Ionis Pharmaceuticals, Inc.
MX ˙ BMV ˙ US4622221004
SecurityMX:IONS / Ionis Pharmaceuticals, Inc.
InstitutionVanguard Group Inc
Latest Disclosed Ownership0 shares
Ownership 0.00%
Vanguard Group Inc ownership in IONS / Ionis Pharmaceuticals, Inc.

2026-03-27 - Vanguard Group Inc has filed an SCHEDULE 13G/A form with the Securities and Exchange Commission (SEC) disclosing ownership of 0 shares of Ionis Pharmaceuticals, Inc. (MX:IONS). This represents 0.0 percent ownership of the company. In their previous filing dated 2025-01-08 , Vanguard Group Inc had reported owning 16,472,539 shares, indicating a decrease of -100.00 percent.

Institutional Ownership: 13D/G Filings

This table shows a history of the 13D/G filings made by the investor and/or investor group. Note that the share values in this table are not directly comparable to any numbers shown in the 13F table (if any).

File
Date		Effective
Date		Form Prev
Shares		 Latest
Shares		 ΔShares
(Percent)		 Ownership
(Percent)		 ΔOwnership
(Percent)
2026-03-27 2026-03-27 13G/A 16,472,539 0 -100.00 0.00 -100.00
2025-01-08 2025-01-08 13G/A 14,203,481 16,472,539 15.98 10.43 5.35
2024-02-13 2024-02-13 13G/A 14,414,917 14,203,481 -1.47 9.90 -1.69
2023-06-09 2023-06-09 13G/A 13,546,694 14,414,917 6.41 10.07 5.56
2023-02-09 2023-02-09 13G/A 12,007,076 13,546,694 12.82 9.54 12.24
2022-02-10 2022-02-10 13G/A 12,244,388 12,007,076 -1.94 8.50 -2.97
2021-02-10 2021-02-10 13G/A 11,966,392 12,244,388 2.32 8.76 3.06
2020-02-12 2020-02-12 13G/A 11,829,388 11,966,392 1.16 8.50 -1.05
2019-02-13 2019-02-13 13G/A 10,106,212 11,829,388 17.05 8.59 6.18
2018-02-09 2018-02-09 13G/A 9,052,966 10,106,212 11.63 8.09 8.45
2017-02-13 2017-02-13 13G/A 8,250,750 9,052,966 9.72 7.46 8.75
2016-02-10 2016-02-10 13G/A 8,250,750 6.86
2015-02-10 2015-02-10 13G/A 7,271,871 6.15
2014-02-11 2014-02-11 13G/A 7,681,946 6.61
2013-02-13 2013-02-13 13G 5,572,099 5.50

Important Note: One of the primary uses of the 13D/G filings is to evaluate the ability of a firm to control a company (ie, the "beneficial ownership"). To that end, firms are required to report not just direct holdings in companies, but indirect holdings that they control. For investment firms, these indirect holdings can include shares in funds they manage, advisory accounts, and in the case of activist campaigns, pledged votes. Therefore, share counts listed in 13D/G filings can differ significantly than share counts listed in 13F filings.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2026-01-29 2025-12-31 13F IONIS PHARMACEUTICALS COM 462222100 16,440,459 -41,271 -0.25 1,300,605 20.62 0.0189
2025-11-07 2025-09-30 13F IONIS PHARMACEUTICALS COM 462222100 16,481,730 -233,116 -1.39 1,078,235 63.27 0.0161
2025-08-11 2025-06-30 13F IONIS PHARMACEUTICALS COM 462222100 16,714,846 330,912 2.02 660,404 33.60 0.0107
2025-05-09 2025-03-31 13F IONIS PHARMACEUTICALS COM 462222100 16,383,934 -88,605 -0.54 494,303 -14.17 0.0089
2025-02-11 2024-12-31 13F IONIS PHARMACEUTICALS COM 462222100 16,472,539 1,416,781 9.41 575,880 -4.52 0.0100
2024-11-13 2024-09-30 13F IONIS PHARMACEUTICALS COM 462222100 15,055,758 1,210,046 8.74 603,134 -8.60 0.0108
2024-08-13 2024-06-30 13F IONIS PHARMACEUTICALS COM 462222100 13,845,712 415,256 3.09 659,887 13.34 0.0127
2024-05-10 2024-03-31 13F IONIS PHARMACEUTICALS COM 462222100 13,430,456 -773,025 -5.44 582,210 -18.97 0.0115
2024-03-11 2023-12-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 14,203,481 -298,544 -2.06 718,554 9.23 0.0157
2024-02-14 2023-12-31 13F IONIS PHARMACEUTICALS COM 462222100 14,203,481 -298,544 718,554 0.0157
2023-12-18 2023-09-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 14,502,025 -21,241 -0.15 657,812 10.39 0.0162
2023-11-14 2023-09-30 13F IONIS PHARMACEUTICALS COM 462222100 14,502,025 -21,241 657,812 0.0029
2023-08-14 2023-06-30 13F IONIS PHARMACEUTICALS COM 462222100 14,523,266 547,476 3.92 595,890 19.30 0.0141
2023-07-14 2023-03-31 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 13,975,790 429,096 3.17 499,495 -2.38 0.0127
2023-05-15 2023-03-31 13F IONIS PHARMACEUTICALS COM 462222100 13,975,790 429,096 499,495 0.0127
2023-02-10 2022-12-31 13F IONIS PHARMACEUTICALS COM 462222100 13,546,694 740,671 5.78 511,659 -9.67 0.0139
2022-11-14 2022-09-30 13F IONIS PHARMACEUTICALS COM 462222100 12,806,023 605,747 4.97 566,411 25.41 0.0167
2022-08-12 2022-06-30 13F IONIS PHARMACEUTICALS COM 462222100 12,200,276 101,242 0.84 451,653 0.78 0.0127
2022-05-13 2022-03-31 13F IONIS PHARMACEUTICALS COM 462222100 12,099,034 91,958 0.77 448,148 22.65 0.0106
2022-02-14 2021-12-31 13F IONIS PHARMACEUTICALS COM 462222100 12,007,076 207,067 1.75 365,376 -7.68 0.0083
2021-11-12 2021-09-30 13F IONIS PHARMACEUTICALS COM 462222100 11,800,009 -855,820 -6.76 395,773 -21.60 0.0098
2021-08-13 2021-06-30 13F IONIS PHARMACEUTICALS COM 462222100 12,655,829 51,680 0.41 504,841 -10.91 0.0126
2021-05-14 2021-03-31 13F IONIS PHARMACEUTICALS COM 462222100 12,604,149 359,761 2.94 566,682 -18.14 0.0153
2021-02-12 2020-12-31 13F IONIS PHARMACEUTICALS COM 462222100 12,244,388 254,358 2.12 692,298 21.69 0.0201
2020-11-16 2020-09-30 13F IONIS PHARMACEUTICALS COM 462222100 11,990,030 -316,221 -2.57 568,926 -21.59 0.0188
2020-08-14 2020-06-30 13F IONIS PHARMACEUTICALS COM 462222100 12,306,251 252,690 2.10 725,576 27.32 0.0257
2020-05-15 2020-03-31 13F IONIS PHARMACEUTICALS COM 462222100 12,053,561 87,169 0.73 569,893 -21.16 0.0243
2020-02-14 2019-12-31 13F IONIS PHARMACEUTICALS COM 462222100 11,966,392 -248,083 -2.03 722,890 -1.21 0.0247
2019-11-14 2019-09-30 13F IONIS PHARMACEUTICALS COM 462222100 12,214,475 -642,390 -5.00 731,769 -11.44 0.0271
2019-08-14 2019-06-30 13F IONIS PHARMACEUTICALS COM 462222100 12,856,865 383,350 3.07 826,311 -18.39 0.0311
2019-05-15 2019-03-31 13F IONIS PHARMACEUTICALS COM 462222100 12,473,515 644,127 5.45 1,012,475 58.32 0.0397
2019-02-14 2018-12-31 13F IONIS PHARMACEUTICALS COM 462222100 11,829,388 738,090 6.65 639,496 11.78 0.0287
2018-12-13 2018-09-30 13F/A-2 IONIS PHARMACEUTICALS COM 462222100 11,091,298 157,770 1.44 572,089 25.57 0.0224
2018-11-23 2018-09-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 11,091,298 0 572,089 0.0224
2018-11-14 2018-09-30 13F IONIS PHARMACEUTICALS COM 462222100 11,091,298 157,770 572,089
2018-08-14 2018-06-30 13F IONIS PHARMACEUTICALS COM 462222100 10,933,528 558,132 5.38 455,600 -0.38 0.0191
2018-05-15 2018-03-31 13F IONIS PHARMACEUTICALS COM 462222100 10,375,396 269,184 2.66 457,347 -10.03 0.0200
2018-02-14 2017-12-31 13F IONIS PHARMACEUTICALS COM 462222100 10,106,212 162,261 1.63 508,343 0.83 0.0222
2017-11-14 2017-09-30 13F IONIS PHARMACEUTICALS COM 462222100 9,943,951 88,791 0.90 504,158 0.56 0.0236
2017-08-24 2017-06-30 13F/A-1 IONIS PHARMACEUTICALS COM 462222100 9,855,160 417,364 4.42 501,332 32.14 0.0247
2017-08-11 2017-06-30 13F IONIS PHARMACEUTICALS COM 462222100 9,855,160 417,364 501,332
2017-05-12 2017-03-31 13F IONIS PHARMACEUTICALS COM 462222100 9,437,796 384,830 4.25 379,399 -12.38 0.0195
2017-02-14 2016-12-31 13F IONIS PHARMACEUTICALS COM 462222100 9,052,966 259,814 2.95 433,004 34.40 0.0242
2016-11-14 2016-09-30 13F IONIS PHARMACEUTICALS COM 462222100 8,793,152 -1,631 -0.02 322,181 57.29 0.0189
2016-08-10 2016-06-30 13F IONIS PHARMACEUTICALS COM 462222100 8,794,783 349,172 4.13 204,831 -40.12 0.0127
2016-05-13 2016-03-31 13F IONIS PHARMACEUTICALS COM 462222100 8,445,611 194,861 2.36 342,047 -33.06 0.0222
2016-02-08 2015-12-31 13F IONIS PHARMACEUTICALS COM 462222100 8,250,750 -557,026 -6.32 510,968 43.53 0.0344
2015-11-12 2015-09-30 13F/A-1 ISIS PHARMACEUTICALS COM 464330109 8,807,776 227,426 2.65 356,009 -27.90 0.0151
2015-11-12 2015-09-30 13F ISIS PHARMACEUTICALS COM 464330109 8,807,776 356,009
2015-08-13 2015-06-30 13F ISIS PHARMACEUTICALS COM 464330109 8,580,350 567,324 7.08 493,799 -3.21 0.0334
2015-05-15 2015-03-31 13F/A-1 ISIS PHARMACEUTICALS COM 464330109 8,013,026 741,155 10.19 510,189 13.64 0.0346
2015-05-14 2015-03-31 13F ISIS PHARMACEUTICALS COM 464330109 8,013,026 510,189
2015-02-12 2014-12-31 13F ISIS PHARMACEUTICALS COM 464330109 7,271,871 14,355 0.20 448,965 59.32 0.0323
2014-11-12 2014-09-30 13F ISIS PHARMACEUTICALS COM 464330109 7,257,516 -12,028 -0.17 281,809 12.53 0.0220
2014-08-11 2014-06-30 13F ISIS PHARMACEUTICALS COM 464330109 7,269,544 -516,802 -6.64 250,436 -25.56 0.0197
2014-05-13 2014-03-31 13F ISIS PHARMACEUTICALS COM 464330109 7,786,346 104,400 1.36 336,448 9.93 0.0283
2014-02-12 2013-12-31 13F ISIS PHARMACEUTICALS COM 464330109 7,681,946 346,234 4.72 306,049 11.14 0.0269
2013-11-07 2013-09-30 13F ISIS PHARMACEUTICALS COM 464330109 7,335,712 634,403 9.47 275,383 52.94 0.0269
2013-08-13 2013-06-30 13F ISIS PHARMACEUTICALS COM 464330109 6,701,309 6,701,309 180,064 0.0189
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.