Ionis Pharmaceuticals, Inc.
US ˙ NasdaqGS ˙ US4622221004

Introdução

Esta página fornece uma análise abrangente do histórico conhecido de negociações internas de Joseph Iii Klein. Insiders são oficiais, diretores ou investidores significativos em uma empresa. É ilegal para insiders realizarem negociações em suas próprias empresas baseados em informações específicas, não públicas. Isso não significa que seja ilegal para eles realizarem qualquer negociação em suas próprias empresas. No entanto, eles devem reportar todas as negociações à SEC através de um Formulário 4. Apesar dessas restrições, pesquisas acadêmicas sugerem que insiders - em geral - tendem a superar o mercado em suas próprias empresas.

Rentabilidade Média de Negociação

A rentabilidade média de negociação é o retorno médio de todas as compras de mercado abertas feitas pelo insider nos últimos três anos. Para calcular isso, examinamos cada compra de mercado aberto, não planejada, feita pelo insider, excluindo todas as negociações que foram marcadas como parte de um plano de negociação 10b5-1. Em seguida, calculamos o desempenho médio dessas negociações ao longo de 3, 6 e 12 meses, fazendo a média de cada uma dessas durações para gerar uma métrica de desempenho final para cada negociação. Finalmente, fazemos a média de todas as métricas de desempenho para calcular uma métrica de desempenho para o insider. Esta lista inclui apenas insiders que fizeram pelo menos três negociações nos últimos dois anos.

Se a rentabilidade de negociação deste insider é "N/A", então o insider ou não fez quaisquer compras de mercado aberto nos últimos três anos, ou as negociações que eles fizeram são muito recentes para calcular uma métrica de desempenho confiável.

Frequência de Atualização: Diariamente

Veja a lista dos negociantes internos mais rentáveis.

Empresas com Posições Internas Reportadas

As declarações à SEC indicam que Joseph Iii Klein reportou posses ou negociações nas seguintes empresas:

Ativo Título Últimas Posições Reportadas
US:IONS / Ionis Pharmaceuticals, Inc. Director 11,014
Director 0
US:US69329YAJ38 / Pdl Biopharma Inc Bond Director 16,983
Como Interpretar os Gráficos

Os gráficos a seguir mostram o desempenho das ações dos a ativos ubsequentes a cada transação de mercado aberto, não planejada feita por Joseph Iii Klein. Transações não planejadas são negociações que não foram feitas como parte de um plano de negociação 10b5-1. O desempenho das ações é representado como mudança percentual cumulativa no preço das ações. Por exemplo, se uma transação interna foi feita em 1 de janeiro de 2019, o gráfico mostrará a mudança percentual diária da segurança até o dia presente. Se o preço da ação passasse de $10 para $15 durante este período, a mudança percentual cumulativa no preço das ações seria de 50%. Uma mudança no preço de $10 para $20 seria de 100%, e uma mudança no preço de $10 para $5 seria de -50%.

Ultimamente, estamos tentando determinar quão estreitamente as negociações do interno correlacionam-se a retornos excessivos (positivos ou negativos) no preço da ação para ver se o interno está cronometrando suas transações para lucrar com informações internas. Considere a situação onde um interno estava fazendo isso. Nesta situação, esperaríamos (a) retornos positivos após compras, ou (b) retornos negativos após vendas. No caso de (a), o gráfico de COMPRA mostraria uma série de curvas ascendentes, indicando retornos positivos após cada transação de compra. No caso de (b), o gráfico de VENDA mostraria uma série de curvas descendentes, indicando retornos negativos após cada transação de venda.

No entanto, isso sozinho não é suficiente para tirar conclusões. Se, por exemplo, o preço da ação da empresa estivesse em uma escalada não cíclica ao longo de muitos anos, então esperaríamos que todos os gráficos pós-compra tivessem uma inclinação ascendente. Da mesma forma, declínios não cíclicos ao longo de muitos anos resultariam em gráficos pós-negociação inclinados para baixo. Nenhum desses gráficos sugeriria atividade de negociação interna.

O indicador mais forte seria uma situação em que o preço da ação fosse extremamente cíclico, e houvesse sinais positivos no gráfico de COMPRA e gráficos negativos no gráfico de VENDA. Esta situação seria altamente sugestiva de um interno que estava cronometrando transações para sua vantagem financeira.

Compras Internas IONS / Ionis Pharmaceuticals, Inc. - Análise de Lucro de Curto Prazo

Nesta seção, analisamos a lucratividade de cada compra interna de mercado aberto, não planejada, feita em IONS / Ionis Pharmaceuticals, Inc.. Esta análise ajuda a entender se o interno gera consistentemente retornos anormais, e vale a pena seguir. Esta análise é para um ano seguinte a cada transação, e os resultados são teóricos.

A tabela a seguir mostra as compras de mercado aberto mais recentes que não faziam parte de um plano de negociação automático.

Data de Negociação Ticker Insider Ações
Reportadas
Preço
Reportado
Ações
Ajustadas
Preço
Ajustado
Base de Custos Dias para
Máx
Preço em
Máx
Lucro
Máx ($)
Retorno Máx (%)
Não há negociações abertas de mercado não planejadas conhecidas para esta combinação de insider e ativo

O Preço Ajustado é o preço ajustado pela divisão. Ações Ajustadas são as ações ajustadas pela divisão.

IONS / Ionis Pharmaceuticals, Inc. Insider Trades
Vendas Internas IONS / Ionis Pharmaceuticals, Inc. - Análise de Perda de Curto Prazo

Nesta seção, analisamos a evitação de perdas de curto prazo de cada venda interna de mercado aberto, não planejada feita em IONS / Ionis Pharmaceuticals, Inc.. Um padrão consistente de evitação de perdas pode sugerir que transações futuras de venda possam prever declínios no preço. Esta análise é para um ano seguinte a cada transação, e os resultados são teóricos.

A tabela a seguir mostra as vendas de mercado aberto mais recentes que não faziam parte de um plano de negociação automático.

Data de Negociação Ticker Insider Ações
Reportadas
Preço
Reportado
Ações
Ajustadas
Preço
Ajustado
Base de Custos Dias para
Mín
Preço em
Mín
Máxima Perda
Evitada ($)
Máxima Perda
Evitada (%)
2024-05-03 IONS KLEIN JOSEPH III 1,318 42.5721 1,318 42.5721 56,110 340 25.5100 -22,488 -40.08
2024-05-03 IONS KLEIN JOSEPH III 682 42.9449 682 42.9449 29,288
2024-05-03 IONS KLEIN JOSEPH III 1,269 42.5875 1,269 42.5875 54,044
2024-05-03 IONS KLEIN JOSEPH III 731 42.9767 731 42.9767 31,416
2024-05-03 IONS KLEIN JOSEPH III 1,070 42.5473 1,070 42.5473 45,526
2024-05-03 IONS KLEIN JOSEPH III 930 42.8957 930 42.8957 39,893
2015-11-11 ISIS KLEIN JOSEPH III 3,750 64.1795 3,750 64.1795 240,673
2015-11-11 ISIS KLEIN JOSEPH III 3,125 64.1795 3,125 64.1795 200,561
2015-03-05 ISIS KLEIN JOSEPH III 7,000 70.9545 7,000 70.9545 496,682
2014-01-24 ISIS KLEIN JOSEPH III 7,500 48.6797 7,500 48.6797 365,098
2014-01-24 ISIS KLEIN JOSEPH III 2,813 48.6102 2,813 48.6102 136,740
2013-11-25 ISIS KLEIN JOSEPH III 6,000 36.8594 6,000 36.8594 221,156
2013-08-09 ISIS KLEIN JOSEPH III 103 28.2300 103 28.2300 2,908
2013-08-09 ISIS KLEIN JOSEPH III 3,647 28.2200 3,647 28.2200 102,918
2013-08-09 ISIS KLEIN JOSEPH III 7,500 28.2200 7,500 28.2200 211,650
2013-08-09 ISIS KLEIN JOSEPH III 7,500 28.2200 7,500 28.2200 211,650

O Preço Ajustado é o preço ajustado pela divisão. Ações Ajustadas são as ações ajustadas pela divisão.

IONS / Ionis Pharmaceuticals, Inc. Insider Trades
Histórico de Negociações Insider

Esta tabela mostra a lista completa de negociações insider realizadas por Joseph Iii Klein conforme divulgadas para a Comissão de Valores Mobiliários (SEC).

Data do Arquivo Data da Transação Formulário Ticker Ativo Código 10b5-1 Ações Ações Restantes Variação
Percentual
Preço
da Ação
Valor
da Transação
Valor
Restante
2026-05-05 2026-05-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1,431 11,014 -11.50 74.45 -106,534 819,964
2026-05-05 2026-05-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -8,680 12,445 -41.09 73.35 -636,704 912,878
2026-05-05 2026-05-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 10,111 21,125 91.80 47.11 476,329 995,199
2026-04-02 2026-04-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -2,216 11,014 -16.75 75.95 -168,314 836,557
2026-04-02 2026-04-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -20,105 13,230 -60.31 75.50 -1,517,988 998,905
2026-04-02 2026-04-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 10,321 33,335 44.85 41.08 423,987 1,369,402
2026-04-02 2026-04-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 12,000 23,014 108.95 38.06 456,720 875,913
2026-03-05 2026-03-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1,012 11,014 -8.42 80.82 -81,788 890,129
2026-03-05 2026-03-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -6,794 12,026 -36.10 80.00 -543,486 962,020
2026-03-05 2026-03-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -13,526 18,820 -41.82 79.17 -1,070,908 1,490,055
2026-03-05 2026-03-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 4,000 32,346 14.11 42.88 171,520 1,386,996
2026-03-05 2026-03-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 12,000 28,346 73.41 40.05 480,600 1,135,257
2025-11-28 2025-11-25 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -4,000 0 -100.00 80.00 -320,000
2025-11-28 2025-11-25 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -4,000 0 -100.00 80.00 -320,000
2025-11-28 2025-11-25 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -4,000 0 -100.00 80.00 -320,000
2025-11-28 2025-11-25 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 4,000 4,000
2025-11-28 2025-11-25 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 4,000 4,000
2025-11-28 2025-11-25 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 4,000 4,000
2025-09-04 2025-09-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -28,000 0 -100.00 60.00 -1,680,000
2025-09-04 2025-09-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 12,000 28,000 75.00
2025-09-04 2025-09-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 16,000 16,000
2025-09-04 2025-09-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -28,000 0 -100.00 60.00 -1,680,000
2025-09-04 2025-09-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 12,000 28,000 75.00
2025-09-04 2025-09-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 16,000 16,000
2024-07-17 2024-07-16 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -12,000 0 -100.00 50.00 -600,000
2024-07-17 2024-07-16 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 12,000 12,000 24.42 293,040 293,040
2024-05-07 2024-05-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -930 0 -100.00 42.90 -39,893
2024-05-07 2024-05-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -1,070 930 -53.50 42.55 -45,526 39,569
2024-05-07 2024-05-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -731 2,000 -26.77 42.98 -31,416 85,953
2024-05-07 2024-05-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -1,269 2,731 -31.72 42.59 -54,044 116,306
2024-05-07 2024-05-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -682 4,000 -14.57 42.94 -29,288 171,780
2024-05-07 2024-05-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale -1,318 4,682 -21.97 42.57 -56,110 199,323
2023-11-17 2023-11-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -2,000 16,346 -10.90 50.00 -100,000 817,300
2023-09-28 2023-09-26 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -2,000 18,346 -9.83 45.13 -90,254 827,896
2023-07-19 2023-07-18 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -3,555 20,346 -14.87 42.00 -149,310 854,532
2023-07-19 2023-07-17 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 5,333 23,901 28.72
2023-07-19 2023-07-17 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 1,777 18,568 10.58
2023-01-18 2023-01-17 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -2,000 16,791 -10.64 40.00 -80,000 671,640
2022-07-19 2022-07-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -644 18,791 -3.31 38.78 -24,974 728,715
2022-07-19 2022-07-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -689 19,435 -3.42 37.74 -26,003 733,477
2022-07-19 2022-07-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 2,665 20,124 15.26
2022-07-19 2022-07-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 5,333 17,459 43.98
2022-02-14 2021-11-30 5 IONS IONIS PHARMACEUTICALS INC
Non-Qualified Stock Option (right to buy)
G - Gift 8,000 8,000
2022-02-14 2021-11-30 5 IONS IONIS PHARMACEUTICALS INC
Non-Qualified Stock Option (right to buy)
G - Gift 12,000 12,000
2022-02-14 2021-11-30 5 IONS IONIS PHARMACEUTICALS INC
Non-Qualified Stock Option (right to buy)
G - Gift 12,000 12,000
2022-02-14 2021-11-30 5 IONS IONIS PHARMACEUTICALS INC
Non-Qualified Stock Option (right to buy)
G - Gift 16,000 16,000
2022-02-14 2021-11-30 5 IONS IONIS PHARMACEUTICALS INC
Non-Qualified Stock Option (right to buy)
G - Gift 16,000 16,000
2022-02-14 2021-11-30 5 IONS IONIS PHARMACEUTICALS INC
Non-Qualified Stock Option (right to buy)
G - Gift 12,000 12,000
2022-02-14 2021-11-30 5 IONS IONIS PHARMACEUTICALS INC
Non-Qualified Stock Option (right to buy)
G - Gift -8,000 8,000 -50.00
2022-02-14 2021-11-30 5 IONS IONIS PHARMACEUTICALS INC
Non-Qualified Stock Option (right to buy)
G - Gift -12,000 0 -100.00
2022-02-14 2021-11-30 5 IONS IONIS PHARMACEUTICALS INC
Non-Qualified Stock Option (right to buy)
G - Gift -12,000 0 -100.00
2022-02-14 2021-11-30 5 IONS IONIS PHARMACEUTICALS INC
Non-Qualified Stock Option (right to buy)
G - Gift -16,000 0 -100.00
2022-02-14 2021-11-30 5 IONS IONIS PHARMACEUTICALS INC
Non-Qualified Stock Option (right to buy)
G - Gift -16,000 0 -100.00
2022-02-14 2021-11-30 5 IONS IONIS PHARMACEUTICALS INC
Non-Qualified Stock Option (right to buy)
G - Gift -12,000 4,000 -75.00
2022-02-14 2021-11-30 5 IONS IONIS PHARMACEUTICALS INC
Common Stock
G - Gift 6,000 6,000
2022-02-14 2021-11-30 5 IONS IONIS PHARMACEUTICALS INC
Common Stock
G - Gift -6,000 12,126 -33.10
2021-07-19 2021-07-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Unit
M - Exercise -1,778 9,775 -15.39
2021-07-19 2021-07-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Unit
M - Exercise -666 11,553 -5.45
2021-07-19 2021-07-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Unit
M - Exercise -889 12,219 -6.78
2021-07-19 2021-07-15 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Unit
M - Exercise -5,333 13,108 -28.92
2021-07-19 2021-07-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -4,334 18,126 -19.30 35.30 -152,989 639,844
2021-07-19 2021-07-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 1,778 22,460 8.60
2021-07-19 2021-07-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 666 20,682 3.33
2021-07-19 2021-07-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 889 20,016 4.65
2021-07-19 2021-07-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 5,333 19,127 38.66
2021-07-06 2021-07-01 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Unit
A - Award 5,333 18,441 40.69
2021-07-06 2021-07-01 4 IONS IONIS PHARMACEUTICALS INC
Non-Qualified Stock Option (right to buy)
A - Award 12,000 12,000
2020-10-22 2020-10-20 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -2,889 13,794 -17.32 46.86 -135,386 646,421
2020-10-13 2020-10-12 4 AKCA AKCEA THERAPEUTICS, INC.
Stock Option (right to buy)
D - Sale to Issuer -26,400 0 -100.00 2.01 -53,064
2020-07-06 2020-07-06 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -667 666 -50.04
2020-07-06 2020-07-06 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 667 16,683 4.16
2020-07-06 2020-07-02 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -889 1,777 -33.35
2020-07-06 2020-07-02 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 889 16,016 5.88
2020-07-06 2020-07-01 4 IONS IONIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
A - Award 12,000 12,000
2020-07-06 2020-07-01 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
A - Award 5,333 5,333
2020-07-06 2020-07-01 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -1,778 5,332 -25.01
2020-07-06 2020-07-01 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -666 0 -100.00
2020-07-06 2020-07-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 1,778 15,127 13.32
2020-07-06 2020-07-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 666 13,349 5.25
2020-04-15 2020-04-13 4 AKCA AKCEA THERAPEUTICS, INC.
Stock Option (right to buy)
A - Award 26,400 26,400
2019-12-23 2019-12-23 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1,000 0 -100.00
2019-12-23 2019-12-23 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1,000 12,683 -7.31 61.87 -61,874 784,750
2019-12-23 2019-12-23 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1,000 13,683 7.88 35.53 35,530 486,157
2019-12-18 2019-12-16 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1,000 1,000 -50.00
2019-12-18 2019-12-16 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1,000 12,683 -7.31 65.45 -65,446 830,058
2019-12-18 2019-12-16 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1,000 13,683 7.88 35.53 35,530 486,157
2019-12-10 2019-12-09 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1,000 2,000 -33.33
2019-12-10 2019-12-09 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1,000 12,683 -7.31 63.74 -63,745 808,474
2019-12-10 2019-12-09 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1,000 13,683 7.88 35.53 35,530 486,157
2019-12-04 2019-12-02 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -1,000 3,000 -25.00
2019-12-04 2019-12-02 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1,000 12,683 -7.31 64.08 -64,083 812,765
2019-12-04 2019-12-02 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1,000 13,683 7.88 35.53 35,530 486,157
2019-11-26 2019-11-25 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -812 12,683 -6.02 62.90 -51,075 797,761
2019-11-21 2019-11-20 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -2,000 13,495 -12.91 60.00 -120,000 809,700
2019-09-23 2019-09-20 4 AKCA AKCEA THERAPEUTICS, INC.
Stock Option (right to buy)
A - Award 53,000 53,000
2019-07-03 2019-07-03 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -667 1,333 -33.35
2019-07-03 2019-07-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 667 15,495 4.50
2019-07-03 2019-07-02 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -889 2,666 -25.01
2019-07-03 2019-07-02 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 889 14,828 6.38
2019-07-03 2019-07-01 4 IONS IONIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
A - Award 16,000 16,000
2019-07-03 2019-07-01 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
A - Award 7,110 7,110
2019-07-03 2019-07-01 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -667 666 -50.04
2019-07-03 2019-07-01 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -666 0 -100.00
2019-07-03 2019-07-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 667 13,939 5.03
2019-07-03 2019-07-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 666 13,272 5.28
2018-07-03 2018-07-03 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -667 2,000 -25.01
2018-07-03 2018-07-03 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 667 12,606 5.59
2018-07-03 2018-07-02 4 IONS IONIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
A - Award 16,000 16,000
2018-07-03 2018-07-02 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
A - Award 3,555 3,555
2018-07-03 2018-07-01 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -2,000 1,999 -50.01
2018-07-03 2018-07-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 2,000 11,939 20.12
2018-03-30 2018-03-29 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise 2,000 0 -100.00
2018-03-30 2018-03-29 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -2,000 9,939 -16.75 46.15 -92,300 458,685
2018-03-30 2018-03-29 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 2,000 11,939 20.12 24.42 48,840 291,550
2018-03-16 2018-03-15 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise 2,000 2,000
2018-03-16 2018-03-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -200 9,939 -1.97 52.11 -10,422 517,921
2018-03-16 2018-03-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 200 10,139 2.01 24.42 4,884 247,594
2018-03-16 2018-03-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -900 9,939 -8.30 51.59 -46,431 512,753
2018-03-16 2018-03-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 900 10,839 9.06 24.42 21,978 264,688
2018-03-16 2018-03-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 900 10,839 9.06 24.42 21,978 264,688
2018-03-16 2018-03-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -900 9,939 -8.30 50.45 -45,405 501,423
2018-03-01 2018-02-28 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise 3,000 0 -100.00
2018-03-01 2018-02-28 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -2,100 9,939 -17.44 52.29 -109,809 519,710
2018-03-01 2018-02-28 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 2,100 12,039 21.13 35.53 74,613 427,746
2018-03-01 2018-02-28 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -900 9,939 -8.30 51.02 -45,918 507,088
2018-03-01 2018-02-28 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 900 10,839 9.06 35.53 31,977 385,110
2018-02-16 2018-02-15 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise 3,000 3,000
2018-02-16 2018-02-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1,600 9,939 -13.87 49.20 -78,720 488,999
2018-02-16 2018-02-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1,600 11,539 16.10 35.53 56,848 409,981
2018-02-16 2018-02-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1,400 9,939 -12.35 48.76 -68,264 484,626
2018-02-16 2018-02-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1,400 11,339 14.09 35.53 49,742 402,875
2018-01-31 2018-01-30 4/A IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise 3,000 6,000 100.00
2018-01-31 2018-01-30 4/A IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -3,000 9,939 -23.19 52.86 -158,580 525,376
2018-01-31 2018-01-30 4/A IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 3,000 12,939 30.18 35.53 106,590 459,723
2018-01-17 2018-01-16 4 IONS IONIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
M - Exercise -3,000 9,000 -25.00
2018-01-17 2018-01-16 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1,400 9,939 -12.35 52.97 -74,158 526,469
2018-01-17 2018-01-16 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1,400 11,339 14.09 35.53 49,742 402,875
2018-01-17 2018-01-16 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1,600 9,939 -13.87 52.13 -83,408 518,120
2018-01-17 2018-01-16 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1,600 11,539 16.10 35.53 56,848 409,981
2018-01-02 2017-12-29 4 IONS IONIS PHARMACEUTICALS INC
Non-Employee Director Stock Option (right to buy)
M - Exercise -3,000 0 -100.00
2018-01-02 2017-12-29 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -3,000 9,939 -23.19 50.56 -151,680 502,516
2018-01-02 2017-12-29 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 3,000 12,939 30.18 28.47 85,410 368,373
2017-12-19 2017-12-15 4 IONS IONIS PHARMACEUTICALS INC
NonEmployee Director stock option (right to buy)
M - Exercise -3,000 3,000 -50.00
2017-12-19 2017-12-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -3,000 9,939 -23.19 51.69 -155,070 513,747
2017-12-19 2017-12-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 3,000 12,939 30.18 28.47 85,410 368,373
2017-12-01 2017-11-30 4 IONS IONIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -3,000 6,000 -33.33
2017-12-01 2017-11-30 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -3,000 9,939 -23.19 53.55 -160,650 532,233
2017-12-01 2017-11-30 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 3,000 12,939 30.18 28.47 85,410 368,373
2017-11-17 2017-11-16 4 IONS IONIS PHARMACEUTICALS INC
Non-Employee Director Stock Option (right to buy)
M - Exercise -2,812 0 -100.00
2017-11-17 2017-11-16 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 2,812 9,939 39.46 12.94 36,387 128,611
2017-11-17 2017-11-15 4 IONS IONIS PHARMACEUTICALS INC
Non-Employee Director Stock Option (right to buy)
M - Exercise -2,250 9,000 -20.00
2017-11-17 2017-11-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -2,250 7,127 -23.99 53.56 -120,510 381,722
2017-11-17 2017-11-15 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 2,250 9,377 31.57 28.47 64,058 266,963
2017-11-14 2017-11-13 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
S - Sale X -3,000 7,127 -29.62 55.39 -166,170 394,765
2017-07-03 2017-07-03 4 IONS IONIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
A - Award 16,000 16,000
2017-07-03 2017-07-03 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
A - Award 2,667 2,667
2017-07-03 2017-07-02 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 2,469 10,127 32.24
2017-07-03 2017-07-01 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -2,469 3,999 -38.17
2016-07-06 2016-07-02 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -312 0 -100.00
2016-07-06 2016-07-02 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 312 7,658 4.25
2016-07-06 2016-07-01 4 IONS IONIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
A - Award 16,000 16,000
2016-07-06 2016-07-01 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
A - Award 2,667 2,667
2016-07-06 2016-07-01 4 IONS IONIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -1,803 3,801 -32.17
2016-07-06 2016-07-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 469 7,346 6.82
2016-07-06 2016-07-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 667 6,877 10.74
2016-07-06 2016-07-01 4 IONS IONIS PHARMACEUTICALS INC
Common Stock
M - Exercise 667 6,877 10.74
2015-11-12 2015-11-11 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -3,125 2,812 -52.64
2015-11-12 2015-11-11 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -3,750 0 -100.00
2015-11-12 2015-11-11 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale -3,125 5,543 -36.05 64.18 -200,561 355,747
2015-11-12 2015-11-11 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 3,125 8,668 56.38 12.94 40,438 112,164
2015-11-12 2015-11-11 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale -3,750 5,543 -40.35 64.18 -240,673 355,747
2015-11-12 2015-11-11 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 3,750 9,293 67.65 9.30 34,875 86,425
2015-07-02 2015-07-02 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -312 312 -50.00
2015-07-02 2015-07-02 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 312 5,543 5.96
2015-07-02 2015-07-01 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
A - Award 16,000 16,000
2015-07-02 2015-07-01 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
A - Award 2,667 2,667
2015-07-02 2015-07-01 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -667 2,000 -25.01
2015-07-02 2015-07-01 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -469 937 -33.36
2015-07-02 2015-07-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 667 5,231 14.61
2015-07-02 2015-07-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 469 4,564 11.45
2015-03-09 2015-03-05 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -2,500 5,937 -29.63
2015-03-09 2015-03-05 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -3,750 3,750 -50.00
2015-03-09 2015-03-05 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -3,750 3,750 -50.00
2015-03-09 2015-03-05 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale -7,000 4,095 -63.09 70.95 -496,682 290,559
2015-03-09 2015-03-05 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 2,500 11,095 29.09 12.94 32,350 143,569
2015-03-09 2015-03-05 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 3,750 8,595 77.40 9.30 34,875 79,934
2015-03-09 2015-03-05 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 3,750 4,845 342.47 9.22 34,575 44,671
2015-02-13 2015-02-11 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
G - Gift -2,000 1,095 -64.62
2014-07-02 2014-07-02 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -313 624 -33.40
2014-07-02 2014-07-02 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 313 3,095 11.25
2014-07-02 2014-07-01 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
A - Award 16,000 16,000
2014-07-02 2014-07-01 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
A - Award 2,667 2,667
2014-07-02 2014-07-01 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -469 1,406 -25.01
2014-07-02 2014-07-01 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 469 2,782 20.28
2014-01-24 2014-01-24 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -2,813 8,437 -25.00
2014-01-24 2014-01-24 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -7,500 0 -100.00
2014-01-24 2014-01-24 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale -2,813 2,313 -54.88 48.61 -136,740 112,435
2014-01-24 2014-01-24 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 2,813 5,126 121.62 12.94 36,400 66,330
2014-01-24 2014-01-24 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale -7,500 2,313 -76.43 48.68 -365,098 112,596
2014-01-24 2014-01-24 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 7,500 9,813 324.25 16.32 122,400 160,148
2013-11-27 2013-11-25 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale -6,000 2,313 -72.18 36.86 -221,156 85,256
2013-08-13 2013-08-09 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -7,500 7,500 -50.00
2013-08-13 2013-08-09 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -7,500 7,500 -50.00
2013-08-13 2013-08-09 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -3,750 0 -100.00
2013-08-13 2013-08-09 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale -7,500 8,313 -47.43 28.22 -211,650 234,593
2013-08-13 2013-08-09 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale -7,500 8,313 -47.43 28.22 -211,650 234,593
2013-08-13 2013-08-09 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 7,500 15,813 90.22 9.22 69,150 145,796
2013-08-13 2013-08-09 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 7,500 15,813 90.22 9.30 69,750 147,061
2013-08-13 2013-08-09 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale -3,647 8,313 -30.49 28.22 -102,918 234,593
2013-08-13 2013-08-09 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 3,647 11,960 43.87 13.88 50,620 166,005
2013-08-13 2013-08-09 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale -103 8,313 -1.22 28.23 -2,908 234,676
2013-08-13 2013-08-09 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 103 8,416 1.24 13.88 1,430 116,814
2013-07-03 2013-07-02 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
M - Exercise -313 937 -25.04
2013-07-03 2013-07-02 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise 313 8,313 3.91
2013-07-03 2013-07-01 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
A - Award 1,875 1,875
2013-07-03 2013-07-01 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
A - Award 11,250 11,250
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -174 0 -100.00 18.00 -3,132
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 174 174 5.93 1,032 1,032
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1,250 0 -100.00 18.00 -22,500
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1,250 1,250 9.22 11,525 11,525
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -2,500 0 -100.00 18.00 -45,000
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 2,500 2,500 16.32 40,800 40,800
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -174 0 -100.00
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -174 0 -100.00
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -1,250 0 -100.00
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -1,250 0 -100.00
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -2,500 0 -100.00
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -2,500 0 -100.00
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -4,167 0 -100.00
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -4,167 0 -100.00
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -3,750 0 -100.00
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -3,750 0 -100.00
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -1,250 0 -100.00
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -2,500 0 -100.00
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -3,750 0 -100.00
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -173 0 -100.00
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -4,166 0 -100.00
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -4,167 0 -100.00 18.00 -75,006
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -4,167 0 -100.00 18.00 -75,006
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 4,167 4,167 9.77 40,712 40,712
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 4,167 4,167 9.77 40,712 40,712
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -3,750 0 -100.00 18.00 -67,500
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 3,750 3,750 13.88 52,050 52,050
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -174 0 -100.00 18.00 -3,132
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 174 174 5.93 1,032 1,032
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1,250 0 -100.00 18.00 -22,500
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -1,250 0 -100.00 18.00 -22,500
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1,250 1,250 9.22 11,525 11,525
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 1,250 1,250 9.22 11,525 11,525
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -2,500 0 -100.00 18.00 -45,000
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 2,500 2,500 16.32 40,800 40,800
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -3,750 0 -100.00 18.00 -67,500
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 3,750 3,750 13.88 52,050 52,050
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -173 100 -63.37 18.00 -3,114 1,800
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 173 273 173.00 5.93 1,026 1,619
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -2,500 100 -96.15 18.00 -45,000 1,800
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 2,500 2,600 2,500.00 16.32 40,800 42,432
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -4,166 100 -97.66 18.00 -74,988 1,800
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 4,166 4,266 4,166.00 9.77 40,702 41,679
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -3,750 100 -97.40 18.00 -67,500 1,800
2013-03-21 2013-03-20 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 3,750 3,850 3,750.00 13.88 52,050 53,438
2013-03-21 2013-03-19 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -3,727 174 -95.54
2013-03-21 2013-03-19 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -3,726 174 -95.54
2013-03-21 2013-03-19 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -3,726 174 -95.54
2013-03-21 2013-03-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -3,727 0 -100.00 18.00 -67,086
2013-03-21 2013-03-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 3,727 3,727 5.93 22,101 22,101
2013-03-21 2013-03-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -3,726 0 -100.00 18.00 -67,068
2013-03-21 2013-03-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -3,726 0 -100.00 18.00 -67,068
2013-03-21 2013-03-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 3,726 3,726 5.93 22,095 22,095
2013-03-21 2013-03-19 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 3,726 3,726 5.93 22,095 22,095
2013-03-14 2013-03-13 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -6,667 0 -100.00
2013-03-14 2013-03-13 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -6,667 0 -100.00
2013-03-14 2013-03-13 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -266 3,901 -6.38
2013-03-14 2013-03-13 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -266 3,901 -6.38
2013-03-14 2013-03-13 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -6,666 0 -100.00
2013-03-14 2013-03-13 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
M - Exercise -268 3,899 -6.43
2013-03-14 2013-03-13 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -6,667 0 -100.00 18.01 -120,052
2013-03-14 2013-03-13 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -6,667 0 -100.00 18.01 -120,052
2013-03-14 2013-03-13 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 6,667 6,667 5.17 34,468 34,468
2013-03-14 2013-03-13 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 6,667 6,667 5.17 34,468 34,468
2013-03-14 2013-03-13 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -266 0 -100.00 18.01 -4,790
2013-03-14 2013-03-13 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -266 0 -100.00 18.01 -4,790
2013-03-14 2013-03-13 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 266 266 5.93 1,577 1,577
2013-03-14 2013-03-13 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 266 266 5.93 1,577 1,577
2013-03-14 2013-03-13 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -6,666 100 -98.52 18.01 -120,034 1,801
2013-03-14 2013-03-13 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 6,666 6,766 6,666.00 5.17 34,463 34,980
2013-03-14 2013-03-13 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
S - Sale X -268 100 -72.83 18.01 -4,826 1,801
2013-03-14 2013-03-13 4 ISIS ISIS PHARMACEUTICALS INC
Common Stock
M - Exercise X 268 368 268.00 5.93 1,589 2,182
2012-07-03 2012-07-02 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
A - Award 11,250 11,250
2012-07-03 2012-07-02 4 ISIS ISIS PHARMACEUTICALS INC
Restricted Stock Units
A - Award 1,250 1,250
2012-01-05 2012-01-04 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
G - Gift 1,250 1,250
2012-01-05 2012-01-04 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
G - Gift 1,250 1,250
2012-01-05 2012-01-04 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
G - Gift 2,500 2,500
2012-01-05 2012-01-04 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
G - Gift 2,500 2,500
2012-01-05 2012-01-04 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
G - Gift 3,750 3,750
2012-01-05 2012-01-04 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
G - Gift 3,750 3,750
2012-01-05 2012-01-04 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
G - Gift 4,167 4,167
2012-01-05 2012-01-04 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
G - Gift 4,167 4,167
2012-01-05 2012-01-04 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
G - Gift 1,250 1,250
2012-01-05 2012-01-04 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
G - Gift 2,500 2,500
2012-01-05 2012-01-04 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
G - Gift 3,750 3,750
2012-01-05 2012-01-04 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
G - Gift 4,166 4,166
2012-01-05 2012-01-04 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
G - Gift -3,750 11,250 -25.00
2012-01-05 2012-01-04 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
G - Gift -7,500 7,500 -50.00
2012-01-05 2012-01-04 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
G - Gift -11,250 3,750 -75.00
2012-01-05 2012-01-04 4 ISIS ISIS PHARMACEUTICALS INC
Employee Stock Option (right to buy)
G - Gift -12,500 0 -100.00
2012-01-03 2011-12-30 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
G - Gift 4,167 4,167
2012-01-03 2011-12-30 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
G - Gift 4,167 4,167
2012-01-03 2011-12-30 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
G - Gift 6,667 6,667
2012-01-03 2011-12-30 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
G - Gift 6,667 6,667
2012-01-03 2011-12-30 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
G - Gift 4,166 4,166
2012-01-03 2011-12-30 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
G - Gift 6,666 6,666
2012-01-03 2011-12-30 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
G - Gift -12,500 0 -100.00
2012-01-03 2011-12-30 4 ISIS ISIS PHARMACEUTICALS INC
Director Stock Option (right to buy)
G - Gift -20,000 0 -100.00
2009-06-08 2009-06-04 4 PDLI PDL BIOPHARMA, INC.
Common Stock
A - Award 6,983 16,983 69.83 7.16 49,998 121,598
2007-09-10 2007-09-06 4 PDLI PDL BIOPHARMA, INC.
Commn Stock
P - Purchase X 500 1,500 50.00 20.12 10,060 30,180
2005-12-15 3 ISIS ISIS PHARMACEUTICALS INC
Common Stock
100
P
Compra de mercado aberto ou privada de ativo não-derivativo ou derivativo
S
Venda de mercado aberto ou privada de ativo não-derivativo ou derivativo
A
Concessão, premiação, ou outra aquisição de ativos da empresa (como uma opção)
C
Conversão de derivativo
D
Venda ou transferência de ativos de volta para a empresa
F
Pagamento do preço de exercício ou responsabilidade fiscal utilizando parte dos ativos recebidos da empresa
G
Doação de ativos pelo ou para o insider
K
Swaps de capital e transações de hedge similares
M
Exercício ou conversão de ativo derivativo recebido da empresa (como uma opção)
V
Uma transação voluntariamente reportada no Formulário 4
J
Outro (acompanhado de uma nota explicativa descrevendo a transação)