Ionis Pharmaceuticals, Inc.
MX ˙ BMV ˙ US4622221004
SecurityMX:IONS / Ionis Pharmaceuticals, Inc.
InstitutionRegions Financial Corp
Latest Disclosed Ownership6,122 shares
Latest Disclosed Value $ 459,701
Regions Financial Corp reports 0.54% increase in ownership of IONS / Ionis Pharmaceuticals, Inc.

On May 5, 2026 - Regions Financial Corp filed a 13F-HR form disclosing ownership of 6,122 shares of Ionis Pharmaceuticals, Inc. (MX:IONS) valued at $459,701 USD as of March 31, 2026. The entity filed a previous 13F-HR on January 27, 2026 disclosing 6,089 shares of Ionis Pharmaceuticals, Inc.. This represents a change in shares of 0.54% during the quarter.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-05-05 2026-03-31 13F IONIS PHARMACEUTICALS COM 462222100 6,122 33 0.54 460 -4.57 0.0026
2026-01-27 2025-12-31 13F IONIS PHARMACEUTICALS COM 462222100 6,089 2,289 60.24 482 93.95 0.0031
2025-11-19 2025-09-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 3,800 3,800 249 0.0016
2025-11-19 2025-09-30 13F IONIS PHARMACEUTICALS COM 462222100 3,800 3,800 249 0.0014
2024-07-31 2024-06-30 13F IONIS PHARMACEUTICALS INC COM COM 462222100 0 -6,785 -100.00 0 -100.00
2024-04-23 2024-03-31 13F IONIS PHARMACEUTICALS INC COM COM 462222100 6,785 2,700 66.10 294 42.72 0.0022
2024-02-06 2023-12-31 13F IONIS PHARMACEUTICALS INC COM COM 462222100 4,085 4,085 207 0.0017
2023-11-01 2023-09-30 13F IONIS PHARMACEUTICALS INC COM COM 462222100 0 -5,110 -100.00 0 -100.00
2023-08-09 2023-06-30 13F IONIS PHARMACEUTICALS INC COM COM 462222100 5,110 5,110 210 0.0018
2023-05-12 2023-03-31 13F IONIS PHARMACEUTICALS INC COM COM 462222100 0 -5,346 -100.00 0 0.0000
2023-02-06 2022-12-31 13F IONIS PHARMACEUTICALS INC COM COM 462222100 5,346 0 0.00 0 -100.00 0.0019
2022-11-03 2022-09-30 13F IONIS PHARMACEUTICALS INC COM COM 462222100 5,346 5,346 236 0.0024
2022-07-25 2022-06-30 13F IONIS PHARMACEUTICALS INC COM COM 462222100 0 -9,323 -100.00 0 -100.00
2022-04-25 2022-03-31 13F IONIS PHARMACEUTICALS INC COM COM 462222100 9,323 0 0.00 345 21.48 0.0028
2022-01-31 2021-12-31 13F IONIS PHARMACEUTICALS INC COM COM 462222100 9,323 -100 -1.06 284 -10.13 0.0022
2021-11-04 2021-09-30 13F IONIS PHARMACEUTICALS INC COM COM 462222100 9,423 0 0.00 316 -15.96 0.0027
2021-07-27 2021-06-30 13F IONIS PHARMACEUTICALS INC COM COM 462222100 9,423 9,423 376 0.0033
2021-06-02 2021-03-31 13F IONIS PHARMACEUTICALS INC COM COM 462222100 0 -4,421 -100.00 0 -100.00
2021-02-05 2020-12-31 13F IONIS PHARMACEUTICALS INC COM COM 462222100 4,421 -120 -2.64 250 16.28 0.0024
2020-10-15 2020-09-30 13F IONIS PHARMACEUTICALS INC COM COM 462222100 4,541 0 0.00 215 -19.78 0.0023
2020-07-27 2020-06-30 13F IONIS PHARMACEUTICALS INC COM COM 462222100 4,541 -26 -0.57 268 24.07 0.0031
2020-04-29 2020-03-31 13F IONIS PHARMACEUTICALS INC COM COM 462222100 4,567 0 0.00 216 -21.74 0.0029
2020-02-03 2019-12-31 13F IONIS PHARMACEUTICALS INC COM COM 462222100 4,567 0 0.00 276 0.73 0.0029
2019-10-24 2019-09-30 13F IONIS PHARMACEUTICALS INC COM COM 462222100 4,567 146 3.30 274 -3.52 0.0030
2019-07-19 2019-06-30 13F Ionis Pharmaceuticals COM 462222100 4,421 49 1.12 284 -19.77 0.0032
2019-04-19 2019-03-31 13F Ionis Pharmaceuticals COM 462222100 4,372 0 0.00 354 50.00 0.0041
2019-01-28 2018-12-31 13F Ionis Pharmaceuticals COM 462222100 4,372 0 0.00 236 4.42 0.0029
2018-10-22 2018-09-30 13F Ionis Pharmaceuticals COM 462222100 4,372 0 0.00 226 24.18 0.0024
2018-07-26 2018-06-30 13F Ionis Pharmaceuticals COM 462222100 4,372 -61 -1.38 182 -7.14 0.0021
2018-04-18 2018-03-31 13F Ionis Pharmaceuticals COM 462222100 4,433 0 0.00 196 -12.11 0.0022
2018-01-18 2017-12-31 13F Ionis Pharmaceuticals COM 462222100 4,433 0 0.00 223 -0.89 0.0024
2017-10-23 2017-09-30 13F IONIS PHARMACEUTICALS COMMON STOCK 462222100 4,433 112 2.59 225 2.27 0.0026
2017-07-31 2017-06-30 13F IONIS PHARMACEUTICALS COMMON STOCK 462222100 4,321 4,321 -2.53 220 -2.22 0.0026
2017-05-02 2017-03-31 13F IONIS PHARMACEUTICALS COMMON STOCK 462222100 0 -5,321 -100.00 0 -100.00
2017-02-03 2016-12-31 13F IONIS PHARMACEUTICALS COMMON STOCK 462222100 5,321 5,321 0.00 255 0.0031
2016-07-26 2016-06-30 13F IONIS PHARMACEUTICALS COMMON STOCK 462222100 0 -5,096 -100.00 0 -100.00
2016-05-02 2016-03-31 13F IONIS PHARMACEUTICALS COMMON STOCK 462222100 5,096 -364 -6.67 206 -39.05 0.0027
2016-01-29 2015-12-31 13F IONIS PHARMACEUTICALS COMMON STOCK 462222100 5,460 -80 -1.44 338 50.89 0.0045
2015-10-20 2015-09-30 13F ISIS PHARMACEUTICALS COMMON STOCK 464330109 5,540 -27 -0.49 224 -30.00 0.0032
2015-07-14 2015-06-30 13F ISIS PHARMACEUTICALS COMMON STOCK 464330109 5,567 -15 -0.27 320 -10.11 0.0042
2015-04-23 2015-03-31 13F ISIS PHARMACEUTICALS COMMON STOCK 464330109 5,582 542 10.75 356 14.47 0.0046
2015-01-21 2014-12-31 13F ISIS PHARMACEUTICALS COMMON STOCK 464330109 5,040 -8,649 -63.18 311 -41.43 0.0040
2014-10-27 2014-09-30 13F ISIS PHARMACEUTICALS COMMON STOCK 464330109 13,689 -914 -6.26 531 5.57 0.0066
2014-07-23 2014-06-30 13F ISIS PHARMACEUTICALS COMMON STOCK 464330109 14,603 8,686 146.80 503 97.25 0.0062
2014-04-17 2014-03-31 13F ISIS PHARMACEUTICALS COMMON STOCK 464330109 5,917 877 17.40 255 26.87 0.0032
2014-01-27 2013-12-31 13F ISIS PHARMACEUTICALS COMMON STOCK 464330109 5,040 5,040 201 0.0025
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.