Ionis Pharmaceuticals, Inc.
MX ˙ BMV ˙ US4622221004
SecurityMX:IONS / Ionis Pharmaceuticals, Inc.
InstitutionM&t Bank Corp
Latest Disclosed Ownership7,198 shares
Latest Disclosed Value $ 540,498
M&t Bank Corp reports 11.68% decrease in ownership of IONS / Ionis Pharmaceuticals, Inc.

On May 12, 2026 - M&t Bank Corp filed a 13F-HR form disclosing ownership of 7,198 shares of Ionis Pharmaceuticals, Inc. (MX:IONS) valued at $540,498 USD as of March 31, 2026. The entity filed a previous 13F-HR/A on January 30, 2026 disclosing 8,150 shares of Ionis Pharmaceuticals, Inc.. This represents a change in shares of -11.68% during the quarter.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-12 2026-03-31 13F IONIS PHARMACEUTICALS COM 462222100 7,198 -952 -11.68 540 -16.15 0.0004
2026-01-30 2025-12-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 8,150 2,140 35.61 644 64.29 0.0021
2026-01-28 2025-12-31 13F IONIS PHARMACEUTICALS COM 462222100 88,510 82,500 1,569 0.0009
2025-11-14 2025-09-30 13F IONIS PHARMACEUTICALS COM 462222100 6,010 -1,641 -21.45 393 29.37 0.0013
2025-08-13 2025-06-30 13F IONIS PHARMACEUTICALS COM 462222100 7,651 7,651 303 0.0010
2025-04-30 2025-03-31 13F IONIS PHARMACEUTICALS COM 462222100 0 -6,096 -100.00 0 -100.00
2025-02-06 2024-12-31 13F IONIS PHARMACEUTICALS COM 462222100 6,096 -2,800 -31.47 214 -40.17 0.0007
2024-11-19 2024-09-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 8,896 70 0.79 357 -15.24 0.0012
2024-11-15 2024-09-30 13F IONIS PHARMACEUTICALS COM 462222100 8,896 70 357 0.0002
2024-07-31 2024-06-30 13F IONIS PHARMACEUTICALS COM 462222100 8,826 2,978 50.92 421 66.01 0.0014
2024-05-07 2024-03-31 13F IONIS PHARMACEUTICALS COM 462222100 5,848 660 12.72 254 -3.80 0.0009
2024-02-06 2023-12-31 13F IONIS PHARMACEUTICALS COM 462222100 5,188 376 7.81 263 20.64 0.0010
2023-11-02 2023-09-30 13F IONIS PHARMACEUTICALS COM 462222100 4,812 -348 -6.74 218 3.32 0.0009
2023-08-09 2023-06-30 13F IONIS PHARMACEUTICALS COM 462222100 5,160 5,160 212 0.0008
2023-02-13 2022-12-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 0 -5,168 -100.00 0 -100.00
2023-02-13 2022-12-31 13F IONIS PHARMACEUTICALS COM 462222100 0 -5,168 0
2022-11-17 2022-09-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 5,168 -333 -6.05 230 12.75 0.0010
2022-11-14 2022-09-30 13F IONIS PHARMACEUTICALS COM 462222100 5,168 -333 229 0.0002
2022-08-05 2022-06-30 13F IONIS PHARMACEUTICALS COM 462222100 5,501 5,501 204 0.0010
2021-05-05 2021-03-31 13F IONIS PHARMACEUTICALS COM 462222100 0 -12,700 -100.00 0 -100.00
2021-02-12 2020-12-31 13F IONIS PHARMACEUTICALS COM 462222100 12,700 46 0.36 717 19.50 0.0031
2020-11-06 2020-09-30 13F IONIS PHARMACEUTICALS COM 462222100 12,654 -303 -2.34 600 -21.57 0.0029
2020-07-29 2020-06-30 13F IONIS PHARMACEUTICALS COM 462222100 12,957 198 1.55 765 26.87 0.0041
2020-05-14 2020-03-31 13F IONIS PHARMACEUTICALS COM 462222100 12,759 -2,286 -15.19 603 -33.66 0.0036
2020-02-07 2019-12-31 13F IONIS PHARMACEUTICALS COM 462222100 15,045 991 7.05 909 7.83 0.0043
2019-11-12 2019-09-30 13F IONIS PHARMACEUTICALS COM 462222100 14,054 201 1.45 843 -5.39 0.0042
2019-08-12 2019-06-30 13F IONIS PHARMACEUTICALS COM 462222100 13,853 1,823 15.15 891 -8.71 0.0047
2019-05-15 2019-03-31 13F IONIS PHARMACEUTICALS COM 462222100 12,030 369 3.16 976 54.92 0.0051
2019-02-01 2018-12-31 13F IONIS PHARMACEUTICALS COM 462222100 11,661 39 0.34 630 5.18 0.0036
2018-11-09 2018-09-30 13F IONIS PHARMACEUTICALS COM 462222100 11,622 -1,167 -9.13 599 12.59 0.0030
2018-08-10 2018-06-30 13F IONIS PHARMACEUTICALS COM 462222100 12,789 555 4.54 532 -1.48 0.0029
2018-05-04 2018-03-31 13F IONIS PHARMACEUTICALS COM 462222100 12,234 172 1.43 540 -10.89 0.0029
2018-02-06 2017-12-31 13F IONIS PHARMACEUTICALS COM 462222100 12,062 -291 -2.36 606 -3.50 0.0032
2017-11-13 2017-09-30 13F IONIS PHARMACEUTICALS COM 462222100 12,353 223 1.84 628 1.78 0.0034
2017-08-11 2017-06-30 13F IONIS PHARMACEUTICALS COM 462222100 12,130 -546 -4.31 617 20.98 0.0036
2017-05-10 2017-03-31 13F IONIS PHARMACEUTICALS COM 462222100 12,676 -663 -4.97 510 -20.19 0.0031
2017-02-14 2016-12-31 13F IONIS PHARMACEUTICALS COM 462222100 13,339 836 6.69 639 39.52 0.0040
2016-11-04 2016-09-30 13F IONIS PHARMACEUTICALS COM 462222100 12,503 12,503 0.00 458 0.0029
2016-08-04 2016-06-30 13F IONIS PHARMACEUTICALS COM 462222100 0 -11,553 -100.00 0 -100.00
2016-05-11 2016-03-31 13F IONIS PHARMACEUTICALS COM 462222100 11,553 -1,469 -11.28 470 -41.69 0.0032
2016-02-12 2015-12-31 13F IONIS PHARMACEUTICALS COM 462222100 13,022 -229 -1.73 806 50.37 0.0053
2015-11-13 2015-09-30 13F ISIS PHARMACEUTICALS COM 464330109 13,251 -10,144 -43.36 536 -60.21 0.0037
2015-08-14 2015-06-30 13F ISIS PHARMACEUTICALS COM 464330109 23,395 -6,913 -22.81 1,347 -30.17 0.0081
2015-05-14 2015-03-31 13F ISIS PHARMACEUTICALS COM 464330109 30,308 14,808 95.54 1,929 101.57 0.0120
2015-02-12 2014-12-31 13F ISIS PHARMACEUTICALS COM 464330109 15,500 -3,326 -17.67 957 30.92 0.0060
2014-11-14 2014-09-30 13F ISIS PHARMACEUTICALS COM 464330109 18,826 18,805 89,547.62 731 73,000.00 0.0051
2014-05-14 2014-03-31 13F ISIS PHARMACEUTICALS COM COMMON STOCK 464330109 21 21 1 0.0000
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.