Estatísticas Básicas
Perfil do Insider SPHERA FUNDS MANAGEMENT LTD.
Valor do Portfólio $ 474,069,298
Posições Atuais 114
Últimas Participações, Desempenho, AUM (de 13F, 13D)

Sphera Funds Management Ltd. divulgou 114 participações totais em seus últimos arquivamentos da SEC. O valor mais recente da carteira é calculado como $ 474,069,298 USD. O Ativo Total Sob Gestão (AUM) é esse valor mais o caixa (que não é divulgado). As principais posições de Sphera Funds Management Ltd. são Teva Pharmaceutical Industries Limited - Depositary Receipt (Common Stock) (US:TEVA) , NICE Ltd. - Depositary Receipt (Common Stock) (US:NICE) , Tower Semiconductor Ltd. (US:TSEM) , Merus N.V. (US:MRUS) , and Nova Ltd. (US:NVMI) . As novas posições de Sphera Funds Management Ltd. incluem Merus N.V. (US:MRUS) , Cidara Therapeutics, Inc. (US:CDTX) , Cellebrite DI Ltd. (US:CLBT) , Rapport Therapeutics, Inc. (US:RAPP) , and uniQure N.V. (US:QURE) . As principais indústrias de Sphera Funds Management Ltd. são "Industrial And Commercial Machinery And Computer Equipment" (sic 35) , "Transportation Equipment" (sic 37) , and "Building Materials, Hardware, Garden Supply, And Mobile Home Dealers" (sic 52) .

Sphera Funds Management Ltd. - Valor do Portfólio
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Maiores Aumentos Este Trimestre

Usamos a mudança na alocação do portfólio porque esta é a métrica mais significativa. As mudanças podem ser devido a operações ou mudanças nos preços das ações.

Ativo Ações
(MM)		 Valor
(MM$)		 % do Portfólio Δ% do Portfólio
0.16 22.79 4.5534 4.5534
0.15 14.12 2.9790 2.9790
0.02 13.78 2.7543 2.7543
0.10 9.58 2.0200 2.0200
0.31 22.54 4.5044 1.8115
0.13 6.75 1.4243 1.4243
0.35 10.60 2.2370 1.3830
0.30 5.54 1.1685 1.1685
0.16 4.68 0.9869 0.9869
0.07 4.38 0.9234 0.9234
Maiores Diminuições Este Trimestre

Usamos a mudança na alocação do portfólio porque esta é a métrica mais significativa. As mudanças podem ser devido a operações ou mudanças nos preços das ações.

Ativo Ações
(MM)		 Valor
(MM$)		 % do Portfólio Δ% do Portfólio
0.39 5.97 1.1919 -2.2618
0.04 14.03 2.8037 -2.0938
0.00 0.00 -2.0211
0.00 0.00 -1.5410
0.00 0.00 -1.3764
0.01 0.07 0.0151 -1.3694
0.00 0.00 -1.1646
0.01 3.02 0.6373 -1.0329
0.03 2.79 0.5577 -0.9754
0.21 5.37 1.0740 -0.9295
Arquivamentos 13D/G

Esta é uma lista de arquivamentos 13D e 13G feitos no último ano (se houver). Clique no ícone de link para ver o histórico completo da transação. Linhas verdes indicam novas posições. Linhas vermelhas indicam posições fechadas.

Data do Arquivo Formulário Ativo Ações
Anteriores 		Ações
Atuais 		ΔAções % % de Propriedade
 % Δde Propriedade
2025-10-23 13G/A PMN / ProMIS Neurosciences, Inc. 1,892,474 3,122,090 64.97 5.51 -44.84
2025-04-10 13G/A OTLK / Outlook Therapeutics, Inc. 1,714,284 2,571,426 50.00 7.49 43.76
2025-04-10 13G/A SKYE / Skye Bioscience, Inc. 1,301,518 1,476,353 13.43 4.77 -11.50
2025-04-10 13G/A CMMB / Chemomab Therapeutics Ltd. - Depositary Receipt (Common Stock) 1,214,575 900,428 -25.86 4.78 -27.13
Arquivamentos 13F e Fundo

Este formulário foi arquivado em 2025-11-14 para o período de relatório 2025-09-30. Clique no ícone de link para ver o histórico completo da transação.

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2022-07-28: Nota Importante - Mudamos o tratamento da coluna Δ % do Portfólio nesta tabela. Anteriormente, estávamos relatando como a mudança percentual na alocação do portfólio. Agora estamos relatando como a mudança bruta na alocação do portfólio (ainda relatada como um percentual). Em termos de fórmula, antes relatávamos como 100 * (alocação atual - alocação anterior) / alocação anterior. Agora estamos relatando como (alocação atual - alocação anterior).
Ativo Tipo Preço Médio por Ação Ações
(MM)		 ΔAções
(%)		 Valor
($MM)		 ΔAções
(%)		 Portfólio
(%)		 ΔPortfólio
(%)
TEVA / Teva Pharmaceutical Industries Limited - Depositary Receipt (Common Stock) 1.51 -7.03 30.44 12.05 6.0826 -0.2927
NICE / NICE Ltd. - Depositary Receipt (Common Stock) 0.16 22.79 4.5534 4.5534
TSEM / Tower Semiconductor Ltd. 0.31 17.78 22.54 96.45 4.5044 1.8115
MRUS / Merus N.V. Call 0.15 14.12 2.9790 2.9790
NVMI / Nova Ltd. 0.04 -42.12 14.03 -32.77 2.8037 -2.0938
QQQ / Invesco QQQ Trust, Series 1 0.02 13.78 2.7543 2.7543
BIIB / Biogen Inc. 0.08 0.00 11.59 11.53 2.4448 0.0064
RARE / Ultragenyx Pharmaceutical Inc. 0.35 252.26 10.60 191.40 2.2370 1.3830
AZN / AstraZeneca PLC - Depositary Receipt (Common Stock) 0.14 0.00 10.36 9.79 2.0704 -0.1444
SNY / Sanofi - Depositary Receipt (Common Stock) 0.22 0.00 10.36 -2.29 2.1856 -0.3030
CDTX / Cidara Therapeutics, Inc. Call 0.10 9.58 2.0200 2.0200
CYTK / Cytokinetics, Incorporated 0.16 -50.56 8.88 -17.77 1.8725 -0.6606
MLYS / Mineralys Therapeutics, Inc. 0.22 -54.28 8.34 28.14 1.6662 0.1391
FOLD / Amicus Therapeutics, Inc. 0.99 0.04 7.81 37.60 1.6475 0.3153
LLY / Eli Lilly and Company 0.01 -13.00 7.66 -14.84 1.5307 -0.5803
JNJ / Johnson & Johnson 0.04 0.00 7.57 21.39 1.5970 0.1334
CDTX / Cidara Therapeutics, Inc. 0.08 -45.11 7.25 7.90 1.5300 -0.0474
FBRX / Forte Biosciences, Inc. 0.47 -4.20 7.11 11.14 1.4216 -0.0807
BBIO / BridgeBio Pharma, Inc. Call 0.13 6.75 1.4243 1.4243
SNDX / Syndax Pharmaceuticals, Inc. 0.39 -75.33 5.97 -59.47 1.1919 -2.2618
TRVI / Trevi Therapeutics, Inc. 0.64 -19.50 5.89 34.67 1.2429 0.2161
NVO / Novo Nordisk A/S - Depositary Receipt (Common Stock) 0.11 0.00 5.86 -19.59 1.1717 -0.5399
ABBV / AbbVie Inc. 0.03 0.00 5.85 24.72 1.1685 0.0683
CLBT / Cellebrite DI Ltd. 0.30 5.54 1.1685 1.1685
ANNX / Annexon, Inc. 1.79 1.70 5.47 29.24 1.0935 0.0999
DYN / Dyne Therapeutics, Inc. 0.43 92.63 5.40 156.05 1.0781 0.5834
CLDX / Celldex Therapeutics, Inc. 0.21 -50.48 5.37 -37.05 1.0740 -0.9295
SOLAREDGE TECHNOLOGIES INC / NOTE 2.250% 7/0 (83417MAE4) 4.00 5.33 0.0000
GSK / GSK plc - Depositary Receipt (Common Stock) 0.12 0.00 5.27 12.40 1.0521 -0.0472
SEDG / SolarEdge Technologies, Inc. 0.14 10.16 5.22 99.81 1.0422 0.4296
ORIC / ORIC Pharmaceuticals, Inc. 0.43 9.37 5.18 29.31 1.0927 0.1526
IMTX / Immatics N.V. 0.58 0.00 4.97 58.37 0.9927 0.2565
GPCR / Structure Therapeutics Inc. - Depositary Receipt (Common Stock) 0.17 81.31 4.87 144.85 1.0273 0.5604
SVRA / Savara Inc. 1.35 3.06 4.82 61.37 0.9632 0.2622
NVS / Novartis AG - Depositary Receipt (Common Stock) 0.04 0.00 4.74 5.96 0.9481 -0.1026
RAPP / Rapport Therapeutics, Inc. 0.16 4.68 0.9869 0.9869
QURE / uniQure N.V. Put 0.07 4.38 0.9234 0.9234
VRNS / Varonis Systems, Inc. 0.07 4.25 0.8959 0.8959
TLT / iShares Trust - iShares 20+ Year Treasury Bond ETF Call 0.05 0.00 4.20 1.28 0.8860 -0.0873
IMVT / Immunovant, Inc. 0.26 0.00 4.14 0.75 0.8270 -0.1370
MRK / Merck & Co., Inc. 0.05 0.00 4.08 6.00 0.8604 -0.0424
MAZE / Maze Therapeutics, Inc. 0.15 -56.70 4.00 -8.48 0.7997 -0.2267
ENGN / enGene Holdings Inc. 0.50 0.00 3.45 87.64 0.6884 0.2575
ESLT / Elbit Systems Ltd. 0.01 12.33 3.44 27.40 0.6866 0.0537
RZLT / Rezolute, Inc. 0.36 -51.57 3.42 2.09 0.6836 -0.1029
ELVN / Enliven Therapeutics, Inc. 0.17 29.76 3.41 32.39 0.6821 0.0771
MDWD / MediWound Ltd. 0.19 3.34 0.6671 0.6671
ELDN / Eledon Pharmaceuticals, Inc. 1.28 -34.67 3.32 -37.57 0.6994 -0.5468
ACAD / ACADIA Pharmaceuticals Inc. 0.15 -14.87 3.18 -15.77 0.6349 -0.2504
PRAX / Praxis Precision Medicines, Inc. 0.06 -47.25 3.07 -33.52 0.6473 -0.4357
CAMT / Camtek Ltd. 0.03 -9.16 3.05 12.87 0.6097 -0.0248
AMZN / Amazon.com, Inc. 0.01 -57.58 3.02 -57.55 0.6373 -1.0329
CRVS / Corvus Pharmaceuticals, Inc. 0.41 122.68 3.00 310.38 0.6338 0.4620
PHVS / Pharvaris N.V. 0.12 -61.47 2.98 -45.38 0.5953 -0.6848
SRPT / Sarepta Therapeutics, Inc. Call 0.15 0.00 2.89 12.67 0.6097 0.0078
META / Meta Platforms, Inc. 0.00 -53.98 2.88 -54.21 0.6079 -0.8689
SLNO / Soleno Therapeutics, Inc. 0.04 2.81 0.5933 0.5933
RVMD / Revolution Medicines, Inc. 0.06 2.80 0.5911 0.5911
ORA / Ormat Technologies, Inc. 0.03 -62.82 2.79 -57.28 0.5577 -0.9754
IDYA / IDEAYA Biosciences, Inc. 0.10 2.72 0.5437 0.5437
AMGN / Amgen Inc. 0.01 0.00 2.68 1.06 0.5357 -0.0868
PRAX / Praxis Precision Medicines, Inc. Call 0.05 -50.00 2.65 -36.98 0.5590 -0.4278
AMD / Advanced Micro Devices, Inc. 0.02 87.52 2.50 113.85 0.5280 0.2532
TVTX / Travere Therapeutics, Inc. Call 0.10 2.43 0.4861 0.4861
ROIV / Roivant Sciences Ltd. Call 0.15 2.29 0.4838 0.4838
ACOG / Alpha Cognition Inc. 0.34 -10.06 2.21 -37.25 0.4406 -0.3840
PFE / Pfizer Inc. 0.09 0.00 2.19 5.13 0.4622 -0.0270
CYBN / Cybin Inc. 0.37 -7.01 2.18 -34.72 0.4602 -0.3240
KURA / Kura Oncology, Inc. 0.25 4.25 2.17 59.94 0.4342 0.1153
AVGO / Broadcom Inc. 0.01 2.16 0.4321 0.4321
CEVA / CEVA, Inc. 0.08 65.75 2.14 99.16 0.4279 0.1756
BBIO / BridgeBio Pharma, Inc. 0.04 -53.22 2.12 -43.74 0.4464 -0.4362
JANX / Janux Therapeutics, Inc. 0.09 0.00 2.10 5.80 0.4192 -0.0461
SKYE / Skye Bioscience, Inc. 0.48 -11.05 1.88 -16.36 0.3761 -0.1521
ATXS / Astria Therapeutics, Inc. 0.25 -2.40 1.83 32.56 0.3654 0.0417
TECX / Tectonic Therapeutic, Inc. 0.12 1.82 0.3836 0.3836
PCVX / Vaxcyte, Inc. 0.05 1.80 0.3799 0.3799
CATX / Perspective Therapeutics, Inc. 0.51 64.44 1.75 64.01 0.3692 0.1187
IMNM / Immunome, Inc. 0.15 1.72 0.3636 0.3636
MIST / Milestone Pharmaceuticals Inc. 0.82 1.64 0.3459 0.3459
JSPR / Jasper Therapeutics, Inc. 0.63 4,190.57 1.50 1,749.38 0.2993 0.2802
QURE / uniQure N.V. 0.02 1.45 0.3066 0.3066
APLS / Apellis Pharmaceuticals, Inc. 0.06 -44.33 1.44 -27.24 0.2879 -0.1766
COGT / Cogent Biosciences, Inc. 0.10 -31.43 1.41 37.15 0.2827 0.0406
GPCR / Structure Therapeutics Inc. - Depositary Receipt (Common Stock) Call 0.05 1.40 0.2953 0.2953
IBIT / iShares Bitcoin Trust ETF 0.02 0.00 1.39 6.17 0.2787 -0.0295
VTYX / Ventyx Biosciences, Inc. 0.44 -20.82 1.37 15.05 0.2887 0.0096
BHVN / Biohaven Ltd. 0.09 -37.30 1.37 -33.30 0.2734 -0.2080
BCAX / Bicara Therapeutics Inc. 0.09 30.55 1.35 121.80 0.2705 0.1274
TSHA / Taysha Gene Therapies, Inc. 0.41 -2.82 1.33 37.53 0.2667 0.0390
DAWN / Day One Biopharmaceuticals, Inc. 0.18 0.00 1.24 8.52 0.2470 -0.0205
HOWL / Werewolf Therapeutics, Inc. 0.63 0.00 1.23 80.67 0.2605 0.1001
TRVI / Trevi Therapeutics, Inc. Call 0.13 1.18 0.2494 0.2494
SABS / SAB Biotherapeutics, Inc. 0.57 1.14 0.2401 0.2401
ENPH / Enphase Energy, Inc. 0.03 0.94 0.1888 0.1888
VYGR / Voyager Therapeutics, Inc. 0.20 0.93 0.1968 0.1968
CLYM / Climb Bio, Inc. 0.43 107.23 0.87 236.15 0.1746 0.1136
LRMR / Larimar Therapeutics, Inc. 0.26 32.42 0.84 48.06 0.1774 0.0441
PEPG / PepGen Inc. 0.17 9.59 0.79 357.80 0.1583 0.1175
BMY / Bristol-Myers Squibb Company 0.02 0.00 0.79 -2.59 0.1665 -0.0236
VSTM / Verastem, Inc. 0.08 -52.05 0.69 2.07 0.1459 -0.0132
ROIV / Roivant Sciences Ltd. 0.04 0.64 0.1359 0.1359
ETNB / 89bio, Inc. 0.04 -80.71 0.58 -71.12 0.1165 -0.3574
ELDN / Eledon Pharmaceuticals, Inc. Put 0.20 0.52 0.1093 0.1093
MLTX / MoonLake Immunotherapeutics 0.07 0.51 0.1074 0.1074
CMMB / Chemomab Therapeutics Ltd. - Depositary Receipt (Common Stock) 0.18 0.47 0.0995 0.0995
ARWR / Arrowhead Pharmaceuticals, Inc. 0.01 -93.84 0.43 -86.59 0.0861 -0.6665
APRE / Aprea Therapeutics, Inc. 0.27 0.00 0.40 -12.72 0.0796 -0.0275
WVE / Wave Life Sciences Ltd. 0.05 0.37 0.0731 0.0731
OKUR / OnKure Therapeutics, Inc. 0.06 0.00 0.17 15.28 0.0332 -0.0007
DSGN / Design Therapeutics, Inc. 0.02 0.17 0.0348 0.0348
PMN / ProMIS Neurosciences, Inc. 0.30 -84.46 0.13 -86.38 0.0265 -0.1892
MLTX / MoonLake Immunotherapeutics Call 0.01 -92.00 0.07 -98.80 0.0151 -1.3694
APLT / Applied Therapeutics, Inc. 0.05 0.00 0.03 100.00 0.0060 0.0024
SLDB / Solid Biosciences Inc. 0.00 -100.00 0.00 0.0000
CMMB / Chemomab Therapeutics Ltd. - Depositary Receipt (Common Stock) 0.00 -100.00 0.00 0.0000
SRRK / Scholar Rock Holding Corporation 0.00 -100.00 0.00 0.0000
ORMAT TECHNOLOGIES INC / DEBT 2.500% 7/1 (686688AC6) 0.00 -100.00 0.00 0.0000
RNA / Avidity Biosciences, Inc. 0.00 -100.00 0.00 0.0000
ELEV / Elevation Oncology, Inc. 0.00 -100.00 0.00 0.0000
CGNT / Cognyte Software Ltd. 0.00 -100.00 0.00 0.0000
CRM / Salesforce, Inc. 0.00 -100.00 0.00 0.0000
WIX / Wix.com Ltd. 0.00 -100.00 0.00 0.0000
NVDD / Direxion Shares ETF Trust - Direxion Daily NVDA Bear 1X Shares 0.00 -100.00 0.00 -100.00 -2.0211
CYBR / CyberArk Software Ltd. 0.00 -100.00 0.00 0.0000
KZR / Kezar Life Sciences, Inc. 0.00 -100.00 0.00 -100.00 -0.0629
ELDN / Eledon Pharmaceuticals, Inc. Call 0.00 -100.00 0.00 -100.00 -0.0198
VTGN / Vistagen Therapeutics, Inc. 0.00 -100.00 0.00 0.0000
NTLA / Intellia Therapeutics, Inc. 0.00 -100.00 0.00 0.0000
NNDM / Nano Dimension Ltd. - Depositary Receipt (Common Stock) 0.00 -100.00 0.00 0.0000
PANW / Palo Alto Networks, Inc. 0.00 -100.00 0.00 0.0000
S / SentinelOne, Inc. 0.00 -100.00 0.00 0.0000
MRVL / Marvell Technology, Inc. 0.00 -100.00 0.00 0.0000
XBI / SPDR Series Trust - State Street SPDR S&P Biotech ETF Put 0.00 -100.00 0.00 0.0000
KRYS / Krystal Biotech, Inc. 0.00 -100.00 0.00 -100.00 -0.2366
AMAT / Applied Materials, Inc. 0.00 -100.00 0.00 -100.00 -0.7733
COGT / Cogent Biosciences, Inc. Call 0.00 -100.00 0.00 -100.00 -0.3370
SRPT / Sarepta Therapeutics, Inc. 0.00 -100.00 0.00 -100.00 -0.6393
TVTX / Travere Therapeutics, Inc. 0.00 -100.00 0.00 -100.00 -1.1646
BBIO / BridgeBio Pharma, Inc. Put 0.00 -100.00 0.00 -100.00 -0.5056
UBER / Uber Technologies, Inc. 0.00 -100.00 0.00 -100.00 -0.6568
RARE / Ultragenyx Pharmaceutical Inc. Call 0.00 -100.00 0.00 -100.00 -1.5410
MSFT / Microsoft Corporation 0.00 -100.00 0.00 -100.00 -1.3764