Vertex Pharmaceuticals Incorporated
US ˙ NasdaqGS ˙ US92532F1003

SecurityVRTX / Vertex Pharmaceuticals Incorporated
InstitutionFirst Horizon Advisors, Inc.
Latest Disclosed Ownership19,719 shares
Latest Disclosed Value $ 8,779,191
First Horizon Advisors, Inc. reports 2.09% increase in ownership of VRTX / Vertex Pharmaceuticals Incorporated

On August 6, 2025 - First Horizon Advisors, Inc. filed a 13F-HR form disclosing ownership of 19,719 shares of Vertex Pharmaceuticals Incorporated (US:VRTX) valued at $8,778,899 USD as of June 30, 2025. The entity filed a previous 13F-HR on April 28, 2025 disclosing 19,315 shares of Vertex Pharmaceuticals Incorporated. This represents a change in shares of 2.09% during the quarter. The current value of the position is $8,710,671 USD.

Institutional Ownership: 13F and NPORT Filings

The Security and Class in the table below are shown exactly as filed by the investor. We do our best to track continuity of investments through acquisitions, and this will be reflected in the table as changes in names. In addition to descriptive data, performance of the investment is shown over time. To calculate quarterly performance, we first calculate cost basis of the shares purchased during the quarter, then use that to calculate gross profit. Quarterly return is Gross Profit / Starting Portfolio value.

Note that cost basis is calculated and stored in thousands, so small quarterly changes in shares frequently result in a cost basis of zero.

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Disclosed Equity Positions (from 13F/NPORT Filings)
File
Date		 Effective
Date		Form Security Class ID Avg Price
Paid (Est)		 Reported
Shares		 ΔShares ΔShares
(%)		 Reported
Value
(x1000)		 ΔValue
(%)		 Alloc
(%)		 ΔAlloc ΔAlloc (%) Cost Basis
(x1000)		 Unrealized
Gain/Loss
(x1000)
2025-08-06 2025-06-30 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 19,719 404 2.09 8,779 -6.25 0.2281
2025-04-28 2025-03-31 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 19,315 17,116 778.35 9,364 958.08 0.2638
2025-02-03 2024-12-31 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 2,199 36 1.66 886 -11.94 0.0248
2024-11-08 2024-09-30 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 2,163 -27 -1.23 1,006 -2.05 0.0279
2024-07-19 2024-06-30 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 2,190 -24 -1.08 1,026 10.92 0.0312
2024-04-26 2024-03-31 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 2,214 1,277 136.29 925 142.78 0.0286
2024-02-06 2023-12-31 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 937 78 9.08 381 27.85 0.0126
2023-10-27 2023-09-30 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 859 543 171.84 299 168.47 0.0108
2023-08-03 2023-06-30 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 316 -17 -5.11 111 6.73 0.0039
2023-05-15 2023-03-31 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 333 4 1.22 105 9.47 0.0037
2023-02-10 2022-12-31 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 329 24 7.87 95 7.95 0.0035
2022-11-09 2022-09-30 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 305 15 5.17 88 8.64 0.0035
2022-08-02 2022-06-30 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 290 170 141.67 81 161.29 0.0029
2022-05-10 2022-03-31 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 120 -39 -24.53 31 -8.82 0.0013
2022-02-09 2021-12-31 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 159 -88 -35.63 34 -22.73 0.0010
2021-11-15 2021-09-30 13F/A-1 VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 247 3 1.23 44 -10.20 0.0014
2021-11-09 2021-09-30 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 422 178 43 0.0006
2021-08-09 2021-06-30 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 244 -189 -43.65 49 -46.74 0.0026
2021-05-11 2021-03-31 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 433 189 77.46 92 61.40 0.0053
2021-02-11 2020-12-31 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 244 0 0.00 57 -13.64 0.0038
2020-11-12 2020-09-30 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 244 -25 -9.29 66 -14.29 0.0049
2020-07-31 2020-06-30 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 269 0 0.00 77 22.22 0.0061
2020-05-05 2020-03-31 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 269 34 14.47 63 23.53 0.0059
2020-01-07 2019-12-31 13F VERTEX PHARMACEUTCLS COMMON STOCK 92532F100 235 95 67.86 51 121.74 0.0038
2019-10-23 2019-09-30 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 140 -52 -27.08 23 -34.29 0.0018
2019-08-05 2019-06-30 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 192 3 1.59 35 0.00 0.0027
2019-04-26 2019-03-31 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 189 178 1,618.18 35 3,400.00 0.0028
2019-02-11 2018-12-31 13F VERTEX PHARMACEUTCLS COMMON STOCK 92532F100 11 -2 -15.38 1 -50.00 0.0001
2018-11-08 2018-09-30 13F/A-2 VERTEX PHARMACEUTCLS COMMON STOCK 92532F100 13 -119 -90.15 2 -90.91 0.0002
2018-11-05 2018-09-30 13F/A-1 VERTEX PHARMACEUTCLS COMMON STOCK 92532F100 13 0 2 0.0001
2018-11-05 2018-09-30 13F VERTEX PHARMACEUTCLS COMMON STOCK 92532F100 13 -119 2 0.0002
2018-08-06 2018-06-30 13F VERTEX PHARMACEUTCLS COMMON STOCK 92532F100 132 0 0.00 22 4.76 0.0018
2018-05-02 2018-03-31 13F VERTEX PHARMACEUTCLS COMMON STOCK 92532F100 132 0 0.00 21 5.00 0.0020
2018-01-25 2017-12-31 13F VERTEX0PHARMACEUTCLS0INC COMMON0STOCK 92532F100 132 -132 -50.00 20 -48.72 0.0019
2017-11-09 2017-09-30 13F VERTEX PHARMACEUTCLS COMMON STOCK 92532F100 264 -10 -3.65 39 -4.88 0.0040
2017-08-14 2017-06-30 13F VERTEX PHARMACEUTCLS COMMON STOCK 92532F100 274 -75 -21.49 41 0.00 0.0045
2017-05-02 2017-03-31 13F VERTEX PHARMACEUTCLS COMMON STOCK 92532F100 349 56 19.11 41 78.26 0.0047
2017-02-13 2016-12-31 13F VERTEX PHARMACEUTCLS COMMON STOCK 92532F100 293 0 0.00 23 0.00 0.0029
2016-10-28 2016-09-30 13F VERTEX PHARMACEUTCLS COMMON STOCK 92532F100 293 -81 -21.66 23 -25.81 0.0029
2016-07-29 2016-06-30 13F VERTEX PHARMACEUTCLS COMMON STOCK 92532F100 374 -1 -0.27 31 -3.12 0.0042
2016-05-09 2016-03-31 13F VERTEX PHARMACEUTCLS COMMON STOCK 92532F100 375 31 9.01 32 -25.58 0.0036
2016-02-08 2015-12-31 13F VERTEX PHARMACEUTCLS COMMON STOCK 92532F100 344 36 11.69 43 34.38 0.0076
2015-11-06 2015-09-30 13F VERTEX PHARMACEUTCLS COMMON STOCK 92532F100 308 4 1.32 32 -13.51 0.0049
2015-08-03 2015-06-30 13F/A-1 VERTEX PHARMACEUTCLS COMMON STOCK 92532F100 304 76 33.33 37 37.04 0.0054
2015-05-04 2015-03-31 13F VERTEX PHARMACEUTCLS COMMON STOCK 92532F100 228 228 0.00 27 0.0039
2015-02-05 2014-12-31 13F VERTEX PHARMACEUTCLS COMMON STOCK 92532F100 0 -139 -100.00 0 -100.00
2014-11-13 2014-09-30 13F/A-1 VERTEX PHARMACEUTCLS COMMON STOCK 92532F100 139 8 6.11 15 36.36 0.0023
2014-11-13 2014-09-30 13F VERTEX PHARMACEUTCLS COMMON STOCK 92532F100 139 8 15 0.0015
2014-08-07 2014-06-30 13F VERTEX PHARMACEUTCLS COMMON STOCK 92532F100 131 93 244.74 11 450.00 0.0016
2014-05-02 2014-03-31 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 38 -4 -9.52 2 -33.33 0.0003
2014-02-07 2013-12-31 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 42 -6 -12.50 3 -25.00 0.0004
2013-11-15 2013-09-30 13F VERTEX PHARMACEUTICALS COMMON STOCK 92532F100 48 48 4 0.0006
2014-02-25 2012-12-31 13F VERTEX PHARMACEUTCLS COMMON STOCK 92532F100 0 -131 -100.00 0 -100.00
2014-02-25 2012-09-30 13F VERTEX PHARMACEUTCLS COMMON STOCK 92532F100 131 0 0.00 7 0.00 0.0056
2014-02-25 2012-06-30 13F VERTEX PHARMACEUTCLS COMMON STOCK 92532F100 131 69 111.29 7 133.33 0.0055
2014-02-25 2012-03-31 13F VERTEX PHARMACEUTCLS COMMON STOCK 92532F100 62 62 3 0.0025
Legend
Shares
The total number of shares held by the institution at the end of the reporting period (the effective date). This is provided in the filing.
Value
The total value of the shares as of the effective date. This is provided in the filing.
Avg. Share Price
The weighted average share price of the shares held by the institution. We use FIFO accounting to determine this price
Class
This is the security class as indicated by the filer. There are a variety of values for this field. Common values include "EC" = equity common, "EP" - equity preferred
Allocation (%)
The percent of the institution's portfolio that this position represents. This is provided in NPORT filings. For 13F filings, we calculate it.
Change in Allocation
The change in allocation from the prior reporting period. This is calculated as current allocation - prior allocation.
Change in Allocation (%)
The percent change in allocation from the prior reporting period. This is calculated as (current allocation - prior allocation) / prior allocation.
Cost Basis
The total cost of the shares held. This is calculated as reported shares * avg. share price
Unrealized Gain/Loss
This is the market value of the position as of the effective date minus the cost basis.