NRSN / NeuroSense Therapeutics Ltd. - Arquivamentos da SEC, Relatório Anual, Declaração de Procuração

NeuroSense Therapeutics Ltd.

Estatísticas Básicas
CIK 1875091
SEC Filings
All companies that sell securities in the United States must register with the Securities and Exchange Commission (SEC) and file reports on a regular basis. These reports include company annual reports (10K, 10Q), news updates (8K), investor presentations (found in 8Ks), insider trades (form 4), ownership reports (13D, and 13G), and reports related to the specific securities sold, such as registration statements and prospectus. This page shows recent SEC filings related to NeuroSense Therapeutics Ltd.
SEC Filings (Chronological Order)
Esta página fornece uma lista completa e cronológica de Arquivamentos da SEC, excluindo os arquivamentos de propriedade que fornecemos em outro lugar.
April 28, 2026 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of April 2026 Commission File Number: 001-4108

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of April 2026 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliya 4

April 28, 2026 EX-99.1

NeuroSense Announces Pricing of Insider-Led PIPE Financing

Exhibit 99.1 NeuroSense Announces Pricing of Insider-Led PIPE Financing Financing led by CEO Alon Ben-Noon and CFO Or Eisenberg, alongside participation from an existing significant shareholder CAMBRIDGE, Mass., April. 28, 2026 /PRNewswire/ - NeuroSense Therapeutics Ltd. (Nasdaq: NRSN) ("NeuroSense"), a late-clinical stage biotechnology company developing novel treatments for severe neurodegenerat

April 24, 2026 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of April 2026 Commission File Number: 001-4108

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of April 2026 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliya 4

April 6, 2026 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of April 2026 Commission File Number: 001-4108

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of April 2026 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliya 4

April 6, 2026 EX-99.1

NeuroSense Granted Brazilian Patent Covering PrimeC Composition

Exhibit 99.1 NeuroSense Granted Brazilian Patent Covering PrimeC Composition ● Patent Protection Through October 2042 ● Follows prior patent grants in the U.S. and Australia ● Further strengthens NeuroSense’s global intellectual property portfolio CAMBRIDGE, Mass., April. 6, 2026 /PRNewswire/ - NeuroSense Therapeutics Ltd. (Nasdaq: NRSN) (“NeuroSense” or the “Company”), a late-clinical stage biote

April 3, 2026 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of April 2026 Commission File Number: 001-4108

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of April 2026 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliya 4

April 3, 2026 EX-99.1

NeuroSense Therapeutics Announces Receipt of Nasdaq Notifications Regarding Minimum Bid Price and Market Value Requirements

Exhibit 99.1 NeuroSense Therapeutics Announces Receipt of Nasdaq Notifications Regarding Minimum Bid Price and Market Value Requirements ● Notifications have no immediate effect on the listing or trading of the Company’s securities on Nasdaq ● Nasdaq has provided the Company until September 29, 2026 to regain compliance with both requirements ● The Company is actively evaluating actions to regain

March 31, 2026 EX-13.2

CERTIFICATION BY CHIEF FINANCIAL OFFICER PURSUANT TO SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

Exhibit 13.2 CERTIFICATION BY CHIEF FINANCIAL OFFICER PURSUANT TO SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002 In connection with the Annual Report of NeuroSense Therapeutics Ltd. (the “Company”) on Form 20-F for the period ended December 31, 2025 as filed with the Securities and Exchange Commission on the date hereof (the “Report”), the undersigned officer of the Company certifies, pursuant to 1

March 31, 2026 EX-2.1

DESCRIPTION OF SHARE CAPITAL AND ARTICLES OF ASSOCIATION

Exhibit 2.1 DESCRIPTION OF SHARE CAPITAL AND ARTICLES OF ASSOCIATION The following descriptions of our share capital and provisions of our amended and restated articles of association are summaries and are qualified by reference to the amended and restated articles of association, which are filed as an exhibit to this Annual Report on Form 20-F. General Our authorized share capital consists of 200

March 31, 2026 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of March 2026 Commission File Number: 001-4108

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of March 2026 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) 11 HaMenofim Street, Building B Herzliya 4672562 Israel +972-9-7996183

March 31, 2026 EX-99.1

NeuroSense Therapeutics Reports Year End 2025 Financial Results and Provides Business Update

Exhibit 99.1 NeuroSense Therapeutics Reports Year End 2025 Financial Results and Provides Business Update ● 2025 marked transition of PrimeC into a late-stage clinical asset with FDA-cleared Phase 3 program in ALS ● Statistically significant survival benefit demonstrated, including 65% reduction in risk of death and >14-month median survival advantage ● Results published in JAMA Neurology, providi

March 31, 2026 EX-1.1

AMENDED AND RESTATED ARTICLES OF ASSOCIATION NeuroSense Therapeutics LTD.

Exhibit 1.1 AMENDED AND RESTATED ARTICLES OF ASSOCIATION of NeuroSense Therapeutics LTD. 1. INTERPRETATION 1.1. In these Articles the following terms shall bear the meanings set opposite to them, unless the context otherwise requires: Terms Meanings Articles These Amended and Restated Articles of Association as may be amended from time to time. Auditor As defined under the Companies Law. Board The

March 31, 2026 EX-13.1

CERTIFICATION BY CHIEF EXECUTIVE OFFICER PURSUANT TO SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

Exhibit 13.1 CERTIFICATION BY CHIEF EXECUTIVE OFFICER PURSUANT TO SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002 In connection with the Annual Report of NeuroSense Therapeutics Ltd. (the “Company”) on Form 20-F for the period ended December 31, 2025 as filed with the Securities and Exchange Commission on the date hereof (the “Report”), the undersigned officer of the Company certifies, pursuant to 1

March 31, 2026 EX-12.2

CERTIFICATION BY CHIEF FINANCIAL OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002

Exhibit 12.2 CERTIFICATION BY CHIEF FINANCIAL OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, Or Eisenberg, certify that: 1. I have reviewed this annual report on Form 20-F of NeuroSense Therapeutics Ltd.; 2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in lig

March 31, 2026 20-F

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 20-F ☐ REGISTRATION STATEMENT PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHA

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 20-F ☐ REGISTRATION STATEMENT PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2025 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT O

March 31, 2026 EX-15.1

Consent of Independent Registered Public Accounting Firm

Exhibit 15.1 Consent of Independent Registered Public Accounting Firm We consent to the incorporation by reference in the registration statements (No. 333-262480 and 333-289658) on Form S-8 and (No. 333-269306, No. 333-284051, 333-283656, 333-260338, 333-291122 and 333-293060) on Form F-3 of our report dated March 31, 2026, with respect to the consolidated financial statements of Neurosense Therap

March 31, 2026 EX-12.1

CERTIFICATION BY CHIEF EXECUTIVE OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002

Exhibit 12.1 CERTIFICATION BY CHIEF EXECUTIVE OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, Alon Ben-Noon, certify that: 1. I have reviewed this annual report on Form 20-F of NeuroSense Therapeutics Ltd.; 2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in li

March 24, 2026 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of March 2026 Commission File Number: 001-4108

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of March 2026 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliya 4

March 24, 2026 EX-99.1

NeuroSense Advances Toward Key Regulatory Milestones with Strengthened Data Package and Near-Term Alzheimer’s Readout

Exhibit 99.1 NeuroSense Advances Toward Key Regulatory Milestones with Strengthened Data Package and Near-Term Alzheimer’s Readout CAMBRIDGE, Mass., March 24, 2026 /PRNewswire/ - NeuroSense Therapeutics Ltd. (NASDAQ: NRSN) (“NeuroSense”), a late-stage clinical biotechnology company focused on developing disease-modifying treatments for neurodegenerative diseases, today provided an update on key re

March 16, 2026 EX-99.1

JAMA Neurology Publishes Results from PARADIGM Phase 2b Trial of PrimeC in ALS Demonstrating Meaningful Clinical Outcomes and Biological Activity The Journal of the American Medical Association (JAMA Neurology) publication highlights consistent clini

Exhibit 99.1 JAMA Neurology Publishes Results from PARADIGM Phase 2b Trial of PrimeC in ALS Demonstrating Meaningful Clinical Outcomes and Biological Activity The Journal of the American Medical Association (JAMA Neurology) publication highlights consistent clinical and biomarker findings from NeuroSense PARADIGM Phase 2b trial in ALS, including slower functional decline, reduced risk of ALS-relat

March 16, 2026 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of March 2026 Commission File Number: 001-4108

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of March 2026 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliya 4

March 11, 2026 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of March 2026 Commission File Number: 001-4108

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of March 2026 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) 11 HaMenofim Street, Building B Herzliya 4672562 Israel +972-9-9531142

February 18, 2026 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of February 2026 Commission File Number: 001-4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of February 2026 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliy

February 18, 2026 EX-99.1

NeuroSense Announces Statistically Significant 65% Reduction in Risk of Death and Greater than 14-Month Median Survival Benefit with PrimeC in ALS

Exhibit 99.1 NeuroSense Announces Statistically Significant 65% Reduction in Risk of Death and Greater than 14-Month Median Survival Benefit with PrimeC in ALS CAMBRIDGE, Mass., Feb. 18, 2026 /PRNewswire/ - NeuroSense Therapeutics Ltd. (Nasdaq: NRSN) (“NeuroSense”), a late-stage clinical biotechnology company focused on developing disease-modifying treatments for neurodegenerative diseases, today

February 13, 2026 EX-99.1

11 Hamenofim St., Building B, Herzliya 4672562, Israel NOTICE OF SPECIAL MEETING OF SHAREHOLDERS TO BE HELD ON MARCH 10, 2026

Exhibit 99.1 11 Hamenofim St., Building B, Herzliya 4672562, Israel NOTICE OF SPECIAL MEETING OF SHAREHOLDERS TO BE HELD ON MARCH 10, 2026 Dear NeuroSense Therapeutics Ltd. Shareholders: We cordially invite you to attend a Special Meeting of Shareholders (the “Meeting”) of NeuroSense Therapeutics Ltd. (the “Company”) to be held at 4:00 p.m. (Israel time) on March 10, 2026 at our offices at 11 Hame

February 13, 2026 EX-99.2

PROXY CARD

Exhibit 99.2

February 13, 2026 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of February 2026 Commission File Number: 001-4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of February 2026 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliy

February 9, 2026 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of February 2026 Commission File Number: 001-4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of February 2026 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliy

February 9, 2026 EX-99.1

NeuroSense Expands Global IP Protection Strategy With Granted Australian Patent Covering PrimeC Composition Strengthens Global IP Portfolio for PrimeC Through 2042

Exhibit 99.1 NeuroSense Expands Global IP Protection Strategy With Granted Australian Patent Covering PrimeC Composition Strengthens Global IP Portfolio for PrimeC Through 2042 CAMBRIDGE, Mass., Feb. 9, 2026 /PRNewswire/ - NeuroSense Therapeutics Ltd. (Nasdaq: NRSN) (“NeuroSense”), a late-clinical stage biotechnology company developing novel treatments for severe neurodegenerative diseases, today

January 29, 2026 EX-FILING FEES

CALCULATION OF FILING FEE TABLES NeuroSense Therapeutics Ltd. Table 1: Newly Registered and Carry Forward Securities

Ex-Filing Fees CALCULATION OF FILING FEE TABLES F-3 NeuroSense Therapeutics Ltd. Table 1: Newly Registered and Carry Forward Securities Line Item Type Security Type Security Class Title Notes Fee Calculation or Carry Forward Rule Amount Registered Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Carry Forward Form Type Carry Forward File

January 29, 2026 F-3

As filed with the Securities and Exchange Commission on January 29, 2026

As filed with the Securities and Exchange Commission on January 29, 2026 Registration No.

January 6, 2026 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of January 2026 Commission File Number: 001-41

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of January 2026 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) 11 HaMenofim Street, Building B Herzliya 4672562 Israel +972-9-953114

December 22, 2025 EX-99.1

NeuroSense Confirms Favorable Safety and Tolerability of PrimeC in an Alzheimer’s Phase 2 Study

Exhibit 99.1 NeuroSense Confirms Favorable Safety and Tolerability of PrimeC in an Alzheimer’s Phase 2 Study Clinical and Biomarker Outcomes Expected to Be Reported in Q1 2026 CAMBRIDGE, Mass., Dec. 22, 2025 /PRNewswire/ - NeuroSense Therapeutics Ltd. (NASDAQ: NRSN) (“NeuroSense”), a late-clinical stage biotechnology company developing novel treatments for severe neurodegenerative diseases, today

December 22, 2025 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of December 2025 Commission File Number: 001-4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of December 2025 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliy

December 8, 2025 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of December 2025 Commission File Number: 001-4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of December 2025 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) 11 HaMenofim Street, Building B Herzliya 4672562 Israel +972-9-79961

December 4, 2025 EX-99.1

NeuroSense to Hold Pre-NDS Meeting with Health Canada in April 2026

Exhibit 99.1 NeuroSense to Hold Pre-NDS Meeting with Health Canada in April 2026 CAMBRIDGE, Mass., Dec. 4, 2025 /PRNewswire/ - NeuroSense Therapeutics Ltd. (NASDAQ: NRSN) (“NeuroSense”), a late-clinical stage biotechnology company developing novel treatments for severe neurodegenerative diseases, today announced that following a productive discussion with Health Canada (“Agency”), the Company is r

December 4, 2025 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of December 2025 Commission File Number: 001-4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of December 2025 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliy

November 26, 2025 424B3

333,334 Ordinary Shares

PROSPECTUS Filed pursuant to Rule 424(b)(3) Registration No. 333 - 291122 333,334 Ordinary Shares This prospectus relates to the resale, from time to time, by the selling shareholder identified in this prospectus under the section “Selling Shareholder,” (the “selling shareholder”) of NeuroSense Therapeutics Ltd. (“NeuroSense,” “we,” “us” or the “Company”) of 333,334 of our ordinary shares, no par

November 24, 2025 EX-99.1

NeuroSense Receives FDA Clearance to Initiate Pivotal Phase 3 Trial for PrimeC in ALS

Exhibit 99.1 NeuroSense Receives FDA Clearance to Initiate Pivotal Phase 3 Trial for PrimeC in ALS CAMBRIDGE, Mass., Nov. 24, 2025 /PRNewswire/ - NeuroSense Therapeutics Ltd. (Nasdaq: NRSN) (“NeuroSense”), a late-clinical stage biotechnology company developing novel treatments for severe neurodegenerative diseases, today announced that the U.S. Food and Drug Administration (FDA) has completed the

November 24, 2025 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of November 2025 Commission File Number: 001-4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of November 2025 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliy

November 24, 2025 CORRESP

NeuroSense Theapeutics Ltd. 11 HaMenofim Street, Building B Herzliya 4672562

NeuroSense Theapeutics Ltd. 11 HaMenofim Street, Building B Herzliya 4672562 November 24, 2025 VIA EDGAR Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, DC 20549 RE: NeuroSense Therapeutics Ltd. (CIK 0001875091) Registration Statement No. 333-291122 on Form F-3 (the “Registration Statement”) Ladies and Gentlemen: NeuroSense Therapeutics Ltd. (the “

November 21, 2025 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the month of November 2025 Commission File Number: 001-4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the month of November 2025 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliy

November 21, 2025 EX-99.2

NEUROSENSE THERAPEUTICS LTD. 11 HAMENOFIM STREET BUILDING B HERZLIYA 4672562 ISRAEL SCAN TO VIEW MATERIALS & VOTE VOTE BY INTERNET - www.proxyvote.com or scan the QR Barcode above Use the Internet to transmit your voting instructions and for electron

Exhibit 99.2 NEUROSENSE THERAPEUTICS LTD. 11 HAMENOFIM STREET BUILDING B HERZLIYA 4672562 ISRAEL SCAN TO VIEW MATERIALS & VOTE VOTE BY INTERNET - www.proxyvote.com or scan the QR Barcode above Use the Internet to transmit your voting instructions and for electronic delivery of information. Vote by 11:59 p.m. Eastern Time on December 29, 2025. Have your proxy card in hand when you access the web si

November 21, 2025 EX-99.1

11 Hamenofim St., Building B, Herzliya 4672562, Israel NOTICE OF SPECIAL MEETING OF SHAREHOLDERS TO BE HELD ON DECEMBER 30, 2025

Exhibit 99.1 11 Hamenofim St., Building B, Herzliya 4672562, Israel NOTICE OF SPECIAL MEETING OF SHAREHOLDERS TO BE HELD ON DECEMBER 30, 2025 Dear NeuroSense Therapeutics Ltd. Shareholders: We cordially invite you to attend a Special Meeting of Shareholders (the “Meeting”) of NeuroSense Therapeutics Ltd. (the “Company”) to be held at 4:00 p.m. (Israel time) on December 30, 2025 at our offices at 1

October 28, 2025 F-3

As filed with the Securities and Exchange Commission on October 28, 2025.

As filed with the Securities and Exchange Commission on October 28, 2025. Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM F-3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 NeuroSense Therapeutics Ltd. (Exact Name of Registrant as Specified in Its Charter) Not Applicable (Translation of Registrant’s name into English) State of Israel 2834

October 28, 2025 EX-FILING FEES

CALCULATION OF FILING FEE TABLES NeuroSense Therapeutics Ltd. Table 1: Newly Registered and Carry Forward Securities

Ex-Filing Fees CALCULATION OF FILING FEE TABLES F-3 NeuroSense Therapeutics Ltd. Table 1: Newly Registered and Carry Forward Securities Line Item Type Security Type Security Class Title Notes Fee Calculation Rule Amount Registered Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Newly Registered Securities Fees to be Paid Equity Ordinary

October 6, 2025 EX-99.1

NeuroSense: PrimeC Produces Statistically Significant Reductions in Alzheimer’s Disease Biomarkers

Exhibit 99.1 NeuroSense: PrimeC Produces Statistically Significant Reductions in Alzheimer’s Disease Biomarkers CAMBRIDGE, Mass., Oct. 6, 2025 /PRNewswire/ - NeuroSense Therapeutics Ltd. (NASDAQ: NRSN) (“NeuroSense”), a late-clinical stage biotechnology company developing novel treatments for severe neurodegenerative diseases, today announced new positive findings based on plasma samples from its

October 6, 2025 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of October 2025 Commission File Number: 001-41

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of October 2025 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliya

September 25, 2025 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of September 2025 Commission File Number: 001-

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of September 2025 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzli

September 10, 2025 EX-99.1

NeuroSense’s Drug Candidate Shows Early Signals of Benefit in Alzheimer’s Patient-Derived Neurons

Exhibit 99.1 NeuroSense’s Drug Candidate Shows Early Signals of Benefit in Alzheimer’s Patient-Derived Neurons Initial Phase 2 RoAD trial results demonstrate improvements in brain-cell connectivity and health, with a favorable safety profile CAMBRIDGE, Mass., Sept. 10, 2025 /PRNewswire/ - NeuroSense Therapeutics Ltd. (Nasdaq: NRSN) (“NeuroSense”), a late-clinical stage biotechnology company develo

September 10, 2025 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of September 2025 Commission File Number: 001-

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of September 2025 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) 11 HaMenofim Street, Building B Herzliya 4672562 Israel +972-9-7996

September 4, 2025 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of September 2025 Commission File Number: 001-

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of September 2025 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) 11 HaMenofim Street, Building B Herzliya 4672562 Israel +972-9-7996

September 4, 2025 EX-10.1

SECURITIES PURCHASE AGREEMENT

Exhibit 10.1 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this “Agreement”) is dated as of September 4, 2025, between NeuroSense Therapeutics Ltd., a company organized under the laws of Israel (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively, the “Purchasers”). WHEREAS, subj

September 4, 2025 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of September 2025 Commission File Number: 001-

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of September 2025 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzli

September 4, 2025 EX-99.1

NeuroSense Therapeutics Announces $500,000 Private Placement at Premium to Market Price Financing at 40% premium to market price provides near-term bridge to anticipated milestones

Exhibit 99.1 NeuroSense Therapeutics Announces $500,000 Private Placement at Premium to Market Price Financing at 40% premium to market price provides near-term bridge to anticipated milestones CAMBRIDGE, Mass., September 4, 2025, - NeuroSense Therapeutics Ltd. (Nasdaq: NRSN) (“NeuroSense”), a late-clinical stage biotechnology company developing novel treatments for severe neurodegenerative diseas

September 2, 2025 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of September 2025 Commission File Number: 001-

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of September 2025 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) 11 HaMenofim Street, Building B Herzliya 4672562 Israel +972-9-7996

August 21, 2025 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of August 2025 Commission File Number: 001-410

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of August 2025 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliya

August 21, 2025 EX-99.1

11 Hamenofim St., Building B, Herzliya 4672562, Israel NOTICE OF ANNUAL GENERAL MEETING OF SHAREHOLDERS TO BE HELD ON SEPTEMBER 25, 2025

Exhibit 99.1 11 Hamenofim St., Building B, Herzliya 4672562, Israel NOTICE OF ANNUAL GENERAL MEETING OF SHAREHOLDERS TO BE HELD ON SEPTEMBER 25, 2025 Dear NeuroSense Therapeutics Ltd. Shareholders: We cordially invite you to attend an Annual General Meeting of Shareholders (the “Meeting”), of NeuroSense Therapeutics Ltd. (the “Company”), to be held at 11:00 a.m. (Israel time) on September 25, 2025

August 21, 2025 EX-99.2

NEUROSENSE THERAPEUTICS LTD. 11 HAMENOFIM STREET BUILDING B HERZLIYA 4672562 ISRAEL SCAN TO VIEW MATERIALS & VOTE Use the Internet to transmit your voting instructions and for electronic delivery of information. Vote by 11:59 p.m. Eastern Time on Sep

Exhibit 99.2 NEUROSENSE THERAPEUTICS LTD. 11 HAMENOFIM STREET BUILDING B HERZLIYA 4672562 ISRAEL SCAN TO VIEW MATERIALS & VOTE Use the Internet to transmit your voting instructions and for electronic delivery of information. Vote by 11:59 p.m. Eastern Time on September 24, 2025. Have your proxy card in hand when you access the web site and follow the instructions to obtain your records and to crea

August 20, 2025 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of August 2025 Commission File Number: 001-410

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of August 2025 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliya

August 15, 2025 POS AM

As filed with the Securities and Exchange Commission on August 15, 2025.

As filed with the Securities and Exchange Commission on August 15, 2025. Registration No. 333-273375 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 POST-EFFECTIVE AMENDMENT NO. 4 TO FORM F-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 NeuroSense Therapeutics Ltd. (Exact Name of Registrant as Specified in Its Charter) Not Applicable (Translation of Registrant’s

August 15, 2025 POS AM

As filed with the Securities and Exchange Commission on August 15, 2025.

As filed with the Securities and Exchange Commission on August 15, 2025. Registration No. 333-283338 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 POST-EFFECTIVE AMENDMENT NO. 2 TO FORM F-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 NeuroSense Therapeutics Ltd. (Exact Name of Registrant as Specified in Its Charter) Not Applicable (Translation of Registrant’s

August 15, 2025 S-8

As filed with the Securities and Exchange Commission on August 15, 2025 UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM S-8 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 NeuroSense Therapeutics Ltd. (Exact name of

Registration No. As filed with the Securities and Exchange Commission on August 15, 2025 UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, DC 20549 FORM S-8 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 NeuroSense Therapeutics Ltd. (Exact name of registrant as specified in its charter) Israel Not Applicable (State or other jurisdiction of incorporation or organization) (I.R.S.

August 15, 2025 EX-FILING FEES

CALCULATION OF FILING FEE TABLES NEUROSENSE THERAPEUTICS LTD. Table 1: Newly Registered and Carry Forward Securities

Ex-Filing Fees CALCULATION OF FILING FEE TABLES S-8 NEUROSENSE THERAPEUTICS LTD. Table 1: Newly Registered and Carry Forward Securities Line Item Type Security Type Security Class Title Notes Fee Calculation Rule Amount Registered Proposed Maximum Offering Price Per Unit Maximum Aggregate Offering Price Fee Rate Amount of Registration Fee Newly Registered Securities Fees to be Paid Equity Ordinary

August 8, 2025 424B5

NeuroSense Therapeutics Ltd. Up to $14,203,914 Ordinary Shares

Filed pursuant to Rule 424(b)(5) Registration No. 333-269306 AMENDMENT NO. 2 TO PROSPECTUS SUPPLEMENT DATED AUGUST 16, 2024 (To prospectus dated January 30, 2023) NeuroSense Therapeutics Ltd. Up to $14,203,914 Ordinary Shares This Amendment No. 2 (the “Amendment”) amends and supplements the information in the prospectus supplement, dated August 16, 2024, as supplemented by the Amendment No. 1 to t

August 1, 2025 EX-99.3

OPERATING AND FINANCIAL REVIEW AND PROSPECTS

Exhibit 99.3 OPERATING AND FINANCIAL REVIEW AND PROSPECTS You should read the following selected financial data and discussion of our operating and financial condition and prospects in conjunction with the financial statements and the notes thereto included elsewhere in this 6-K. Our financial statements are prepared in in conformity with United States of America, or U.S. GAAP. Unless otherwise in

August 1, 2025 EX-99.2

The accompanying notes are an integral part of the condensed interim financial statements.

Exhibit 99.2 NeuroSense Therapeutics Ltd. Condensed Interim Unaudited balance sheets U.S. dollars in thousands June 30, December 31, 2025 2024 Assets Current assets: Cash and cash equivalent 666 3,378 Other receivables 847 989 Restricted deposit 43 35 Total current assets 1,556 4,402 Non-current assets: Property, plant and equipment, net 63 66 Operating right of use assets 42 84 Restricted deposit

August 1, 2025 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of August 2025 Commission File Number: 001-410

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of August 2025 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliya

August 1, 2025 EX-99.1

NeuroSense Provides Business Update and Progress for the First Half of 2025

Exhibit 99.1 NeuroSense Provides Business Update and Progress for the First Half of 2025 CAMBRIDGE, Mass., August 1, 2025 /PRNewswire/ - NeuroSense Therapeutics Ltd. (NASDAQ: NRSN) (“NeuroSense”), a late-stage clinical biotechnology company developing novel treatments for severe neurodegenerative diseases, today provided business update with corporate highlights to date and financial results of th

July 10, 2025 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of July 2025 Commission File Number: 001-41084

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of July 2025 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliya 46

June 26, 2025 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of June 2025 Commission File Number: 001-41084

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of June 2025 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) 11 HaMenofim Street, Building B Herzliya 4672562 Israel +972-9-7996183 (

May 7, 2025 EX-99.1

NeuroSense Therapeutics Announces Successful Completion of Commercial Manufacturing Scale-Up for PrimeC in Preparation for Potential Canadian Market Launch

Exhibit 99.1 NeuroSense Therapeutics Announces Successful Completion of Commercial Manufacturing Scale-Up for PrimeC in Preparation for Potential Canadian Market Launch NeuroSense Announces Global CDMO Selection and Manufacturing Scale-Up, Enabling Rapid Pathway to Commercialization for What is Projected to be a $100-150M Canadian Market Opportunity CAMBRIDGE, Mass., May 6, 2025 /PRNewswire/ - Neu

May 7, 2025 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of May 2025 Commission File Number: 001-41084

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of May 2025 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliya 467

April 24, 2025 EX-99.1

2

Exhibit 99.1 NeuroSense Therapeutics Releases Letter to Shareholders Outlining Clinical Progress, Regulatory Strategy, and Partnership Update Letter outlines Phase 3 timeline for PrimeC in ALS, provides update on Canadian regulatory pathway and strategic partnership discussions; Company optimistic about ongoing partnership discussions with global pharmaceutical company CAMBRIDGE, Mass., April 24,

April 24, 2025 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of April 2025 Commission File Number: 001-4108

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of April 2025 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) 11 HaMenofim Street, Building B Herzliya 4672562 Israel +972-9-7996183

April 11, 2025 POS AM

As filed with the Securities and Exchange Commission on April 11, 2025.

As filed with the Securities and Exchange Commission on April 11, 2025. Registration No. 333-283338 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM F-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 NeuroSense Therapeutics Ltd. (Exact Name of Registrant as Specified in Its Charter) Not Applicable (Translation of Registrant’s n

April 11, 2025 POS AM

As filed with the Securities and Exchange Commission on April 11, 2025.

As filed with the Securities and Exchange Commission on April 11, 2025. Registration No. 333-273375 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 POST-EFFECTIVE AMENDMENT NO. 3 TO FORM F-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 NeuroSense Therapeutics Ltd. (Exact Name of Registrant as Specified in Its Charter) Not Applicable (Translation of Registrant’s n

April 7, 2025 EX-2.1

DESCRIPTION OF SHARE CAPITAL AND ARTICLES OF ASSOCIATION

Exhibit 2.1 DESCRIPTION OF SHARE CAPITAL AND ARTICLES OF ASSOCIATION The following descriptions of our share capital and provisions of our amended and restated articles of association are summaries and are qualified by reference to the amended and restated articles of association, which are filed as an exhibit to this Annual Report on Form 20-F. General Our authorized share capital consists of 90,

April 7, 2025 20-F

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 20-F ☐ REGISTRATION STATEMENT PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHA

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 20-F ☐ REGISTRATION STATEMENT PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2024 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT O

April 7, 2025 EX-13.2

CERTIFICATION BY CHIEF FINANCIAL OFFICER PURSUAN TO SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

Exhibit 13.2 CERTIFICATION BY CHIEF FINANCIAL OFFICER PURSUAN TO SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002 In connection with the Annual Report of NeuroSense Therapeutics Ltd. (the “Company”) on Form 20-F for the period ended December 31, 2024 as filed with the Securities and Exchange Commission on the date hereof (the “Report”), the undersigned officer of the Company certifies, pursuant to 18

April 7, 2025 EX-15.1

Consent of Independent Registered Public Accounting Firm

Exhibit 15.1 Consent of Independent Registered Public Accounting Firm We consent to the incorporation by reference in the registration statements (No. 333-262480) on Form S-8 and (No. 333-269306, No. 333-284051, 333-283656 and 333-260338) on Form F-3 of our report dated April 7, 2025, with respect to the consolidated financial statements of Neurosense Therapeutics Ltd. /s/ Somekh Chaikin Member Fi

April 7, 2025 EX-1.1

AMENDED AND RESTATED ARTICLES OF ASSOCIATION NeuroSense Therapeutics LTD.

Exhibit 1.1 AMENDED AND RESTATED ARTICLES OF ASSOCIATION of NeuroSense Therapeutics LTD. 1. INTERPRETATION 1.1. In these Articles the following terms shall bear the meanings set opposite to them, unless the context otherwise requires: Terms Meanings Articles These Amended and Restated Articles of Association as may be amended from time to time. Auditor As defined under the Companies Law. Board The

April 7, 2025 EX-12.2

CERTIFICATION BY CHIEF FINANCIAL OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002

Exhibit 12.2 CERTIFICATION BY CHIEF FINANCIAL OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, Or Eisenberg, certify that: 1. I have reviewed this annual report on Form 20-F of NeuroSense Therapeutics Ltd.; 2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in lig

April 7, 2025 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of April 2025 Commission File Number: 001-4108

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of April 2025 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) 11 HaMenofim Street, Building B Herzliya 4672562 Israel +972-9-7996183

April 7, 2025 EX-12.1

CERTIFICATION BY CHIEF EXECUTIVE OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002

Exhibit 12.1 CERTIFICATION BY CHIEF EXECUTIVE OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, Alon Ben-Noon, certify that: 1. I have reviewed this annual report on Form 20-F of NeuroSense Therapeutics Ltd.; 2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in li

April 7, 2025 EX-99.1

NeuroSense Therapeutics Reports Year End 2024 Financial Results and Provides Business Updates

Exhibit 99.1 NeuroSense Therapeutics Reports Year End 2024 Financial Results and Provides Business Updates ● Phase 2b study completed in amyotrophic lateral sclerosis (ALS) demonstrated lead asset PrimeC slows disease progression and functional decline ● Ongoing partnership discussions to advance PrimeC to Phase 3 study in ALS and commercialization ● Phase 3 study design for PrimeC in ALS aligned

April 7, 2025 EX-13.1

CERTIFICATION BY CHIEF EXECUTIVE OFFICER PURSUAN TO SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

Exhibit 13.1 CERTIFICATION BY CHIEF EXECUTIVE OFFICER PURSUAN TO SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002 In connection with the Annual Report of NeuroSense Therapeutics Ltd. (the “Company”) on Form 20-F for the period ended December 31, 2024 as filed with the Securities and Exchange Commission on the date hereof (the “Report”), the undersigned officer of the Company certifies, pursuant to 18

April 7, 2025 EX-4.2

NEUROSENSE THERAPEUTICS LTD. 2018 SHARE INCENTIVE PLAN AMENDED BY THE BOARD OF DIRECTORS ON AUGUST 30, 2022 NEUROSENSE THERAPEUTICS LTD. 2018 SHARE INCENTIVE PLAN

Exhibit 4.2 NEUROSENSE THERAPEUTICS LTD. 2018 SHARE INCENTIVE PLAN AMENDED BY THE BOARD OF DIRECTORS ON AUGUST 30, 2022 NEUROSENSE THERAPEUTICS LTD. 2018 SHARE INCENTIVE PLAN 1. Purpose. The purpose of this 2018 Share Incentive Plan (the “Plan”) is to advance the interests of the Company and its shareholders by attracting and retaining the best available personnel for positions of substantial resp

April 7, 2025 EX-11.1

NeuroSense TherapEutics Ltd. Insider Trading Compliance Policy Effective Date: November 9, 2021

Exhibit 11.1 NeuroSense TherapEutics Ltd. Insider Trading Compliance Policy Effective Date: November 9, 2021 U.S. federal securities laws prohibit trading in the securities of a company while in possession of material nonpublic information and providing material nonpublic information to others so that they can trade. Violating such laws can undermine investor trust, harm the Company’s reputation,

March 27, 2025 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of March 2025 Commission File Number: 001-4108

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of March 2025 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliya 4

March 19, 2025 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of March 2025 Commission File Number: 001-4108

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of March 2025 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) 11 HaMenofim Street, Building B Herzliya 4672562 Israel +972-9-7996183

February 21, 2025 424B5

NeuroSense Therapeutics Ltd. Up to $2,556,428 Ordinary Shares

Filed pursuant to Rule 424(b)(5) Registration No. 333-269306 AMENDMENT NO. 1 TO PROSPECTUS SUPPLEMENT DATED AUGUST 16, 2024 (To prospectus dated January 30, 2023) NeuroSense Therapeutics Ltd. Up to $2,556,428 Ordinary Shares This Amendment No. 1 (the “Amendment”) amends and supplements the information in the prospectus supplement, dated August 16, 2024 (the “Prospectus Supplement”), to the prospec

February 19, 2025 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of February 2025 Commission File Number: 001-4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of February 2025 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) 11 HaMenofim Street, Building B Herzliya 4672562 Israel +972-9-79961

January 17, 2025 424B3

5,280,000 Ordinary Shares Up to 3,520,000 Warrants to Purchase up to 3,520,000 Ordinary Shares Up to 1,656,271 Pre-Funded Warrants to Purchase up to 1,656,271 Ordinary Shares

PROSPECTUS Filed pursuant to Rule 424(b)(3) Registration No. 333 - 284051 5,280,000 Ordinary Shares Up to 3,520,000 Warrants to Purchase up to 3,520,000 Ordinary Shares Up to 1,656,271 Pre-Funded Warrants to Purchase up to 1,656,271 Ordinary Shares This prospectus relates to the resale, from time to time, by the selling shareholder identified in this prospectus under the section “Selling Sharehold

January 16, 2025 CORRESP

NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliya 4672562 Israel

NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliya 4672562 Israel January 16, 2025 VIA EDGAR Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, DC 20549 RE: NeuroSense Therapeutics Ltd. (CIK 0001875091) Registration Statement No. 333-284051 on Form F-3 (the “Registration Statement”) Ladies and Gentlemen: NeuroSense Therapeutics Ltd.

January 6, 2025 CORRESP

January 6, 2025

January 6, 2025 VIA EDGAR AND EMAIL U.S. Securities and Exchange Commission Division of Corporation Finance, Office of Life Sciences 100 F Street, N.E. Washington, D.C. 20549 Attn: Joshua Gorsky Re: NeuroSense Therapeutics Ltd. Registration Statement on Form F-3 Filed December 26, 2024 File No. 333-284051 Dear Mr. Gorsky: On behalf of NeuroSense Therapeutics Ltd. (the “Company”), we are writing to

January 6, 2025 EX-99.1

2

Exhibit 99.1 NeuroSense Regains Compliance with Nasdaq’s Minimum Equity Requirement ● NeuroSense in Compliance with all Nasdaq Listing Requirements CAMBRIDGE, Mass., Jan. 6, 2025 /PRNewswire/ - NeuroSense Therapeutics Ltd. (Nasdaq: NRSN) (“NeuroSense”), a late-stage clinical biotechnology company developing novel treatments for severe neurodegenerative diseases, today announced that the Company re

January 6, 2025 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of January 2025 Commission File Number: 001-41

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of January 2025 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliya

January 3, 2025 LETTER

LETTER

January 3, 2025 Alon Ben-Noon Chief Executive Officer NeuroSense Therapeutics Ltd.

December 26, 2024 EX-FILING FEES

Calculation of Filing Fee Table Form F-3 (Form Type) NeuroSense Therapeutics Ltd. (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered Securities

Exhibit 107 Calculation of Filing Fee Table Form F-3 (Form Type) NeuroSense Therapeutics Ltd.

December 26, 2024 F-3

As filed with the Securities and Exchange Commission on December 26, 2024.

F-3 1 ea0226024-f3neurosense.htm REGISTRATION STATEMENT As filed with the Securities and Exchange Commission on December 26, 2024. Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM F-3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 NeuroSense Therapeutics Ltd. (Exact Name of Registrant as Specified in Its Charter) Not Applicable (Translatio

December 23, 2024 EX-99.1

2

EX-99.1 2 ea022572501ex99-1neuro.htm PRESS RELEASE, DATED DECEMBER 23, 2024, ENTITLED "NEUROSENSE THERAPEUTICS ENTERS BINDING TERM SHEET TO ADVANCE PRIMEC FOR ALS." Exhibit 99.1 NeuroSense Therapeutics Enters Binding Term Sheet to Advance PrimeC for ALS · Binding Term Sheet with a leading global pharmaceutical company includes a substantial upfront payment and funding for the Phase 3 study · Addit

December 23, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of December 2024 Commission File Number: 001-4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of December 2024 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliy

December 18, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of December 2024 Commission File Number: 001-4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of December 2024 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) 11 HaMenofim Street, Building B Herzliya 4672562 Israel +972-9-799-6

December 18, 2024 EX-99.1

2

Exhibit 99.1 NeuroSense Provides Business Update and Third Quarter 2024 Financial Results CAMBRIDGE, Mass., Dec. 18, 2024 /PRNewswire/ - NeuroSense Therapeutics Ltd. (Nasdaq: NRSN) (“NeuroSense”), a late-stage clinical biotechnology company developing novel treatments for severe neurodegenerative diseases, today provided business update with corporate highlights to date and third quarter financial

December 17, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of December 2024 Commission File Number: 001-4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of December 2024 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) 11 HaMenofim Street, Building B Herzliya 4672562 Israel +972-9-95311

December 12, 2024 424B3

6,600,000 Ordinary Shares Up to 4,400,000 Warrants to Purchase up to 4,400,000 Ordinary Shares

PROSPECTUS Filed pursuant to Rule 424(b)(3) Registration No. 333 - 283656 6,600,000 Ordinary Shares Up to 4,400,000 Warrants to Purchase up to 4,400,000 Ordinary Shares This prospectus relates to the resale, from time to time, by the selling shareholder identified in this prospectus under the section “Selling Shareholder,” (the “selling shareholder”) of NeuroSense Therapeutics Ltd. (“NeuroSense,”

December 12, 2024 LETTER

LETTER

December 12, 2024 Or Eisenberg Chief Financial Officer NeuroSense Therapeutics Ltd.

December 12, 2024 CORRESP

NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliya 4672562 Israel

NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliya 4672562 Israel December 12, 2024 VIA EDGAR Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, DC 20549 RE: NeuroSense Therapeutics Ltd. (CIK 0001875091) Registration Statement No. 333-283656 on Form F-3 (the “Registration Statement”) Ladies and Gentlemen: NeuroSense Therapeutics Ltd

December 11, 2024 EX-99.1

NeuroSense Receives Positive FDA Feedback on Phase 3 Study Design for PrimeC

Exhibit 99.1 NeuroSense Receives Positive FDA Feedback on Phase 3 Study Design for PrimeC ● The Type C meeting with the FDA, combined with the recent 18-month Phase 2b PARADIGM study readout, has the Company on track to commence a Phase 3 study in mid-2025. ● PrimeC has already demonstrated a significant impact on slowing disease progression and increasing survival rates in people living with ALS

December 11, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of December 2024 Commission File Number: 001-4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of December 2024 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliy

December 9, 2024 SC 13G

NRSN / NeuroSense Therapeutics Ltd. / Rimon Gold Assets Ltd - SCHEDULE 13G Passive Investment

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G Under the Securities Exchange Act of 1934 (Amendment No. )* NeuroSense Therapeutics Ltd. (Name of Issuer) Ordinary Shares, no par value (Title of Class of Securities) M74240108 (CUSIP Number) December 2, 2024 (Date of Event Which Requires Filing of Statement) Check the appropriate box to designate the rule pursuan

December 9, 2024 EX-99.1

JOINT FILING UNDERTAKING

EX-99.1 2 ea022405101ex99-1neuro.htm JOINT FILING UNDERTAKING Exhibit 99.1 JOINT FILING UNDERTAKING The undersigned, who, together, may be deemed to form a group under section 13(d)(3) of the Securities Exchange Act, being authorized thereunto, hereby agree that the Statement on Schedule 13G, dated December 9, 2024, with respect to the ordinary shares, no par value, of NeuroSense Therapeutics, Ltd

December 6, 2024 F-3

As filed with the Securities and Exchange Commission on December 6, 2024.

As filed with the Securities and Exchange Commission on December 6, 2024. Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM F-3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 NeuroSense Therapeutics Ltd. (Exact Name of Registrant as Specified in Its Charter) Not Applicable (Translation of Registrant’s name into English) State of Israel 2834

December 6, 2024 EX-FILING FEES

Calculation of Filing Fee Table Form F-1 (Form Type) NeuroSense Therapeutics Ltd. (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered Securities

Exhibit 107 Calculation of Filing Fee Table Form F-1 (Form Type) NeuroSense Therapeutics Ltd.

December 4, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of December 2024 Commission File Number: 001-4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of December 2024 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliy

December 4, 2024 EX-99.1

NeuroSense Announces Completion of PARADIGM Study Highlighting PrimeC’s Significant Efficacy and Survival Benefits in ALS

Exhibit 99.1 NeuroSense Announces Completion of PARADIGM Study Highlighting PrimeC’s Significant Efficacy and Survival Benefits in ALS ● In participants who received PrimeC from the start of the 18-month study compared to those initially on placebo before transitioning to PrimeC, disease progression was slowed by 33% (p=0.007), demonstrated in a 58% improvement in survival rates ● Consistent data

December 2, 2024 EX-99.1

NeuroSense Therapeutics Announces $5 Million Private Placement at Premium to Market Price

Exhibit 99.1 NeuroSense Therapeutics Announces $5 Million Private Placement at Premium to Market Price CAMBRIDGE, Mass., Dec. 2, 2024 /PRNewswire/ - NeuroSense Therapeutics Ltd. (Nasdaq: NRSN) (“NeuroSense”), a late-clinical stage biotechnology company developing novel treatments for severe neurodegenerative diseases, today announced the entry into a definitive agreement with a single investor and

December 2, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of December 2024 Commission File Number: 001-4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of December 2024 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliy

December 2, 2024 EX-10.1

SECURITIES PURCHASE AGREEMENT

Exhibit 10.1 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this “Agreement”) is dated as of December 2, 2024, between NeuroSense Therapeutics Ltd., a company organized under the laws of Israel (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively, the “Purchasers”). WHEREAS, subje

December 2, 2024 EX-10.2

PRE-FUNDED ORDINARY SHARES PURCHASE WARRANT NEUROSENSE THERAPEUTICS LTD.

Exhibit 10.2 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGIST

December 2, 2024 EX-10.3

ORDINARY SHARES PURCHASE WARRANT NEUROSENSE THERAPEUTICS LTD.

Exhibit 10.3 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGIST

November 22, 2024 424B3

Up to 10,000,000 Ordinary Shares NeuroSense Therapeutics Ltd.

PROSPECTUS Filed pursuant to Rule 424(b)(3) Registration No. 333-283338 Up to 10,000,000 Ordinary Shares NeuroSense Therapeutics Ltd. This prospectus relates to the offer and sale of up to 10,000,000 of our ordinary shares, no par value per share, by YA II PN, LTD., or YA or the Selling Shareholder, a Cayman Islands exempt limited partnership. The ordinary shares represented by ordinary shares bei

November 21, 2024 LETTER

LETTER

November 21, 2024 Alon Ben-Noon Chief Executive Officer NeuroSense Therapeutics Ltd.

November 21, 2024 CORRESP

NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliya 4672562 Israel

NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliya 4672562 Israel November 21, 2024 VIA EDGAR Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, DC 20549 RE: NeuroSense Therapeutics Ltd. (CIK 0001875091) Registration Statement No. 333-283338 on Form F-1 (the “Registration Statement”) Ladies and Gentlemen: NeuroSense Therapeutics Ltd

November 19, 2024 F-1

As filed with the Securities and Exchange Commission on November 19, 2024.

As filed with the Securities and Exchange Commission on November 19, 2024. Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM F-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 NeuroSense Therapeutics Ltd. (Exact Name of Registrant as Specified in Its Charter) Not Applicable (Translation of Registrant’s name into English) State of Israel 283

November 19, 2024 EX-FILING FEES

Calculation of Filing Fee Table Form F-1 (Form Type) NeuroSense Therapeutics Ltd. (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered Securities

Exhibit 107 Calculation of Filing Fee Table Form F-1 (Form Type) NeuroSense Therapeutics Ltd.

November 12, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of November 2024 Commission File Number: 001-4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of November 2024 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) 11 HaMenofim Street, Building B Herzliya 4672562 Israel +972-9-95311

October 31, 2024 EX-10.1

STANDBY EQUITY PURCHASE AGREEMENT

Exhibit 10.1 STANDBY EQUITY PURCHASE AGREEMENT THIS STANDBY EQUITY PURCHASE AGREEMENT (this “Agreement”) dated as of October 31, 2024, is made by and between YA II PN, LTD., a Cayman Islands exempt limited company (the “Investor”), and NEUROSENSE THERAPEUTICS LTD., a company incorporated under the laws of the State of Israel (the “Company”). WHEREAS, the parties desire that, upon the terms and sub

October 31, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of October 2024 Commission File Number: 001-41

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of October 2024 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) 11 HaMenofim Street, Building B Herzliya 4672562 Israel +972-9-799618

October 30, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of October 2024 Commission File Number: 001-41

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of October 2024 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) 11 HaMenofim Street, Building B Herzliya 4672562 Israel +972-9-799618

October 28, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of October 2024 Commission File Number: 001-41

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of October 2024 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliya

October 28, 2024 EX-99.1

NeuroSense Secures Key FDA Meeting to Advance its Phase 3 ALS Trial and NDA Submission

Exhibit 99.1 NeuroSense Secures Key FDA Meeting to Advance its Phase 3 ALS Trial and NDA Submission ● Meeting discussion to focus on finalizing Phase 3 study design and NDA readiness, ensuring a clear regulatory path for submission based on trial success ● Parallel preparations in Canada: NeuroSense plans to submit its dossier in Q2 2025, with a regulatory decision on commercialization expected by

October 24, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of October 2024 Commission File Number: 001-41

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of October 2024 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliya

October 24, 2024 EX-99.1

New Analysis Shows PrimeC Significantly Improves Key miRNAs in ALS Patients

Exhibit 99.1 New Analysis Shows PrimeC Significantly Improves Key miRNAs in ALS Patients Groundbreaking PARADIGM Trial Offers New Hope for ALS Treatment CAMBRIDGE, Mass., Oct. 24, 2024 /PRNewswire/ - NeuroSense Therapeutics Ltd. (Nasdaq: NRSN) (“NeuroSense”), a late-clinical stage biotechnology company developing novel treatments for severe neurodegenerative diseases, today announced transformativ

October 15, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of October 2024 Commission File Number: 001-41

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of October 2024 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliya

October 15, 2024 EX-99.1

NeuroSense Advances Plans for Early Commercialization of Groundbreaking ALS Treatment in Canada, Provides Further Updates

Exhibit 99.1 NeuroSense Advances Plans for Early Commercialization of Groundbreaking ALS Treatment in Canada, Provides Further Updates ● Dossier submission planned for Q2 2025; regulatory decision expected by Q1 2026 ● Estimated potential market opportunity: peak of $100M to $150M in annual revenue ● Company aims to expand approval efforts to additional global markets CAMBRIDGE, Mass., Oct. 15, 20

October 9, 2024 EX-99.1

2

Exhibit 99.1 NeuroSense Therapeutics Plans to File for Early Commercialization of ALS Treatment in Canada · The preparations for the regulatory submission for early commercialization in Canada follows the positive Phase 2b trial results which show PrimeC reduces ALS disease progression by 36% and improves survival rates by 43% · Company plans to seek approval in additional countries CAMBRIDGE, Mas

October 9, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of October 2024 Commission File Number: 001-41

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of October 2024 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) 11 HaMenofim Street, Building B Herzliya 4672562 Israel +972-9-799618

October 1, 2024 POS AM

As filed with the Securities and Exchange Commission on September 30, 2024.

As filed with the Securities and Exchange Commission on September 30, 2024. Registration No. 333-273375 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 POST-EFFECTIVE AMENDMENT NO. 2 TO FORM F-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 NeuroSense Therapeutics Ltd. (Exact Name of Registrant as Specified in Its Charter) Not Applicable (Translation of Registrant

September 30, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of September 2024 Commission File Number: 001-

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of September 2024 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) 11 HaMenofim Street, Building B Herzliya 4672562 Israel +972-9-7996

September 30, 2024 EX-99.2

OPERATING AND FINANCIAL REVIEW AND PROSPECTS

Exhibit 99.2 OPERATING AND FINANCIAL REVIEW AND PROSPECTS You should read the following selected financial data and discussion of our operating and financial condition and prospects in conjunction with the financial statements and the notes thereto included elsewhere in this 6-K. Our financial statements are prepared in in conformity with United States of America, or U.S. GAAP. Unless otherwise in

September 30, 2024 EX-99.1

The accompanying notes are an integral part of the condensed interim financial statements.

Exhibit 99.1 NeuroSense Therapeutics Ltd. Condensed Interim Unaudited balance sheets U.S. dollars in thousands June 30, December 31, 2024 2023 Assets Current assets: Cash and cash equivalent 1,208 2,640 Other receivables 376 236 Restricted deposit 35 40 Total current assets 1,619 2,916 Non-current assets: Property, plant and equipment, net 77 85 Operating right of use assets 123 162 Restricted dep

September 24, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of September 2024 Commission File Number: 001-

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of September 2024 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) 11 HaMenofim Street, Building B Herzliya 4672562 Israel +972-9-7996

September 24, 2024 EX-99.2

NeuroSense Therapeutics Granted Key U.S. Patent for Novel PrimeC Formulation, its Lead Asset for ALS and Alzheimer’s The Company’s intellectual property now covers the combination, formulation, and method of use of PrimeC Patent protection extends th

Exhibit 99.2 NeuroSense Therapeutics Granted Key U.S. Patent for Novel PrimeC Formulation, its Lead Asset for ALS and Alzheimer’s The Company’s intellectual property now covers the combination, formulation, and method of use of PrimeC Patent protection extends through 2042, adding four additional years to PrimeC's IP umbrella CAMBRIDGE, Mass., September 24, 2024, - NeuroSense Therapeutics Ltd. (Na

September 24, 2024 EX-99.1

NeuroSense Regains Compliance with NASDAQ Minimum Bid Price Rule

Exhibit 99.1 NeuroSense Regains Compliance with NASDAQ Minimum Bid Price Rule CAMBRIDGE, Mass., September 24, 2024 /PRNewswire/ - NeuroSense Therapeutics Ltd. (Nasdaq: NRSN) (“NeuroSense”), a company developing treatments for severe neurodegenerative diseases, today announced that it has received notice from The Nasdaq Stock Market LLC (“Nasdaq”) informing the Company that it has regained complian

September 16, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of September 2024 Commission File Number: 001-

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of September 2024 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) 11 HaMenofim Street, Building B Herzliya 4672562 Israel +972-9-7996

September 9, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of September 2024 Commission File Number: 001-

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of September 2024 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) 11 HaMenofim Street, Building B Herzliya 4672562 Israel +972-9-7996

August 30, 2024 EX-99.1

NeuroSense Therapeutics Announces Receipt of Nasdaq Minimum Bid Price Notification

Exhibit 99.1 NeuroSense Therapeutics Announces Receipt of Nasdaq Minimum Bid Price Notification CAMBRIDGE, Mass., Aug. 30, 2024 /PRNewswire/ - NeuroSense Therapeutics Ltd. (Nasdaq: NRSN) (“NeuroSense” or the “Company”), a late-clinical stage biotechnology company developing novel treatments for severe neurodegenerative diseases, today announced that it has received a notification letter from the N

August 30, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of August 2024 Commission File Number: 001-410

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of August 2024 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliya

August 28, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of August 2024 Commission File Number: 001-410

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of August 2024 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) 11 HaMenofim Street, Building B Herzliya 4672562 Israel +972-9-9531142

August 26, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of August 2024 Commission File Number: 001-410

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of August 2024 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliya

August 16, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of August 2024 Commission File Number: 001-410

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of August 2024 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliya

August 16, 2024 EX-10.1

NeuroSense Therapeutics Ltd. Ordinary Shares (no par value per share) Capital on Demand™ Sales Agreement

Exhibit 10.1 NeuroSense Therapeutics Ltd. Ordinary Shares (no par value per share) Capital on Demand™ Sales Agreement August 16, 2024 JonesTrading Institutional Services LLC 325 Hudson Street., 6th Floor New York, NY 10013 Ladies and Gentlemen: NeuroSense Therapeutics Ltd., a company organized under the laws of the State of Israel (the “Company”), confirms its agreement (this “Agreement”) with Jon

August 16, 2024 424B5

NeuroSense Therapeutics Ltd. Up to $2,524,437 Ordinary Shares

Filed pursuant to Rule 424(b)(5) Registration No. 333-269306 PROSPECTUS SUPPLEMENT (To prospectus dated January 30, 2023) NeuroSense Therapeutics Ltd. Up to $2,524,437 Ordinary Shares We have entered into a Capital on Demand™ Sales Agreement with JonesTrading Institutional Services LLC, or Jones, dated August 16, 2024, or the Sales Agreement, relating to the sale of our ordinary shares, no par val

August 7, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of August 2024 Commission File Number: 001-410

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of August 2024 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliya

August 7, 2024 EX-10.2

ORDINARY SHARES PURCHASE WARRANT NEUROSENSE THERAPEUTICS LTD.

Exhibit 10.2 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGIST

August 7, 2024 EX-10.1

SECURITIES PURCHASE AGREEMENT

Exhibit 10.1 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this “Agreement”) is dated as of August 6, 2024, between NeuroSense Therapeutics Ltd., a company organized under the laws of Israel (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively, the “Purchasers”). WHEREAS, subject

August 1, 2024 EX-99.1

NeuroSense Therapeutics Announces Positive Biomarker Data from ALS Phase 2b Clinical Trial 12-month data demonstrated regulation of iron levels, which aligns with improved ALS survival and disease mitigation Previous results showed PrimeC slowed dise

Exhibit 99.1 NeuroSense Therapeutics Announces Positive Biomarker Data from ALS Phase 2b Clinical Trial 12-month data demonstrated regulation of iron levels, which aligns with improved ALS survival and disease mitigation Previous results showed PrimeC slowed disease progression by 36% and improved survival rates, highlighting its potential as a transformative ALS therapy CAMBRIDGE, Mass., August 1

August 1, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of August 2024 Commission File Number: 001-410

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of August 2024 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliya

July 9, 2024 EX-99.1

NeuroSense’s PARADIGM ALS Clinical Trial Demonstrates Up to 73% Improved Complication-Free Survival Following Statistically Significant Slowing of Disease Progression NeuroSense to submit the 12-month data to FDA to discuss path forward

Exhibit 99.1 NeuroSense’s PARADIGM ALS Clinical Trial Demonstrates Up to 73% Improved Complication-Free Survival Following Statistically Significant Slowing of Disease Progression NeuroSense to submit the 12-month data to FDA to discuss path forward CAMBRIDGE, Mass., July 9, 2024 /PRNewswire/ - NeuroSense Therapeutics Ltd. (NASDAQ: NRSN) (“NeuroSense”), a late-clinical stage biotechnology company

July 9, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of July 2024 Commission File Number: 001-41084

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of July 2024 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliya 46

July 3, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of July 2024 Commission File Number: 001-41084

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of July 2024 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) 11 HaMenofim Street, Building B Herzliya 4672562 Israel +972-9-9531142 (

July 1, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of July 2024 Commission File Number: 001-41084

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of July 2024 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliya 46

July 1, 2024 EX-99.1

NeuroSense Demonstrates Statistically Significant Efficacy and Survival Benefits in People Living with ALS: The Promising Results from the 12-Month PARADIGM Study Highlight PrimeC’s Potential as a Disease Modifying Drug

Exhibit 99.1 NeuroSense Demonstrates Statistically Significant Efficacy and Survival Benefits in People Living with ALS: The Promising Results from the 12-Month PARADIGM Study Highlight PrimeC’s Potential as a Disease Modifying Drug ● Disease progression was slowed by 36% (p=0.009) in participants who received PrimeC for 12 months compared to those who initially received a placebo ● Consistent dat

June 27, 2024 EX-10.2

AMENDMENT NO. 1 TO THE NEUROSENSE THERAPEUTICS LTD. ORDINARY SHARES PURCHASE WARRANT June 26, 2024

Exhibit 10.2 AMENDMENT NO. 1 TO THE NEUROSENSE THERAPEUTICS LTD. ORDINARY SHARES PURCHASE WARRANT June 26, 2024 This Amendment No. 1 to the Ordinary Shares Purchase Warrant (the “Amendment”) originally issued by NeuroSense Therapeutics Ltd., a company organized under the laws of Israel (the “Company”) to Armistice Capital Master Fund Ltd. (the “Investor”) on April 15, 2024 for the purchase of 2,98

June 27, 2024 424B3

3,000,000 Ordinary Shares 3,000,000 Ordinary Warrants to purchase up to 3,000,000 Ordinary Shares

PROSPECTUS SUPPLEMENT NO. 2 (to prospectus dated April 8, 2024) Filed Pursuant to Rule 424(b)(3) Registration No. 333-273375 3,000,000 Ordinary Shares 3,000,000 Ordinary Warrants to purchase up to 3,000,000 Ordinary Shares This prospectus supplement updates, amends and supplements the prospectus dated April 8, 2024 (as supplemented or amended from time to time, the “Prospectus”), which forms a par

June 27, 2024 EX-10.1

AMENDMENT NO. 1 TO THE NEUROSENSE THERAPEUTICS LTD. ORDINARY SHARES PURCHASE WARRANT June 26, 2024

Exhibit 10.1 AMENDMENT NO. 1 TO THE NEUROSENSE THERAPEUTICS LTD. ORDINARY SHARES PURCHASE WARRANT June 26, 2024 This Amendment No. 1 to the Ordinary Shares Purchase Warrant (the “Amendment”) originally issued by NeuroSense Therapeutics Ltd., a company organized under the laws of Israel (the “Company”) to Armistice Capital Master Fund Ltd. (the “Investor”) on June 26, 2023 for the purchase of 3,000

June 27, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of June 2024 Commission File Number: 001-41084

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of June 2024 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliya 46

June 27, 2024 424B3

Up to 3,050,964 Ordinary Shares Ordinary Warrants to Purchase up to 2,980,000 Ordinary Shares

PROSPECTUS SUPPLEMENT NO. 2 (to prospectus dated May 22, 2024) Filed Pursuant to Rule 424(b)(3) Registration No. 333-279324 Up to 3,050,964 Ordinary Shares Ordinary Warrants to Purchase up to 2,980,000 Ordinary Shares This prospectus supplement updates, amends and supplements the prospectus dated May 22, 2024 (as supplemented or amended from time to time, the “Prospectus”), which forms a part of o

June 24, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of June 2024 Commission File Number: 001-41084

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of June 2024 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliya 46

June 24, 2024 EX-99.1

NeuroSense Management Provides Corporate Update and First Quarter 2024 Financial Results Following positive 6-month clinical outcomes from phase 2b (PARADIGM) clinical trial, Company expects additional biomarker and 12-month clinical in the near term

Exhibit 99.1 NeuroSense Management Provides Corporate Update and First Quarter 2024 Financial Results Following positive 6-month clinical outcomes from phase 2b (PARADIGM) clinical trial, Company expects additional biomarker and 12-month clinical in the near term CAMBRIDGE, Mass., June 24, 2024 /PRNewswire/ - NeuroSense Therapeutics Ltd. (NASDAQ: NRSN) (“NeuroSense”), a company developing novel tr

June 21, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of June 2024 Commission File Number: 001-41084

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of June 2024 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliya 46

June 21, 2024 EX-99.1

NeuroSense Receives Delisting Notice from Nasdaq and Intends to Appeal

Exhibit 99.1 NeuroSense Receives Delisting Notice from Nasdaq and Intends to Appeal CAMBRIDGE, Mass., June 21, 2024, - NeuroSense Therapeutics Ltd. (Nasdaq: NRSN) (“NeuroSense”), a company developing novel treatments for severe neurodegenerative diseases, announces that it has received a notice of delisting from Nasdaq. The staff of the Listing Qualifications Department has determined that the Com

June 17, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of June 2024 Commission File Number: 001-41084

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of June 2024 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliya 46

June 17, 2024 424B3

Up to 3,050,964 Ordinary Shares Ordinary Warrants to Purchase up to 2,980,000 Ordinary Shares

PROSPECTUS SUPPLEMENT NO. 1 (to prospectus dated May 22, 2024) Filed Pursuant to Rule 424(b)(3) Registration No. 333-279324 Up to 3,050,964 Ordinary Shares Ordinary Warrants to Purchase up to 2,980,000 Ordinary Shares This prospectus supplement updates, amends and supplements the prospectus dated May 22, 2024 (as supplemented or amended from time to time, the “Prospectus”), which forms a part of o

June 17, 2024 EX-99.1

INDEX TO CONSOLIDATED FINANCIAL STATEMENTS

Exhibit 99.1 INDEX TO CONSOLIDATED FINANCIAL STATEMENTS Page Report of Independent Registered Public Accounting Firm F-2 Consolidated Balance Sheets as of December 31, 2023 and 2022 F-3 Consolidated Statements of Operations and Comprehensive Loss for the Years Ended December 31, 2023, 2022 and 2021 F-4 Consolidated Statements of Changes in Shareholders’ Equity for the Years Ended December 31, 2023

June 17, 2024 EX-99.2

OPERATING AND FINANCIAL REVIEW AND PROSPECTS

Exhibit 99.2 OPERATING AND FINANCIAL REVIEW AND PROSPECTS You should read the following selected financial data and discussion of our operating and financial condition and prospects in conjunction with the financial statements and the notes thereto included elsewhere in this 6-K. Our financial statements are prepared in in accordance with generally accepted accounting principles of the United Stat

June 17, 2024 424B3

3,000,000 Ordinary Shares 3,000,000 Ordinary Warrants to purchase up to 3,000,000 Ordinary Shares

PROSPECTUS SUPPLEMENT NO. 1 (to prospectus dated April 8, 2024) Filed Pursuant to Rule 424(b)(3) Registration No. 333-273375 3,000,000 Ordinary Shares 3,000,000 Ordinary Warrants to purchase up to 3,000,000 Ordinary Shares This prospectus supplement updates, amends and supplements the prospectus dated April 8, 2024 (as supplemented or amended from time to time, the “Prospectus”), which forms a par

June 17, 2024 EX-99.3

Consent of Independent Registered Public Accounting Firm

Exhibit 99.3 Consent of Independent Registered Public Accounting Firm We consent to the incorporation by reference in the registration statements (No. 333-262480) on Form S-8 and (Nos. 333-269306 and 333-260338) on Form F-3 of our report dated June 17, 2024, with respect to the consolidated financial statements of NeuroSense Therapeutics Ltd. Somekh Chaikin Member Firm of KPMG International Tel Av

May 28, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of May 2024 Commission File Number: 001-41084

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of May 2024 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliya 467

May 28, 2024 EX-99.2

EX-99.2

Exhibit 99.2

May 28, 2024 EX-99.1

11 Hamenofim St., Building B, Herzliya 4672562, Israel NOTICE OF ANNUAL GENERAL MEETING OF SHAREHOLDERS TO BE HELD ON JUNE 27, 2024

Exhibit 99.1 11 Hamenofim St., Building B, Herzliya 4672562, Israel NOTICE OF ANNUAL GENERAL MEETING OF SHAREHOLDERS TO BE HELD ON JUNE 27, 2024 Dear NeuroSense Therapeutics Ltd. Shareholders: We cordially invite you to attend an Annual General Meeting of Shareholders (the “Meeting”), of NeuroSense Therapeutics Ltd. (the “Company”), to be held at 11:00 a.m. (Israel time) on June 27, 2024 at our of

May 23, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of May 2024 Commission File Number: 001-41084

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of May 2024 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliya 467

May 23, 2024 EX-99.1

11 Hamenofim St., Building B, Herzliya 4672562, Israel NOTICE OF ANNUAL GENERAL MEETING OF SHAREHOLDERS TO BE HELD ON JUNE 27, 2024

Exhibit 99.1 11 Hamenofim St., Building B, Herzliya 4672562, Israel NOTICE OF ANNUAL GENERAL MEETING OF SHAREHOLDERS TO BE HELD ON JUNE 27, 2024 Dear NeuroSense Therapeutics Ltd. Shareholders: We cordially invite you to attend an Annual General Meeting of Shareholders (the “Meeting”), of NeuroSense Therapeutics Ltd. (the “Company”), to be held at 11:00 a.m. (Israel time) on June 27, 2024 at our of

May 22, 2024 424B3

Up to 3,050,964 Ordinary Shares Ordinary Warrants to Purchase up to 2,980,000 Ordinary Shares

PROSPECTUS Filed Pursuant to Rule 424(b)(3) Registration No. 333-279324 Up to 3,050,964 Ordinary Shares Ordinary Warrants to Purchase up to 2,980,000 Ordinary Shares This prospectus relates to the resale, from time to time, by the selling shareholders identified in this prospectus under the section “Selling Shareholders,” (each a “selling shareholder” and collectively the “selling shareholders”) o

May 21, 2024 CORRESP

NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliya 4672562 Israel

NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliya 4672562 Israel May 21, 2024 VIA EDGAR Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, DC 20549 RE: NeuroSense Therapeutics Ltd. (CIK 0001875091) Registration Statement No. 333-279324 on Form F-1 (the “Registration Statement”) Ladies and Gentlemen: NeuroSense Therapeutics Ltd. (th

May 20, 2024 EX-99.1

NeuroSense Vice President of R&D Shiran Zimri, Ph.D. to Participate in the 3rd Annual ALS Drug Development Summit

Exhibit 99.1 NeuroSense Vice President of R&D Shiran Zimri, Ph.D. to Participate in the 3rd Annual ALS Drug Development Summit CAMBRIDGE, Mass., May 20, 2024, - NeuroSense Therapeutics Ltd. (Nasdaq: NRSN) (“NeuroSense”), a company developing novel treatments for severe neurodegenerative diseases, announces that Vice President of R&D, Dr. Shiran Zimri will be a key presenter at the ALS Drug Develop

May 20, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of May 2024 Commission File Number: 001-41084

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of May 2024 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliya 467

May 20, 2024 F-1/A

As filed with the Securities and Exchange Commission on May 20, 2024.

As filed with the Securities and Exchange Commission on May 20, 2024. Registration No. 333-279324 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 AMENDMENT NO. 1 FORM F-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 NeuroSense Therapeutics Ltd. (Exact Name of Registrant as Specified in Its Charter) Not Applicable (Translation of Registrant’s name into English) St

May 14, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of May 2024 Commission File Number: 001-41084

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of May 2024 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliya 467

May 14, 2024 LETTER

LETTER

United States securities and exchange commission logo May 14, 2024 Alon Ben-Noon Chief Executive Officer NeuroSense Therapeutics Ltd.

May 14, 2024 EX-99.1

NeuroSense Partners with PhaseV to Optimize Upcoming ALS Phase 3 Trial Using Advanced Causal Machine Learning

Exhibit 99.1 NeuroSense Partners with PhaseV to Optimize Upcoming ALS Phase 3 Trial Using Advanced Causal Machine Learning PhaseV’s Causal Machine Learning Predicts High Probability of Success in Multiple ALS Subgroups for NeuroSense’s Phase 3 Trial CAMBRIDGE, Mass., May 14, 2024 /PRNewswire/ - NeuroSense Therapeutics (Nasdaq: NRSN) (“NeuroSense”), a company developing novel treatments for severe

May 10, 2024 EX-FILING FEES

Calculation of Filing Fee Table Form F-1 (Form Type) NeuroSense Therapeutics Ltd. (Exact Name of Registrant as Specified in its Charter) Table 1: Newly Registered Securities

Exhibit 107 Calculation of Filing Fee Table Form F-1 (Form Type) NeuroSense Therapeutics Ltd.

May 10, 2024 F-1

As filed with the Securities and Exchange Commission on May 10, 2024.

As filed with the Securities and Exchange Commission on May 10, 2024. Registration No. 333- UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM F-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 NeuroSense Therapeutics Ltd. (Exact Name of Registrant as Specified in Its Charter) Not Applicable (Translation of Registrant’s name into English) State of Israel 2834 Not

May 7, 2024 EX-99.1

NeuroSense Announces New Positive Data Analysis from PARADIGM Clinical Trial Demonstrating Statistically Significant Slowing of Disease Progression in High-Risk ALS Patients

Exhibit 99.1 NeuroSense Announces New Positive Data Analysis from PARADIGM Clinical Trial Demonstrating Statistically Significant Slowing of Disease Progression in High-Risk ALS Patients ● PrimeC slowed disease progression by 43% (p=0.02) in pre-specified high-risk ALS patients ● Consistent data across subgroups underscore the potential of PrimeC to redefine the ALS treatment paradigm CAMBRIDGE, M

May 7, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of May 2024 Commission File Number: 001-41084

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of May 2024 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliya 467

April 12, 2024 EX-4.1

FORM OF PRE-FUNDED ORDINARY SHARES PURCHASE WARRANT NEUROSENSE THERAPEUTICS LTD.

Exhibit 4.1 FORM OF PRE-FUNDED ORDINARY SHARES PURCHASE WARRANT NEUROSENSE THERAPEUTICS LTD. Warrant Shares: Issue Date: April 15, 2024 THIS PRE-FUNDED ORDINARY SHARES PURCHASE WARRANT (the “Warrant”) certifies that, for value received, or its assigns (the “Holder”) is entitled, upon the terms and subject to the limitations on exercise and the conditions hereinafter set forth, at any time on or af

April 12, 2024 EX-10.2

SECURITIES PURCHASE AGREEMENT

Exhibit 10.2 SECURITIES PURCHASE AGREEMENT This Securities Purchase Agreement (this “Agreement”) is dated as of April 10, 2024, between NeuroSense Therapeutics Ltd., a company organized under the laws of Israel (the “Company”), and each purchaser identified on the signature pages hereto (each, including its successors and assigns, a “Purchaser” and collectively, the “Purchasers”). WHEREAS, subject

April 12, 2024 EX-99.1

NeuroSense Announces Pricing of $4.5 Million Registered Direct Offering and Concurrent Private Placement

Exhibit 99.1 NeuroSense Announces Pricing of $4.5 Million Registered Direct Offering and Concurrent Private Placement CAMBRIDGE, Mass., April 10, 2024 /PRNewswire/ - NeuroSense Therapeutics Ltd. (Nasdaq: NRSN) (“NeuroSense” or the “Company”), a company developing novel treatments for severe neurodegenerative diseases, today announced it has entered into a securities purchase agreement with a singl

April 12, 2024 EX-10.3

FORM OF ORDINARY SHARES PURCHASE WARRANT NEUROSENSE THERAPEUTICS LTD.

Exhibit 10.3 NEITHER THIS SECURITY NOR THE SECURITIES FOR WHICH THIS SECURITY IS EXERCISABLE HAVE BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGIST

April 12, 2024 EX-10.1

[The remainder of this page has been intentionally left blank.]

Exhibit 10.1 April 10, 2024 NeuroSense Therapeutics Ltd. Attention: Alon Ben-Noon Building B 11 HaMenofim Street Herzliya 4672562 Dear Mr. Ben-Noon This letter (the “Agreement”) constitutes the agreement between A.G.P./Alliance Global Partners (the “Placement Agent”) and NeuroSense Therapeutics Ltd., a company organized under the laws of Israel (the “Company”), that the Placement Agent shall serve

April 12, 2024 424B5

1,732,000 Ordinary Shares Pre-Funded Warrants to Purchase up to 1,248,000 Ordinary Shares

Filed Pursuant to Rule 424(b)(5) Registration No. 333-269306 PROSPECTUS SUPPLEMENT (To the Prospectus dated January 30, 2023) 1,732,000 Ordinary Shares Pre-Funded Warrants to Purchase up to 1,248,000 Ordinary Shares We are offering on a “reasonable best efforts” basis 1,732,000 ordinary shares, no par value, or the Ordinary Shares. The purchase price of each Ordinary Share is $1.50. We are also of

April 12, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of April 2024 Commission File Number: 001-4108

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of April 2024 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliya 5

April 10, 2024 EX-99.1

April 2024 Nasdaq: NRSN Forward - Looking Statements This presentation and oral statements made regarding the subject of this presentation contain "forward - looking statements" within the meaning of the U . S . Private Securities Litigation Reform A

Exhibit 99.1 April 2024 Nasdaq: NRSN Forward - Looking Statements This presentation and oral statements made regarding the subject of this presentation contain "forward - looking statements" within the meaning of the U . S . Private Securities Litigation Reform Act of 1995 that involve substantial risks and uncertainties . All statements contained in this presentation other than statements of hist

April 10, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of April 2024 Commission File Number: 001-4108

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of April 2024 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) 11 HaMenofim Street, Building B Herzliya 4672562 Israel +972-9-7996183

April 9, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of April 2024 Commission File Number: 001-4108

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of April 2024 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliya 4

April 9, 2024 EX-99.1

NeuroSense Collaborates with Lonza to Identify Exosome-based Biomarkers, in order to Advance Neurodegenerative Disease Treatments and Diagnostics

Exhibit 99.1 NeuroSense Collaborates with Lonza to Identify Exosome-based Biomarkers, in order to Advance Neurodegenerative Disease Treatments and Diagnostics ● NeuroSense will leverage its extensive experience in biomarker utilization to advance early diagnosis and treatment in the neurodegeneration field ● Lonza to develop, optimize, and qualify a method utilizing Neuron-Derived Exosomes (“NDEs”

April 5, 2024 EX-99.1

NeuroSense Announces Year End 2023 Financial Results and Provides Business Update

Exhibit 99.1 NeuroSense Announces Year End 2023 Financial Results and Provides Business Update CAMBRIDGE, Mass., April 5, 2024 /PRNewswire/ - NeuroSense Therapeutics Ltd. (Nasdaq: NRSN) (“NeuroSense”), a company developing novel treatments for severe neurodegenerative diseases, today reported its financial results for the year ended December 31, 2023 and provides a business update. Corporate Highl

April 5, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of April 2024 Commission File Number: 001-4108

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of April 2024 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliya 4

April 4, 2024 POS AM

As filed with the Securities and Exchange Commission on April 4, 2024.

As filed with the Securities and Exchange Commission on April 4, 2024. Registration No. 333-260338 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 POST-EFFECTIVE AMENDMENT NO. 4 TO FORM F-1 ON FORM F-3 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 NeuroSense Therapeutics Ltd. (Exact Name of Registrant as Specified in Its Charter) Not Applicable (Translation of Reg

April 4, 2024 EX-12.1

CERTIFICATION BY CHIEF EXECUTIVE OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002

Exhibit 12.1 CERTIFICATION BY CHIEF EXECUTIVE OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, Alon Ben-Noon, certify that: 1. I have reviewed this annual report on Form 20-F of NeuroSense Therapeutics Ltd.; 2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in li

April 4, 2024 EX-13.2

CERTIFICATION BY CHIEF FINANCIAL OFFICER PURSUAN TO SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

Exhibit 13.2 CERTIFICATION BY CHIEF FINANCIAL OFFICER PURSUAN TO SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002 In connection with the Annual Report of NeuroSense Therapeutics Ltd. (the “Company”) on Form 20-F for the period ended December 31, 2023 as filed with the Securities and Exchange Commission on the date hereof (the “Report”), the undersigned officer of the Company certifies, pursuant to 18

April 4, 2024 EX-15.1

Consent of Independent Registered Public Accounting Firm

Exhibit 15.1 Consent of Independent Registered Public Accounting Firm We consent to the incorporation by reference in the registration statements (No. 333-262480) on Form S-8 and (No. 333-269306) on Form F-3 of our report dated April 3, 2024, with respect to the consolidated financial statements of Neurosense Therapeutics Ltd. /s/ Somekh Chaikin Member Firm of KPMG International Tel Aviv, Israel A

April 4, 2024 20-F

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 20-F ☐ REGISTRATION STATEMENT PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHA

UNITED STATES SECURITIES AND EXCHANGE COMMISSION WASHINGTON, D.C. 20549 FORM 20-F ☐ REGISTRATION STATEMENT PURSUANT TO SECTION 12(b) OR (g) OF THE SECURITIES EXCHANGE ACT OF 1934 OR ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the fiscal year ended December 31, 2023 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT O

April 4, 2024 POS AM

As filed with the Securities and Exchange Commission on April 4, 2024.

As filed with the Securities and Exchange Commission on April 4, 2024. Registration No. 333-273375 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 POST-EFFECTIVE AMENDMENT NO. 1 TO FORM F-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 NeuroSense Therapeutics Ltd. (Exact Name of Registrant as Specified in Its Charter) Not Applicable (Translation of Registrant’s na

April 4, 2024 EX-97.1

NeuroSense Therapeutics Ltd. Compensation Clawback Policy Adopted August, 2023

Exhibit 97.1 NeuroSense Therapeutics Ltd. Compensation Clawback Policy Adopted August, 2023 Purpose The Board of Directors (the “Board”) of NeuroSense Therapeutics Ltd. (the “Company”) has adopted this compensation clawback policy (the “Policy”) which provides for the recoupment of incentive-based compensation in the event of an accounting restatement. This Policy is intended to comply with Sectio

April 4, 2024 EX-12.2

CERTIFICATION BY CHIEF FINANCIAL OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002

Exhibit 12.2 CERTIFICATION BY CHIEF FINANCIAL OFFICER PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002 I, Or Eisenberg, certify that: 1. I have reviewed this annual report on Form 20-F of NeuroSense Therapeutics Ltd.; 2. Based on my knowledge, this report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in lig

April 4, 2024 EX-2.1

DESCRIPTION OF SHARE CAPITAL AND ARTICLES OF ASSOCIATION

Exhibit 2.1 DESCRIPTION OF SHARE CAPITAL AND ARTICLES OF ASSOCIATION The following descriptions of our share capital and provisions of our amended and restated articles of association are summaries and are qualified by reference to the amended and restated articles of association, which are filed as an exhibit to this Annual Report on Form 20-F. General Our authorized share capital consists of 60,

April 4, 2024 EX-13.1

CERTIFICATION BY CHIEF EXECUTIVE OFFICER PURSUAN TO SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

Exhibit 13.1 CERTIFICATION BY CHIEF EXECUTIVE OFFICER PURSUAN TO SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002 In connection with the Annual Report of NeuroSense Therapeutics Ltd. (the “Company”) on Form 20-F for the period ended December 31, 2023 as filed with the Securities and Exchange Commission on the date hereof (the “Report”), the undersigned officer of the Company certifies, pursuant to 18

February 22, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of February 2024 Commission File Number: 001-4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of February 2024 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) 11 HaMenofim Street, Building B Herzliya 4672562 Israel +972-9-79961

February 22, 2024 EX-99.1

February 2024 Nasdaq: NRSN Forward - Looking Statements This presentation and oral statements made regarding the subject of this presentation contain "forward - looking statements" within the meaning of the U . S . Private Securities Litigation Refor

Exhibit 99.1 February 2024 Nasdaq: NRSN Forward - Looking Statements This presentation and oral statements made regarding the subject of this presentation contain "forward - looking statements" within the meaning of the U . S . Private Securities Litigation Reform Act of 1995 that involve substantial risks and uncertainties . All statements contained in this presentation other than statements of h

February 13, 2024 SC 13G/A

NRSN / NeuroSense Therapeutics Ltd. / Gordon Ariel - AMENDMENT NO. 2 TO SCHEDULE 13G Passive Investment

SC 13G/A 1 ea193576-13ga2gordonneuro.htm AMENDMENT NO. 2 TO SCHEDULE 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A UNDER THE SECURITIES EXCHANGE ACT OF 1934 (Amendment No. 2)* NeuroSense Therapeutics Ltd. (Name of Issuer) Ordinary Shares, no par value (Title of Class of Securities) M74240 108 (CUSIP Number) December 31, 2023 (Date of Event Which Require

February 13, 2024 SC 13G/A

NRSN / NeuroSense Therapeutics Ltd. / Ben-Noon Alon - AMENDMENT NO. 2 TO SCHEDULE 13G Passive Investment

SC 13G/A 1 ea193567-13ga2bennoonneuro.htm AMENDMENT NO. 2 TO SCHEDULE 13G UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 SCHEDULE 13G/A UNDER THE SECURITIES EXCHANGE ACT OF 1934 (AMENDMENT NO. 2) NeuroSense Therapeutics Ltd. (Name of Issuer) Ordinary Shares, no par value (Title of Class of Securities) M74240 108 (CUSIP Number) December 31, 2023 (Date of Event Which Require

February 7, 2024 EX-99.1

NeuroSense Regains Compliance with NASDAQ Minimum Bid Price Rule

Exhibit 99.1 NeuroSense Regains Compliance with NASDAQ Minimum Bid Price Rule CAMBRIDGE, Mass., February 7, 2024 - NeuroSense Therapeutics Ltd. (Nasdaq: NRSN) (“NeuroSense”), a company developing treatments for severe neurodegenerative diseases, today announced that it has received notice from The Nasdaq Stock Market LLC (“Nasdaq”) informing the Company that it has regained compliance with the min

February 7, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of February 2024 Commission File Number: 001-4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of February 2024 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliy

January 9, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of January 2024 Commission File Number: 001-41

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of January 2024 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliya

January 9, 2024 EX-99.1

NeuroSense Recaps Positive 2023 Achievements Including Statistically Significant Slowing of Disease Progression in Phase 2b ALS Trial of PrimeC and Highlights Anticipated 2024 Catalysts End of Phase 2 meeting with the FDA and EMA expected in Q2 2024

Exhibit 99.1 NeuroSense Recaps Positive 2023 Achievements Including Statistically Significant Slowing of Disease Progression in Phase 2b ALS Trial of PrimeC and Highlights Anticipated 2024 Catalysts End of Phase 2 meeting with the FDA and EMA expected in Q2 2024 and several biomarker study results anticipated as early as Q1 2024, as the Company advances partnership discussions CAMBRIDGE, Mass., Ja

January 9, 2024 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of January 2024 Commission File Number: 001-41

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of January 2024 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliya

January 9, 2024 EX-99.1

EX-99.1

Exhibit 99.1

December 27, 2023 424B3

Up to 1,755,000 Ordinary Shares Underlying Previously Issued Warrants

PROSPECTUS SUPPLEMENT NO. 3 (to prospectus dated December 4, 2023) Filed Pursuant to Rule 424(b)(3) Registration No. 333-260338 Up to 1,755,000 Ordinary Shares Underlying Previously Issued Warrants This prospectus supplement updates, amends and supplements the prospectus dated December 4, 2023 (as supplemented or amended from time to time, the “Prospectus”), which forms a part of our Registration

December 27, 2023 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of December 2023 Commission File Number: 001-4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of December 2023 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliy

December 27, 2023 EX-99.1

NeuroSense Announces Receipt of Nasdaq Notice Regarding Minimum Stockholders’ Equity Requirement

Exhibit 99.1 NeuroSense Announces Receipt of Nasdaq Notice Regarding Minimum Stockholders’ Equity Requirement ● This notification has no immediate effect on the listing or trading of NeuroSense’s ordinary shares on the Nasdaq Capital Market CAMBRIDGE, Mass., December 27, 2023 - NeuroSense Therapeutics Ltd. (Nasdaq: NRSN) (“NeuroSense” or the “Company”), a company developing treatments for severe n

December 21, 2023 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of December 2023 Commission File Number: 001-4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of December 2023 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) 11 HaMenofim Street, Building B Herzliya 4672562 Israel +972-9-799-6

December 21, 2023 EX-99.1

December 2023 Nasdaq: NRSN Forward - Looking Statements 2 This presentation and oral statements made regarding the subject of this presentation contain "forward - looking statements" within the meaning of the U . S . Private Securities Litigation Ref

Exhibit 99.1 December 2023 Nasdaq: NRSN Forward - Looking Statements 2 This presentation and oral statements made regarding the subject of this presentation contain "forward - looking statements" within the meaning of the U . S . Private Securities Litigation Reform Act of 1995 that involve substantial risks and uncertainties . All statements contained in this presentation other than statements of

December 14, 2023 424B3

Up to 1,755,000 Ordinary Shares Underlying Previously Issued Warrants

PROSPECTUS SUPPLEMENT NO. 2 (to prospectus dated December 4, 2023) Filed Pursuant to Rule 424(b)(3) Registration No. 333-260338 Up to 1,755,000 Ordinary Shares Underlying Previously Issued Warrants This prospectus supplement updates, amends and supplements the prospectus dated December 4, 2023 (as supplemented or amended from time to time, the “Prospectus”), which forms a part of our Registration

December 14, 2023 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of December 2023 Commission File Number: 001-4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of December 2023 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) 11 HaMenofim Street, Building B Herzliya 4672562 Israel +972-9-799-6

December 14, 2023 EX-99.1

NeuroSense Reports New Data: Statistically Significant Clinical Efficacy in Phase 2b ALS Trial

Exhibit 99.1 NeuroSense Reports New Data: Statistically Significant Clinical Efficacy in Phase 2b ALS Trial ● A statistically significant, 37.4% difference (P=0.03), slowing of disease progression in-ALSFRS-R, in patients treated with PrimeC compared to placebo, in the pre-specified Per Protocol (PP) population analysis ● Neurofilament biomarker results from Biogen collaboration expected in Januar

December 5, 2023 424B3

Up to 1,755,000 Ordinary Shares Underlying Previously Issued Warrants

PROSPECTUS SUPPLEMENT NO. 1 (to prospectus dated December 4, 2023) Filed Pursuant to Rule 424(b)(3) Registration No. 333-260338 Up to 1,755,000 Ordinary Shares Underlying Previously Issued Warrants This prospectus supplement updates, amends and supplements the prospectus dated December 4, 2023 (as supplemented or amended from time to time, the “Prospectus”), which forms a part of our Registration

December 5, 2023 424B3

Up to 1,755,000 Ordinary Shares Underlying Previously Issued Warrants NeuroSense Therapeutics Ltd.

Filed Pursuant to Rule 424(b)(3) PROSPECTUS Registration No. 333-260338 Up to 1,755,000 Ordinary Shares Underlying Previously Issued Warrants NeuroSense Therapeutics Ltd. This prospectus relates to the issuance of up to (i) 1,655,000 of our ordinary shares, no par value per share (the “ordinary shares”) issuable upon the exercise of warrants that were issued as part of an initial public offering (

December 5, 2023 EX-99.2

NeuroSense’s Phase 2b ALS Trial Achieves Primary Safety and Tolerability & Secondary Clinical Efficacy Endpoints

Exhibit 99.2 NeuroSense’s Phase 2b ALS Trial Achieves Primary Safety and Tolerability & Secondary Clinical Efficacy Endpoints ● Top-Line Results from 6-month double-blind Phase 2b PARADIGM trial with NeuroSense’s lead drug candidate for ALS, PrimeC, include: o PrimeC achieved primary safety and tolerability endpoints with a safety and tolerability profile comparable to placebo o Meaningful slowing

December 5, 2023 EX-99.1

NeuroSense to Report Phase 2b ALS Topline Primary Safety and Tolerability & Secondary Clinical Efficacy Endpoints on December 5, 2023

Exhibit 99.1 NeuroSense to Report Phase 2b ALS Topline Primary Safety and Tolerability & Secondary Clinical Efficacy Endpoints on December 5, 2023 Data to be announced in a premarket press release followed by a conference call at 8:30 am ET CAMBRIDGE, Mass., Dec. 4, 2023 /PRNewswire/ - NeuroSense Therapeutics Ltd. (Nasdaq: NRSN) (“NeuroSense”), a company developing treatments for neurodegenerative

December 5, 2023 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of December 2023 Commission File Number: 001-4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of December 2023 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) 11 HaMenofim Street, Building B Herzliya 4672562 Israel +972-9-799-6

December 4, 2023 POS AM

As filed with the Securities and Exchange Commission on December 4, 2023.

As filed with the Securities and Exchange Commission on December 4, 2023. Registration No. 333-260338 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 POST-EFFECTIVE AMENDMENT NO. 3 TO FORM F-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 NeuroSense Therapeutics Ltd. (Exact Name of Registrant as Specified in Its Charter) Not Applicable (Translation of Registrant’s

December 4, 2023 CORRESP

NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliya 4672562 Israel

NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliya 4672562 Israel December 4, 2023 Via EDGAR Securities and Exchange Commission Division of Corporation Finance 100 F Street, N.E. Washington, D.C. 20549-3561 Attn: Lauren Hamill Re: NeuroSense Therapeutics Ltd. Post-Effective Amendment No. 3 to Registration Statement on Form F-1 Filed December 4, 2023 File No. 333-260338 Ladies an

November 28, 2023 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of November 2023 Commission File Number: 001-4

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K Report of Foreign Private Issuer Pursuant to Rule 13a-16 or 15d-16 Under the Securities Exchange Act of 1934 For the Month of November 2023 Commission File Number: 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) 11 HaMenofim Street, Building B Herzliya 4672562 Israel +972-9-799-6

November 28, 2023 EX-99.1

NeuroSense Announces Third Quarter 2023 Financial Results and Provides Business Update

Exhibit 99.1 NeuroSense Announces Third Quarter 2023 Financial Results and Provides Business Update ● Topline clinical secondary efficacy results and primary safety endpoints from Phase 2b ALS trial (PARADIGM) expected in early December 2023 ● Patients who completed the 18-month PARADIGM trial, including the 6-month double-blind study plus the 12-month open label extension, have requested to conti

November 21, 2023 EX-10.2

NEUROSENSE THERAPEUTICS LTD. 2018 SHARE INCENTIVE PLAN AMENDED BY THE BOARD OF DIRECTORS ON AUGUST 30, 2022 NEUROSENSE THERAPEUTICS LTD. 2018 SHARE INCENTIVE PLAN

Exhibit 10.2 NEUROSENSE THERAPEUTICS LTD. 2018 SHARE INCENTIVE PLAN AMENDED BY THE BOARD OF DIRECTORS ON AUGUST 30, 2022 NEUROSENSE THERAPEUTICS LTD. 2018 SHARE INCENTIVE PLAN 1. Purpose. The purpose of this 2018 Share Incentive Plan (the “Plan”) is to advance the interests of the Company and its shareholders by attracting and retaining the best available personnel for positions of substantial res

November 21, 2023 POS AM

As filed with the Securities and Exchange Commission on November 21, 2023.

As filed with the Securities and Exchange Commission on November 21, 2023. Registration No. 333-260338 UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 POST-EFFECTIVE AMENDMENT NO. 2 TO FORM F-1 REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933 NeuroSense Therapeutics Ltd. (Exact Name of Registrant as Specified in Its Charter) Not Applicable (Translation of Registrant’

November 13, 2023 6-K

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 FOR THE MONTH OF NOVEMBER 2023 COMMISSION FILE NUMBER 001-41

UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 6-K REPORT OF FOREIGN PRIVATE ISSUER PURSUANT TO RULE 13a-16 OR 15d-16 UNDER THE SECURITIES EXCHANGE ACT OF 1934 FOR THE MONTH OF NOVEMBER 2023 COMMISSION FILE NUMBER 001-41084 NeuroSense Therapeutics Ltd. (Translation of registrant’s name into English) NeuroSense Therapeutics Ltd. 11 HaMenofim Street, Building B Herzliya

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