Ionis Pharmaceuticals, Inc.
MX ˙ BMV ˙ US4622221004
SecurityMX:IONS / Ionis Pharmaceuticals, Inc.
InstitutionEversept Partners, LP
Latest Disclosed Ownership632,100 shares
Latest Disclosed Value $ 47,464,389
Eversept Partners, LP reports 17.44% increase in ownership of IONS / Ionis Pharmaceuticals, Inc.

On May 15, 2026 - Eversept Partners, LP filed a 13F-HR form disclosing ownership of 632,100 shares of Ionis Pharmaceuticals, Inc. (MX:IONS) valued at $47,464,389 USD as of March 31, 2026. The entity filed a previous 13F-HR on February 17, 2026 disclosing 538,218 shares of Ionis Pharmaceuticals, Inc.. This represents a change in shares of 17.44% during the quarter.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-15 2026-03-31 13F IONIS PHARMACEUTICALS COM 462222100 632,100 93,882 17.44 47,464 11.48 2.5028
2026-02-17 2025-12-31 13F IONIS PHARMACEUTICALS COM 462222100 538,218 -443 -0.08 42,578 20.83 2.1456
2025-11-14 2025-09-30 13F IONIS PHARMACEUTICALS COM 462222100 538,661 -50,239 -8.53 35,239 51.45 2.4286
2025-08-14 2025-06-30 13F IONIS PHARMACEUTICALS COM 462222100 588,900 71,879 13.90 23,267 49.17 2.1401
2025-05-15 2025-03-31 13F IONIS PHARMACEUTICALS COM 462222100 517,021 302,069 140.53 15,599 107.59 1.5841
2025-02-14 2024-12-31 13F IONIS PHARMACEUTICALS COM 462222100 214,952 -256,403 -54.40 7,515 -60.21 0.6671
2024-11-14 2024-09-30 13F IONIS PHARMACEUTICALS COM 462222100 471,355 14,474 3.17 18,882 -13.28 1.2935
2024-08-14 2024-06-30 13F IONIS PHARMACEUTICALS COM 462222100 456,881 80,443 21.37 21,775 33.44 1.4911
2024-05-15 2024-03-31 13F IONIS PHARMACEUTICALS COM 462222100 376,438 51,784 15.95 16,319 -0.65 1.0886
2024-02-14 2023-12-31 13F IONIS PHARMACEUTICALS COM 462222100 324,654 72,208 28.60 16,424 43.44 1.4429
2023-11-14 2023-09-30 13F IONIS PHARMACEUTICALS COM 462222100 252,446 10,874 4.50 11,451 15.53 0.9690
2023-11-08 2023-06-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 241,572 -61,797 -20.37 9,912 -8.59 0.8287
2023-08-14 2023-06-30 13F IONIS PHARMACEUTICALS COM 462222100 241,572 -61,797 9,912 1.0259
2023-11-08 2023-03-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 303,369 62,394 25.89 10,842 19.13 0.7560
2023-05-15 2023-03-31 13F IONIS PHARMACEUTICALS COM 462222100 303,369 62,394 10,842 0.9460
2023-11-08 2022-12-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 240,975 39,142 19.39 9,102 1.95 0.7973
2023-02-14 2022-12-31 13F IONIS PHARMACEUTICALS COM 462222100 240,975 39,142 9,102 0.8413
2023-11-08 2022-09-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 201,833 115,522 133.84 8,927 179.41 0.7742
2022-11-14 2022-09-30 13F IONIS PHARMACEUTICALS COM 462222100 201,833 115,522 8,927 0.9124
2023-11-08 2022-06-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 86,311 -72,495 -45.65 3,195 -45.68 0.2273
2022-08-15 2022-06-30 13F IONIS PHARMACEUTICALS COM 462222100 86,311 -72,495 3,195 0.2611
2023-11-08 2022-03-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 158,806 -225,983 -58.73 5,882 -49.77 0.4517
2022-05-16 2022-03-31 13F IONIS PHARMACEUTICALS COM 462222100 158,806 -225,983 5,882 0.4852
2023-11-08 2021-12-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 384,789 -65,712 -14.59 11,709 -22.50 0.7483
2022-02-14 2021-12-31 13F IONIS PHARMACEUTICALS COM 462222100 384,789 -65,712 11,709 0.8619
2023-11-08 2021-09-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 450,501 8,501 1.92 15,110 -14.30 1.0489
2021-11-15 2021-09-30 13F IONIS PHARMACEUTICALS COM 462222100 450,501 8,501 15,110 1.1314
2023-11-08 2021-06-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 442,000 442,000 17,631 1.1751
2021-08-16 2021-06-30 13F IONIS PHARMACEUTICALS COM 462222100 442,000 442,000 17,631 1.3825
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.