BMYMP / Bristol-Myers Squibb Company - Preferred Security - Arquivamentos da SEC, Relatório Anual, Declaração de Procuração

Bristol-Myers Squibb Company - Preferred Security
US ˙ OTCPK ˙ US1101221570
ESTE SÍMBOLO NÃO ESTÁ MAIS ATIVO

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LEI HLYYNH7UQUORYSJQCN42
CIK 14272
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to Bristol-Myers Squibb Company - Preferred Security
SEC Filings (Chronological Order)
Esta página fornece uma lista completa e cronológica de Arquivamentos da SEC, excluindo os arquivamentos de propriedade que fornecemos em outro lugar.
June 5, 2026 EX-23.A

Consent of Independent Registered Public Accounting Firm

Exhibit 23a Consent of Independent Registered Public Accounting Firm We consent to the incorporation by reference in Registration Statement Nos.

June 5, 2026 EX-23.A

Consent of Independent Registered Public Accounting Firm

Exhibit 23a Consent of Independent Registered Public Accounting Firm We consent to the incorporation by reference in Registration Statement Nos.

June 5, 2026 11-K

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 11-K x ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2025 ¨ TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECU

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 11-K x ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2025 ¨ TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to COMMISSION FILE NUMBER 001-01136 A. Full title of the plan and the address of plan, if d

June 5, 2026 EX-23.A

Consent of Independent Registered Public Accounting Firm

Exhibit 23a Consent of Independent Registered Public Accounting Firm We consent to the incorporation by reference in Registration Statement Nos.

June 5, 2026 11-K

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 11-K x ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2025 ¨ TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECU

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 11-K x ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2025 ¨ TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to COMMISSION FILE NUMBER 001-01136 A. Full title of the plan and the address of plan, if d

June 5, 2026 11-K

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 11-K x ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2025 ¨ TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECU

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 11-K x ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2025 ¨ TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to COMMISSION FILE NUMBER 001-01136 A. Full title of the plan and the address of plan, if d

May 8, 2026 EX-FILING FEES

CALCULATION OF FILING FEE TABLE Form S-8 (Form Type) Bristol-Myers Squibb Company (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered Securities

Exhibit 107 CALCULATION OF FILING FEE TABLE Form S-8 (Form Type) Bristol-Myers Squibb Company (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered Securities Security Type Security Class Title Fee Calculation Rule Amount Registered(1) Proposed Maximum Offering Price Per Unit(2) Maximum Aggregate Offering Price(2) Fee Rate Amount of Registration Fee Equity Common Stock, $0.

May 8, 2026 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 5, 2026 BRISTOL-MYERS SQUIBB COMPANY (Exact Name of Registrant as Specified in its Charter) Delaware 001-01136 22-0790350 (State or Other Jurisdiction of Incorporation) (Commissio

May 8, 2026 S-8

As filed with the Securities and Exchange Commission on May 8, 2026

As filed with the Securities and Exchange Commission on May 8, 2026 Registration No.

April 30, 2026 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 30, 2026 BRISTOL-MYERS SQUI

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 30, 2026 BRISTOL-MYERS SQUIBB COMPANY (Exact name of registrant as specified in its charter) Delaware 001-01136 22-0790350 (State or other jurisdiction of incorporation or organ

April 30, 2026 EX-10.A

NOTICE OF GRANT OF PERFORMANCE SHARE UNITS UNDER THE BRISTOL-MYERS SQUIBB COMPANY 2021 STOCK AWARD AND INCENTIVE PLAN 2026 Performance Share Units Award

EXHIBIT 10a NOTICE OF GRANT OF PERFORMANCE SHARE UNITS UNDER THE BRISTOL-MYERS SQUIBB COMPANY 2021 STOCK AWARD AND INCENTIVE PLAN 2026 Performance Share Units Award BRISTOL-MYERS SQUIBB COMPANY, a Delaware corporation (the “Company”), has granted to you an award of Performance Share Units (such units, “PSUs”; such award, “Award”) under the 2021 Stock Award and Incentive Plan (the “Plan”), as descr

April 30, 2026 EX-10.E

NOTICE OF GRANT OF RESTRICTED STOCK UNITS UNDER THE BRISTOL-MYERS SQUIBB COMPANY 2021 STOCK AWARD AND INCENTIVE PLAN 2026 Restricted Stock Units Award

EXHIBIT 10e NOTICE OF GRANT OF RESTRICTED STOCK UNITS UNDER THE BRISTOL-MYERS SQUIBB COMPANY 2021 STOCK AWARD AND INCENTIVE PLAN 2026 Restricted Stock Units Award BRISTOL-MYERS SQUIBB COMPANY, a Delaware corporation (the “Company”), has granted to you an award of Restricted Stock Units (such units, “RSUs”; such award, “Award”) under the 2021 Stock Award and Incentive Plan (the “Plan”), as describe

April 30, 2026 EX-10.C

NOTICE OF GRANT OF RESTRICTED STOCK UNITS UNDER THE BRISTOL-MYERS SQUIBB COMPANY 2021 STOCK AWARD AND INCENTIVE PLAN 2026 Restricted Stock Units Award

EXHIBIT 10c NOTICE OF GRANT OF RESTRICTED STOCK UNITS UNDER THE BRISTOL-MYERS SQUIBB COMPANY 2021 STOCK AWARD AND INCENTIVE PLAN 2026 Restricted Stock Units Award BRISTOL-MYERS SQUIBB COMPANY, a Delaware corporation (the “Company”), has granted to you an award of Restricted Stock Units (such units, “RSUs”; such award, “Award”) under the 2021 Stock Award and Incentive Plan (the “Plan”), as describe

April 30, 2026 EX-99.1

Bristol Myers Squibb Reports First Quarter Financial Results for 2026 Financial Results Reflect Strong Execution and a Strengthened Foundation with Significant Pipeline Milestones Ahead

Exhibit 99.1 Bristol Myers Squibb Reports First Quarter Financial Results for 2026 Financial Results Reflect Strong Execution and a Strengthened Foundation with Significant Pipeline Milestones Ahead •First quarter revenues increased 3% (+1% Ex-FX) to $11.5 billion ◦Growth Portfolio revenues increased 12% (+9% Ex-FX) to $6.2 billion •GAAP EPS was $1.31 and non-GAAP EPS was $1.58; Both figures inclu

April 30, 2026 EX-10.D

NOTICE OF GRANT OF RESTRICTED STOCK UNITS UNDER THE BRISTOL-MYERS SQUIBB COMPANY 2021 STOCK AWARD AND INCENTIVE PLAN 2026 Restricted Stock Units Award

EXHIBIT 10d NOTICE OF GRANT OF RESTRICTED STOCK UNITS UNDER THE BRISTOL-MYERS SQUIBB COMPANY 2021 STOCK AWARD AND INCENTIVE PLAN 2026 Restricted Stock Units Award BRISTOL-MYERS SQUIBB COMPANY, a Delaware corporation (the “Company”), has granted to you an award of Restricted Stock Units (such units, “RSUs”; such award, “Award”) under the 2021 Stock Award and Incentive Plan (the “Plan”), as describe

April 30, 2026 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2026 ☐ TRANSITION REPORT PURSUANT TO

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2026 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number 001-01136 BRISTOL-MYERS SQUIBB

April 30, 2026 EX-10.B

NOTICE OF GRANT OF MARKET SHARE UNITS UNDER THE BRISTOL-MYERS SQUIBB COMPANY 2021 STOCK AWARD AND INCENTIVE PLAN 2026 Market Share Units Award

EXHIBIT 10b NOTICE OF GRANT OF MARKET SHARE UNITS UNDER THE BRISTOL-MYERS SQUIBB COMPANY 2021 STOCK AWARD AND INCENTIVE PLAN 2026 Market Share Units Award BRISTOL-MYERS SQUIBB COMPANY, a Delaware corporation (the “Company”), has granted to you an award of Market Share Units (such units, “MSUs”; such award, “Award”) under the 2021 Stock Award and Incentive Plan (the “Plan”), as described in this No

April 30, 2026 EX-10.F

NOTICE OF GRANT OF RESTRICTED STOCK UNITS UNDER THE BRISTOL-MYERS SQUIBB COMPANY 2021 STOCK AWARD AND INCENTIVE PLAN 2026 Restricted Stock Units Award

EXHIBIT 10f NOTICE OF GRANT OF RESTRICTED STOCK UNITS UNDER THE BRISTOL-MYERS SQUIBB COMPANY 2021 STOCK AWARD AND INCENTIVE PLAN 2026 Restricted Stock Units Award BRISTOL-MYERS SQUIBB COMPANY, a Delaware corporation (the “Company”), has granted to you an award of Restricted Stock Units (such units, “RSUs”; such award, “Award”) under the 2021 Stock Award and Incentive Plan (the “Plan”), as describe

April 30, 2026 EX-31.B

CERTIFICATION BY THE CHIEF FINANCIAL OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002

EXHIBIT 31b CERTIFICATION BY THE CHIEF FINANCIAL OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, David V.

April 30, 2026 EX-32.B

Certification by the Chief Financial Officer Pursuant to 18 U. S. C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002

EXHIBIT 32b Certification by the Chief Financial Officer Pursuant to 18 U. S. C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 Pursuant to 18 U.S.C. Section 1350, I, David V. Elkins, hereby certify that, to the best of my knowledge, Bristol-Myers Squibb Company’s Quarterly Report on Form 10-Q for the quarter ended March 31, 2026 (the "Report"), as filed with th

April 30, 2026 EX-32.A

Certification by the Chief Executive Officer Pursuant to 18 U. S. C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002

EXHIBIT 32a Certification by the Chief Executive Officer Pursuant to 18 U. S. C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 Pursuant to 18 U.S.C. Section 1350, I, Christopher Boerner, hereby certify that, to the best of my knowledge, Bristol-Myers Squibb Company’s Quarterly Report on Form 10-Q for the quarter ended March 31, 2026 (the "Report"), as filed wit

April 30, 2026 EX-99.2

Not for Product Promotional Use Q1 2026 Results April 30, 2026 Not for Product Promotional UseQ1 2026 Results Forward Looking Statements and Non-GAAP Financial Information 2 This presentation contains statements about Bristol-Myers Squibb Company’s (

q12026earningspresentati Not for Product Promotional Use Q1 2026 Results April 30, 2026 Not for Product Promotional UseQ1 2026 Results Forward Looking Statements and Non-GAAP Financial Information 2 This presentation contains statements about Bristol-Myers Squibb Company’s (the “Company”) future financial results, plans, business development strategy, anticipated clinical trials, results and regulatory approvals that constitute forward-looking statements for purposes of the safe harbor provisions under the Private Securities Litigation Reform Act of 1995.

April 30, 2026 EX-31.A

CERTIFICATION BY THE CHIEF EXECUTIVE OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002

EXHIBIT 31a CERTIFICATION BY THE CHIEF EXECUTIVE OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, Christopher Boerner, certify that: 1.

April 17, 2026 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.   )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.   ) Filed by the Registrant ☒ Filed by a Party other than the Registrant  ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ De

March 27, 2026 15-12G

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 15 CERTIFICATION AND NOTICE OF TERMINATION OF REGISTRATION UNDER SECTION 12(g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR SUSPENSION OF DUTY TO FILE REPORTS UNDER SECTIONS 13

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 15 CERTIFICATION AND NOTICE OF TERMINATION OF REGISTRATION UNDER SECTION 12(g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR SUSPENSION OF DUTY TO FILE REPORTS UNDER SECTIONS 13 AND 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934. Commission File Number: 000-54969 BRISTOL-MYERS SQUIBB COMPANY (Exact name of registrant as specifi

March 25, 2026 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.   )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.   ) Filed by the Registrant ☒ Filed by a Party other than the Registrant  ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ De

March 25, 2026 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ Defini

March 25, 2026 ARS

ARS

2025 ANNUAL REPORT AR-2025-v4-FINAL.indd 1         ɐ3 0Our Mission To discover, develop and deliver innovative medicines that help patients prevail over serious diseases Our Vision To be the world's leading biopharma company that transforms patients' lives through science Our Values Integrity • Innovation • Urgency Passion • Accountability • Inclusion Geri and Jim's story Geri and Ji

February 5, 2026 EX-99.2

Not for Product Promotional Use Q4 2025 Results February 5, 2026 Not for Product Promotional UseQ4 2025 Results Forward Looking Statements and Non-GAAP Financial Information 2 This presentation contains statements about Bristol-Myers Squibb Company’s

q42025earningspresentati Not for Product Promotional Use Q4 2025 Results February 5, 2026 Not for Product Promotional UseQ4 2025 Results Forward Looking Statements and Non-GAAP Financial Information 2 This presentation contains statements about Bristol-Myers Squibb Company’s (the “Company”) future financial results, plans, business development strategy, anticipated clinical trials, results and regulatory approvals that constitute forward-looking statements for purposes of the safe harbor provisions under the Private Securities Litigation Reform Act of 1995.

February 5, 2026 EX-99.1

Bristol Myers Squibb Reports Fourth Quarter and Full-Year Financial Results for 2025 Financial results reflect disciplined execution and focus on delivering long-term growth

Exhibit 99.1 Bristol Myers Squibb Reports Fourth Quarter and Full-Year Financial Results for 2025 Financial results reflect disciplined execution and focus on delivering long-term growth •Fourth quarter revenues increased 1% to $12.5 billion; Growth Portfolio revenues increased 16% to $7.4 billion ◦GAAP EPS was $0.53 and non-GAAP EPS was $1.26; Both figures include net impact of $(0.60) due to the

February 5, 2026 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 5, 2026 BRISTOL-MYERS SQ

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 5, 2026 BRISTOL-MYERS SQUIBB COMPANY (Exact name of registrant as specified in its charter) Delaware 001-01136 22-0790350 (State or other jurisdiction of incorporation or org

January 12, 2026 EX-99.1

1 Bristol Myers Squibb: Built for Growth 44th Annual J.P. Morgan Healthcare Conference Christopher Boerner, Ph.D., Board Chair & CEO January 12th, 2026 Forward Looking Statements 2 This presentation (as well as the oral statements made with respect t

Exhibit 99.1 1 Bristol Myers Squibb: Built for Growth 44th Annual J.P. Morgan Healthcare Conference Christopher Boerner, Ph.D., Board Chair & CEO January 12th, 2026 Forward Looking Statements 2 This presentation (as well as the oral statements made with respect to the information contained in this presentation) contains statements about Bristol-Myers Squibb Company’s (the “Company”) future financi

January 12, 2026 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 12, 2026 BRISTOL-MYERS SQ

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 12, 2026 BRISTOL-MYERS SQUIBB COMPANY (Exact name of registrant as specified in its charter) Delaware 001-01136 22-0790350 (State or other jurisdiction of incorporation or org

November 18, 2025 EX-99.2

Bristol Myers Squibb Announces Accepted Amounts and Pricing Terms of its Tender Offers

Exhibit 99.2 Bristol Myers Squibb Announces Accepted Amounts and Pricing Terms of its Tender Offers PRINCETON, N.J.-(BUSINESS WIRE)- Bristol-Myers Squibb Company (NYSE: BMY) (“Bristol Myers Squibb”), today announced the accepted amounts and pricing terms of the previously announced tender offers to purchase for cash its outstanding notes listed in the tables below. The outstanding debt securities

November 18, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 17, 2025 BRISTOL-MYERS SQUIBB COMPANY (Exact name of registrant as specified in its charter) Delaware 001-01136 22-0790350 (State or other jurisdiction of incorporation or or

November 18, 2025 EX-99.1

Bristol Myers Squibb Announces Early Participation Results, Amendment and Early Settlement of Tender Offers

Exhibit 99.1 Bristol Myers Squibb Announces Early Participation Results, Amendment and Early Settlement of Tender Offers PRINCETON, N.J.-(BUSINESS WIRE)- Bristol-Myers Squibb Company (NYSE: BMY) (“Bristol Myers Squibb”), today announced the early participation results, as of 5:00 p.m. (New York City time) on November 17, 2025, (the “Early Tender Deadline”) of the previously announced tender offers

November 12, 2025 CERT

NYSE CERTIFICATION

New York Stock Exchange 11 Wall Street New York, NY 10005 Tel: +1 212.656.3000 nyse.com November 12, 2025 Chief, Information Technology Securities and Exchange Commission Division of Corporate Finance 100 F Street, NE MS 3040 Washington, DC 20549 To whom it may concern: The New York Stock Exchange certifies its approval for listing and registration of the following securities of BMS Ireland Capita

November 10, 2025 EX-4.2

BMS IRELAND CAPITAL FUNDING DESIGNATED ACTIVITY COMPANY, as Issuer BRISTOL-MYERS SQUIBB COMPANY, as Parent Guarantor THE BANK OF NEW YORK MELLON, as Trustee FIRST SUPPLEMENTAL INDENTURE Dated as of November 10, 2025 Dated as of October 31, 2025 2.973

Exhibit 4.2 BMS IRELAND CAPITAL FUNDING DESIGNATED ACTIVITY COMPANY, as Issuer BRISTOL-MYERS SQUIBB COMPANY, as Parent Guarantor and THE BANK OF NEW YORK MELLON, as Trustee FIRST SUPPLEMENTAL INDENTURE Dated as of November 10, 2025 to INDENTURE Dated as of October 31, 2025 2.973% Notes due 2030 3.363% Notes due 2033 3.857% Notes due 2038 4.289% Notes due 2045 4.581% Notes due 2055 TABLE OF CONTENT

November 10, 2025 8-A12B

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-A FOR REGISTRATION OF CERTAIN CLASSES OF SECURITIES PURSUANT TO SECTION 12(B) OR 12(G) OF THE SECURITIES EXCHANGE ACT OF 1934 Bristol-Myers Squibb Company (Exact name of reg

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM 8-A FOR REGISTRATION OF CERTAIN CLASSES OF SECURITIES PURSUANT TO SECTION 12(B) OR 12(G) OF THE SECURITIES EXCHANGE ACT OF 1934 Bristol-Myers Squibb Company (Exact name of registrant as specified in its charter) Delaware 22-0790350 (State or other jurisdiction of incorporation) (IRS Employer Identification No.

November 10, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 10, 2025 (October 31, 20

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 10, 2025 (October 31, 2025) BRISTOL-MYERS SQUIBB COMPANY (Exact name of registrant as specified in its charter) Delaware 001-01136 22-0790350 (State or other jurisdiction of

November 10, 2025 EX-1.1

UNDERWRITING AGREEMENT dated as of November 5, 2025 BMS Ireland Capital Funding Designated Activity Company €750,000,000 2.973% Notes due 2030 €1,150,000,000 3.363% Notes due 2033 €1,150,000,000 3.857% Notes due 2038 €750,000,000 4.289% Notes due 204

Exhibit 1.1 Execution Version UNDERWRITING AGREEMENT dated as of November 5, 2025 BMS Ireland Capital Funding Designated Activity Company €750,000,000 2.973% Notes due 2030 €1,150,000,000 3.363% Notes due 2033 €1,150,000,000 3.857% Notes due 2038 €750,000,000 4.289% Notes due 2045 €1,200,000,000 4.581% Notes due 2055 (as fully and unconditionally guaranteed by Bristol Myers Squibb Company) New Yor

November 7, 2025 EX-FILING FEES

Calculation of Filing Fee Tables (Form Type) Bristol-Myers Squibb Company BMS Ireland Capital Funding Designated Activity Company (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered and Carry Forward Securities

Exhibit 107 Calculation of Filing Fee Tables 424(b)(5) (Form Type) Bristol-Myers Squibb Company BMS Ireland Capital Funding Designated Activity Company (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered and Carry Forward Securities Security Type Security Class Title Fee Calculation or Carry Forward Rule Amount Registered(1) Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Carry Forward Form Type Carry Forward File Number Carry Forward Initial Effective Date Filing Fee Previously Paid in Connection with Unsold Securities to be Carried Forward Newly Registered Securities Fees to be Paid 2 Debt 2.

November 7, 2025 424B5

BMS Ireland Capital Funding Designated Activity Company €750,000,000 2.973% Notes due 2030 €1,150,000,000 3.363% Notes due 2033 €1,150,000,000 3.857% Notes due 2038 €750,000,000 4.289% Notes due 2045 €1,200,000,000 4.581% Notes due 2055 Fully and Unc

TABLE OF CONTENTS Filed Pursuant to Rule 424(b)(5) Registration Nos. 333-283810 and 333-283810-01 PROSPECTUS SUPPLEMENT (to Prospectus dated October 31, 2025) €5,000,000,000   BMS Ireland Capital Funding Designated Activity Company €750,000,000 2.973% Notes due 2030 €1,150,000,000 3.363% Notes due 2033 €1,150,000,000 3.857% Notes due 2038 €750,000,000 4.289% Notes due 2045 €1,200,000,000 4.581% No

November 5, 2025 FWP

BMS Ireland Capital Funding Designated Activity Company (as fully and unconditionally guaranteed by Bristol-Myers Squibb Company) Pricing Term Sheet November 5, 2025 €5,000,000,000 aggregate principal amount, consisting of: €750,000,000 2.973% Notes

Issuer Free Writing Prospectus, dated November 5, 2025 Filed Pursuant to Rule 433 of the Securities Act of 1933 Registration Statement Nos.

November 3, 2025 EX-99.1

Bristol Myers Squibb Announces Cash Tender Offers to Purchase Certain Notes

Exhibit 99.1 Bristol Myers Squibb Announces Cash Tender Offers to Purchase Certain Notes (Princeton, N.J., November 3, 2025) – Bristol-Myers Squibb Company (NYSE:BMY) (“Bristol Myers Squibb” or the “Offeror”), announced the commencement of tender offers (“Offers”) to purchase for cash certain of its outstanding notes (collectively, the “Notes”) as described in the tables below. Pool 1 Offers to pu

November 3, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 3, 2025 BRISTOL-MYERS SQ

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 3, 2025 BRISTOL-MYERS SQUIBB COMPANY (Exact name of registrant as specified in its charter) Delaware 001-01136 22-0790350 (State or other jurisdiction of incorporation or org

November 3, 2025 424B2

Subject to Completion, dated November 3, 2025

TABLE OF CONTENTS Filed Pursuant to Rule 424(b)(2) Registration Nos. 333-283810 and 333-283810-01 Subject to Completion, dated November 3, 2025 The information in this preliminary prospectus supplement and the accompanying prospectus is not complete and may be changed. This preliminary prospectus supplement and the accompanying prospectus do not constitute an offer to sell or the solicitation of a

October 31, 2025 POSASR

As filed with the Securities and Exchange Commission on October 31, 2025

TABLE OF CONTENTS As filed with the Securities and Exchange Commission on October 31, 2025 No.

October 31, 2025 EX-4.(C)

BMS IRELAND CAPITAL FUNDING DESIGNATED ACTIVITY COMPANY BRISTOL-MYERS SQUIBB COMPANY, as Parent Guarantor THE BANK OF NEW YORK MELLON, as Trustee Dated as of October 31, 2025 DEBT SECURITIES Reconciliation and tie between Trust Indenture Act of 1939

Exhibit 4(c) BMS IRELAND CAPITAL FUNDING DESIGNATED ACTIVITY COMPANY BRISTOL-MYERS SQUIBB COMPANY, as Parent Guarantor and THE BANK OF NEW YORK MELLON, as Trustee INDENTURE Dated as of October 31, 2025 DEBT SECURITIES Reconciliation and tie between Trust Indenture Act of 1939 and Indenture* Trust Indenture Act Section Indenture Section § 310 (a)(1) 11.

October 31, 2025 EX-FILING FEES

CALCULATION OF FILING FEE TABLES (Form Type) Bristol-Myers Squibb Company BMS Ireland Capital Funding Designated Activity Company (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered and Carry Forward Securities

Exhibit 107 CALCULATION OF FILING FEE TABLES S-3 (Form Type) Bristol-Myers Squibb Company BMS Ireland Capital Funding Designated Activity Company (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered and Carry Forward Securities Security Type Security Class Title Fee Calculation or Carry Forward Rule Amount Registered Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Carry Forward Form Type Carry Forward File Number Carry Forward Initial Effective Date Filing Fee Previously Paid In Connection with Unsold Securities to be carried Forward Newly Registered Securities Fees to Be Paid 1 Debt Debt Securities of Bristol-Myers Squibb Company 457(r) 0.

October 31, 2025 EX-5.(A)

601 Lexington Avenue New York, NY 10022 United States +1 212 446 4800

Exhibit 5(a) 601 Lexington Avenue New York, NY 10022 United States +1 212 446 4800 www.

October 31, 2025 EX-23.(A)

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

Exhibit 23(a) CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM We consent to the incorporation by reference in this Post-Effective Amendment to the Registration Statement on Form S-3 of our reports dated February 12, 2025 relating to the financial statements of Bristol-Myers Squibb Company and the effectiveness of Bristol-Myers Squibb Company's internal control over financial reporting, appearing in the Annual Report on Form 10-K of Bristol-Myers Squibb Company for the year ended December 31, 2024.

October 31, 2025 EX-5.(B)

SCHEDULE Transaction Documents

Exhibit 5(b) 31 October 2025 To: Bristol-Myers Squibb Company Route 206 & Province Line Road, Princeton, New Jersey 08543 BMS Ireland Capital Funding DAC Plaza 254, Blanchardstown Corporate Park 2 Dublin 15, Ireland Re: BMS Ireland Capital Funding DAC - Post-Effective Amendment No.

October 31, 2025 EX-25.C

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549

Exhibit 25(c) UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM T-1 STATEMENT OF ELIGIBILITY UNDER THE TRUST INDENTURE ACT OF 1939 OF A CORPORATION DESIGNATED TO ACT AS TRUSTEE CHECK IF AN APPLICATION TO DETERMINE ELIGIBILITY OF A TRUSTEE PURSUANT TO SECTION 305(b)(2) ☐ The Bank of New York Mellon (Exact name of trustee as specified in its charter) New York 13-5160382 (J

October 30, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2025 ☐ TRANSITION REPORT PURSUANT

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2025 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number 001-01136 BRISTOL-MYERS SQU

October 30, 2025 EX-31.B

Section 302 Certification Letter (filed herewith).

EXHIBIT 31b CERTIFICATION BY THE CHIEF FINANCIAL OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, David V.

October 30, 2025 EX-31.A

Section 302 Certification Letter (filed herewith).

EXHIBIT 31a CERTIFICATION BY THE CHIEF EXECUTIVE OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, Christopher Boerner, certify that: 1.

October 30, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 30, 2025 BRISTOL-MYERS SQ

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 30, 2025 BRISTOL-MYERS SQUIBB COMPANY (Exact name of registrant as specified in its charter) Delaware 001-01136 22-0790350 (State or other jurisdiction of incorporation or org

October 30, 2025 EX-99.1

Bristol Myers Squibb Reports Third Quarter Financial Results for 2025 Performance Marked by Continued Growth Portfolio Momentum, Pipeline Advancements and Strategic Business Development

Exhibit 99.1 Bristol Myers Squibb Reports Third Quarter Financial Results for 2025 Performance Marked by Continued Growth Portfolio Momentum, Pipeline Advancements and Strategic Business Development •Third quarter revenues increased 3% (+2% Ex-FX) to $12.2 billion ◦Growth Portfolio revenues increased 18% (+17% Ex-FX) to $6.9 billion •GAAP EPS was $1.08 and non-GAAP EPS was $1.63; Both figures incl

October 30, 2025 EX-32.A

Section 906 Certification Letter (furnished herewith).

EXHIBIT 32a Certification by the Chief Executive Officer Pursuant to 18 U. S. C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 Pursuant to 18 U.S.C. Section 1350, I, Christopher Boerner, hereby certify that, to the best of my knowledge, Bristol-Myers Squibb Company’s Quarterly Report on Form 10-Q for the quarter ended September 30, 2025 (the "Report"), as filed

October 30, 2025 EX-32.B

Section 906 Certification Letter (furnished herewith).

EXHIBIT 32b Certification by the Chief Financial Officer Pursuant to 18 U. S. C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 Pursuant to 18 U.S.C. Section 1350, I, David V. Elkins, hereby certify that, to the best of my knowledge, Bristol-Myers Squibb Company’s Quarterly Report on Form 10-Q for the quarter ended September 30, 2025 (the "Report"), as filed wit

October 30, 2025 EX-99.2

Not for Product Promotional Use Q3 2025 Results October 30, 2025 Not for Product Promotional UseQ3 2025 Results Forward Looking Statements and Non-GAAP Financial Information 2 This presentation contains statements about Bristol-Myers Squibb Company’s

q32025earningspresentati Not for Product Promotional Use Q3 2025 Results October 30, 2025 Not for Product Promotional UseQ3 2025 Results Forward Looking Statements and Non-GAAP Financial Information 2 This presentation contains statements about Bristol-Myers Squibb Company’s (the “Company”) future financial results, plans, business development strategy, anticipated clinical trials, results and regulatory approvals that constitute forward-looking statements for purposes of the safe harbor provisions under the Private Securities Litigation Reform Act of 1995.

September 2, 2025 144

144

144 0001451604 XXXXXXXX LIVE 0000014272 BRISTOL MYERS SQUIBB CO 001-01136 ROUTE 206 AND PROVINCE LINE ROAD PRINCETON NJ 08543 6092524621 Elkins David V Officer Common Fidelity Brokerage Services LLC 900 Salem Street Smithfield RI 02917 56000 2648800.

July 31, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 31, 2025 BRISTOL-MYERS SQUIB

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 31, 2025 BRISTOL-MYERS SQUIBB COMPANY (Exact name of registrant as specified in its charter) Delaware 001-01136 22-0790350 (State or other jurisdiction of incorporation or organi

July 31, 2025 EX-32.A

Section 906 Certification Letter (furnished herewith).

EXHIBIT 32a Certification by the Chief Executive Officer Pursuant to 18 U. S. C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 Pursuant to 18 U.S.C. Section 1350, I, Christopher Boerner, hereby certify that, to the best of my knowledge, Bristol-Myers Squibb Company’s Quarterly Report on Form 10-Q for the quarter ended June 30, 2025 (the "Report"), as filed with

July 31, 2025 EX-99.1

Bristol Myers Squibb Reports Second Quarter Financial Results for 2025 Performance Underscores Continued Execution Against Long-Term Growth Strategy

Exhibit 99.1 Bristol Myers Squibb Reports Second Quarter Financial Results for 2025 Performance Underscores Continued Execution Against Long-Term Growth Strategy •Second quarter revenues were $12.3 billion ◦Growth Portfolio revenues were $6.6 billion, +18% (+17% Ex-FX) •GAAP EPS was $0.64 and non-GAAP EPS was $1.46; Both figures include net impact of $(0.57) due to the Acquired IPRD charge associa

July 31, 2025 EX-31.B

Section 302 Certification Letter (filed herewith).

EXHIBIT 31b CERTIFICATION BY THE CHIEF FINANCIAL OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, David V.

July 31, 2025 EX-99.2

Not for Product Promotional Use Q2 2025 Results July 31, 2025 Not for Product Promotional UseQ2 2025 Results Forward Looking Statements and Non-GAAP Financial Information 2 This presentation contains statements about Bristol-Myers Squibb Company’s (t

q22025earningspresentati Not for Product Promotional Use Q2 2025 Results July 31, 2025 Not for Product Promotional UseQ2 2025 Results Forward Looking Statements and Non-GAAP Financial Information 2 This presentation contains statements about Bristol-Myers Squibb Company’s (the “Company”) future financial results, plans, business development strategy, anticipated clinical trials, results and regulatory approvals that constitute forward-looking statements for purposes of the safe harbor provisions under the Private Securities Litigation Reform Act of 1995.

July 31, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2025 ☐ TRANSITION REPORT PURSUANT TO S

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2025 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number 001-01136 BRISTOL-MYERS SQUIBB C

July 31, 2025 EX-31.A

Section 302 Certification Letter (filed herewith).

EXHIBIT 31a CERTIFICATION BY THE CHIEF EXECUTIVE OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, Christopher Boerner, certify that: 1.

July 31, 2025 EX-32.B

Section 906 Certification Letter (furnished herewith).

EXHIBIT 32b Certification by the Chief Financial Officer Pursuant to 18 U. S. C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 Pursuant to 18 U.S.C. Section 1350, I, David V. Elkins, hereby certify that, to the best of my knowledge, Bristol-Myers Squibb Company’s Quarterly Report on Form 10-Q for the quarter ended June 30, 2025 (the "Report"), as filed with the

July 25, 2025 EX-99.1

Cristian Massacesi, M.D., Joins Bristol Myers Squibb as Executive Vice President, Chief Medical Officer and Head of Development

Exhibit 99.1 Cristian Massacesi, M.D., Joins Bristol Myers Squibb as Executive Vice President, Chief Medical Officer and Head of Development Dr. Massacesi will join BMS August 1 and serve on the Executive Leadership Team Samit Hirawat, M.D., Executive Vice President, to step down from his role on August 1 and will depart BMS on November 1 PRINCETON, N.J., [BUSINESS WIRE] – Bristol Myers Squibb (NY

July 25, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 21, 2025 BRISTOL-MYERS SQUIB

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 21, 2025 BRISTOL-MYERS SQUIBB COMPANY (Exact name of registrant as specified in its charter) Delaware 001-01136 22-0790350 (State or other jurisdiction of incorporation or organi

June 6, 2025 EX-23.A

EXHIBIT 23a – Consent of Independent Registered Public Accounting Firm

Exhibit 23a Consent of Independent Registered Public Accounting Firm We consent to the incorporation by reference in Registration Statement Nos.

June 6, 2025 11-K

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 11-K x ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2024 ¨ TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECU

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 11-K x ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2024 ¨ TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to COMMISSION FILE NUMBER 001-01136 A. Full title of the plan and the address of plan, if d

June 6, 2025 11-K

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 11-K x ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2024 ¨ TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECU

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 11-K x ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2024 ¨ TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to COMMISSION FILE NUMBER 001-01136 A. Full title of the plan and the address of plan, if d

June 6, 2025 EX-23.A

EXHIBIT 23a – Consent of Independent Registered Public Accounting Firm

Exhibit 23a Consent of Independent Registered Public Accounting Firm We consent to the incorporation by reference in Registration Statement Nos.

June 6, 2025 11-K

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 11-K x ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2024 ¨ TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECU

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 11-K x ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2024 ¨ TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to COMMISSION FILE NUMBER 001-01136 A. Full title of the plan and the address of plan, if d

June 6, 2025 EX-23.A

EXHIBIT 23a – Consent of Independent Registered Public Accounting Firm

Exhibit 23a Consent of Independent Registered Public Accounting Firm We consent to the incorporation by reference in Registration Statement Nos.

May 15, 2025 EX-99.25

EX-99.25

NOTIFICATION OF THE REMOVAL FROM LISTING AND REGISTRATION OF THE STATED SECURITIES The New York Stock Exchange hereby notifies the SEC of its intention to remove the entire class of the stated securities from listing and registration on the Exchange at the opening of business on May 27, 2025, pursuant to the provisions of Rule 12d2-2 (a).

May 13, 2025 SC TO-T/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR 13(e)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 5) 2SEVENTY BIO, INC. (Name of Subject Company (Issuer

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR 13(e)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 5) 2SEVENTY BIO, INC. (Name of Subject Company (Issuer)) DAYBREAK MERGER SUB INC. (Offeror) A Wholly Owned Subsidiary of BRISTOL-MYERS SQUIBB COMPANY (Parent of Offeror) (Names of Filing Persons (identify

May 7, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 6, 2025 BRISTOL-MYERS SQUIBB

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 6, 2025 BRISTOL-MYERS SQUIBB COMPANY (Exact Name of Registrant as Specified in its Charter) Delaware 1-1136 22-0790350 (State or Other Jurisdiction of Incorporation) (Commission F

May 6, 2025 SC TO-T/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR 13(e)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 4) 2SEVENTY BIO, INC. (Name of Subject Company (Issuer

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR 13(e)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 4) 2SEVENTY BIO, INC. (Name of Subject Company (Issuer)) DAYBREAK MERGER SUB INC. (Offeror) A Wholly Owned Subsidiary of BRISTOL-MYERS SQUIBB COMPANY (Parent of Offeror) (Names of Filing Persons (identify

May 5, 2025 SC TO-T/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR 13(e)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 3) 2SEVENTY BIO, INC. (Name of Subject Company (Issuer

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR 13(e)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 3) 2SEVENTY BIO, INC. (Name of Subject Company (Issuer)) DAYBREAK MERGER SUB INC. (Offeror) A Wholly Owned Subsidiary of BRISTOL-MYERS SQUIBB COMPANY (Parent of Offeror) (Names of Filing Persons (identify

April 24, 2025 EX-10.A

Form of 2025 Performance Share Units Award Agreement under the 2021 Stock Award and Incentive Plan (filed herewith).

EXHIBIT 10a NOTICE OF GRANT OF PERFORMANCE SHARE UNITS UNDER THE BRISTOL-MYERS SQUIBB COMPANY 2021 STOCK AWARD AND INCENTIVE PLAN 2025 Performance Share Units Award BRISTOL-MYERS SQUIBB COMPANY, a Delaware corporation (the “Company”), has granted to you an award of Performance Share Units (such units, “PSUs”; such award, “Award”) under the 2021 Stock Award and Incentive Plan (the “Plan”), as descr

April 24, 2025 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2025 ☐ TRANSITION REPORT PURSUANT TO

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2025 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number 001-01136 BRISTOL-MYERS SQUIBB

April 24, 2025 EX-99.2

Not for Product Promotional Use Q1 2025 Results April 24, 2025 Not for Product Promotional UseQ1 2025 Results Forward Looking Statements and Non-GAAP Financial Information 2 This presentation contains statements about Bristol-Myers Squibb Company’s (

Not for Product Promotional Use Q1 2025 Results April 24, 2025 Not for Product Promotional UseQ1 2025 Results Forward Looking Statements and Non-GAAP Financial Information 2 This presentation contains statements about Bristol-Myers Squibb Company’s (the “Company”) future financial results, plans, business development strategy, anticipated clinical trials, results and regulatory approvals that constitute forward-looking statements for purposes of the safe harbor provisions under the Private Securities Litigation Reform Act of 1995.

April 24, 2025 EX-10.B

Form of 2025 Market Share Units Award Agreement under the 2021 Stock Award and Incentive Plan (filed herewith).

EXHIBIT 10b NOTICE OF GRANT OF MARKET SHARE UNITS UNDER THE BRISTOL-MYERS SQUIBB COMPANY 2021 STOCK AWARD AND INCENTIVE PLAN 2025 Market Share Units Award BRISTOL-MYERS SQUIBB COMPANY, a Delaware corporation (the “Company”), has granted to you an award of Market Share Units (such units, “MSUs”; such award, “Award”) under the 2021 Stock Award and Incentive Plan (the “Plan”), as described in this No

April 24, 2025 EX-10.C

Form of 2025 Restricted Stock Units Award Agreement with three-year, four-year, or five-year prorated vesting under the 2021 Stock Award and Incentive Plan (filed herewith).

EXHIBIT 10c NOTICE OF GRANT OF RESTRICTED STOCK UNITS UNDER THE BRISTOL-MYERS SQUIBB COMPANY 2021 STOCK AWARD AND INCENTIVE PLAN 2025 Restricted Stock Units Award BRISTOL-MYERS SQUIBB COMPANY, a Delaware corporation (the “Company”), has granted to you an award of Restricted Stock Units (such units, “RSUs”; such award, “Award”) under the 2021 Stock Award and Incentive Plan (the “Plan”), as describe

April 24, 2025 8-K

Regulation FD Disclosure, Financial Statements and Exhibits, Results of Operations and Financial Condition

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 24, 2025 BRISTOL-MYERS SQUIBB COMPANY (Exact name of registrant as specified in its charter) Delaware 001-01136 22-0790350 (State or other jurisdiction of incorporation or organ

April 24, 2025 EX-10.E

Form of 2025 Restricted Stock Units Award Agreement with two-year cliff vesting with a one-year post-vest holding period under the 2021 Stock Award and Incentive Plan (filed herewith).

EXHIBIT 10e NOTICE OF GRANT OF RESTRICTED STOCK UNITS UNDER THE BRISTOL-MYERS SQUIBB COMPANY 2021 STOCK AWARD AND INCENTIVE PLAN 2025 Restricted Stock Units Award BRISTOL-MYERS SQUIBB COMPANY, a Delaware corporation (the “Company”), has granted to you an award of Restricted Stock Units (such units, “RSUs”; such award, “Award”) under the 2021 Stock Award and Incentive Plan (the “Plan”), as describe

April 24, 2025 EX-32.A

Section 906 Certification Letter

EXHIBIT 32a Certification by the Chief Executive Officer Pursuant to 18 U. S. C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 Pursuant to 18 U.S.C. Section 1350, I, Christopher Boerner, hereby certify that, to the best of my knowledge, Bristol-Myers Squibb Company’s Quarterly Report on Form 10-Q for the quarter ended March 31, 2025 (the "Report"), as filed wit

April 24, 2025 EX-31.A

Section 302 Certification Letter

EXHIBIT 31a CERTIFICATION BY THE CHIEF EXECUTIVE OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, Christopher Boerner, certify that: 1.

April 24, 2025 EX-32.B

Section 906 Certification Letter

EXHIBIT 32b Certification by the Chief Financial Officer Pursuant to 18 U. S. C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 Pursuant to 18 U.S.C. Section 1350, I, David V. Elkins, hereby certify that, to the best of my knowledge, Bristol-Myers Squibb Company’s Quarterly Report on Form 10-Q for the quarter ended March 31, 2025 (the "Report"), as filed with th

April 24, 2025 EX-10.G

Bristol-Myers Squibb Company Severance Benefits Plan (filed herewith).

EXHIBIT 10g BRISTOL-MYERS SQUIBB COMPANY SEVERANCE BENEFITS PLAN AND SUMMARY PLAN DESCRIPTION 1.

April 24, 2025 EX-99.1

Bristol Myers Squibb Reports First Quarter Financial Results for 2025 Results Reflect Continued Growth Portfolio Momentum and Disciplined Execution

Exhibit 99.1 Bristol Myers Squibb Reports First Quarter Financial Results for 2025 Results Reflect Continued Growth Portfolio Momentum and Disciplined Execution •First quarter revenues were $11.2 billion, -6% (-4% Ex-FX) ◦Growth Portfolio revenues were $5.6 billion, +16% (+18% Ex-FX) •GAAP EPS was $1.20 and non-GAAP EPS was $1.80 •Raising 2025 revenue guidance to a range of ~$45.8 billion to $46.8

April 24, 2025 EX-31.B

Section 302 Certification Letter

EXHIBIT 31b CERTIFICATION BY THE CHIEF FINANCIAL OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, David V.

April 24, 2025 EX-10.D

Form of 2025 Restricted Stock Units Award Agreement with three-year cliff vesting under the 2021 Stock Award and Incentive Plan (filed herewith).

EXHIBIT 10d NOTICE OF GRANT OF RESTRICTED STOCK UNITS UNDER THE BRISTOL-MYERS SQUIBB COMPANY 2021 STOCK AWARD AND INCENTIVE PLAN 2025 Restricted Stock Units Award BRISTOL-MYERS SQUIBB COMPANY, a Delaware corporation (the “Company”), has granted to you an award of Restricted Stock Units (such units, “RSUs”; such award, “Award”) under the 2021 Stock Award and Incentive Plan (the “Plan”), as describe

April 24, 2025 EX-10.F

Form of 2025 Restricted Stock Units Award Agreement with one-year cliff vesting with a two-year post-vest holding period under the 2021 Stock Award and Incentive Plan (filed herewith).

EXHIBIT 10f NOTICE OF GRANT OF RESTRICTED STOCK UNITS UNDER THE BRISTOL-MYERS SQUIBB COMPANY 2021 STOCK AWARD AND INCENTIVE PLAN 2025 Restricted Stock Units Award BRISTOL-MYERS SQUIBB COMPANY, a Delaware corporation (the “Company”), has granted to you an award of Restricted Stock Units (such units, “RSUs”; such award, “Award”) under the 2021 Stock Award and Incentive Plan (the “Plan”), as describe

April 23, 2025 SC TO-T/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR 13(e)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 2) 2SEVENTY BIO, INC. (Name of Subject Company (Issuer

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR 13(e)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 2) 2SEVENTY BIO, INC. (Name of Subject Company (Issuer)) DAYBREAK MERGER SUB INC. (Offeror) A Wholly Owned Subsidiary of BRISTOL-MYERS SQUIBB COMPANY (Parent of Offeror) (Names of Filing Persons (identify

April 17, 2025 SC TO-T/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR 13(e)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 1) 2SEVENTY BIO, INC. (Name of Subject Company (Issuer

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR 13(e)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 1) 2SEVENTY BIO, INC. (Name of Subject Company (Issuer)) DAYBREAK MERGER SUB INC. (Offeror) A Wholly Owned Subsidiary of BRISTOL-MYERS SQUIBB COMPANY (Parent of Offeror) (Names of Filing Persons (identify

April 15, 2025 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.   )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.   ) Filed by the Registrant ☒ Filed by a Party other than the Registrant  ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ De

April 14, 2025 EX-99.(A)(1)(II)

Letter of Transmittal to Tender Shares of Common Stock 2SEVENTY BIO, INC. At $5.00 Net per Share Pursuant to the Offer to Purchase Dated April 14, 2025 by Daybreak Merger Sub Inc. a wholly owned subsidiary of Bristol-Myers Squibb Company

Exhibit (a)(1)(ii) Letter of Transmittal to Tender Shares of Common Stock of 2SEVENTY BIO, INC.

April 14, 2025 EX-99.(A)(1)(III)

Offer to Purchase for Cash All Outstanding Shares of Common Stock 2SEVENTY BIO, INC. $5.00 Net Per Share Pursuant to the Offer to Purchase Dated April 14, 2025 DAYBREAK MERGER SUB INC. a wholly owned subsidiary of Bristol-Myers Squibb Company

Exhibit (a)(1)(iii) Offer to Purchase for Cash All Outstanding Shares of Common Stock of 2SEVENTY BIO, INC.

April 14, 2025 EX-99.(A)(1)(I)

Offer to Purchase for Cash All Outstanding Shares of Common Stock 2SEVENTY BIO, INC. $5.00 Net Per Share DAYBREAK MERGER SUB INC. a wholly owned subsidiary of BRISTOL-MYERS SQUIBB COMPANY THE OFFER AND WITHDRAWAL RIGHTS EXPIRE ONE MINUTE FOLLOWING 11

TABLE OF CONTENTS Exhibit (a)(1)(i) Offer to Purchase for Cash All Outstanding Shares of Common Stock of 2SEVENTY BIO, INC.

April 14, 2025 EX-99.(D)(2)

TENDER AND SUPPORT AGREEMENT

Exhibit (d)(2) TENDER AND SUPPORT AGREEMENT This Tender and Support Agreement (this “Agreement”), dated as of March 10, 2025, is entered into by and between Bristol-Myers Squibb Company, a Delaware corporation (“Parent”), and the undersigned stockholder of 2seventy bio, Inc.

April 14, 2025 SC TO-T

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR 13(e)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 2SEVENTY BIO, INC. (Name of Subject Company (Issuer)) DAYBREAK MERGER

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR 13(e)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 2SEVENTY BIO, INC. (Name of Subject Company (Issuer)) DAYBREAK MERGER SUB INC. (Offeror) A Wholly Owned Subsidiary of BRISTOL-MYERS SQUIBB COMPANY (Parent of Offeror) (Names of Filing Persons (identifying status as offe

April 14, 2025 EX-99.(A)(1)(VI)

Notice of Offer to Purchase for Cash All Outstanding Shares of Common Stock 2SEVENTY BIO, INC. $5.00 Net Per Share DAYBREAK MERGER SUB INC. a wholly owned subsidiary of BRISTOL-MYERS SQUIBB COMPANY

Exhibit (a)(1)(vi) This announcement is neither an offer to purchase nor a solicitation of an offer to sell Shares (as defined below).

April 14, 2025 EX-FILING FEES

Calculation of Filing Fee Tables Schedule TO-T (Rule 14d-100) 2SEVENTY BIO, INC. (Name of Subject Company (Issuer)) DAYBREAK MERGER SUB INC. a wholly owned subsidiary of BRISTOL-MYERS SQUIBB COMPANY (Names of Filing Persons (Offerors))

Exhibit 107 Calculation of Filing Fee Tables Schedule TO-T (Rule 14d-100) 2SEVENTY BIO, INC.

April 14, 2025 EX-99.(A)(1)(V)

NOTICE OF GUARANTEED DELIVERY to Tender Shares of Common Stock 2SEVENTY BIO, INC. $5.00 Net Per Share Pursuant to the Offer to Purchase Dated April 14, 2025 DAYBREAK MERGER SUB INC. a wholly owned subsidiary of Bristol-Myers Squibb Company

Exhibit (a)(1)(v) NOTICE OF GUARANTEED DELIVERY to Tender Shares of Common Stock of 2SEVENTY BIO, INC.

April 14, 2025 EX-99.(A)(1)(IV)

Offer to Purchase for Cash All Outstanding Shares of Common Stock 2SEVENTY BIO, INC. $5.00 Net Per Share Pursuant to the Offer to Purchase Dated April 14, 2025 DAYBREAK MERGER SUB INC. a wholly owned subsidiary of Bristol-Myers Squibb Company

Exhibit (a)(1)(iv) Offer to Purchase for Cash All Outstanding Shares of Common Stock of 2SEVENTY BIO, INC.

March 26, 2025 ARS

ARS

2024 ANNUAL REPORT We are in the business of breakthroughs—the kind that transform patients’ lives.

March 26, 2025 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.   )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.   ) Filed by the Registrant ☒ Filed by a Party other than the Registrant  ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ De

March 26, 2025 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.)

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.) Filed by the Registrant ☒ Filed by a Party other than the Registrant ☐ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☒ Defini

March 13, 2025 SC TO-C

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR 13(e)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 2SEVENTY BIO, INC. (Name of Subject Company (Issuer)) DAYBREAK MERGER

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR 13(e)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 2SEVENTY BIO, INC. (Name of Subject Company (Issuer)) DAYBREAK MERGER SUB INC. (Offeror) A Wholly Owned Subsidiary of BRISTOL-MYERS SQUIBB COMPANY (Offeror) (Name of Filing Persons (identifying status as offeror, issuer

March 13, 2025 EX-99.1

-BMS CONFIDENTIAL-

Exhibit 99.1 -BMS CONFIDENTIAL- From: Lynelle Hoch To: 2seventy bio employees Date: Thursday, 3/13 Subject: Continuing our work together to bring Abecma to patients Dear 2seventy bio colleagues, Monday was an important day with the announcement that Bristol Myers Squibb (BMS) has entered into an agreement to acquire 2seventy bio. As the president of BMS’ Cell Therapy Organization, I have had a fro

February 18, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 18, 2025 (February 14, 2025) BRISTOL-MYERS SQUIBB COMPANY (Exact name of registrant as specified in its charter) Delaware 001-01136 22-0790350 (State or other jurisdiction of

February 12, 2025 EX-32.B

Section 906 Certification Letter (filed herewith).

EXHIBIT 32b Certification by the Chief Financial Officer Pursuant to 18 U. S. C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 Pursuant to 18 U. S. C. Section 1350, I, David V. Elkins, hereby certify that, to the best of my knowledge, Bristol-Myers Squibb Company’s Annual Report on Form 10-K for the year ended December 31, 2024 (the Report), as filed with the S

February 12, 2025 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2024 ☐ TRANSITION REPORT PURSUANT TO SECTI

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number 001-01136 BRISTOL-MYERS SQUIBB COMPA

February 12, 2025 EX-32.A

Section 906 Certification Letter (filed herewith).

EXHIBIT 32a Certification by the Chief Executive Officer Pursuant to 18 U. S. C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 Pursuant to 18 U. S. C. Section 1350, I, Christopher Boerner, hereby certify that, to the best of my knowledge, Bristol-Myers Squibb Company’s Annual Report on Form 10-K for the year ended December 31, 2024 (the Report), as filed with t

February 12, 2025 EX-31.A

Section 302 Certification Letter (filed herewith).

EXHIBIT 31a CERTIFICATION BY THE CHIEF EXECUTIVE OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, Christopher Boerner, certify that: 1.

February 12, 2025 EX-21

Subsidiaries of the Registrant (filed herewith).

EXHIBIT 21 Subsidiaries of Bristol-Myers Squibb Company The following are subsidiaries of the Bristol-Myers Squibb Company at December 31, 2024.

February 12, 2025 EX-31.B

Section 302 Certification Letter (filed herewith).

EXHIBIT 31b CERTIFICATION BY THE CHIEF FINANCIAL OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, David V.

February 6, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 6, 2025 BRISTOL-MYERS SQ

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 6, 2025 BRISTOL-MYERS SQUIBB COMPANY (Exact name of registrant as specified in its charter) Delaware 001-01136 22-0790350 (State or other jurisdiction of incorporation or org

February 6, 2025 EX-99.1

Bristol Myers Squibb Reports Fourth Quarter and Full-Year Financial Results for 2024 Performance Reflects Progress Toward Delivering Sustained, Top-Tier Growth

Exhibit 99.1 Bristol Myers Squibb Reports Fourth Quarter and Full-Year Financial Results for 2024 Performance Reflects Progress Toward Delivering Sustained, Top-Tier Growth •Fourth Quarter Revenues were $12.3 Billion, Increasing 8% (+9% Adjusting for Foreign Exchange); GAAP Earnings Per Share (EPS) was $0.04 and Non-GAAP EPS was $1.67 ◦Growth Portfolio Revenues were $6.4 Billion, Increasing 21% (+

February 6, 2025 EX-99.2

Not for Product Promotional Use Q4 2024 Results February 6, 2025 Not for Product Promotional UseQ4 2024 Results Forward Looking Statements and Non-GAAP Financial Information 2 This presentation contains statements about Bristol-Myers Squibb Company’s

Not for Product Promotional Use Q4 2024 Results February 6, 2025 Not for Product Promotional UseQ4 2024 Results Forward Looking Statements and Non-GAAP Financial Information 2 This presentation contains statements about Bristol-Myers Squibb Company’s (the “Company”) future financial results, plans, business development strategy, anticipated clinical trials, results and regulatory approvals that constitute forward-looking statements for purposes of the safe harbor provisions under the Private Securities Litigation Reform Act of 1995.

January 13, 2025 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 13, 2025 BRISTOL-MYERS SQ

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 13, 2025 BRISTOL-MYERS SQUIBB COMPANY (Exact name of registrant as specified in its charter) Delaware 001-01136 22-0790350 (State or other jurisdiction of incorporation or org

January 13, 2025 EX-99.1

43rd Annual J.P. Morgan Healthcare Conference January 13th, 2025 Christopher Boerner, Ph.D., Board Chair and Chief Executive Officer Forward Looking Statements and Non-GAAP Financial Information 2 This presentation (as well as the oral statements mad

Exhibit 99.1 43rd Annual J.P. Morgan Healthcare Conference January 13th, 2025 Christopher Boerner, Ph.D., Board Chair and Chief Executive Officer Forward Looking Statements and Non-GAAP Financial Information 2 This presentation (as well as the oral statements made with respect to the information contained in this presentation) contains statements about Bristol-Myers Squibb Company’s (the “Company”

December 13, 2024 EX-FILING FEES

Calculation of Filing Fee Tables Form S-3 (Form Type) Bristol-Myers Squibb Company (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered and Carry Forward Securities

Exhibit 107 Calculation of Filing Fee Tables Form S-3 (Form Type) Bristol-Myers Squibb Company (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered and Carry Forward Securities Security Type Security Class Title Fee Calculation or Carry Forward Rule Amount Registered Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registratio

December 13, 2024 EX-23.A

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

Exhibit 23a CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM We consent to the incorporation by reference in this Registration Statement on Form S-3 of our reports dated February 12, 2024 relating to the financial statements of Bristol-Myers Squibb Company, and the effectiveness of Bristol-Myers Squibb Company’s internal control over financial reporting, appearing in the Annual Report on Form 10-K of Bristol-Myers Squibb Company for the year ended December 31, 2023.

December 13, 2024 S-3ASR

As filed with the Securities and Exchange Commission on December 13, 2024

TABLE OF CONTENTS As filed with the Securities and Exchange Commission on December 13, 2024 No.

December 13, 2024 EX-25.1

= = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM T-1 STATEMENT OF ELIGIBILITY UNDER THE TRUST INDENTURE ACT OF 1939 OF A CORPORATION D

Exhibit 25.1 = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = = UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM T-1 STATEMENT OF ELIGIBILITY UNDER THE TRUST INDENTURE ACT OF 1939 OF A CORPORATION DESIGNATED TO ACT AS TRUSTEE CHECK IF AN APPLICATION TO DETERMINE ELIGIBILITY OF A TRUSTEE PURSUANT TO SECTION 305(b)(2) || THE BANK OF NE

November 13, 2024 SC 13G/A

RNA / Avidity Biosciences, Inc. / BRISTOL MYERS SQUIBB CO - SC 13G/A Passive Investment

SC 13G/A 1 ef20038544sc13ga.htm SC 13G/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Avidity Biosciences, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 05370A108 (CUSIP Number) September 30, 2024 (Date of Event Which Requires Filing of this Statemen

November 13, 2024 SC 13G/A

QURE / uniQure N.V. / BRISTOL MYERS SQUIBB CO - SC 13G/A Passive Investment

SC 13G/A 1 ef20038542sc13ga.htm SC 13G/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 2)* uniQure N.V. (Name of Issuer) Ordinary Shares (Title of Class of Securities) N90064101 (CUSIP Number) September 30, 2024 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designa

November 13, 2024 SC 13G/A

IKNA / Ikena Oncology, Inc. / BRISTOL MYERS SQUIBB CO - SC 13G/A Passive Investment

SC 13G/A 1 ef20038543sc13ga.htm SC 13G/A UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. 1)* Ikena Oncology, Inc. (Name of Issuer) Common Stock, $0.001 par value (Title of Class of Securities) 45175G108 (CUSIP Number) September 30, 2024 (Date of Event Which Requires Filing of this Statement) Check the app

November 13, 2024 SC 13G

QTTB / Q32 Bio Inc. / BRISTOL MYERS SQUIBB CO - SC 13G Passive Investment

SC 13G 1 ef20038540sc13g.htm SC 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G UNDER THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. )* Q32 Bio Inc. (Name of Issuer) Common stock, par value $0.0001 per share (Title of Class of Securities) 746964105 (CUSIP Number) March 25, 2024 (Date of Event Which Requires Filing of this Statement) Check the Appropriat

October 31, 2024 EX-99.1

Bristol Myers Squibb Reports Third Quarter Financial Results for 2024 Performance Reflects Continued Focus on Near-Term Execution and Building a Foundation for Long-Term Sustainable Growth

Exhibit 99.1 Bristol Myers Squibb Reports Third Quarter Financial Results for 2024 Performance Reflects Continued Focus on Near-Term Execution and Building a Foundation for Long-Term Sustainable Growth •Third Quarter Revenues were $11.9 Billion, increasing 8% (+10% Adjusting for Foreign Exchange) •Growth Portfolio Revenues were $5.8 Billion, increasing 18% (+20% Adjusting for Foreign Exchange) •GA

October 31, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 31, 2024 BRISTOL-MYERS SQ

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): October 31, 2024 BRISTOL-MYERS SQUIBB COMPANY (Exact name of registrant as specified in its charter) Delaware 001-01136 22-0790350 (State or other jurisdiction of incorporation or org

October 31, 2024 EX-32.A

Section 906 Certification Letter.

EXHIBIT 32a Certification by the Chief Executive Officer Pursuant to 18 U. S. C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 Pursuant to 18 U.S.C. Section 1350, I, Christopher Boerner, hereby certify that, to the best of my knowledge, Bristol-Myers Squibb Company’s Quarterly Report on Form 10-Q for the quarter ended September 30, 2024 (the "Report"), as filed

October 31, 2024 EX-31.A

Section 302 Certification Letter.

EXHIBIT 31a CERTIFICATION BY THE CHIEF EXECUTIVE OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, Christopher Boerner, certify that: 1.

October 31, 2024 EX-32.B

Section 906 Certification Letter.

EXHIBIT 32b Certification by the Chief Financial Officer Pursuant to 18 U. S. C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 Pursuant to 18 U.S.C. Section 1350, I, David V. Elkins, hereby certify that, to the best of my knowledge, Bristol-Myers Squibb Company’s Quarterly Report on Form 10-Q for the quarter ended September 30, 2024 (the "Report"), as filed wit

October 31, 2024 EX-99.2

Not for Product Promotional Use Q3 2024 Results October 31, 2024 Not for Product Promotional UseQ3 2024 Results Forward Looking Statements and Non-GAAP Financial Information 2 This presentation contains statements about Bristol-Myers Squibb Company’s

q32024earningspresentati Not for Product Promotional Use Q3 2024 Results October 31, 2024 Not for Product Promotional UseQ3 2024 Results Forward Looking Statements and Non-GAAP Financial Information 2 This presentation contains statements about Bristol-Myers Squibb Company’s (the “Company”) future financial results, plans, business development strategy, anticipated clinical trials, results and regulatory approvals that constitute forward-looking statements for purposes of the safe harbor provisions under the Private Securities Litigation Reform Act of 1995.

October 31, 2024 EX-31.B

Section 302 Certification Letter.

EXHIBIT 31b CERTIFICATION BY THE CHIEF FINANCIAL OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, David V.

October 31, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2024 ☐ TRANSITION REPORT PURSUANT

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended September 30, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number 001-01136 BRISTOL-MYERS SQU

October 4, 2024 SC 13G

PRME / Prime Medicine, Inc. / BRISTOL MYERS SQUIBB CO - SC 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 SCHEDULE 13G UNDER THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. )* Prime Medicine, Inc. (Name of Issuer) Common Stock, par value $0.00001 per share (Title of Class of Securities) 74168J101 (CUSIP Number) September 30, 2023 (Date of Event Which Requires Filing of this Statement) Check the appropriate box to designate the

July 26, 2024 EX-32.A

Section 906 Certification Letter.

EXHIBIT 32a Certification by the Chief Executive Officer Pursuant to 18 U. S. C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 Pursuant to 18 U.S.C. Section 1350, I, Christopher Boerner, hereby certify that, to the best of my knowledge, Bristol-Myers Squibb Company’s Quarterly Report on Form 10-Q for the quarter ended June 30, 2024 (the "Report"), as filed with

July 26, 2024 EX-32.B

Section 906 Certification Letter.

EXHIBIT 32b Certification by the Chief Financial Officer Pursuant to 18 U. S. C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 Pursuant to 18 U.S.C. Section 1350, I, David V. Elkins, hereby certify that, to the best of my knowledge, Bristol-Myers Squibb Company’s Quarterly Report on Form 10-Q for the quarter ended June 30, 2024 (the "Report"), as filed with the

July 26, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2024 ☐ TRANSITION REPORT PURSUANT TO S

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended June 30, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number 001-01136 BRISTOL-MYERS SQUIBB C

July 26, 2024 EX-31.A

Section 302 Certification Letter.

EXHIBIT 31a CERTIFICATION BY THE CHIEF EXECUTIVE OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, Christopher Boerner, certify that: 1.

July 26, 2024 EX-99.2

Q2 2024 Results July 26, 2024 Q2 2024 Results Not for Product Promotional Use Forward Looking Statements and Non-GAAP Financial Information 2 This presentation contains statements about Bristol-Myers Squibb Company’s (the “Company”) future financial

q22024earningspresentati Q2 2024 Results July 26, 2024 Q2 2024 Results Not for Product Promotional Use Forward Looking Statements and Non-GAAP Financial Information 2 This presentation contains statements about Bristol-Myers Squibb Company’s (the “Company”) future financial results, plans, business development strategy, anticipated clinical trials, results and regulatory approvals that constitute forward-looking statements for purposes of the safe harbor provisions under the Private Securities Litigation Reform Act of 1995.

July 26, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 26, 2024 BRISTOL-MYERS SQUIB

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): July 26, 2024 BRISTOL-MYERS SQUIBB COMPANY (Exact name of registrant as specified in its charter) Delaware 001-01136 22-0790350 (State or other jurisdiction of incorporation or organi

July 26, 2024 EX-99.1

Bristol Myers Squibb Reports Second Quarter Financial Results for 2024 Results Underscore Continued Progress on Commercial Execution, Driving the Growth Portfolio and Pipeline Advancement

Exhibit 99.1 Bristol Myers Squibb Reports Second Quarter Financial Results for 2024 Results Underscore Continued Progress on Commercial Execution, Driving the Growth Portfolio and Pipeline Advancement •Second Quarter Revenues were $12.2 Billion, increasing 9% (+11% Adjusting for Foreign Exchange) •Growth Portfolio Revenues were $5.6 Billion, increasing 18% (+21% Adjusting for Foreign Exchange) •GA

July 26, 2024 EX-3.A

Amended and Restated Certificate of Incorporation of Bristol-Myers Squibb Company, as

Exhibit 3a AMENDED AND RESTATED CERTIFICATE OF INCORPORATION of BRISTOL-MYERS SQUIBB COMPANY This Amended and Restated Certificate of Incorporation of Bristol-Myers Squibb Company, originally incorporated as Bristol-Myers Company, was duly proposed by the board of directors of the corporation and adopted by the stockholders in accordance with the provisions of Sections 242 and 245 of the General Corporation Law of the State of Delaware.

July 26, 2024 EX-31.B

Section 302 Certification Letter.

EXHIBIT 31b CERTIFICATION BY THE CHIEF FINANCIAL OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, David V.

June 25, 2024 EX-23.A

EXHIBIT 23a – Consent of Independent Registered Public Accounting Firm

Exhibit 23a Consent of Independent Registered Public Accounting Firm We consent to the incorporation by reference in Registration Statement Nos.

June 25, 2024 11-K

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 11-K x ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 ¨ TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECU

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 11-K x ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 ¨ TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to COMMISSION FILE NUMBER 001-01136 A. Full title of the plan and the address of plan, if d

June 25, 2024 EX-23.A

EXHIBIT 23a – Consent of Independent Registered Public Accounting Firm

Exhibit 23a Consent of Independent Registered Public Accounting Firm We consent to the incorporation by reference in Registration Statement Nos.

June 25, 2024 11-K

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 11-K x ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 ¨ TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECU

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 11-K x ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 ¨ TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to COMMISSION FILE NUMBER 001-01136 A. Full title of the plan and the address of plan, if d

June 25, 2024 11-K

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 11-K x ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 ¨ TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECU

SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 11-K x ANNUAL REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 ¨ TRANSITION REPORT PURSUANT TO SECTION 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to COMMISSION FILE NUMBER 001-01136 A. Full title of the plan and the address of plan, if d

June 25, 2024 EX-23.A

EXHIBIT 23a – Consent of Independent Registered Public Accounting Firm

Exhibit 23a Consent of Independent Registered Public Accounting Firm We consent to the incorporation by reference in Registration Statement Nos.

June 18, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 18, 2024 BRISTOL-MYERS SQUIB

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): June 18, 2024 BRISTOL-MYERS SQUIBB COMPANY (Exact name of registrant as specified in its charter) Delaware 001-01136 22-0790350 (State or other jurisdiction of incorporation or organi

June 18, 2024 EX-99.1

Bristol Myers Squibb Elects Michael R. McMullen to Board of Directors

Exhibit 99.1 Bristol Myers Squibb Elects Michael R. McMullen to Board of Directors (Princeton, N.J., June 18, 2024) – Bristol Myers Squibb (NYSE: BMY) today announced that its Board of Directors has elected independent director Michael R. McMullen to the Board, effective July 1, 2024. Mr. McMullen will serve as a member of the Audit Committee of the Board of Directors. “We are pleased to welcome M

May 9, 2024 8-K

Amendments to Articles of Incorporation or Bylaws; Change in Fiscal Year, Financial Statements and Exhibits, Submission of Matters to a Vote of Security Holders

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): May 7, 2024 BRISTOL-MYERS SQUIBB COMPANY (Exact Name of Registrant as Specified in its Charter) Delaware 1-1136 22-0790350 (State or Other Jurisdiction of Incorporation) (Commission F

May 9, 2024 EX-3.A

CERTIFICATE OF AMENDMENT TO THE AMENDED AND RESTATED CERTIFICATE OF INCORPORATION BRISTOL-MYERS SQUIBB COMPANY Pursuant to Section 242 of the General Corporation Law of the State of Delaware

Exhibit 3a CERTIFICATE OF AMENDMENT TO THE AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF BRISTOL-MYERS SQUIBB COMPANY Pursuant to Section 242 of the General Corporation Law of the State of Delaware Bristol-Myers Squibb Company, a corporation duly organized and existing under the General Corporation Law of the State of Delaware (the “Corporation”), does hereby certify that: 1.

April 25, 2024 EX-32.A

Section 906 Certification Letter.

EXHIBIT 32a Certification by the Chief Executive Officer Pursuant to 18 U. S. C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 Pursuant to 18 U.S.C. Section 1350, I, Christopher Boerner, hereby certify that, to the best of my knowledge, Bristol-Myers Squibb Company’s Quarterly Report on Form 10-Q for the quarter ended March 31, 2024 (the "Report"), as filed wit

April 25, 2024 EX-31.A

Section 302 Certification Letter.

EXHIBIT 31a CERTIFICATION BY THE CHIEF EXECUTIVE OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, Christopher Boerner, certify that: 1.

April 25, 2024 10-Q

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2024 ☐ TRANSITION REPORT PURSUANT TO

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-Q ☒ QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the quarterly period ended March 31, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number 001-01136 BRISTOL-MYERS SQUIBB

April 25, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 25, 2024 BRISTOL-MYERS SQUI

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 25, 2024 BRISTOL-MYERS SQUIBB COMPANY (Exact name of registrant as specified in its charter) Delaware 001-01136 22-0790350 (State or other jurisdiction of incorporation or organ

April 25, 2024 EX-99.2

Q1 2024 Results April 25, 2024 Q1 2024 Results Not for Product Promotional Use Forward Looking Statements and Non-GAAP Financial Information 2 This presentation contains statements about Bristol-Myers Squibb Company’s (the “Company”) future financial

q12024earningspresentati Q1 2024 Results April 25, 2024 Q1 2024 Results Not for Product Promotional Use Forward Looking Statements and Non-GAAP Financial Information 2 This presentation contains statements about Bristol-Myers Squibb Company’s (the “Company”) future financial results, plans, business development strategy, anticipated clinical trials, results and regulatory approvals that constitute forward-looking statements for purposes of the safe harbor provisions under the Private Securities Litigation Reform Act of 1995.

April 25, 2024 EX-99.1

Bristol Myers Squibb Reports First Quarter Financial Results for 2024 Performance Reflects Execution and Actions to Strengthen the Company's Long-Term Growth Profile

Exhibit 99.1 Bristol Myers Squibb Reports First Quarter Financial Results for 2024 Performance Reflects Execution and Actions to Strengthen the Company's Long-Term Growth Profile •First Quarter Revenues were $11.9 Billion, increasing 5% (+6% Adjusting for Foreign Exchange) ◦Growth Portfolio Revenues were $4.8 Billion, increasing 8% (+11% Adjusting for Foreign Exchange) •Strengthened Long-Term Grow

April 25, 2024 EX-31.B

Section 302 Certification Letter.

EXHIBIT 31b CERTIFICATION BY THE CHIEF FINANCIAL OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, David V.

April 25, 2024 EX-32.B

Section 906 Certification Letter.

EXHIBIT 32b Certification by the Chief Financial Officer Pursuant to 18 U. S. C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 Pursuant to 18 U.S.C. Section 1350, I, David V. Elkins, hereby certify that, to the best of my knowledge, Bristol-Myers Squibb Company’s Quarterly Report on Form 10-Q for the quarter ended March 31, 2024 (the "Report"), as filed with th

April 22, 2024 DEFA14A

Bristol-Myers Squibb Company

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No. ) Filed by the Registrant ☒ Filed by a Party other than the Registrant  ☐ Check the appropriate box:  ☐ Preliminary Proxy Statement  ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2)) ☐ De

March 28, 2024 DEF 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.   )

TABLE OF CONTENTS UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.   ) Filed by the Registrant ☒ Filed by a Party other than the Registrant  ☐ Check the appropriate box:  ☐ Preliminary Proxy Statement  ☐ Confidential, for Use of the Commission Only (as permitted by Ru

March 28, 2024 DEFA14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.   )

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.   ) Filed by the Registrant ☒ Filed by a Party other than the Registrant  ☐ Check the appropriate box: ☐ Preliminary Proxy Statement  ☐ Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))  ☐

March 28, 2024 ARS

ARS

2023 Annual ReportOur Mission To discover, develop and deliver innovative medicines that help patients prevail over serious diseases Our Vision To be the world's leading biopharma company that transforms patients' lives through science Our Values Integrity • Innovation • Urgency Passion • Accountability • Inclusion Atiba Page is always a naturally happy person.

March 18, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 18, 2024 BRISTOL-MYERS SQUI

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 18, 2024 BRISTOL-MYERS SQUIBB COMPANY (Exact name of registrant as specified in its charter) Delaware 001-01136 22-0790350 (State or Other Jurisdiction of Incorporation) (Commis

March 18, 2024 EX-99.1

Bristol Myers Squibb Completes Acquisition of Karuna Therapeutics, Strengthening Neuroscience Portfolio KarXT, Karuna’s Lead Asset, Is a Potential First-in-Class Treatment for Schizophrenia with Multi-Billion Dollar Sales Potential Across Multiple In

Exhibit 99.1 Bristol Myers Squibb Completes Acquisition of Karuna Therapeutics, Strengthening Neuroscience Portfolio KarXT, Karuna’s Lead Asset, Is a Potential First-in-Class Treatment for Schizophrenia with Multi-Billion Dollar Sales Potential Across Multiple Indications PRINCETON, N.J. – March 18, 2024 – Bristol Myers Squibb (NYSE: BMY) today announced that it has successfully completed its acqu

March 18, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 13, 2024 BRISTOL-MYERS SQUI

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): March 13, 2024 BRISTOL-MYERS SQUIBB COMPANY (Exact name of registrant as specified in its charter) Delaware 001-01136 22-0790350 (State or other jurisdiction of incorporation or organ

March 18, 2024 PRE 14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.   )

TABLE OF CONTENTS UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A Proxy Statement Pursuant to Section 14(a) of the Securities Exchange Act of 1934 (Amendment No.   ) Filed by the Registrant ☒ Filed by a Party other than the Registrant  ☐ Check the appropriate box: ☒ Preliminary Proxy Statement  ☐ Confidential, for Use of the Commission Only (as permitted by Rul

February 23, 2024 EX-99.(A)(5)(XII)

Exhibit (a)(5)(xii)

Exhibit (a)(5)(xii) Bristol Myers Squibb Announces Expiration of RayzeBio Tender Offer PRINCETON, N.

February 23, 2024 SC TO-T/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR 13(e)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 3) RAYZEBIO, INC. (Name of Subject Company (Issuer)) R

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR 13(e)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 3) RAYZEBIO, INC. (Name of Subject Company (Issuer)) RUDOLPH MERGER SUB INC. (Offeror) A Wholly Owned Subsidiary of BRISTOL-MYERS SQUIBB COMPANY (Parent of Offeror) (Names of Filing Persons (identifying s

February 22, 2024 EX-1.1

UNDERWRITING AGREEMENT, dated as of February 14, 2024 Bristol-Myers Squibb Company $500,000,000 Floating Rate Notes due 2026 $1,000,000,000 4.950% Notes due 2026 $1,000,000,000 4.900% Notes due 2027 $1,750,000,000 4.900% Notes due 2029 $1,250,000,000

Exhibit 1.1 Execution Version UNDERWRITING AGREEMENT, dated as of February 14, 2024 Bristol-Myers Squibb Company $500,000,000 Floating Rate Notes due 2026 $1,000,000,000 4.950% Notes due 2026 $1,000,000,000 4.900% Notes due 2027 $1,750,000,000 4.900% Notes due 2029 $1,250,000,000 5.100% Notes due 2031 $2,500,000,000 5.200% Notes due 2034 $500,000,000 5.500% Notes due 2044 $2,750,000,000 5.550% Not

February 22, 2024 8-K

Entry into a Material Definitive Agreement, Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 22, 2024 (February 14, 2024) BRISTOL-MYERS SQUIBB COMPANY (Exact name of registrant as specified in its charter) Delaware 001-01136 22-0790350 (State or other jurisdiction of

February 22, 2024 EX-4.1

Fifteenth Supplemental Indenture, dated as of February 22, 2024, by and between Bristol-Myers Squibb Company and The Bank of New York Mellon, as Trustee, to the Indenture dated as of June 1, 1993

Exhibit 4.1 Execution Version BRISTOL-MYERS SQUIBB COMPANY and THE BANK OF NEW YORK MELLON, as Trustee FIFTEENTH SUPPLEMENTAL INDENTURE Dated as of February 22, 2024 to INDENTURE Dated as of June 1, 1993 $500,000,000 Floating Rate Notes due 2026 $1,000,000,000 4.950% Notes due 2026 $1,000,000,000 4.900% Notes due 2027 $1,750,000,000 4.900% Notes due 2029 $1,250,000,000 5.100% Notes due 2031 $2,500

February 16, 2024 424B5

$500,000,000 Floating Rate Notes due 2026 $1,000,000,000 4.950% Notes due 2026 $1,000,000,000 4.900% Notes due 2027 $1,750,000,000 4.900% Notes due 2029 $1,250,000,000 5.100% Notes due 2031 $2,500,000,000 5.200% Notes due 2034 $500,000,000 5.500% Not

TABLE OF CONTENTS Filed Pursuant to Rule 424(b)(5) Registration No. 333-261623 PROSPECTUS SUPPLEMENT (to Prospectus dated December 13, 2021) $13,000,000,000   $500,000,000 Floating Rate Notes due 2026 $1,000,000,000 4.950% Notes due 2026 $1,000,000,000 4.900% Notes due 2027 $1,750,000,000 4.900% Notes due 2029 $1,250,000,000 5.100% Notes due 2031 $2,500,000,000 5.200% Notes due 2034 $500,000,000 5

February 16, 2024 SC TO-T/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR 13(e)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 2) RAYZEBIO, INC. (Name of Subject Company (Issuer)) R

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR 13(e)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 2) RAYZEBIO, INC. (Name of Subject Company (Issuer))   RUDOLPH MERGER SUB INC. (Offeror) A Wholly Owned Subsidiary of BRISTOL-MYERS SQUIBB COMPANY (Parent of Offeror) (Names of Filing Persons (identifying

February 16, 2024 EX-FILING FEES

Calculation of Filing Fee Tables

Exhibit 107 Calculation of Filing Fee Tables 424(b)(5) (Form Type) Bristol-Myers Squibb Company (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered and Carry Forward Securities Security Type Security Class Title Fee Calculation or Carry Forward Rule(1) Amount Registered Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Carry Forward Form Type Carry Forward File Number Carry Forward Initial Effective Date Filing Fee Previously Paid In Connection with Unsold Securities to be Carried Forward Newly Registered Securities Fees to Be Paid Debt Floating Rate Notes due 2026 Rule 457(r) $500,000,000 100.

February 16, 2024 CORRESP

February 16, 2024

February 16, 2024 VIA EDGAR U.S. Securities and Exchange Commission Division of Corporation Finance 100 F Street, NE Washington, DC 20549 Attention: Laura McKenzie and Christina Chalk, Division of Corporation Finance, Office of Mergers & Acquisitions Re: Bristol-Myers Squibb Company RayzeBio, Inc. Schedule TO-T filed January 25, 2024 File No. 005-94159 Dear Ms. McKenzie and Ms. Chalk: This letter

February 15, 2024 FWP

Bristol-Myers Squibb Company Pricing Term Sheet February 14, 2024 $500,000,000 Floating Rate Notes due 2026 (the “Floating Rate Notes”) $1,000,000,000 4.950% Notes due 2026 (the “2026 Notes”) $1,000,000,000 4.900% Notes due 2027 (the “2027 Notes”) $1

Issuer Free Writing Prospectus, dated February 14, 2024 Filed Pursuant to Rule 433 of the Securities Act of 1933 Registration Statement No.

February 15, 2024 8-K

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers, Financial Statements and Exhibits

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 13, 2024 BRISTOL-MYERS SQUIBB COMPANY (Exact name of registrant as specified in its charter) Delaware 001-01136 22-0790350 (State or other jurisdiction of incorporation or or

February 14, 2024 8-K

Financial Statements and Exhibits, Other Events

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 14, 2024 BRISTOL-MYERS SQUIBB COMPANY (Exact name of registrant as specified in its charter) Delaware 001-01136 22-0790350 (State or other jurisdiction of incorporation or or

February 14, 2024 EX-99.1

Bristol Myers Squibb Recommends Stockholders Reject “Mini-Tender” Offer by Tutanota LLC

Exhibit 99.1 Bristol Myers Squibb Recommends Stockholders Reject “Mini-Tender” Offer by Tutanota LLC (Princeton, N.J., February 14, 2024) – Bristol Myers Squibb (NYSE: BMY) today announced that it recently became aware of an unsolicited “mini-tender” offer by Tutanota LLC (“Tutanota”) to purchase up to five hundred thousand shares of Bristol Myers Squibb’s common stock, representing significantly

February 13, 2024 EX-21

Subsidiaries of the Registrant (filed herewith).

EXHIBIT 21 Subsidiaries of Bristol-Myers Squibb Company The following are subsidiaries of the Bristol-Myers Squibb Company at December 31, 2023.

February 13, 2024 EX-31.B

Section 302 Certification Letter (filed herewith).

EXHIBIT 31b CERTIFICATION BY THE CHIEF FINANCIAL OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, David V.

February 13, 2024 EX-10.CC

Form of Restricted Stock Units Agreement with four year vesting under the 2021 Stock Award and Incentive Plan (

EXHIBIT 10cc RESTRICTED STOCK UNITS AGREEMENT UNDER THE BRISTOL-MYERS SQUIBB COMPANY 2021 STOCK AWARD AND INCENTIVE PLAN BRISTOL-MYERS SQUIBB COMPANY, a Delaware corporation (the “Company”), has granted to you an award of Restricted Stock Units (“RSUs” or “Award”) under the 2021 Stock Award and Incentive Plan (the “Plan”), on the terms and conditions specified in this Restricted Stock Units Agreement (including Addendum A and Addendum B, the “Agreement”), the Plan, and the Prospectus (which summarizes various aspects of the Plan, including your risk in participating in the Plan, restrictions on resales of delivered shares, federal income tax consequences, and other Plan information).

February 13, 2024 SC 13G/A

BMY / Bristol-Myers Squibb Company / VANGUARD GROUP INC - SCHEDULE 13G/A Passive Investment

SC 13G/A 1 tv0481-bristolmyerssquibbco.htm SCHEDULE 13G/A SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 Schedule 13G Under the Securities Exchange Act of 1934 (Amendment No.: 9)* Name of issuer: Bristol-Myers Squibb Co Title of Class of Securities: Common Stock CUSIP Number: 110122108 Date of Event Which Requires Filing of this Statement: December 29, 2023 Check the appropriate box to

February 13, 2024 EX-19

Standard Operating Procedure BMS-SOP-5k: Securities Trading (

EXHIBIT 19 Standard Operating Procedure BMS-SOP-5k: Securities Trading PURPOSE To provide the Bristol-Myers Squibb Company (BMS) principles and expectations to prevent the illegal trading of Securities based on Material Non-Public Information (or “Insider Trading”) and other restrictions on trading of Securities.

February 13, 2024 EX-10.DD

Form of Restricted Stock Units Agreement with three year vesting under the 2021 Stock Award and Incentive Plan (

EXHIBIT 10dd RESTRICTED STOCK UNITS AGREEMENT UNDER THE BRISTOL-MYERS SQUIBB COMPANY 2021 STOCK AWARD AND INCENTIVE PLAN BRISTOL-MYERS SQUIBB COMPANY, a Delaware corporation (the “Company”), has granted to you an award of Restricted Stock Units (“RSUs” or “Award”) under the 2021 Stock Award and Incentive Plan (the “Plan”), on the terms and conditions specified in this Restricted Stock Units Agreement (including Addendum A and Addendum B, the “Agreement”), the Plan, and the Prospectus (which summarizes various aspects of the Plan, including your risk in participating in the Plan, restrictions on resales of delivered shares, federal income tax consequences, and other Plan information).

February 13, 2024 EX-10.EE

Form of Restricted Stock Units Agreement with two-year cliff vesting with a one-year post-vest holding period under the 2021 Stock Award and Incentive Plan (

EXHIBIT 10ee RESTRICTED STOCK UNITS AGREEMENT UNDER THE BRISTOL-MYERS SQUIBB COMPANY 2021 STOCK AWARD AND INCENTIVE PLAN BRISTOL-MYERS SQUIBB COMPANY, a Delaware corporation (the “Company”), has granted to you an award of Restricted Stock Units (“RSUs” or “Award”) under the 2021 Stock Award and Incentive Plan (the “Plan”), on the terms and conditions specified in this Restricted Stock Units Agreement (including Addendum A and Addendum B, the “Agreement”), the Plan and the Prospectus (which summarizes various aspects of the Plan, including your risk in participating in the Plan, restrictions on resales of delivered shares, federal income tax consequences, and other Plan information).

February 13, 2024 EX-10.GG

Form of Market Share Units Agreement under the 2021 Stock Award and Incentive Plan (

EXHIBIT 10gg MARKET SHARE UNITS AGREEMENT UNDER THE BRISTOL-MYERS SQUIBB COMPANY 2021 STOCK AWARD AND INCENTIVE PLAN BRISTOL-MYERS SQUIBB COMPANY, a Delaware corporation (the “Company”), has granted to you an award of Market Share Units (“MSUs” or “Award”) under the 2021 Stock Award and Incentive Plan (the “Plan”), on the terms and conditions specified in this Market Share Units Agreement (including, Exhibit A, Addendum A and Addendum B, the “Agreement”), the Plan, and the Prospectus (which summarizes various aspects of the Plan, including your risk in participating in the Plan, restrictions on resales of delivered shares, federal income tax consequences, and other Plan information).

February 13, 2024 EX-32.B

Section 906 Certification Letter (filed herewith).

EXHIBIT 32b Certification by the Chief Financial Officer Pursuant to 18 U. S. C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 Pursuant to 18 U. S. C. Section 1350, I, David V. Elkins, hereby certify that, to the best of my knowledge, Bristol-Myers Squibb Company’s Annual Report on Form 10-K for the year ended December 31, 2023 (the Report), as filed with the S

February 13, 2024 EX-31.A

Section 302 Certification Letter (filed herewith).

EXHIBIT 31a CERTIFICATION BY THE CHIEF EXECUTIVE OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, Christopher Boerner, certify that: 1.

February 13, 2024 424B2

Subject to Completion, dated February 13, 2024

TABLE OF CONTENTS Filed Pursuant to Rule 424(b)(2) Registration No. 333-261623 Subject to Completion, dated February 13, 2024 The information in this preliminary prospectus supplement and the accompanying prospectus is not complete and may be changed. This preliminary prospectus supplement and the accompanying prospectus do not constitute an offer to sell or the solicitation of an offer to buy, no

February 13, 2024 EX-10.FF

Form of Restricted Stock Units Agreement with one-year cliff vesting with a two-year post-vest holding period under the 2021 Stock Award and Incentive Plan (

EXHIBIT 10ff RESTRICTED STOCK UNITS AGREEMENT UNDER THE BRISTOL-MYERS SQUIBB COMPANY 2021 STOCK AWARD AND INCENTIVE PLAN BRISTOL-MYERS SQUIBB COMPANY, a Delaware corporation (the “Company”), has granted to you an award of Restricted Stock Units (“RSUs” or “Award”) under the 2021 Stock Award and Incentive Plan (the “Plan”), on the terms and conditions specified in this Restricted Stock Units Agreement (including Addendum A and Addendum B, the “Agreement”), the Plan and the Prospectus (which summarizes various aspects of the Plan, including your risk in participating in the Plan, restrictions on resales of delivered shares, federal income tax consequences, and other Plan information).

February 13, 2024 EX-10.BB

Form of Restricted Stock Units Agreement with five year vesting under the 2021 Stock Award and Incentive Plan

EXHIBIT 10bb RESTRICTED STOCK UNITS AGREEMENT UNDER THE BRISTOL-MYERS SQUIBB COMPANY 2021 STOCK AWARD AND INCENTIVE PLAN BRISTOL-MYERS SQUIBB COMPANY, a Delaware corporation (the “Company”), has granted to you an award of Restricted Stock Units (“RSUs” or “Award”) under the 2021 Stock Award and Incentive Plan (the “Plan”), on the terms and conditions specified in this Restricted Stock Units Agreement (including Addendum A and Addendum B, the “Agreement”), the Plan, and the Prospectus (which summarizes various aspects of the Plan, including your risk in participating in the Plan, restrictions on resales of delivered shares, federal income tax consequences, and other Plan information).

February 13, 2024 EX-32.A

Section 906 Certification Letter (filed herewith).

EXHIBIT 32a Certification by the Chief Executive Officer Pursuant to 18 U. S. C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 Pursuant to 18 U. S. C. Section 1350, I, Christopher Boerner, hereby certify that, to the best of my knowledge, Bristol-Myers Squibb Company’s Annual Report on Form 10-K for the year ended December 31, 2023 (the Report), as filed with t

February 13, 2024 EX-97

Policies and Procedures for the Recoupment of

EXHIBIT 97 Policies and Procedures for the Recoupment of Compensation for Accounting Restatement Introduction/Purpose Bristol-Myers Squibb Company (the “Company”) believes that it is in the best interests of the Company and its shareholders to create and maintain a culture that emphasizes integrity and accountability and that reinforces the Company’s pay-for-performance compensation philosophy.

February 13, 2024 EX-10.I

incorporated herein by reference to Exhibit 10i to the Form 10-K for the fiscal year ended December 31, 2023

EXHIBIT 10i PERFORMANCE SHARE UNITS AGREEMENT UNDER THE BRISTOL-MYERS SQUIBB COMPANY 2021 STOCK AWARD AND INCENTIVE PLAN 2024-2026 Performance Share Units Award BRISTOL-MYERS SQUIBB COMPANY, a Delaware corporation (the “Company”), has granted to you an award of Performance Share Units (“PSUs” or “Award”) under the 2021 Stock Award and Incentive Plan (the “Plan”), on the terms and conditions specified in this Performance Share Units Agreement (including, Exhibit A, Addendum A and Addendum B, the “Agreement”), the Plan, and the Prospectus (which summarizes various aspects of the Plan, including your risk in participating in the Plan, restrictions on resales of delivered shares, federal income tax consequences, and other Plan information).

February 13, 2024 10-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 ☐ TRANSITION REPORT PURSUANT TO SECTI

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the transition period from to Commission File Number 001-01136 BRISTOL-MYERS SQUIBB COMPA

February 12, 2024 SC TO-T/A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR 13(e)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 1) RAYZEBIO, INC. (Name of Subject Company (Issuer)) R

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR 13(e)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 1) RAYZEBIO, INC. (Name of Subject Company (Issuer))   RUDOLPH MERGER SUB INC. (Offeror) A Wholly Owned Subsidiary of BRISTOL-MYERS SQUIBB COMPANY (Parent of Offeror) (Names of Filing Persons (identifying

February 12, 2024 EX-99.(A)(5)(XI)

Bristol Myers Squibb and RayzeBio Announce Expiration of HSR Act Waiting Period

Exhibit (a)(5)(xi) Bristol Myers Squibb and RayzeBio Announce Expiration of HSR Act Waiting Period PRINCETON, NJ & SAN DIEGO, CA – February 12, 2024 – Bristol Myers Squibb (NYSE: BMY) and RayzeBio, Inc.

February 2, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 2, 2024 BRISTOL-MYERS SQ

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): February 2, 2024 BRISTOL-MYERS SQUIBB COMPANY (Exact name of registrant as specified in its charter) Delaware 001-01136 22-0790350 (State or other jurisdiction of incorporation or org

February 2, 2024 EX-99.2

Q4 2023 Results February 2, 2024 Q4 2023 Results Not for Product Promotional Use Forward Looking Statements and Non-GAAP Financial Information 2 This presentation contains statements about Bristol-Myers Squibb Company’s (the “Company”) future financi

q42023earningspresentati Q4 2023 Results February 2, 2024 Q4 2023 Results Not for Product Promotional Use Forward Looking Statements and Non-GAAP Financial Information 2 This presentation contains statements about Bristol-Myers Squibb Company’s (the “Company”) future financial results, plans, business development strategy, anticipated clinical trials, results and regulatory approvals that constitute forward-looking statements for purposes of the safe harbor provisions under the Private Securities Litigation Reform Act of 1995.

February 2, 2024 EX-99.1

Bristol Myers Squibb Reports Fourth Quarter and Full-Year Financial Results for 2023 Results Reflect Continued Strength of In-Line and New Products, Pipeline Execution and Business Development Activity, Supporting Growth Momentum into 2024

Exhibit 99.1 Bristol Myers Squibb Reports Fourth Quarter and Full-Year Financial Results for 2023 Results Reflect Continued Strength of In-Line and New Products, Pipeline Execution and Business Development Activity, Supporting Growth Momentum into 2024 •Reports Fourth Quarter Revenues of $11.5 Billion; GAAP EPS of $0.87 and Non-GAAP EPS of $1.70 ◦In-Line and New Product Portfolio Revenues Increase

January 25, 2024 EX-99.(A)(1)(II)

LETTER OF TRANSMITTAL to Tender Shares of Common Stock RAYZEBIO, INC. $62.50 Net per Share Pursuant to the Offer to Purchase Dated January 25, 2024 RUDOLPH MERGER SUB INC. a wholly owned subsidiary of BRISTOL-MYERS SQUIBB COMPANY THE OFFER AND WITHDR

Exhibit (a)(1)(ii) LETTER OF TRANSMITTAL   to Tender Shares of Common Stock   of RAYZEBIO, INC.

January 25, 2024 SC 13G/A

BMY / Bristol-Myers Squibb Company / BlackRock Inc. Passive Investment

SC 13G/A 1 us1101221083012524.txt us1101221083012524.txt SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No: 14) BRISTOL MYERS SQUIBB CO - (Name of Issuer) Common Stock - (Title of Class of Securities) 110122108 - (CUSIP Number) December 31, 2023 - (Date of Event Which Requires Filing of this Statement) Check the appropria

January 25, 2024 EX-99.(A)(1)(III)

Offer to Purchase for Cash All Outstanding Shares of Common Stock RAYZEBIO, INC. $62.50 Net Per Share Pursuant to the Offer to Purchase Dated January 25, 2024 RUDOLPH MERGER SUB INC. a wholly owned subsidiary of Bristol-Myers Squibb Company THE OFFER

Exhibit (a)(1)(iii) Offer to Purchase for Cash All Outstanding Shares of Common Stock   of   RAYZEBIO, INC.

January 25, 2024 EX-99.(A)(1)(V)

Notice of Offer to Purchase for Cash All Outstanding Shares of Common Stock RAYZEBIO, INC. at $62.50 Net Per Share by RUDOLPH MERGER SUB INC. a wholly owned subsidiary of BRISTOL-MYERS SQUIBB COMPANY

Exhibit (a)(1)(v) This announcement is neither an offer to purchase nor a solicitation of an offer to sell Shares (as defined below).

January 25, 2024 EX-99.(A)(1)(IV)

Offer to Purchase for Cash All Outstanding Shares of Common Stock RAYZEBIO, INC. $62.50 Net Per Share Pursuant to the Offer to Purchase Dated January 25, 2024 RUDOLPH MERGER SUB INC. a wholly owned subsidiary of Bristol-Myers Squibb Company THE OFFER

Exhibit (a)(1)(iv) Offer to Purchase for Cash All Outstanding Shares of Common Stock   of   RAYZEBIO, INC.

January 25, 2024 SC TO-T

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR 13(e)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 RAYZEBIO, INC. (Name of Subject Company (Issuer)) RUDOLPH MERGER SUB

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR 13(e)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 RAYZEBIO, INC. (Name of Subject Company (Issuer))   RUDOLPH MERGER SUB INC. (Offeror) A Wholly Owned Subsidiary of BRISTOL-MYERS SQUIBB COMPANY (Parent of Offeror) (Names of Filing Persons (identifying status as offeror

January 25, 2024 EX-99.(D)(2)

[Remainder of page intentionally left blank; signature page follows]

Exhibit (d)(2) JOINDER This Joinder to the Agreement and Plan of Merger (this “Joinder”), is made and entered into as of December 26, 2023, by Rudolph Merger Sub Inc.

January 25, 2024 EX-FILING FEES

Calculation of Filing Fee Tables Schedule TO-T (Rule 14d-100) RAYZEBIO, INC. (Name of Subject Company (Issuer)) RUDOLPH MERGER SUB INC. a wholly owned subsidiary of BRISTOL-MYERS SQUIBB COMPANY (Names of Filing Persons (Offerors))

Exhibit 107 Calculation of Filing Fee Tables Schedule TO-T (Rule 14d-100) RAYZEBIO, INC.

January 25, 2024 EX-99.(A)(1)(I)

Offer to Purchase for Cash All Outstanding Shares of Common Stock RAYZEBIO, INC. $62.50 Net Per Share RUDOLPH MERGER SUB INC. a wholly owned subsidiary of BRISTOL-MYERS SQUIBB COMPANY THE OFFER AND WITHDRAWAL RIGHTS EXPIRE ONE MINUTE FOLLOWING 11:59

TABLE OF CONTENTS Exhibit (a)(1)(i) Offer to Purchase for Cash   All Outstanding Shares of Common Stock   of   RAYZEBIO, INC.

January 25, 2024 EX-99.(D)(3)

CONFIDENTIALITY AGREEMENT

Exhibit (d)(3) CONFIDENTIALITY AGREEMENT THIS CONFIDENTIALITY AGREEMENT (“Agreement”) is being entered into as of December 16, 2023, between RayzeBio, Inc.

January 8, 2024 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 8, 2024 BRISTOL-MYERS SQU

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): January 8, 2024 BRISTOL-MYERS SQUIBB COMPANY (Exact Name of Registrant as Specified in its Charter) Delaware 1-1136 22-0790350 (State or Other Jurisdiction of Incorporation) (Commissi

January 8, 2024 EX-99.1

January 8, 2024 J.P. Morgan Presentation Forward looking statements and non-GAAP financial information 2 This presentation (as well as the oral statements made with respect to information contained in this presentation) contains statements about Bris

Exhibit 99.1 January 8, 2024 J.P. Morgan Presentation Forward looking statements and non-GAAP financial information 2 This presentation (as well as the oral statements made with respect to information contained in this presentation) contains statements about Bristol-Myers Squibb Company’s (the “Company”) future financial results, plans, business development strategy, anticipated clinical trials, r

December 26, 2023 EX-99.5

Letter to RayzeBio Employees dated December 26, 2023

Exhibit 99.5 BMS-RYZB Letter to RYZB Employees Subject: Welcome to the Bristol Myers Squibb Team! To: RayzeBio Employees Date: December 26, 2023 Dear RayzeBio Team, On behalf of everyone at Bristol Myers Squibb, I am writing to share how excited we are about the proposed transaction. We deeply admire what RayzeBio has accomplished, and all of us at BMS are impressed by your technology, differentia

December 26, 2023 EX-99.4

Enterprise Letter dated December 26, 2023

Exhibit 99.4 BMS-RYZB BMS Employee Letter Subject: Broadening our Oncology Capabilities with Acquisition of RayzeBio To: Bristol Myers Squibb Employees Date: December 26, 2023 Dear Colleagues, We hope that you are reading this following a quiet and restful Shutdown Week. We are excited to share that today, December 26, 2023, we announced an agreement to acquire RayzeBio, a radiopharmaceutical ther

December 26, 2023 EX-99.3

Bristol Myers Squibb Social Media Content dated December 26, 2023

Exhibit 99.3 Social Media Content Twitter/X LinkedIn Additional Information about the Tender Offer and Where to Find It The tender offer described in this communication has not yet commenced. This communication is for informational purposes only and is neither an offer to purchase nor a solicitation of an offer to sell any shares of the common stock of RayzeBio or any other securities, nor is it a

December 26, 2023 SC TO-C

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR 13(e)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 RAYZEBIO, INC. (Name of Subject Company (Issuer)) RUDOLPH MERGER SUB

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE TO TENDER OFFER STATEMENT UNDER SECTION 14(d)(1) OR 13(e)(1) OF THE SECURITIES EXCHANGE ACT OF 1934 RAYZEBIO, INC. (Name of Subject Company (Issuer)) RUDOLPH MERGER SUB INC. (Offeror) A Wholly Owned Subsidiary of BRISTOL-MYERS SQUIBB COMPANY (Offeror) (Name of Filing Persons (identifying status as offeror, issuer or o

December 26, 2023 EX-99.2

Transaction Infographic dated December 26, 2023

Exhibit 99.2 Bristol Myers Squibb Adds Premier Radiopharmaceutical Platform with Acquisition of RayzeBio Transaction Brings RayzeBio’s Differentiated Actinium-Based Radiopharmaceutical Platform » Lead program, RYZ101, in Phase 3 development for treatment of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) and early-stage development for treatment of small cell lung cancer and potentially ot

December 26, 2023 EX-99.1

Joint Press Release dated December 26, 2023

Exhibit 99.1 Bristol Myers Squibb Adds Premier Radiopharmaceutical Platform with Acquisition of RayzeBio Transaction Brings RayzeBio’s Differentiated Actinium-Based Radiopharmaceutical Platform, Including Rich Pipeline of Multiple Drug Development Programs, to Bristol Myers Squibb’s Leading Oncology Franchise Lead Program, RYZ101, in Phase 3 Development for Treatment of Gastroenteropancreatic Neur

December 22, 2023 EX-99.1

Bristol Myers Squibb Strengthens Neuroscience Portfolio with Acquisition of Karuna Therapeutics Transaction Delivers KarXT, a First-in-Class M1 / M4 Muscarinic Receptor Agonist, with Differentiated Efficacy and Safety KarXT Is a Potential First-in-Cl

Exhibit 99.1 Bristol Myers Squibb Strengthens Neuroscience Portfolio with Acquisition of Karuna Therapeutics Transaction Delivers KarXT, a First-in-Class M1 / M4 Muscarinic Receptor Agonist, with Differentiated Efficacy and Safety KarXT Is a Potential First-in-Class Treatment for Schizophrenia and as an Adjunctive Therapy, and First-in-Disease Treatment for Alzheimer’s Disease Psychosis, with Prom

December 22, 2023 DFAN14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 22, 2023 BRISTOL-MYERS S

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 22, 2023 BRISTOL-MYERS SQUIBB COMPANY (Exact name of registrant as specified in its charter) Delaware 001-01136 22-0790350 (State or Other Jurisdiction of Incorporation) (Com

December 22, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 22, 2023 BRISTOL-MYERS S

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): December 22, 2023 BRISTOL-MYERS SQUIBB COMPANY (Exact name of registrant as specified in its charter) Delaware 001-01136 22-0790350 (State or Other Jurisdiction of Incorporation) (Com

December 22, 2023 EX-99.1

Bristol Myers Squibb Strengthens Neuroscience Portfolio with Acquisition of Karuna Therapeutics Transaction Delivers KarXT, a First-in-Class M1 / M4 Muscarinic Receptor Agonist, with Differentiated Efficacy and Safety KarXT Is a Potential First-in-Cl

Exhibit 99.1 Bristol Myers Squibb Strengthens Neuroscience Portfolio with Acquisition of Karuna Therapeutics Transaction Delivers KarXT, a First-in-Class M1 / M4 Muscarinic Receptor Agonist, with Differentiated Efficacy and Safety KarXT Is a Potential First-in-Class Treatment for Schizophrenia and as an Adjunctive Therapy, and First-in-Disease Treatment for Alzheimer’s Disease Psychosis, with Prom

December 22, 2023 DFAN14A

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 14A (Rule 14a-101) PROXY STATEMENT PURSUANT TO SECTION 14(a) OF THE SECURITIES EXCHANGE ACT OF 1934 (AMENDMENT NO. ) Filed by the Registrant ☐ Filed by a Party other than the Registrant ☒ Check the appropriate box: ☐ Preliminary Proxy Statement ☐ Confidential, for Use of the Commission Only (as permitted by Rule14a-6(

December 4, 2023 SC 13G

RNA / Avidity Biosciences Inc / BRISTOL MYERS SQUIBB CO - SC 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No.)* Avidity Biosciences, Inc. (Name of Issuer) Common Stock, par value $0.0001 per share (Title of Class of Securities) 05370A108 (CUSIP Number) November 27, 2023 (Date of Event Which Requires Filing of This Statement) Check the appropriate box to designate th

November 13, 2023 8-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 13, 2023 (October 30, 20

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): November 13, 2023 (October 30, 2023) BRISTOL-MYERS SQUIBB COMPANY (Exact name of registrant as specified in its charter) Delaware 001-01136 22-0790350 (State or other jurisdiction of

November 13, 2023 EX-4.1

Fourteenth Supplemental Indenture, dated as of November 13, 2023, by and between Bristol-Myers Squibb Company and The Bank of New York Mellon, as Trustee, to the Indenture dated as of June 1, 1993 (incorporated herein by reference to Exhibit 4.1 to the Form 8-K

Exhibit 4.1 Bristol-Myers Squibb Company and THE BANK OF NEW YORK MELLON, as Trustee FOURTEENTH SUPPLEMENTAL INDENTURE Dated as of November 13, 2023 to INDENTURE Dated as of June 1, 1993 $1,000,000,000 5.750% Notes due 2031 $1,000,000,000 5.900% Notes due 2033 $1,250,000,000 6.250% Notes due 2053 $1,250,000,000 6.400% Notes due 2063 TABLE OF CONTENTS Page ARTICLE I DEFINITIONS 2 Section 1.01 Defin

November 13, 2023 EX-1.1

UNDERWRITING AGREEMENT, dated as of October 30, 2023 Bristol-Myers Squibb Company $1,000,000,000 5.750% Notes due 2031 $1,000,000,000 5.900% Notes due 2033 $1,250,000,000 6.250% Notes due 2053 $1,250,000,000 6.400% Notes due 2063

Exhibit 1.1 Execution Version UNDERWRITING AGREEMENT, dated as of October 30, 2023 Bristol-Myers Squibb Company $1,000,000,000 5.750% Notes due 2031 $1,000,000,000 5.900% Notes due 2033 $1,250,000,000 6.250% Notes due 2053 $1,250,000,000 6.400% Notes due 2063 New York, New York October 30, 2023 To the Representatives named in Schedule I hereto of the Underwriters named in Schedule II hereto Ladies

November 1, 2023 EX-FILING FEES

Calculation of Filing Fee Tables

Exhibit 107 Calculation of Filing Fee Tables 424(b)(5) (Form Type) Bristol-Myers Squibb Company (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered and Carry Forward Securities Security Type Security Class Title Fee Calculation or Carry Forward Rule(1) Amount Registered Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Carry Forward Form Type Carry Forward File Number Carry Forward Initial Effective Date Filing Fee Previously Paid In Connection with Unsold Securities to be Carried Forward Newly Registered Securities Fees to Be Paid Debt 5.

November 1, 2023 424B5

$1,000,000,000 5.750% Notes due 2031 $1,000,000,000 5.900% Notes due 2033 $1,250,000,000 6.250% Notes due 2053 $1,250,000,000 6.400% Notes due 2063

TABLE OF CONTENTS Filed Pursuant to Rule 424(b)(5) Registration Statement No. 333-261623 PROSPECTUS SUPPLEMENT (to Prospectus dated December 13, 2021) $4,500,000,000   $1,000,000,000 5.750% Notes due 2031 $1,000,000,000 5.900% Notes due 2033 $1,250,000,000 6.250% Notes due 2053 $1,250,000,000 6.400% Notes due 2063 We are offering $1,000,000,000 aggregate principal amount of 5.750% Notes due 2031 (

October 31, 2023 8-K/A

Departure of Directors or Certain Officers; Election of Directors; Appointment of Certain Officers; Compensatory Arrangements of Certain Officers

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 8-K/A (Amendment No. 1) CURRENT REPORT Pursuant to Section 13 OR 15(d) of The Securities Exchange Act of 1934 Date of Report (Date of earliest event reported): April 21, 2023 BRISTOL-MYERS SQUIBB COMPANY (Exact name of registrant as specified in its charter) Delaware 001-01136 22-0790350 (State or other jurisdiction of in

October 30, 2023 FWP

Bristol-Myers Squibb Company Pricing Term Sheet October 30, 2023 $1,000,000,000 5.750% Notes due 2031 (the “2031 Notes”) $1,000,000,000 5.900% Notes due 2033 (the “2033 Notes”) $1,250,000,000 6.250% Notes due 2053 (the “2053 Notes”) $1,250,000,000 6.

Issuer Free Writing Prospectus, dated October 30, 2023 Filed Pursuant to Rule 433 of the Securities Act of 1933 Registration Statement No.

October 30, 2023 424B3

Subject to Completion, dated October 30, 2023

TABLE OF CONTENTS The information in this preliminary prospectus supplement and the accompanying prospectus is not complete and may be changed.

October 26, 2023 EX-31.B

Section 302 Certification Letter.

EXHIBIT 31b CERTIFICATION BY THE CHIEF FINANCIAL OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, David V.

October 26, 2023 EX-99.1

Bristol Myers Squibb Reports Third Quarter Financial Results for 2023

Exhibit 99.1 Bristol Myers Squibb Reports Third Quarter Financial Results for 2023 •Reports Third Quarter Revenues of $11.0 Billion •Posts Third Quarter GAAP Earnings Per Share of $0.93 and Non-GAAP EPS of $2.00; Includes Net Impact of ($0.03) Per Share for GAAP and Non-GAAP EPS Due to Acquired IPRD Charges and Licensing Income •Reports Third Quarter Revenue Growth for In-Line Products and New Pro

October 26, 2023 EX-32.A

Section 906 Certification Letter.

EXHIBIT 32a Certification by the Chief Executive Officer Pursuant to 18 U. S. C. Section 1350, as Adopted Pursuant to Section 906 of the Sarbanes-Oxley Act of 2002 Pursuant to 18 U.S.C. Section 1350, I, Giovanni Caforio, hereby certify that, to the best of my knowledge, Bristol-Myers Squibb Company’s Quarterly Report on Form 10-Q for the quarter ended September 30, 2023 (the "Report"), as filed wi

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