	381.1216	873	381.1216	332,719
2025-08-20	MDGL	BAKER BROS. ADVISORS LP	9,477	381.1216	9,477	381.1216	3,611,889
2025-08-20	MDGL	BAKER BROS. ADVISORS LP	105	382.2891	105	382.2891	40,140
2025-08-20	MDGL	BAKER BROS. ADVISORS LP	1,136	382.2891	1,136	382.2891	434,280
2025-08-20	MDGL	BAKER BROS. ADVISORS LP	262	382.8213	262	382.8213	100,299
2025-08-20	MDGL	BAKER BROS. ADVISORS LP	2,838	382.8213	2,838	382.8213	1,086,447
2025-08-20	MDGL	BAKER BROS. ADVISORS LP	373	383.7872	373	383.7872	143,153
2025-08-20	MDGL	BAKER BROS. ADVISORS LP	4,049	383.7872	4,049	383.7872	1,553,954
2025-08-20	MDGL	BAKER BROS. ADVISORS LP	1,248	385.0573	1,248	385.0573	480,552
2025-08-20	MDGL	BAKER BROS. ADVISORS LP	13,545	385.0573	13,545	385.0573	5,215,601
2025-08-20	MDGL	BAKER BROS. ADVISORS LP	409	387.0680	409	387.0680	158,311
2025-08-20	MDGL	BAKER BROS. ADVISORS LP	4,441	387.0680	4,441	387.0680	1,718,969
2025-08-20	MDGL	BAKER BROS. ADVISORS LP	34	389.0000	34	389.0000	13,226
2025-08-20	MDGL	BAKER BROS. ADVISORS LP	366	389.0000	366	389.0000	142,374
2025-08-20	MDGL	BAKER BROS. ADVISORS LP	231	389.8878	231	389.8878	90,064
2025-08-20	MDGL	BAKER BROS. ADVISORS LP	2,506	389.8878	2,506	389.8878	977,059
2025-08-20	MDGL	BAKER BROS. ADVISORS LP	862	392.2429	862	392.2429	338,113
2025-08-20	MDGL	BAKER BROS. ADVISORS LP	9,362	392.2429	9,362	392.2429	3,672,178
2025-08-18	MDGL	BAKER BROS. ADVISORS LP	177	353.8755	177	353.8755	62,636
2025-08-18	MDGL	BAKER BROS. ADVISORS LP	1,923	353.8755	1,923	353.8755	680,503
2025-08-18	MDGL	BAKER BROS. ADVISORS LP	84	355.0000	84	355.0000	29,820
2025-08-18	MDGL	BAKER BROS. ADVISORS LP	916	355.0000	916	355.0000	325,180
2025-08-18	MDGL	BAKER BROS. ADVISORS LP	767	357.0232	767	357.0232	273,837
2025-08-18	MDGL	BAKER BROS. ADVISORS LP	8,328	357.0232	8,328	357.0232	2,973,289
2025-08-18	MDGL	BAKER BROS. ADVISORS LP	228	358.2100	228	358.2100	81,672
2025-08-18	MDGL	BAKER BROS. ADVISORS LP	2,472	358.2100	2,472	358.2100	885,495
2025-08-18	MDGL	BAKER BROS. ADVISORS LP	784	359.3931	784	359.3931	281,764
2025-08-18	MDGL	BAKER BROS. ADVISORS LP	8,514	359.3931	8,514	359.3931	3,059,873
2025-08-18	MDGL	BAKER BROS. ADVISORS LP	502	361.3736	502	361.3736	181,410
2025-08-18	MDGL	BAKER BROS. ADVISORS LP	5,443	361.3736	5,443	361.3736	1,966,957
2025-08-18	MDGL	BAKER BROS. ADVISORS LP	515	362.3881	515	362.3881	186,630
2025-08-18	MDGL	BAKER BROS. ADVISORS LP	5,587	362.3881	5,587	362.3881	2,024,662
2025-08-18	MDGL	BAKER BROS. ADVISORS LP	255	363.7474	255	363.7474	92,756
2025-08-18	MDGL	BAKER BROS. ADVISORS LP	2,772	363.7474	2,772	363.7474	1,008,308
2025-08-18	MDGL	BAKER BROS. ADVISORS LP	211	366.2992	211	366.2992	77,289
2025-08-18	MDGL	BAKER BROS. ADVISORS LP	2,289	366.2992	2,289	366.2992	838,459
2025-08-18	MDGL	BAKER BROS. ADVISORS LP	442	367.7710	442	367.7710	162,555
2025-08-18	MDGL	BAKER BROS. ADVISORS LP	4,798	367.7710	4,798	367.7710	1,764,565
2025-08-18	MDGL	BAKER BROS. ADVISORS LP	131	368.8400	131	368.8400	48,318
2025-08-18	MDGL	BAKER BROS. ADVISORS LP	1,419	368.8400	1,419	368.8400	523,384
2025-08-18	MDGL	BAKER BROS. ADVISORS LP	253	369.3350	253	369.3350	93,442
2025-08-18	MDGL	BAKER BROS. ADVISORS LP	2,747	369.3350	2,747	369.3350	1,014,563
2025-08-18	MDGL	BAKER BROS. ADVISORS LP	506	371.0050	506	371.0050	187,729
2025-08-18	MDGL	BAKER BROS. ADVISORS LP	5,494	371.0050	5,494	371.0050	2,038,301
2025-08-18	MDGL	BAKER BROS. ADVISORS LP	933	372.1573	933	372.1573	347,223
2025-08-18	MDGL	BAKER BROS. ADVISORS LP	10,128	372.1573	10,128	372.1573	3,769,209
2025-08-18	MDGL	BAKER BROS. ADVISORS LP	2,460	372.8693	2,460	372.8693	917,258
2025-08-18	MDGL	BAKER BROS. ADVISORS LP	26,704	372.8693	26,704	372.8693	9,957,102
2025-08-18	MDGL	BAKER BROS. ADVISORS LP	675	374.4338	675	374.4338	252,743
2025-08-18	MDGL	BAKER BROS. ADVISORS LP	7,325	374.4338	7,325	374.4338	2,742,728
2023-12-14	MDGL	BAKER BROS. ADVISORS LP	107	226.9710	107	226.9710	24,286
2023-12-14	MDGL	BAKER BROS. ADVISORS LP	1,343	226.9710	1,343	226.9710	304,822
2023-12-14	MDGL	BAKER BROS. ADVISORS LP	925	227.8570	925	227.8570	210,768
2023-12-14	MDGL	BAKER BROS. ADVISORS LP	11,602	227.8570	11,602	227.8570	2,643,597
2023-12-14	MDGL	BAKER BROS. ADVISORS LP	176	228.7893	176	228.7893	40,267
2023-12-14	MDGL	BAKER BROS. ADVISORS LP	2,204	228.7893	2,204	228.7893	504,252
2023-12-14	MDGL	BAKER BROS. ADVISORS LP	316	229.8647	316	229.8647	72,637
2023-12-14	MDGL	BAKER BROS. ADVISORS LP	3,960	229.8647	3,960	229.8647	910,264
2023-12-13	MDGL	BAKER BROS. ADVISORS LP	818	216.6994	818	216.6994	177,260
2023-12-13	MDGL	BAKER BROS. ADVISORS LP	10,264	216.6994	10,264	216.6994	2,224,203
2023-12-13	MDGL	BAKER BROS. ADVISORS LP	869	217.5152	869	217.5152	189,021
2023-12-13	MDGL	BAKER BROS. ADVISORS LP	10,894	217.5152	10,894	217.5152	2,369,611
2023-12-13	MDGL	BAKER BROS. ADVISORS LP	2,373	218.4583	2,373	218.4583	518,402
2023-12-13	MDGL	BAKER BROS. ADVISORS LP	29,738	218.4583	29,738	218.4583	6,496,513
2023-12-13	MDGL	BAKER BROS. ADVISORS LP	360	219.8652	360	219.8652	79,151
2023-12-13	MDGL	BAKER BROS. ADVISORS LP	4,518	219.8652	4,518	219.8652	993,351
2023-12-13	MDGL	BAKER BROS. ADVISORS LP	361	221.7787	361	221.7787	80,062
2023-12-13	MDGL	BAKER BROS. ADVISORS LP	4,532	221.7787	4,532	221.7787	1,005,101
2023-12-13	MDGL	BAKER BROS. ADVISORS LP	738	222.6760	738	222.6760	164,335
2023-12-13	MDGL	BAKER BROS. ADVISORS LP	9,262	222.6760	9,262	222.6760	2,062,425
2023-12-13	MDGL	BAKER BROS. ADVISORS LP	29	223.9374	29	223.9374	6,494
2023-12-13	MDGL	BAKER BROS. ADVISORS LP	363	223.9374	363	223.9374	81,289
2023-12-13	MDGL	BAKER BROS. ADVISORS LP	446	224.9117	446	224.9117	100,311
2023-12-13	MDGL	BAKER BROS. ADVISORS LP	5,594	224.9117	5,594	224.9117	1,258,156
2023-12-12	MDGL	BAKER BROS. ADVISORS LP	7	205.3200	7	205.3200	1,437
2023-12-12	MDGL	BAKER BROS. ADVISORS LP	93	205.3200	93	205.3200	19,095
2023-12-12	MDGL	BAKER BROS. ADVISORS LP	56	205.6000	56	205.6000	11,514
2023-12-12	MDGL	BAKER BROS. ADVISORS LP	708	205.6000	708	205.6000	145,565
2023-12-12	MDGL	BAKER BROS. ADVISORS LP	52	206.9321	52	206.9321	10,760
2023-12-12	MDGL	BAKER BROS. ADVISORS LP	648	206.9321	648	206.9321	134,092
2023-12-12	MDGL	BAKER BROS. ADVISORS LP	30	208.6913	30	208.6913	6,261
2023-12-12	MDGL	BAKER BROS. ADVISORS LP	370	208.6913	370	208.6913	77,216
2023-12-12	MDGL	BAKER BROS. ADVISORS LP	7	209.7650	7	209.7650	1,468
2023-12-12	MDGL	BAKER BROS. ADVISORS LP	93	209.7650	93	209.7650	19,508
2023-12-12	MDGL	BAKER BROS. ADVISORS LP	52	212.0414	52	212.0414	11,026
2023-12-12	MDGL	BAKER BROS. ADVISORS LP	648	212.0414	648	212.0414	137,403
2023-12-12	MDGL	BAKER BROS. ADVISORS LP	15	213.6250	15	213.6250	3,204
2023-12-12	MDGL	BAKER BROS. ADVISORS LP	185	213.6250	185	213.6250	39,521
2023-12-12	MDGL	BAKER BROS. ADVISORS LP	41	213.7994	41	213.7994	8,766
2023-12-12	MDGL	BAKER BROS. ADVISORS LP	515	213.7994	515	213.7994	110,107
2023-12-12	MDGL	BAKER BROS. ADVISORS LP	53	214.7223	53	214.7223	11,380
2023-12-12	MDGL	BAKER BROS. ADVISORS LP	668	214.7223	668	214.7223	143,434
2023-12-12	MDGL	BAKER BROS. ADVISORS LP	141	216.6683	141	216.6683	30,550
2023-12-12	MDGL	BAKER BROS. ADVISORS LP	1,769	216.6683	1,769	216.6683	383,286
2023-12-12	MDGL	BAKER BROS. ADVISORS LP	15	217.9000	15	217.9000	3,268
2023-12-12	MDGL	BAKER BROS. ADVISORS LP	185	217.9000	185	217.9000	40,312
2023-12-12	MDGL	BAKER BROS. ADVISORS LP	229	217.9078	229	217.9078	49,901
2023-12-12	MDGL	BAKER BROS. ADVISORS LP	2,873	217.9078	2,873	217.9078	626,049
2023-12-12	MDGL	BAKER BROS. ADVISORS LP	1,195	219.2410	1,195	219.2410	261,993
2023-12-12	MDGL	BAKER BROS. ADVISORS LP	15,005	219.2410	15,005	219.2410	3,289,711
2023-12-12	MDGL	BAKER BROS. ADVISORS LP	352	220.6546	352	220.6546	77,670
2023-12-12	MDGL	BAKER BROS. ADVISORS LP	4,408	220.6546	4,408	220.6546	972,645
2023-12-12	MDGL	BAKER BROS. ADVISORS LP	308	221.2418	308	221.2418	68,142
2023-12-12	MDGL	BAKER BROS. ADVISORS LP	3,857	221.2418	3,857	221.2418	853,330
2023-11-21	MDGL	BAKER BROS. ADVISORS LP	12	185.9442	12	185.9442	2,231
2023-11-21	MDGL	BAKER BROS. ADVISORS LP	146	185.9442	146	185.9442	27,148
2023-11-21	MDGL	BAKER BROS. ADVISORS LP	31	183.1600	31	183.1600	5,678
2023-11-21	MDGL	BAKER BROS. ADVISORS LP	369	183.1600	369	183.1600	67,586
2023-11-21	MDGL	BAKER BROS. ADVISORS LP	53	186.3171	53	186.3171	9,875
2023-11-21	MDGL	BAKER BROS. ADVISORS LP	647	186.3171	647	186.3171	120,547
2023-11-21	MDGL	BAKER BROS. ADVISORS LP	115	186.5930	115	186.5930	21,458
2023-11-21	MDGL	BAKER BROS. ADVISORS LP	1,385	186.5930	1,385	186.5930	258,431
2023-11-21	MDGL	BAKER BROS. ADVISORS LP	176	187.2439	176	187.2439	32,955
2023-11-21	MDGL	BAKER BROS. ADVISORS LP	2,124	187.2439	2,124	187.2439	397,706
2023-11-21	MDGL	BAKER BROS. ADVISORS LP	388	187.2707	388	187.2707	72,661
2023-11-21	MDGL	BAKER BROS. ADVISORS LP	4,712	187.2707	4,712	187.2707	882,420
2023-11-21	MDGL	BAKER BROS. ADVISORS LP	1,076	188.3232	1,076	188.3232	202,636
2023-11-21	MDGL	BAKER BROS. ADVISORS LP	13,011	188.3232	13,011	188.3232	2,450,273
2023-11-21	MDGL	BAKER BROS. ADVISORS LP	1,117	188.4649	1,117	188.4649	210,515
2023-11-21	MDGL	BAKER BROS. ADVISORS LP	13,505	188.4649	13,505	188.4649	2,545,218
2023-11-21	MDGL	BAKER BROS. ADVISORS LP	1,291	188.7029	1,291	188.7029	243,615
2023-11-21	MDGL	BAKER BROS. ADVISORS LP	15,620	188.7029	15,620	188.7029	2,947,539
2023-11-21	MDGL	BAKER BROS. ADVISORS LP	655	190.1361	655	190.1361	124,539
2023-11-21	MDGL	BAKER BROS. ADVISORS LP	7,917	190.1361	7,917	190.1361	1,505,308
2023-11-20	MDGL	BAKER BROS. ADVISORS LP	153	181.9300	153	181.9300	27,835
2023-11-20	MDGL	BAKER BROS. ADVISORS LP	1,847	181.9300	1,847	181.9300	336,025
2023-11-20	MDGL	BAKER BROS. ADVISORS LP	579	183.3999	579	183.3999	106,189
2023-11-20	MDGL	BAKER BROS. ADVISORS LP	7,010	183.3999	7,010	183.3999	1,285,633
2023-11-20	MDGL	BAKER BROS. ADVISORS LP	100	185.8650	100	185.8650	18,586
2023-11-20	MDGL	BAKER BROS. ADVISORS LP	1,206	185.8650	1,206	185.8650	224,153
2023-11-20	MDGL	BAKER BROS. ADVISORS LP	405	187.3450	405	187.3450	75,875
2023-11-20	MDGL	BAKER BROS. ADVISORS LP	4,895	187.3450	4,895	187.3450	917,054
2023-11-20	MDGL	BAKER BROS. ADVISORS LP	95	188.8359	95	188.8359	17,939
2023-11-20	MDGL	BAKER BROS. ADVISORS LP	1,147	188.8359	1,147	188.8359	216,595
2023-11-20	MDGL	BAKER BROS. ADVISORS LP	250	189.6978	250	189.6978	47,424
2023-11-20	MDGL	BAKER BROS. ADVISORS LP	3,022	189.6978	3,022	189.6978	573,267
2023-11-17	MDGL	BAKER BROS. ADVISORS LP	54	167.6300	54	167.6300	9,052
2023-11-17	MDGL	BAKER BROS. ADVISORS LP	646	167.6300	646	167.6300	108,289
2023-11-17	MDGL	BAKER BROS. ADVISORS LP	93	168.7825	93	168.7825	15,697
2023-11-17	MDGL	BAKER BROS. ADVISORS LP	1,107	168.7825	1,107	168.7825	186,842
2023-11-17	MDGL	BAKER BROS. ADVISORS LP	39	171.7900	39	171.7900	6,700
2023-11-17	MDGL	BAKER BROS. ADVISORS LP	461	171.7900	461	171.7900	79,195
2023-11-17	MDGL	BAKER BROS. ADVISORS LP	350	173.2016	350	173.2016	60,621
2023-11-17	MDGL	BAKER BROS. ADVISORS LP	4,151	173.2016	4,151	173.2016	718,960
2023-11-17	MDGL	BAKER BROS. ADVISORS LP	140	173.7481	140	173.7481	24,325
2023-11-17	MDGL	BAKER BROS. ADVISORS LP	1,660	173.7481	1,660	173.7481	288,422
2023-11-17	MDGL	BAKER BROS. ADVISORS LP	82	174.6698	82	174.6698	14,323
2023-11-17	MDGL	BAKER BROS. ADVISORS LP	978	174.6698	978	174.6698	170,827
2023-11-17	MDGL	BAKER BROS. ADVISORS LP	1,528	174.8748	1,528	174.8748	267,209
2023-11-17	MDGL	BAKER BROS. ADVISORS LP	18,125	174.8748	18,125	174.8748	3,169,606
2023-11-17	MDGL	BAKER BROS. ADVISORS LP	415	175.7185	415	175.7185	72,923
2023-11-17	MDGL	BAKER BROS. ADVISORS LP	4,923	175.7185	4,923	175.7185	865,062
2023-11-17	MDGL	BAKER BROS. ADVISORS LP	903	175.8179	903	175.8179	158,764
2023-11-17	MDGL	BAKER BROS. ADVISORS LP	10,715	175.8179	10,715	175.8179	1,883,889
2023-11-15	MDGL	BAKER BROS. ADVISORS LP	1,181	161.9660	1,181	161.9660	191,282
2023-11-15	MDGL	BAKER BROS. ADVISORS LP	14,018	161.9660	14,018	161.9660	2,270,439
2023-11-14	MDGL	BAKER BROS. ADVISORS LP	299	154.5969	299	154.5969	46,224
2023-11-14	MDGL	BAKER BROS. ADVISORS LP	3,542	154.5969	3,542	154.5969	547,582
2023-11-14	MDGL	BAKER BROS. ADVISORS LP	507	152.4800	507	152.4800	77,307
2023-11-14	MDGL	BAKER BROS. ADVISORS LP	6,022	152.4800	6,022	152.4800	918,235
2023-11-14	MDGL	BAKER BROS. ADVISORS LP	54	152.2129	54	152.2129	8,219
2023-11-14	MDGL	BAKER BROS. ADVISORS LP	646	152.2129	646	152.2129	98,330
2023-11-14	MDGL	BAKER BROS. ADVISORS LP	242	153.2523	242	153.2523	37,087
2023-11-14	MDGL	BAKER BROS. ADVISORS LP	2,877	153.2523	2,877	153.2523	440,907
2023-11-14	MDGL	BAKER BROS. ADVISORS LP	683	153.9736	683	153.9736	105,164
2023-11-14	MDGL	BAKER BROS. ADVISORS LP	8,098	153.9736	8,098	153.9736	1,246,878
2023-11-14	MDGL	BAKER BROS. ADVISORS LP	1,142	154.7801	1,142	154.7801	176,759
2023-11-14	MDGL	BAKER BROS. ADVISORS LP	13,548	154.7801	13,548	154.7801	2,096,961
2023-11-14	MDGL	BAKER BROS. ADVISORS LP	2,658	156.4244	2,658	156.4244	415,776
2023-11-14	MDGL	BAKER BROS. ADVISORS LP	31,530	156.4244	31,530	156.4244	4,932,061
2023-11-13	MDGL	BAKER BROS. ADVISORS LP	265	136.1805	265	136.1805	36,088
2023-11-13	MDGL	BAKER BROS. ADVISORS LP	3,144	136.1805	3,144	136.1805	428,151
2023-11-13	MDGL	BAKER BROS. ADVISORS LP	311	136.9089	311	136.9089	42,579
2023-11-13	MDGL	BAKER BROS. ADVISORS LP	3,693	136.9089	3,693	136.9089	505,605
2023-11-13	MDGL	BAKER BROS. ADVISORS LP	390	137.6855	390	137.6855	53,697
2023-11-13	MDGL	BAKER BROS. ADVISORS LP	4,631	137.6855	4,631	137.6855	637,622
2023-11-13	MDGL	BAKER BROS. ADVISORS LP	427	140.9024	427	140.9024	60,165
2023-11-13	MDGL	BAKER BROS. ADVISORS LP	5,072	140.9024	5,072	140.9024	714,657
2023-11-13	MDGL	BAKER BROS. ADVISORS LP	910	141.4450	910	141.4450	128,715
2023-11-13	MDGL	BAKER BROS. ADVISORS LP	10,790	141.4450	10,790	141.4450	1,526,192
2023-11-13	MDGL	BAKER BROS. ADVISORS LP	109	142.8575	109	142.8575	15,571
2023-11-13	MDGL	BAKER BROS. ADVISORS LP	1,291	142.8575	1,291	142.8575	184,429
2023-11-13	MDGL	BAKER BROS. ADVISORS LP	537	145.4592	537	145.4592	78,112
2023-11-13	MDGL	BAKER BROS. ADVISORS LP	6,369	145.4592	6,369	145.4592	926,430
2023-11-13	MDGL	BAKER BROS. ADVISORS LP	252	145.9775	252	145.9775	36,786
2023-11-13	MDGL	BAKER BROS. ADVISORS LP	2,994	145.9775	2,994	145.9775	437,057
2023-11-13	MDGL	BAKER BROS. ADVISORS LP	2,228	146.2104	2,228	146.2104	325,757
2023-11-13	MDGL	BAKER BROS. ADVISORS LP	26,426	146.2104	26,426	146.2104	3,863,756

Data de Negociação	Ticker	Insider	Ações Reportadas	Preço Reportado	Ações Ajustadas	Preço Ajustado	Base de Custos	Dias para Máx	Preço em Máx	Lucro Máx ($)	Retorno Máx (%)
2016-05-11	NTLA	BAKER BROS. ADVISORS LP	20,469	18.0000	20,469	18.0000	368,442	20	29.57	236,826	64.28
2016-05-11	NTLA	BAKER BROS. ADVISORS LP	179,531	18.0000	179,531	18.0000	3,231,558

Data de Negociação	Ticker	Insider	Ações Reportadas	Preço Reportado	Ações Ajustadas	Preço Ajustado	Base de Custos	Dias para Máx	Preço em Máx	Lucro Máx ($)	Retorno Máx (%)
2021-01-11	PRLD	BAKER BROS. ADVISORS LP	12,444	60.0000	12,444	60.0000	746,640	30	91.68	394,226	52.80
2021-01-11	PRLD	BAKER BROS. ADVISORS LP	154,222	60.0000	154,222	60.0000	9,253,320
2020-09-29	PRLD	BAKER BROS. ADVISORS LP	104,628	19.0000	104,628	19.0000	1,987,932
2020-09-29	PRLD	BAKER BROS. ADVISORS LP	1,474,319	19.0000	1,474,319	19.0000	28,012,061

Data de Negociação	Ticker	Insider	Ações Reportadas	Preço Reportado	Ações Ajustadas	Preço Ajustado	Base de Custos	Dias para Máx	Preço em Máx	Lucro Máx ($)	Retorno Máx (%)
2017-10-05	RYTM	BAKER BROS. ADVISORS LP	87,809	17.0000	87,809	17.0000	1,492,753	273	35.85	1,655,200	110.88
2017-10-05	RYTM	BAKER BROS. ADVISORS LP	797,191	17.0000	797,191	17.0000	13,552,247

Data de Negociação	Ticker	Insider	Ações Reportadas	Preço Reportado	Ações Ajustadas	Preço Ajustado	Base de Custos	Dias para Máx	Preço em Máx	Lucro Máx ($)	Retorno Máx (%)
2022-05-11	TCRX	BAKER BROS. ADVISORS LP	2,882	1.9853	2,882	1.9853	5,722	364	4.8500	8,257	144.32
2022-05-11	TCRX	BAKER BROS. ADVISORS LP	22,983	1.9853	22,983	1.9853	45,628
2022-05-10	TCRX	BAKER BROS. ADVISORS LP	40,800	1.7000	40,800	1.7000	69,360
2022-05-10	TCRX	BAKER BROS. ADVISORS LP	325,373	1.7000	325,373	1.7000	553,134
2022-05-10	TCRX	BAKER BROS. ADVISORS LP	12,769	1.9342	12,769	1.9342	24,698
2022-05-10	TCRX	BAKER BROS. ADVISORS LP	101,831	1.9342	101,831	1.9342	196,962
2022-05-10	TCRX	BAKER BROS. ADVISORS LP	95,060	1.9500	95,060	1.9500	185,367
2022-05-10	TCRX	BAKER BROS. ADVISORS LP	758,094	1.9500	758,094	1.9500	1,478,283
2021-07-20	TCRX	BAKER BROS. ADVISORS LP	104,698	15.0000	104,698	15.0000	1,570,470
2021-07-20	TCRX	BAKER BROS. ADVISORS LP	1,320,302	15.0000	1,320,302	15.0000	19,804,530

Data de Negociação	Ticker	Insider	Ações Reportadas	Preço Reportado	Ações Ajustadas	Preço Ajustado	Base de Custos	Dias para Máx	Preço em Máx	Lucro Máx ($)	Retorno Máx (%)
2025-11-20	TRDA	BAKER BROS. ADVISORS LP	1,213	9.0688	1,213	9.0688	11,000	167	16.0300	8,444	76.77
2025-11-20	TRDA	BAKER BROS. ADVISORS LP	13,386	9.0688	13,386	9.0688	121,395
2025-11-20	TRDA	BAKER BROS. ADVISORS LP	1,186	9.0728	1,186	9.0728	10,760
2025-11-20	TRDA	BAKER BROS. ADVISORS LP	13,082	9.0728	13,082	9.0728	118,690
2025-11-12	TRDA	BAKER BROS. ADVISORS LP	7,321	7.7315	7,321	7.7315	56,602
2025-11-12	TRDA	BAKER BROS. ADVISORS LP	80,881	7.7315	80,881	7.7315	625,331
2025-11-12	TRDA	BAKER BROS. ADVISORS LP	1,040	7.9547	1,040	7.9547	8,273
2025-11-12	TRDA	BAKER BROS. ADVISORS LP	11,494	7.9547	11,494	7.9547	91,431
2025-11-11	TRDA	BAKER BROS. ADVISORS LP	1,059	7.3909	1,059	7.3909	7,827
2025-11-11	TRDA	BAKER BROS. ADVISORS LP	11,701	7.3909	11,701	7.3909	86,481
2025-11-11	TRDA	BAKER BROS. ADVISORS LP	2,795	7.5395	2,795	7.5395	21,073
2025-11-11	TRDA	BAKER BROS. ADVISORS LP	30,879	7.5395	30,879	7.5395	232,812
2025-11-10	TRDA	BAKER BROS. ADVISORS LP	2,296	7.2139	2,296	7.2139	16,563
2025-11-10	TRDA	BAKER BROS. ADVISORS LP	25,364	7.2139	25,364	7.2139	182,973
2025-11-10	TRDA	BAKER BROS. ADVISORS LP	267	7.2244	267	7.2244	1,929
2025-11-10	TRDA	BAKER BROS. ADVISORS LP	2,947	7.2244	2,947	7.2244	21,290
2022-06-06	TRDA	BAKER BROS. ADVISORS LP	921	6.3537	921	6.3537	5,852
2022-06-06	TRDA	BAKER BROS. ADVISORS LP	7,815	6.3537	7,815	6.3537	49,654
2022-06-06	TRDA	BAKER BROS. ADVISORS LP	3,118	6.4215	3,118	6.4215	20,022
2022-06-06	TRDA	BAKER BROS. ADVISORS LP	26,450	6.4215	26,450	6.4215	169,849
2022-06-02	TRDA	BAKER BROS. ADVISORS LP	279	5.8202	279	5.8202	1,624
2022-06-02	TRDA	BAKER BROS. ADVISORS LP	2,364	5.8202	2,364	5.8202	13,759
2022-05-24	TRDA	BAKER BROS. ADVISORS LP	179	5.9300	179	5.9300	1,061
2022-05-24	TRDA	BAKER BROS. ADVISORS LP	1,521	5.9300	1,521	5.9300	9,020
2022-05-24	TRDA	BAKER BROS. ADVISORS LP	2,334	5.7415	2,334	5.7415	13,401
2022-05-24	TRDA	BAKER BROS. ADVISORS LP	19,789	5.7415	19,789	5.7415	113,619
2022-05-23	TRDA	BAKER BROS. ADVISORS LP	827	5.9874	827	5.9874	4,952
2022-05-23	TRDA	BAKER BROS. ADVISORS LP	7,010	5.9874	7,010	5.9874	41,972
2022-05-20	TRDA	BAKER BROS. ADVISORS LP	883	5.8409	883	5.8409	5,158
2022-05-20	TRDA	BAKER BROS. ADVISORS LP	7,248	5.8409	7,248	5.8409	42,335
2022-05-20	TRDA	BAKER BROS. ADVISORS LP	946	5.8421	946	5.8421	5,527
2022-05-20	TRDA	BAKER BROS. ADVISORS LP	7,772	5.8421	7,772	5.8421	45,405
2022-05-18	TRDA	BAKER BROS. ADVISORS LP	84	5.9180	84	5.9180	497
2022-05-18	TRDA	BAKER BROS. ADVISORS LP	692	5.9180	692	5.9180	4,095
2022-05-18	TRDA	BAKER BROS. ADVISORS LP	3,654	6.0000	3,654	6.0000	21,924
2022-05-18	TRDA	BAKER BROS. ADVISORS LP	30,003	6.0000	30,003	6.0000	180,018
2022-05-17	TRDA	BAKER BROS. ADVISORS LP	2,010	6.1301	2,010	6.1301	12,322
2022-05-17	TRDA	BAKER BROS. ADVISORS LP	16,501	6.1301	16,501	6.1301	101,153
2022-05-16	TRDA	BAKER BROS. ADVISORS LP	2,063	5.8259	2,063	5.8259	12,019
2022-05-16	TRDA	BAKER BROS. ADVISORS LP	16,937	5.8259	16,937	5.8259	98,673

Data de Negociação	Ticker	Insider	Ações Reportadas	Preço Reportado	Ações Ajustadas	Preço Ajustado	Base de Custos	Dias para Máx	Preço em Máx	Lucro Máx ($)	Retorno Máx (%)
2013-08-19	XOMA	BAKER BROS. ADVISORS LP	882,323	3.6200	44,116	72.4000	3,194,009	197	188.8	5,135,092	160.77
2013-08-19	XOMA	BAKER BROS. ADVISORS LP	1,854,058	3.6200	92,703	72.4000	6,711,690
2013-08-19	XOMA	BAKER BROS. ADVISORS LP	21,410	3.6200	1,070	72.4000	77,504
2012-10-29	XOMA	BAKER JULIAN	336,639	3.0000	16,832	60.0000	1,009,917
2012-10-29	XOMA	BAKER JULIAN	4,282,419	3.0000	214,121	60.0000	12,847,257
2012-10-29	XOMA	BAKER JULIAN	103,608	3.0000	5,180	60.0000	310,824

Data de Negociação	Ticker	Insider	Ações Reportadas	Preço Reportado	Ações Ajustadas	Preço Ajustado	Base de Custos	Dias para Mín	Preço em Mín	Máxima Perda Evitada ($)	Máxima Perda Evitada (%)
2015-07-22	XOMA	BAKER BROS. ADVISORS LP	1,359,253	1.0925	67,963	21.8500	1,484,984	341	9.01	-872,645	-58.76
2015-07-22	XOMA	BAKER BROS. ADVISORS LP	9,411,311	1.0925	470,566	21.8500	10,281,857
2015-07-22	XOMA	BAKER BROS. ADVISORS LP	229,436	1.0925	11,472	21.8500	250,659
2015-01-06	XOMA	BAKER BROS. ADVISORS LP	118,571	3.8600	5,929	77.2000	457,684
2015-01-06	XOMA	BAKER BROS. ADVISORS LP	859,988	3.8600	42,999	77.2000	3,319,554
2015-01-06	XOMA	BAKER BROS. ADVISORS LP	21,441	3.8600	1,072	77.2000	82,762
2015-01-05	XOMA	BAKER BROS. ADVISORS LP	118,652	3.8115	5,933	76.2300	452,242
2015-01-05	XOMA	BAKER BROS. ADVISORS LP	863,100	3.8115	43,155	76.2300	3,289,706
2015-01-05	XOMA	BAKER BROS. ADVISORS LP	21,548	3.8115	1,077	76.2300	82,130
2015-01-02	XOMA	BAKER BROS. ADVISORS LP	25,092	3.5537	1,255	71.0740	89,169
2015-01-02	XOMA	BAKER BROS. ADVISORS LP	182,454	3.5537	9,123	71.0740	648,387
2015-01-02	XOMA	BAKER BROS. ADVISORS LP	4,554	3.5537	228	71.0740	16,184
2014-12-30	XOMA	BAKER BROS. ADVISORS LP	46,362	3.6495	2,318	72.9900	169,198
2014-12-30	XOMA	BAKER BROS. ADVISORS LP	337,123	3.6495	16,856	72.9900	1,230,330
2014-12-30	XOMA	BAKER BROS. ADVISORS LP	8,415	3.6495	421	72.9900	30,711
2014-12-29	XOMA	BAKER BROS. ADVISORS LP	26,137	3.6762	1,307	73.5240	96,085
2014-12-29	XOMA	BAKER BROS. ADVISORS LP	190,117	3.6762	9,506	73.5240	698,908
2014-12-29	XOMA	BAKER BROS. ADVISORS LP	4,746	3.6762	237	73.5240	17,447
2014-12-26	XOMA	BAKER BROS. ADVISORS LP	15,420	3.7106	771	74.2120	57,217
2014-12-26	XOMA	BAKER BROS. ADVISORS LP	112,855	3.7106	5,643	74.2120	418,760
2014-12-26	XOMA	BAKER BROS. ADVISORS LP	2,825	3.7106	141	74.2120	10,482
2014-12-19	XOMA	BAKER BROS. ADVISORS LP	88,937	4.2085	4,447	84.1700	374,291
2014-12-19	XOMA	BAKER BROS. ADVISORS LP	647,781	4.2085	32,389	84.1700	2,726,186
2014-12-19	XOMA	BAKER BROS. ADVISORS LP	16,182	4.2085	809	84.1700	68,102
2014-12-18	XOMA	BAKER BROS. ADVISORS LP	19,599	4.2890	980	85.7800	84,060
2014-12-18	XOMA	BAKER BROS. ADVISORS LP	142,543	4.2890	7,127	85.7800	611,367
2014-12-18	XOMA	BAKER BROS. ADVISORS LP	3,558	4.2890	178	85.7800	15,260
2014-12-17	XOMA	BAKER BROS. ADVISORS LP	81,109	4.3090	4,055	86.1800	349,499
2014-12-17	XOMA	BAKER BROS. ADVISORS LP	590,638	4.3090	29,532	86.1800	2,545,059
2014-12-17	XOMA	BAKER BROS. ADVISORS LP	14,753	4.3090	738	86.1800	63,571
2014-12-16	XOMA	BAKER BROS. ADVISORS LP	37,592	4.2709	1,880	85.4180	160,552
2014-12-16	XOMA	BAKER BROS. ADVISORS LP	274,734	4.2709	13,737	85.4180	1,173,361
2014-12-16	XOMA	BAKER BROS. ADVISORS LP	6,874	4.2709	344	85.4180	29,358
2014-12-15	XOMA	BAKER BROS. ADVISORS LP	54,396	4.4502	2,720	89.0040	242,073
2014-12-15	XOMA	BAKER BROS. ADVISORS LP	396,496	4.4502	19,825	89.0040	1,764,486
2014-12-15	XOMA	BAKER BROS. ADVISORS LP	9,908	4.4502	495	89.0040	44,093
2014-12-12	XOMA	BAKER BROS. ADVISORS LP	29,960	4.7140	1,498	94.2800	141,231
2014-12-12	XOMA	BAKER BROS. ADVISORS LP	218,383	4.7140	10,919	94.2800	1,029,457
2014-12-12	XOMA	BAKER BROS. ADVISORS LP	5,457	4.7140	273	94.2800	25,724
2014-12-09	XOMA	BAKER BROS. ADVISORS LP	46,383	4.6159	2,319	92.3180	214,099
2014-12-09	XOMA	BAKER BROS. ADVISORS LP	337,541	4.6159	16,877	92.3180	1,558,056
2014-12-09	XOMA	BAKER BROS. ADVISORS LP	8,429	4.6159	421	92.3180	38,907
2014-12-04	XOMA	BAKER BROS. ADVISORS LP	153,618	4.5457	7,681	90.9140	698,301
2014-12-04	XOMA	BAKER BROS. ADVISORS LP	1,122,584	4.5457	56,129	90.9140	5,102,930
2014-12-04	XOMA	BAKER BROS. ADVISORS LP	28,086	4.5457	1,404	90.9140	127,671
2014-12-03	XOMA	BAKER BROS. ADVISORS LP	69,153	4.8402	3,458	96.8040	334,714
2014-12-03	XOMA	BAKER BROS. ADVISORS LP	486,800	4.8402	24,340	96.8040	2,356,209
2014-12-03	XOMA	BAKER BROS. ADVISORS LP	11,965	4.8402	598	96.8040	57,913
2014-12-02	XOMA	BAKER BROS. ADVISORS LP	60,883	5.3591	3,044	107.1820	326,278
2014-12-02	XOMA	BAKER BROS. ADVISORS LP	428,583	5.3591	21,429	107.1820	2,296,819
2014-12-02	XOMA	BAKER BROS. ADVISORS LP	10,534	5.3591	527	107.1820	56,453